Geographically weighted linear combination test for gene-set analysis of a continuous spatial phenotype as applied to intratumor heterogeneity.
(2023)
Journal Article
Amini, P., Hajihosseini, M., Pyne, S., & Dinu, I. (2023). Geographically weighted linear combination test for gene-set analysis of a continuous spatial phenotype as applied to intratumor heterogeneity. Frontiers in Cell and Developmental Biology, 11, Article 1065586. https://doi.org/10.3389/fcell.2023.1065586
Background: The impact of gene-sets on a spatial phenotype is not necessarily uniform across different locations of cancer tissue. This study introduces a computational platform, GWLCT, for combining gene set analysis with spatial data modeling to pr... Read More about Geographically weighted linear combination test for gene-set analysis of a continuous spatial phenotype as applied to intratumor heterogeneity..