Correction: Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes
(2024)
Journal Article
Gamez, M., Elhegni, H. E., Fawaz, S., Ho Ho, K., Campbell, N. W., Copland, D. A., …Foster, R. R. (in press). Correction: Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes. Cardiovascular Diabetology, 23(1), 74. https://doi.org/10.1186/s12933-024-02170-w
Outputs (52)
Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes (2024)
Journal Article
Gamez, M., Elhegni, H. E., Fawaz, S., Ho, K. H., Campbell, N. W., Copland, D. A., …Foster, R. R. (in press). Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes. Cardiovascular Diabetology, 23(1), Article 50. https://doi.org/10.1186/s12933-024-02133-1Background Diabetes mellitus is a chronic disease which is detrimental to cardiovascular health, often leading to secondary microvascular complications, with huge global health implications. Therapeutic interventions that can be applied to multiple... Read More about Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes.
Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects that Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells (2023)
Journal Article
Pagani, I., Ottoboni, L., Panina-Bordignon, P., Martino, G., Poli, G., Taylor, S., …Vicenzi, E. (in press). Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects that Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells. Pharmaceuticals, 16(10), Article 1385. https://doi.org/10.3390/ph16101385Zika virus (ZIKV) infection during pregnancy can result in severe birth defects, such as microcephaly, as well as a range of other related health complications. Heparin, a clinical-grade anticoagulant, is shown to protect neural progenitor cells from... Read More about Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects that Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells.
Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination. (2023)
Journal Article
Turnbull. (2023). Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination. Glia, 71(7), 1683-1698. https://doi.org/10.1002/glia.24363There is an urgent need for therapies that target the multicellular pathology of central nervous system (CNS) disease. Modified, nonanticoagulant heparins mimic the heparan sulfate glycan family and are known regulators of multiple cellular processes... Read More about Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination..
Validation of Recombinant Heparan Sulphate Reagents for CNS Repair. (2023)
Journal Article
Turnbull. (2023). Validation of Recombinant Heparan Sulphate Reagents for CNS Repair. Biology, 12(3), Article 407. https://doi.org/10.3390/biology12030407Therapies that target the multicellular pathology of central nervous system (CNS) disease/injury are urgently required. Modified non-anticoagulant heparins mimic the heparan sulphate (HS) glycan family and have been proposed as therapeutics for CNS r... Read More about Validation of Recombinant Heparan Sulphate Reagents for CNS Repair..
Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State. (2023)
Journal Article
Devlin, A. J., Mycroft-West, C. J., Turnbull, J. E., Andrade De Lima, M., Guerrini, M., Yates, E. A., & Skidmore, M. A. (2023). Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State. ACS Central Science, 9, 381-392. https://doi.org/10.1021/acscentsci.2c01176Heparin is a polydisperse, heterogeneous polysaccharide of the glycosaminoglycan (GAG) class that has found widespread clinical use as a potent anticoagulant and is classified as an essential medicine by the World Health Organization. The importance... Read More about Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State..
High sensitivity (zeptomole) detection of BODIPY- labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts. (2023)
Journal Article
Maciej-Hulme, M. L., Leprince, A. C., Lavin, A., Guimond, S. E., Turnbull, J. E., Pelletier, J., …Skidmore, M. A. (2023). High sensitivity (zeptomole) detection of BODIPY- labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts. Analytical Methods, 15(11), 1461-1469. https://doi.org/10.1039/d2ay01803aThe fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in... Read More about High sensitivity (zeptomole) detection of BODIPY- labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts..
Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors. (2023)
Journal Article
Gray, A., Karlsson, R., Roberts, A., Ridley, A., Pun, N., Khan, B., …Salanga, C. (2023). Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors. Cell Reports, 111930 - ?. https://doi.org/10.1016/j.celrep.2022.111930Leukocyte recruitment from the vasculature into tissues is a crucial component of the immune system but is also key to inflammatory disease. Chemokines are central to this process but have yet to be therapeutically targeted during inflammation due to... Read More about Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors..
Editorial: C. elegans as an emerging model of pharmacological innovation. (2022)
Journal Article
Turnbull. (2022). Editorial: C. elegans as an emerging model of pharmacological innovation. Frontiers in Pharmacology, 1029752 - ?. https://doi.org/10.3389/fphar.2022.1029752
Evidence for multiple binding modes in the initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans. (2022)
Journal Article
Parafioriti, M., Ni, M., Petitou, M., Mycroft‐West, C. J., Rudd, T. R., Gandhi, N. S., …Elli, S. (2023). Evidence for multiple binding modes in the initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans. Chemistry - A European Journal, 29(1), https://doi.org/10.1002/chem.202202599Infection of host cells by SARS-CoV-2 begins with recognition by the virus S (spike) protein of cell surface heparan sulfate (HS), tethering the virus to the extracellular matrix environment, and causing the subunit S1-RBD to undergo a conformational... Read More about Evidence for multiple binding modes in the initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans..
Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction. (2022)
Journal Article
Guimond, S., Mycroft-West, C. J., Gandhi, N. S., Tree, J. A., C.Le, T. T., Spalluto, M., …Turnbull, J. E. (2022). Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction. ACS Central Science, 8(5), 527 - 545. https://doi.org/10.1021/acscentsci.1c01293Heparan sulfate (HS) is a cell surface polysaccharide recently identified as a coreceptor with the ACE2 protein for the S1 spike protein on SARS-CoV-2 virus, providing a tractable new therapeutic target. Clinically used heparins demonstrate an inhibi... Read More about Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction..
Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain. (2021)
Journal Article
Schuurs, Z. P., Hammond, E., Elli, S., Rudd, T. R., Mycroft-West, C. J., Lima, M. A., …Gandhi, N. S. (2021). Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain. Computational and Structural Biotechnology Journal, 19, 2806 - 2818. https://doi.org/10.1016/j.csbj.2021.05.002SARS-CoV-2 has rapidly spread throughout the world's population since its initial discovery in 2019. The virus infects cells via a glycosylated spike protein located on its surface. The protein primarily binds to the angiotensin-converting enzyme-2 (... Read More about Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain..
Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates (2021)
Journal Article
Karlsson, R., Chopra, P., Joshi, A., Yang, Z., Vakhrushev, S. Y., Clausen, T. M., …Miller, R. L. (2021). Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates. Science Advances, 7(52), https://doi.org/10.1126/sciadv.abl6026Heparan sulfate (HS) polysaccharides are master regulators of diverse biological processes via sulfated motifs that can recruit specific proteins. 3-O-sulfation of HS/heparin is crucial for anticoagulant activity, but despite emerging evidence for ro... Read More about Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates.
Tian-Huang Formula, a Traditional Chinese Medicinal Prescription, Improves Hepatosteatosis and Glucose Intolerance Targeting AKT-SREBP Nexus in Diet-Induced Obese Rats (2021)
Journal Article
Li, K., Yu, Y., Yuan, M., Zhang, C., Rong, X., Turnbull, J. E., & Guo, J. (2021). Tian-Huang Formula, a Traditional Chinese Medicinal Prescription, Improves Hepatosteatosis and Glucose Intolerance Targeting AKT-SREBP Nexus in Diet-Induced Obese Rats. Evidence-Based Complementary and Alternative Medicine, 2021, 1-15. https://doi.org/10.1155/2021/6617586
Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations. (2021)
Journal Article
Tree, J., Turnbull, J., Buttigieg, K., Elmore, M., Coombes, N., Hogwood, J., …Carroll, M. (2021). Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations. British Journal of Pharmacology, 178, 626--635. https://doi.org/10.1111/bph.15304BACKGROUND AND PURPOSE: Currently, there are no licensed vaccines and limited antivirals for the treatment of COVID-19. Heparin (delivered systemically) is currently used to treat anticoagulant anomalies in COVID-19 patients. Additionally, in the Uni... Read More about Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations..
Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. (2020)
Journal Article
Mycroft-West, C. J., Su, D., Pagani , I., Rudd , T. R., Elli , S., Gandhi , N. S., …Skidmore , M. A. (2020). Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. Thrombosis and Haemostasis, 120(12), 1700 - 1715. https://doi.org/10.1055/s-0040-1721319The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and extracellular glycosaminoglycan heparan sulfate (HS) is exploited by many microbial pathogens as a means o... Read More about Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin..
Cryogenic Infrared Spectroscopy Reveals Structural Modularity in the Vibrational Fingerprints of Heparan Sulfate Diastereomers (2020)
Journal Article
Lettow, M., Grabarics, M., Greis, K., Mucha, E., Thomas, D. A., Chopra, P., …Pagel, K. (2020). Cryogenic Infrared Spectroscopy Reveals Structural Modularity in the Vibrational Fingerprints of Heparan Sulfate Diastereomers. Analytical Chemistry, 92(15), 10228-10232. https://doi.org/10.1021/acs.analchem.0c02048Heparan sulfate and heparin are highly acidic polysaccharides with a linear sequence, consisting of alternating glucosamine and hexuronic acid building blocks. The identity of hexuronic acid units shows a variability along their sequence, as d-glucur... Read More about Cryogenic Infrared Spectroscopy Reveals Structural Modularity in the Vibrational Fingerprints of Heparan Sulfate Diastereomers.
Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain (2020)
Journal Article
Mycroft-West, C. J., Su, D., Li, Y., Guimond, S. E., Rudd, T. R., Elli, S., …Skidmore, M. A. Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain. bioRxiv, https://doi.org/10.1101/2020.04.29.068767The glycosaminoglycan (GAG) class of polysaccharides are utilised by a plethora of microbial pathogens as receptors for adherence and invasion. The GAG heparin prevents infection by a range of viruses when added exogenously, including the S-associate... Read More about Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain.
SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins (2020)
Journal Article
Mycroft-West, C. J., Su, D., Li, Y., Guimond, S. E., Rudd, T. R., Elli, S., …Skidmore, M. A. SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins. arXiv, https://doi.org/10.1101/2020.04.29.068486The dependence of the host on the interaction of hundreds of extracellular proteins with the cell surface glycosaminoglycan heparan sulphate (HS) for the regulation of homeostasis is exploited by many microbial pathogens as a means of adherence and i... Read More about SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins.
Better growth-factor binding aids tissue repair (2020)
Journal Article
Lord, M., Whitelock, J., & Turnbull, J. E. (2020). Better growth-factor binding aids tissue repair. Nature Biomedical Engineering, 4(4), 368-369. https://doi.org/10.1038/s41551-020-0548-3
Interaction with the heparin-derived binding inhibitors destabilizes galectin-3 protein structure (2020)
Journal Article
Sindrewicz, P., Yates, E. A., Turnbull, J. E., Lian, L., & Yu, L. (2020). Interaction with the heparin-derived binding inhibitors destabilizes galectin-3 protein structure. Biochemical and Biophysical Research Communications, 523(2), 336-341. https://doi.org/10.1016/j.bbrc.2019.12.054
Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides (2020)
Journal Article
Miller, R. L., Guimond, S. E., Schwörer, R., Zubkova, O. V., Tyler, P. C., Xu, Y., …Pagel, K. (2020). Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides. Nature communications, 11, Article 1481. https://doi.org/10.1038/s41467-020-15284-yDespite evident regulatory roles of heparan sulfate (HS) saccharides in numerous biological processes, definitive information on the bioactive sequences of these polymers is lacking, with only a handful of natural structures sequenced to date. Here,... Read More about Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides.
Omics Insights into Metabolic Stress and Resilience of Rats in Response to Short‐term Fructose Overfeeding (2019)
Journal Article
Li, K., Yuan, M., He, Z., Wu, Q., Zhang, C., Lei, Z., …Guo, J. (2019). Omics Insights into Metabolic Stress and Resilience of Rats in Response to Short‐term Fructose Overfeeding. Molecular Nutrition and Food Research, 63(23), 1900773. https://doi.org/10.1002/mnfr.201900773
Intrinsic tryptophan fluorescence spectroscopy reliably determines galectin-ligand interactions (2019)
Journal Article
Sindrewicz, P., Li, X., Yates, E. A., Turnbull, J. E., Lian, L., & Yu, L. Intrinsic tryptophan fluorescence spectroscopy reliably determines galectin-ligand interactions. Scientific reports, 9(1), https://doi.org/10.1038/s41598-019-47658-8
Heparan Sulfate Proteoglycan Synthesis Is Dysregulated in Human Osteoarthritic Cartilage (2019)
Journal Article
Chanalaris, A., Clarke, H., Guimond, S. E., Vincent, T. L., Turnbull, J. E., & Troeberg, L. (2019). Heparan Sulfate Proteoglycan Synthesis Is Dysregulated in Human Osteoarthritic Cartilage. American Journal of Pathology, 189(3), 632-647. https://doi.org/10.1016/j.ajpath.2018.11.011
By-Products of Heparin Production Provide a Diverse Source of Heparin-like and Heparan Sulfate Glycosaminoglycans (2019)
Journal Article
Taylor, S. L., Hogwood, J., Guo, W., Yates, E. A., & Turnbull, J. E. By-Products of Heparin Production Provide a Diverse Source of Heparin-like and Heparan Sulfate Glycosaminoglycans. Scientific reports, 9(1), https://doi.org/10.1038/s41598-019-39093-6
Low sulfated heparins target multiple proteins for central nervous system repair (2018)
Journal Article
McCanney, G. A., McGrath, M. A., Otto, T. D., Burchmore, R., Yates, E. A., Bavington, C. D., …Barnett, S. C. (2019). Low sulfated heparins target multiple proteins for central nervous system repair. Glia, 67(4), 668-687. https://doi.org/10.1002/glia.23562
Dendrimer Heparan Sulfate Glycomimetics: Potent Heparanase Inhibitors for Anticancer Therapy (2018)
Journal Article
Zubkova, O. V., Ahmed, Y. A., Guimond, S. E., Noble, S., Miller, J. H., Alfred Smith, R. A., …Turnbull, J. E. (2018). Dendrimer Heparan Sulfate Glycomimetics: Potent Heparanase Inhibitors for Anticancer Therapy. ACS chemical biology, 13(12), 3236-3242. https://doi.org/10.1021/acschembio.8b00909
Enhancing the glycosciences toolkit: new GAGs in the lineup (2018)
Journal Article
Turnbull, J. E. (2018). Enhancing the glycosciences toolkit: new GAGs in the lineup. Nature Methods, 15(11), 867-868. https://doi.org/10.1038/s41592-018-0190-0
The Satellite Cell Niche Regulates the Balance between Myoblast Differentiation and Self-Renewal via p53 (2018)
Journal Article
Flamini, V., Ghadiali, R. S., Antczak, P., Rothwell, A., Turnbull, J. E., & Pisconti, A. (2018). The Satellite Cell Niche Regulates the Balance between Myoblast Differentiation and Self-Renewal via p53. Stem Cell Reports, 10(3), 970-983. https://doi.org/10.1016/j.stemcr.2018.01.007
Versatile Separation and Analysis of Heparan Sulfate Oligosaccharides Using Graphitized Carbon Liquid Chromatography and Electrospray Mass Spectrometry (2017)
Journal Article
Miller, R. L., Guimond, S. E., Prescott, M., Turnbull, J. E., & Karlsson, N. (2017). Versatile Separation and Analysis of Heparan Sulfate Oligosaccharides Using Graphitized Carbon Liquid Chromatography and Electrospray Mass Spectrometry. Analytical Chemistry, 89(17), 8942-8950. https://doi.org/10.1021/acs.analchem.7b01417
How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans (2017)
Journal Article
Cartmell, A., Lowe, E. C., Baslé, A., Basle, A., Firbank, S. J., Ndeh, D. A., …Bolam, D. N. (2017). How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans. Proceedings of the National Academy of Sciences of the United States of America, 114(27), 7037-7042. https://doi.org/10.1073/pnas.1704367114
Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling (2017)
Journal Article
Ghadiali, R., Guimond, S., Turnbull, J., & Pisconti, A. (2017). Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling. Matrix Biology, 59, 54-68. https://doi.org/10.1016/j.matbio.2016.07.007
Label-Free Discovery Array Platform for the Characterization of Glycan Binding Proteins and Glycoproteins (2017)
Journal Article
Gray, C. J., Sánchez-Ruíz, A., Šardzíková, I., Ahmed, Y. A., Miller, R. L., Reyes Martinez, J. E., …Flitsch, S. L. (2017). Label-Free Discovery Array Platform for the Characterization of Glycan Binding Proteins and Glycoproteins. Analytical Chemistry, 89(8), 4444-4451. https://doi.org/10.1021/acs.analchem.6b04122
Sulfatase-mediated manipulation of the astrocyte-Schwann cell interface. (2017)
Journal Article
Turnbull, & Guimond. (2017). Sulfatase-mediated manipulation of the astrocyte-Schwann cell interface. Glia, 19 - 33. https://doi.org/10.1002/glia.23047Schwann cell (SC) transplantation following spinal cord injury (SCI) may have therapeutic potential. Functional recovery is limited however, due to poor SC interactions with host astrocytes and the induction of astrogliosis. Olfactory ensheathing cel... Read More about Sulfatase-mediated manipulation of the astrocyte-Schwann cell interface..
Panels of chemically-modified heparin polysaccharides and natural heparan sulfate saccharides both exhibit differences in binding to Slit and Robo, as well as variation between protein binding and cellular activity (2016)
Journal Article
Ahmed, Y. A., Yates, E. A., Moss, D. J., Loeven, M. A., Hussain, S., Hohenester, E., …Powell, A. K. Panels of chemically-modified heparin polysaccharides and natural heparan sulfate saccharides both exhibit differences in binding to Slit and Robo, as well as variation between protein binding and cellular activity. Molecular BioSystems, 12(10), 3166-3175. https://doi.org/10.1039/c6mb00432f
Enrichment of Two Isomeric Heparin Oligosaccharides Exhibiting Different Affinities toward Monocyte Chemoattractant Protein-1 (2016)
Journal Article
Miller, R. L., Dykstra, A. B., Wei, W., Holsclaw, C., Turnbull, J. E., & Leary, J. A. (2016). Enrichment of Two Isomeric Heparin Oligosaccharides Exhibiting Different Affinities toward Monocyte Chemoattractant Protein-1. Analytical Chemistry, 88(23), 11551-11558. https://doi.org/10.1021/acs.analchem.6b02803
Heparin Isomeric Oligosaccharide Separation Using Volatile Salt Strong Anion Exchange Chromatography (2016)
Journal Article
Miller, R. L., Guimond, S. E., Shivkumar, M., Blocksidge, J., Austin, J. A., Leary, J. A., & Turnbull, J. E. (2016). Heparin Isomeric Oligosaccharide Separation Using Volatile Salt Strong Anion Exchange Chromatography. Analytical Chemistry, 88(23), 11542-11550. https://doi.org/10.1021/acs.analchem.6b02801
Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding (2015)
Journal Article
Solari, V., Rudd, T. R., Guimond, S. E., Powell, A. K., Turnbull, J. E., & Yates, E. A. Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding. Organic and Biomolecular Chemistry, 13(21), 6066-6072. https://doi.org/10.1039/c5ob00564g
Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions (2015)
Journal Article
Kalus, I., Rohn, S., Puvirajesinghe, T. M., Guimond, S. E., Eyckerman-Kölln, P. J., ten Dam, G., …Dierks, T. Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions. PloS one, 10(10), e0139853. https://doi.org/10.1371/journal.pone.0139853
Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis (2015)
Journal Article
Duckworth, C. A., Guimond, S. E., Sindrewicz, P., Hughes, A. J., French, N. S., Lian, L., …Yu, L. (2015). Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis. Oncotarget, 6(27), 23671-23687. https://doi.org/10.18632/oncotarget.4409
2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline (2015)
Journal Article
Chan, W. K., Howe, K., Clegg, J. M., Guimond, S. E., Price, D. J., Turnbull, J. E., & Pratt, T. 2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline. PloS one, 10(6), e0130147. https://doi.org/10.1371/journal.pone.0130147
Composition, Sequencing and Ion Mobility Mass Spectrometry of Heparan Sulfate-like Octasaccharide Isomers Differing in Glucuronic and Iduronic Acid Content (2015)
Journal Article
Miller, R. L., Wei, W., Schwörer, R., Zubkova, O. V., Tyler, P. C., Turnbull, J. E., & Leary, J. A. (2015). Composition, Sequencing and Ion Mobility Mass Spectrometry of Heparan Sulfate-like Octasaccharide Isomers Differing in Glucuronic and Iduronic Acid Content. European Journal of Mass Spectrometry, 21(3), 245-254. https://doi.org/10.1255/ejms.1337
Distinct patterns of heparan sulphate in pancreatic islets suggest novel roles in paracrine islet regulation (2015)
Journal Article
Theodoraki, A., Hu, Y., Poopalasundaram, S., Oosterhof, A., Guimond, S. E., Disterer, P., …Bouloux, P. (2015). Distinct patterns of heparan sulphate in pancreatic islets suggest novel roles in paracrine islet regulation. Molecular and Cellular Endocrinology, 399, 296-310. https://doi.org/10.1016/j.mce.2014.09.011
Single-Entity Heparan Sulfate Glycomimetic Clusters for Therapeutic Applications (2015)
Journal Article
Tyler, P. C., Guimond, S. E., Turnbull, J. E., & Zubkova, O. V. (2015). Single-Entity Heparan Sulfate Glycomimetic Clusters for Therapeutic Applications. Angewandte Chemie International Edition, 54(9), 2718-2723. https://doi.org/10.1002/anie.201410251
Nanoscale self-assembled multivalent (SAMul) heparin binders in highly competitive, biologically relevant, aqueous media (2014)
Journal Article
Bromfield, S. M., Posocco, P., Chan, C. W., Calderon, M., Guimond, S. E., Turnbull, J. E., …Smith, D. K. (2014). Nanoscale self-assembled multivalent (SAMul) heparin binders in highly competitive, biologically relevant, aqueous media. Chemical Science, 5(4), 1484. https://doi.org/10.1039/c4sc00298a
MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival (2014)
Journal Article
Solari, V., Borriello, L., Turcatel, G., Shimada, H., Sposto, R., Fernandez, G. E., …DeClerck, Y. A. (2014). MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival. Cancer Research, 74(21), 5999-6009. https://doi.org/10.1158/0008-5472.can-13-2513
Heparan Sulfotransferases Hs6st1 and Hs2st Keep Erk in Check for Mouse Corpus Callosum Development (2014)
Journal Article
Clegg, J. M., Conway, C. D., Howe, K. M., Price, D. J., Mason, J. O., Turnbull, J. E., …Pratt, T. (2014). Heparan Sulfotransferases Hs6st1 and Hs2st Keep Erk in Check for Mouse Corpus Callosum Development. Journal of Neuroscience, 34(6), 2389-2401. https://doi.org/10.1523/jneurosci.3157-13.2014
Synthesis of a Targeted Library of Heparan Sulfate Hexa- to Dodecasaccharides as Inhibitors of β-Secretase: Potential Therapeutics for Alzheimer’s Disease (2013)
Journal Article
Schwörer, R., Zubkova, O. V., Turnbull, J. E., & Tyler, P. C. (2013). Synthesis of a Targeted Library of Heparan Sulfate Hexa- to Dodecasaccharides as Inhibitors of β-Secretase: Potential Therapeutics for Alzheimer’s Disease. Chemistry - A European Journal, 19(21), 6817-6823. https://doi.org/10.1002/chem.201204519
Interactions of heparin/heparan sulfate with proteins: Appraisal of structural factors and experimental approaches (2004)
Journal Article
Powell, A. K., Yates, E., Fernig, D., & Turnbull, J. Interactions of heparin/heparan sulfate with proteins: Appraisal of structural factors and experimental approaches. Glycobiology, 14(4), 17R-30R. https://doi.org/10.1093/glycob/cwh051
The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding
Journal Article
Mycroft-West, C., Su, D., Elli, S., Li, Y., Guimond, S., Miller, G., …Skidmore, M. (2020). The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding. arXiv, https://doi.org/10.1101/2020.02.29.971093Many pathogens take advantage of the dependence of the host on the interaction of hundreds of extracellular proteins with the glycosaminoglycans heparan sulphate to regulate homeostasis and use heparan sulphate as a means to adhere and gain access to... Read More about The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding.
Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin
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Mycroft-West, C. J., Su, D., Pagani, I., Rudd, T. R., Elli, S., Guimond, S. E., …Skidmore, M. A. Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin. [Preprint article]