Helen Twohig's Outputs (40)

Reducing pressurised metered dose inhaler prescriptions for asthma to reduce carbon emissions: a qualitative study of healthcare professional perspectives (2025)
Journal Article
Franklin, L., Mallen, C., & Twohig, H. (in press). Reducing pressurised metered dose inhaler prescriptions for asthma to reduce carbon emissions: a qualitative study of healthcare professional perspectives. British Journal of General Practice Open (BJGP Open), 1-17. https://doi.org/10.3399/BJGPO.2024.0208

Background
Prescribing of pressurised metered dose inhalers (pMDIs) is a key NHS carbon hotspot and reducing the number of these devices prescribed will help achieve NHS net zero targets.

Aim
To explore primary healthcare professionals’ perspe... Read More about Reducing pressurised metered dose inhaler prescriptions for asthma to reduce carbon emissions: a qualitative study of healthcare professional perspectives.

The Longitudinal Relationship Between Pain and Depression in People with Inflammatory Arthritis: a Narrative Review (2025)
Journal Article
Cox, N., Farooq, S., Twohig, H., & C Scott, I. (in press). The Longitudinal Relationship Between Pain and Depression in People with Inflammatory Arthritis: a Narrative Review. Arthritis Care & Research, 1-32. https://doi.org/10.1002/acr.25532

As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Co-morbid depression is prevalent in adults with IA, affecting 15 to 39% of people. Whilst pain and depression... Read More about The Longitudinal Relationship Between Pain and Depression in People with Inflammatory Arthritis: a Narrative Review.

Implementation of decarbonisation actions in general practice: a systematic review and narrative synthesis (2025)
Journal Article
Nunes, A. R., Karaba, F., Geddes, O., Bickerton, A., Atherton, H., Dahlmann, F., Eccles, A., Gregg, M., Spencer, R., Twohig, H., & Dale, J. (2025). Implementation of decarbonisation actions in general practice: a systematic review and narrative synthesis. BMJ Open, 15(2), 1-9. https://doi.org/10.1136/bmjopen-2024-091404

Objectives: To summarise and synthesise existing literature on the implementation of decarbonisation actions in general practice, to outline the actions being implemented, factors influencing decarbonisation, identify evidence gaps and questions for... Read More about Implementation of decarbonisation actions in general practice: a systematic review and narrative synthesis.

30-day Unplanned Readmission Rates and Causes in Patients Hospitalized for Acute Coronary Syndrome Based on DANish CoMorbidity Index for Acute Myocardial Infarction Score. (2025)
Journal Article
Sokhal, B. S., Matetić, A., Marshall, M., Twohig, H., Shepherd, T., Mallen, C. D., & Mamas, M. A. (2025). 30-day Unplanned Readmission Rates and Causes in Patients Hospitalized for Acute Coronary Syndrome Based on DANish CoMorbidity Index for Acute Myocardial Infarction Score. Hellenic Journal of Cardiology, https://doi.org/10.1016/j.hjc.2025.01.006

Introduction
This study aimed to investigate the association of the DANish CoMorbidity Index for Acute Myocardial Infarction (DANCAMI) score with 30-day unplanned readmission rates and causes in patients with acut... Read More about 30-day Unplanned Readmission Rates and Causes in Patients Hospitalized for Acute Coronary Syndrome Based on DANish CoMorbidity Index for Acute Myocardial Infarction Score..

Supporting the drive for net zero by decarbonising general practice – A longitudinal study protocol [version 1; peer review: awaiting peer review] (2024)
Journal Article
Raquel Nunes, A., Atherton, H., Dahlmann, F., Eccles, A., Geddes, O., Gregg, M., Jowett, S., Karaba, F., Nelson, L., Spencer, R., Twohig, H., & Dale, J. (2024). Supporting the drive for net zero by decarbonising general practice – A longitudinal study protocol [version 1; peer review: awaiting peer review]. NIHR Open Research, 1-11. https://doi.org/10.3310/nihropenres.13833.1

Introduction
The urgency to address climate change and reduce carbon emissions in healthcare, highlighted in the United Kingdom (UK) by the 'Delivering a 'Net Zero' National Health Service (NHS)' report, emphasises the need for healthcare organisati... Read More about Supporting the drive for net zero by decarbonising general practice – A longitudinal study protocol [version 1; peer review: awaiting peer review].

Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum (2024)
Journal Article
Scott, I. C., Daud, N., Bailey, J., Twohig, H., Hider, S. L., Mallen, C. D., Jordan, K. P., & Muller, S. (2024). Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum. BMC Medicine, 22(1), 575. https://doi.org/10.1186/s12916-024-03774-5

Background: Gabapentinoids are increasingly prescribed in inflammatory arthritis (IA), despite no trial evidence for efficacy at managing pain in this population. Observational studies in non-IA populations suggest gabapentinoids are associated with... Read More about Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum.

Optimising inhaled therapy for patients with asthma. (2024)
Journal Article
Bansal, A., Franklin, L., & Twohig, H. (in press). Optimising inhaled therapy for patients with asthma. BMJ, 386, 1-6. https://doi.org/10.1136/bmj-2024-080353

What you need to know
Sub-optimally controlled asthma is common, in part because of normalisation of symptoms, underuse of preventer therapy, overuse of reliever therapy, and poor inhaler technique. Ensuring patients are using the right inhaled medi... Read More about Optimising inhaled therapy for patients with asthma..

Implementation of decarbonisation actions in general practice: a systematic review and narrative synthesis protocol (2024)
Journal Article
Karaba, F., Raquel Nunes, A., Geddes, O., O, G., Atherton, H., Dahlmann, F., F, D., Eccles, A., A, E., Gregg, M., M, G., Spencer, R., Twohig, H., H, T., & Dale, J. (2024). Implementation of decarbonisation actions in general practice: a systematic review and narrative synthesis protocol. BMJ Open, 14(9), https://doi.org/10.1136/bmjopen-2024-087795

Introduction: There is growing recognition of the importance of primary care in addressing climate change. The World Organisation of Family Doctors has urged general practitioners worldwide to commit to tackling climate change and to serve as agents... Read More about Implementation of decarbonisation actions in general practice: a systematic review and narrative synthesis protocol.

The prescription and monitoring of conventional synthetic disease-modifying anti-rheumatic drugs: British Society for Rheumatology guideline scope (2024)
Journal Article
Mercer, L., Abhishek, A., Kavirayani, A., Ahmed, A., Davidson, A., Foulkes, A., Jones, C., Nash, C., Rose-Parfitt, E., Dhillon, E., Zabate, G., Twohig, H., De Vere, H., Scott, J., Reynolds, J., Holmes, J., Hartley, K., Warrier, K., Nowak, K., Parsons, K., …Galloway, J. (in press). The prescription and monitoring of conventional synthetic disease-modifying anti-rheumatic drugs: British Society for Rheumatology guideline scope. Rheumatology Advances in Practice, 8(3), Article rkae077. https://doi.org/10.1093/rap/rkae077

Lay Summary: What does this mean for patients? A revised guideline, produced by the British Society for Rheumatology (BSR), will provide up-to-date information about the safe prescribing and monitoring of the effects of non-biologic (or conventional... Read More about The prescription and monitoring of conventional synthetic disease-modifying anti-rheumatic drugs: British Society for Rheumatology guideline scope.

AB0228 GABAPENTINOID USE AND THE RISK OF FRACTURES IN PEOPLE WITH INFLAMMATORY ARTHRITIS: NESTED CASE-CONTROL STUDY IN THE CLINICAL PRACTICE RESEARCH DATALINK (CPRD) AURUM (2024)
Presentation / Conference Contribution
Scott, I., Daud, N., Bailey, J., Twohig, H., Hider, S., Mallen, C., Jordan, K., & Muller, S. AB0228 GABAPENTINOID USE AND THE RISK OF FRACTURES IN PEOPLE WITH INFLAMMATORY ARTHRITIS: NESTED CASE-CONTROL STUDY IN THE CLINICAL PRACTICE RESEARCH DATALINK (CPRD) AURUM. Presented at EULAR 2024 European Congress of Rheumatology, 12-15 June. Vienna, Austria, Vienna

Background: Recent observational studies suggest gabapentinoids associate with an increased risk of fractures. The potential for confounding inherent to non-randomised studies of interventions, however, alongside th... Read More about AB0228 GABAPENTINOID USE AND THE RISK OF FRACTURES IN PEOPLE WITH INFLAMMATORY ARTHRITIS: NESTED CASE-CONTROL STUDY IN THE CLINICAL PRACTICE RESEARCH DATALINK (CPRD) AURUM.

Coproducing Health Information Materials With Young People: Reflections and Lessons Learned (2024)
Journal Article
Faux-Nightingale, A., Somayajula, G., Bradbury, C., Bray, L., Burton, C., Chew-Graham, C. A., Gardner, A., Griffin, A., Twohig, H., & Welsh, V. (2024). Coproducing Health Information Materials With Young People: Reflections and Lessons Learned. Health Expectations, 27(3), Article e14115. https://doi.org/10.1111/hex.14115

Background
This paper describes and critically reflects on how children and young people (CYP) acted as public advisors to co-produce health information materials about Long Covid for younger audiences. This work was underpinned by the Lundy model,... Read More about Coproducing Health Information Materials With Young People: Reflections and Lessons Learned.

44 Impact of the danish comorbidity index for acute myocardial infarction score on 30-day unplanned readmission rates and causes in hospitalised patients with acute coronary syndrome (2024)
Presentation / Conference Contribution
Sokhal, B. S., Matetić, A., Marshall, M., Twohig, H., Shepherd, T., Mallen, C., & Mamas, M. (2024, June). 44 Impact of the danish comorbidity index for acute myocardial infarction score on 30-day unplanned readmission rates and causes in hospitalised patients with acute coronary syndrome. Paper presented at British Cardiovascular Society Annual Conference, ‘Back to the patient’, 3–5 June 2024, Manchester

Introduction This study aimed to investigate the association of the DANish CoMorbidity Index for Acute Myocardial Infarction (DANCAMI) score with the 30-day unplanned readmission rates and causes and in acute coronary syndrome (ACS) patients.

Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis [version 1; peer review: awaiting peer review] (2024)
Journal Article
Twohig, H., Bajpai, R., Corp, N., Faux-Nightingale, A., Mallen, C., Robinson, T., Somayajula, G., van-Der-Windt, D., Welsh, V., & Burton, C. (2024). Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis [version 1; peer review: awaiting peer review]. NIHR Open Research, 4(22), https://doi.org/10.3310/nihropenres.13549.1

Background
Children and young people (CYP) may experience prolonged symptoms following COVID-19, commonly termed ‘Long-COVID’. The characteristics of Long-COVID in CYP are unclear, as are the sequalae of acute COVID-19. We aimed to systematically sy... Read More about Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis [version 1; peer review: awaiting peer review].

Treatment of polymyalgia rheumatica: British Society for Rheumatology guideline scope (2024)
Journal Article
Toyoda, T., Armitstead, Z., Bhide, S., Engamba, S., Henderson, E., Jones, C., MacKeith, P., Maddock, J., Reynolds, G., Scrafton, N., Subesinghe, M., Subesinghe, S., Twohig, H., Mackie, S. L., & Yates, M. (in press). Treatment of polymyalgia rheumatica: British Society for Rheumatology guideline scope. Rheumatology Advances in Practice, 8(1), Article rkae002. https://doi.org/10.1093/rap/rkae002

The last British Society for Rheumatology (BSR) guideline on PMR was published in 2009. The guideline needs to be updated to provide a summary of the current evidence for pharmacological and non-pharmacological management of adults with PMR. This gui... Read More about Treatment of polymyalgia rheumatica: British Society for Rheumatology guideline scope.

A Scoping Review of the Effects of Ambient Air Quality on Cognitive Frailty (2023)
Journal Article
Hodgson, J. R., Benkowitz, C., Castellani, B. C., Ellison, A., Yassaie, R., Twohig, H., Bhudia, R., Jutila, O.-E. I., & Fowler-Davis, S. (2023). A Scoping Review of the Effects of Ambient Air Quality on Cognitive Frailty. Environments, 11(1), Article 4. https://doi.org/10.3390/environments11010004

Environmental and public health research has given considerable attention to the impact of air quality on brain health, with systematic reviews being widespread. No literature review has been conducted for cognitive frailty—a multidimensional syndrom... Read More about A Scoping Review of the Effects of Ambient Air Quality on Cognitive Frailty.

Experiences and care needs of children with long Covid: a qualitative study. (2023)
Journal Article
Faux-Nightingale, A., Saunders, B., Burton, C., Chew-Graham, C. A., Somayajula, G., Twohig, H., & Welsh, V. (2023). Experiences and care needs of children with long Covid: a qualitative study. British Journal of General Practice Open (BJGP Open), 8(1), Article 0143. https://doi.org/10.3399/BJGPO.2023.0143

Long Covid, the patient-preferred term, describes symptoms persisting after an acute episode of Covid-19 infection. Symptoms in children and young people (CYP) can affect daily routine, with broader impacts on education, health-related quality of lif... Read More about Experiences and care needs of children with long Covid: a qualitative study..

Analgesic Prescribing in Patients with Inflammatory Arthritis in England: Observational Studies in the Clinical Practice Research Datalink (2023)
Journal Article
Scott, I. C., Jordan, K. P., Twohig, H., Whittle, R., Muller, S., Hider, S. L., Mallen, C. D., & Bailey, J. (2023). Analgesic Prescribing in Patients with Inflammatory Arthritis in England: Observational Studies in the Clinical Practice Research Datalink. Rheumatology, Article kead463. https://doi.org/10.1093/rheumatology/kead463

Despite little evidence that analgesics are effective in inflammatory arthritis (IA), studies report substantial opioid prescribing. The extent this applies to other analgesics is uncertain. We undertook a comprehensive evaluation of analgesic prescr... Read More about Analgesic Prescribing in Patients with Inflammatory Arthritis in England: Observational Studies in the Clinical Practice Research Datalink.

The relationship between pain and depression and anxiety in patients with inflammatory arthritis: a systematic review protocol (2023)
Journal Article
Cox, N., Hawarden, A., Bajpai, R., Farooq, S., Twohig, H., Muller, S., & Scott, I. C. (2024). The relationship between pain and depression and anxiety in patients with inflammatory arthritis: a systematic review protocol. Rheumatology International, 44, 435–440. https://doi.org/10.1007/s00296-023-05450-y

Pain is a major challenge for patients with inflammatory arthritis (IA). Depression and anxiety are common comorbidities in IA, associating with worse outcomes. How they relate to pain is uncertain, with existing systematic reviews (a) mainly conside... Read More about The relationship between pain and depression and anxiety in patients with inflammatory arthritis: a systematic review protocol.

Applying the consolidated framework for implementation research to evaluate the community rapid intervention service (2023)
Journal Article
Moult, A., Baker, D., Twohig, H., Missen, M., Iqbal, Z., Duffy, H., & Paskins, Z. (2023). Applying the consolidated framework for implementation research to evaluate the community rapid intervention service. BMC Health Services Research, 23(1), 844. https://doi.org/10.1186/s12913-023-09864-z

Background: Developed in 2019, the Community Rapid Intervention Service (CRIS) is a community intervention service aiming to prevent hospital admissions. CRIS provides a response within two hours to patients with sub-acute medical needs in their usua... Read More about Applying the consolidated framework for implementation research to evaluate the community rapid intervention service.

Test-retest reliability of pain VAS/NRS, stiffness VAS/NRS, HAQ-DI and mHAQ in polymyalgia rheumatica: An OMERACT study (2023)
Journal Article
Leung, J. L., Twohig, H., Muller, S., Maxwell, L., Mackie, S. L., Neill, L. M., & Owen, C. E. (2023). Test-retest reliability of pain VAS/NRS, stiffness VAS/NRS, HAQ-DI and mHAQ in polymyalgia rheumatica: An OMERACT study. Seminars in Arthritis and Rheumatism, 62, 152239. https://doi.org/10.1016/j.semarthrit.2023.152239

Objective
To examine the test-retest reliability of four measurement instruments in polymyalgia rheumatica (PMR): pain severity visual analogue scale (VAS) / numerical rating score (NRS), stiffness severity VAS/NR... Read More about Test-retest reliability of pain VAS/NRS, stiffness VAS/NRS, HAQ-DI and mHAQ in polymyalgia rheumatica: An OMERACT study.