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Tina Dale's Outputs (33)

Growth Factor‐Loaded Mesoporous Silica Particles, Incorporated in Electrospun PCL Fibres, Provide Topographical and Chemical Cues for Tendon Tissue Engineering (2025)
Journal Article
Citro, V., Clerici, M., Shephard, M. T., Dale, T. P., Boccaccini, A. R., & Forsyth, N. R. (online). Growth Factor‐Loaded Mesoporous Silica Particles, Incorporated in Electrospun PCL Fibres, Provide Topographical and Chemical Cues for Tendon Tissue Engineering. Advanced Materials Technologies, Article 2500246. https://doi.org/10.1002/admt.202500246

This study develops a biomaterial‐based strategy to address challenges in controlled growth factor delivery for tenogenic differentiation of mesenchymal stromal cells (MSCs) and tendon stem cells (TSCs). The 20% polycaprolactone (PCL) fibres, electro... Read More about Growth Factor‐Loaded Mesoporous Silica Particles, Incorporated in Electrospun PCL Fibres, Provide Topographical and Chemical Cues for Tendon Tissue Engineering.

Human tendon stem/progenitor cell-derived extracellular vesicle production promoted by dynamic culture (2025)
Journal Article
Clerici, M., Camilla Ciardulli, M., Pavel Lamparelli, E., Lovecchio, J., Giordano, E., Dale, T. P., Forsyth, N. R., Maffulli, N., & Della Porta, G. (2025). Human tendon stem/progenitor cell-derived extracellular vesicle production promoted by dynamic culture. Artificial Cells, Nanomedicine, and Biotechnology, 53(1), 1-16. https://doi.org/10.1080/21691401.2025.2475099

Tendon injuries significantly impact quality of life, prompting the exploration of innovative solutions beyond conventional surgery. Extracellular Vesicles (EVs) have emerged as a promising strategy to enhance tendon regeneration. In this study, huma... Read More about Human tendon stem/progenitor cell-derived extracellular vesicle production promoted by dynamic culture.

Decellularisation and Characterisation of Porcine Pleura as Bioscaffolds in Tissue Engineering (2024)
Journal Article
Vikranth, T., Dale, T., & Forsyth, N. R. (2024). Decellularisation and Characterisation of Porcine Pleura as Bioscaffolds in Tissue Engineering. Journal of Tissue Engineering and Regenerative Medicine, https://doi.org/10.1155/2024/9940673

Persistent air leaks caused by thoracic surgery, physical trauma, or spontaneous pneumothoraces are a cause of patient morbidity with need for extended chest tube durations and surgical interventions. Current treatment measures involve mechanical clo... Read More about Decellularisation and Characterisation of Porcine Pleura as Bioscaffolds in Tissue Engineering.

Tuning the properties of all natural polymeric scaffolds for tendon repair with cellulose microfibers (2024)
Journal Article
Diaz, F., Zimmermann, L., Dale, T. P., Forsyth, N. R., & Boccaccini, A. R. (2024). Tuning the properties of all natural polymeric scaffolds for tendon repair with cellulose microfibers. Carbohydrate Polymer Technologies and Applications, 7, Article 100447. https://doi.org/10.1016/j.carpta.2024.100447

Rotator cuff injuries affect a large percentage of the population worldwide. Surgical repair has rates of failure of up to 70%, and existing materials used in the reinforcement of injuries often lack appropriate mechanical properties and biodegradabi... Read More about Tuning the properties of all natural polymeric scaffolds for tendon repair with cellulose microfibers.

Injectable hydrogels: An emerging therapeutic strategy for cartilage regeneration (2023)
Journal Article
Atwal, A., Dale, T. P., Snow, M., Forsyth, N. R., & Davoodi, P. (2023). Injectable hydrogels: An emerging therapeutic strategy for cartilage regeneration. Advances in colloid and interface science, 321, Article 103030. https://doi.org/10.1016/j.cis.2023.103030

The impairment of articular cartilage due to traumatic incidents or osteoarthritis has posed significant challenges for healthcare practitioners, researchers, and individuals suffering from these conditions. Due to the absence of an approved treatmen... Read More about Injectable hydrogels: An emerging therapeutic strategy for cartilage regeneration.

Endotenon-Derived Type II Tendon Stem Cells Have Enhanced Proliferative and Tenogenic Potential (2023)
Journal Article
Clerici, M., Citro, V., Byrne, A. L., P. Dale, T., Boccaccini, A. R., Della Porta, G., Maffulli, N., & Forsyth, N. R. (2023). Endotenon-Derived Type II Tendon Stem Cells Have Enhanced Proliferative and Tenogenic Potential. International Journal of Molecular Sciences, 24(20), Article 15107. https://doi.org/10.3390/ijms242015107

Tendon injuries caused by overuse or age-related deterioration are frequent. Incomplete knowledge of somatic tendon cell biology and their progenitors has hindered interventions for the effective repair of injured tendons. Here, we sought to compare... Read More about Endotenon-Derived Type II Tendon Stem Cells Have Enhanced Proliferative and Tenogenic Potential.

The Human Mesenchymal Stem Cell Secretome Directs Macrophage Differentiation in an Oxygen-Dependent Manner (2023)
Preprint / Working Paper
Shephard, M. T., Merkhan, M. M., Dale, T. P., & Forsyth, N. R. (2023). The Human Mesenchymal Stem Cell Secretome Directs Macrophage Differentiation in an Oxygen-Dependent Manner

Background
Chronic disease states can share inflammation as an underlying pathology. Macrophages are associated with chronic inflammation; in general, M1 phenotype macrophage activity inhibits cell proliferation and causes tissue damage whilst M2 ma... Read More about The Human Mesenchymal Stem Cell Secretome Directs Macrophage Differentiation in an Oxygen-Dependent Manner.

Decellularisation and characterisation of porcine pleura for lung tissue engineering (2023)
Journal Article
Vikranth, T., Dale, T., & Forsyth, N. R. (in press). Decellularisation and characterisation of porcine pleura for lung tissue engineering. bioRxiv, https://doi.org/10.1101/2023.06.20.545830

Decellularisation offers a broad range of biomimetic scaffolds of allogeneic and xenogeneic origins, exhibiting innate tissue-specific characteristics. We explored a physico-chemical method for decellularising porcine pleural membranes (PPM) as poten... Read More about Decellularisation and characterisation of porcine pleura for lung tissue engineering.

Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro (2023)
Journal Article
Dale, T. P., Santer, M. D., Haris, M., Zuo, W., & Forsyth, N. R. (2023). Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro. Experimental Lung Research, 49(1), 12-26. https://doi.org/10.1080/01902148.2022.2158404

PURPOSE: Chronic obstructive pulmonary disease (COPD) patients experience hypoxemia and lung tissue hypoxia, causing vasoconstriction, and at its most severe Cor pulmonale. However, minimal attention has been given to the effects of hypoxia at the ce... Read More about Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro.

3D in-vitro cultures of human bone marrow and Wharton's jelly derived mesenchymal stromal cells show high chondrogenic potential. (2022)
Journal Article
Dale. (2022). 3D in-vitro cultures of human bone marrow and Wharton's jelly derived mesenchymal stromal cells show high chondrogenic potential. Frontiers in Bioengineering and Biotechnology, -. https://doi.org/10.3389/fbioe.2022.986310

In this study, chondrogenic potentials of 3D high-density cultures of Bone Marrow (BM) and Wharton's Jelly (WJ)-derived mesenchymal stromal cells (MSCs) was investigated by chondrogenesis- and cytokine-related gene expression over a 16-day culture pe... Read More about 3D in-vitro cultures of human bone marrow and Wharton's jelly derived mesenchymal stromal cells show high chondrogenic potential..

Decellularised Pleural Membrane Patches In Pulmonary Regenerative Medicine (2022)
Journal Article
Dale. (2022). Decellularised Pleural Membrane Patches In Pulmonary Regenerative Medicine. Tissue engineering. Part A, 249 - 250. https://doi.org/10.1089/ten.tea.2022.29030.abstracts

*Purpose/Objectives: Prolonged alveolar air leaks as post-surgical complications to routine lung resections and biopsies are a significant cause for patient morbidity. Extended duration of chest tube drainage and emergency revision surgeries are the... Read More about Decellularised Pleural Membrane Patches In Pulmonary Regenerative Medicine.

SUCCESSFUL ISOLATION AND CULTURE OF MULTIPOTENTIAL DISTAL AIRWAY STEM CELLS FROM COPD PATIENTS (2022)
Journal Article
Dale. (2022). SUCCESSFUL ISOLATION AND CULTURE OF MULTIPOTENTIAL DISTAL AIRWAY STEM CELLS FROM COPD PATIENTS. Tissue engineering. Part A, S451 - S452

Chronic Obstructive Pulmonary Disease (COPD) presents a significant, incurable, worldwide health burden, identifying it as a prospective regenerative medicine target. Sourcing cells for lung therapies is challenging; progress has been made in culturi... Read More about SUCCESSFUL ISOLATION AND CULTURE OF MULTIPOTENTIAL DISTAL AIRWAY STEM CELLS FROM COPD PATIENTS.

Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency (2022)
Journal Article
Barreto, S., Al-Zubaidi, M., Dale, T., Worrall, A., Kapacee, Z., Kimber, S., Sulé-Suso, J., Forsyth, N., & Rutter, A. (2022). Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency. Preprints, https://doi.org/10.20944/preprints202203.0143.v1

<jats:p>Human pluripotent stem cells (hPSCs) have widespread potential biomedical applications. There is a need for large-scale in vitro production of hPSCs, and optimal culture methods are vital in achieving this. Physiological oxygen (2% O2) improv... Read More about Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency.

DECELLULARISED PLEURAL PATCHES FOR PROLONGED ALVEOLAR AIR LEAKS (2021)
Presentation / Conference
Vikranth, T., Dale, T., & Forsyth, N. (2021, November). DECELLULARISED PLEURAL PATCHES FOR PROLONGED ALVEOLAR AIR LEAKS. Presented at TERMIS 6th World Congress, Maastricht, Netherlands

Prolonged alveolar air leaks (PALs) as post‐surgical complications to lung resections at an incidence of 26%, is a source of patient morbidity. The gold standard approach to managing PALs is conservative, through extended duration of chest tube drain... Read More about DECELLULARISED PLEURAL PATCHES FOR PROLONGED ALVEOLAR AIR LEAKS.

3D Biomimetic Scaffold for Growth Factor Controlled Delivery: An In-Vitro Study of Tenogenic Events on Wharton's Jelly Mesenchymal Stem Cells. (2021)
Journal Article
Camilla Ciardulli, M., Lovecchio, J., Scala, P., Pavel Lamparelli, E., Dale, T., Giudice, V., Giordano, E., Selleri, C., Robert Forsyth, N., Maffulli, N., & Della Porta, G. (2021). 3D Biomimetic Scaffold for Growth Factor Controlled Delivery: An In-Vitro Study of Tenogenic Events on Wharton's Jelly Mesenchymal Stem Cells. Pharmaceutics, 13(9), https://doi.org/10.3390/pharmaceutics13091448

The present work described a bio-functionalized 3D fibrous construct, as an interactive teno-inductive graft model to study tenogenic potential events of human mesenchymal stem cells collected from Wharton's Jelly (hWJ-MSCs). The 3D-biomimetic and bi... Read More about 3D Biomimetic Scaffold for Growth Factor Controlled Delivery: An In-Vitro Study of Tenogenic Events on Wharton's Jelly Mesenchymal Stem Cells..

Chondrogenic Commitment of Human Bone Marrow Mesenchymal Stem Cells in a Perfused Collagen Hydrogel Functionalized with hTGF-ß1-Releasing PLGA Microcarrier (2021)
Journal Article
Dale, T., Forsyth, N., & Maffulli, N. (2021). Chondrogenic Commitment of Human Bone Marrow Mesenchymal Stem Cells in a Perfused Collagen Hydrogel Functionalized with hTGF-ß1-Releasing PLGA Microcarrier. Pharmaceutics,

Tissue engineering strategies can be relevant for cartilage repair and regeneration. A collagen matrix was functionalized with the addition of poly-lactic-co-glycolic acid microcarriers (PLGA-MCs) carrying a human Transforming Growth Factor ß1 (hTFG-... Read More about Chondrogenic Commitment of Human Bone Marrow Mesenchymal Stem Cells in a Perfused Collagen Hydrogel Functionalized with hTGF-ß1-Releasing PLGA Microcarrier.

Genetically engineered distal airway stem cell transplantation protects mice from pulmonary infection (2020)
Journal Article
Dale, T., & Forsyth, N. (2020). Genetically engineered distal airway stem cell transplantation protects mice from pulmonary infection. EMBO Molecular Medicine, https://doi.org/10.15252/emmm.201810233

Severe pulmonary infection is a major threat to human health accompanied by substantial, which increases medical costs, prolonged inpatient requirements, and high mortality rates. New anti-microbial therapeutic strategies are urgently required to add... Read More about Genetically engineered distal airway stem cell transplantation protects mice from pulmonary infection.