Charlotte Hulme's Outputs (6)

Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model (2024)
Journal Article
Perry, J., Mennan, C., Cool, P., McCarthy, H. S., Newell, K., Hopkins, T., …Roberts, S. (2024). Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model. Cartilage, https://doi.org/10.1177/19476035241287832

Objective To determine if mesenchymal stromal cells (MSCs) derived from human umbilical cords (hUC) could reduce degeneration developing when injected into the knee of a large animal model of osteoarthritis (OA). Design Ten million culture-expanded U... Read More about Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model.

V2 Ovine UC-MSCs Revised Manuscript (2024)
Journal Article
Perry, J., Mennan, C., Cool, P., McCarthy, H., Newell, K., Hopkins, T., …Roberts, S. (in press). V2 Ovine UC-MSCs Revised Manuscript. Cartilage,

681 USING NANOPORE SEQUENCING TO DIAGNOSE PROSTHETIC JOINT INFECTIONS (2024)
Presentation / Conference
Wilkinson, H., Cool, P., Perry, J., Wright, K. T., McCarthy, H. S., & Hulme, C. H. (2024, April). 681 USING NANOPORE SEQUENCING TO DIAGNOSE PROSTHETIC JOINT INFECTIONS. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study (2024)
Journal Article
Wilkinson, H., McDonald, J., McCarthy, H., Perry, J., Wright, K., Hulme, C., & Cool, P. (in press). Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study. Briefings in Functional Genomics, Article elae008. https://doi.org/10.1093/bfgp/elae008

This project investigates if third-generation genomic sequencing can be used to identify the species of bacteria causing prosthetic joint infections (PJIs) at the time of revision surgery. Samples of prosthetic fluid were taken during revision surger... Read More about Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study.

A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome (2022)
Journal Article
Harrington, G. M. B., Cool, P., Hulme, C., Osman, A., Chowdhury, J. R., Kumar, N., …Wright, K. (2022). A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome. arXiv, https://doi.org/10.1101/2022.07.12.499696

<jats:sec><jats:label>1</jats:label><jats:title>Abstract</jats:title><jats:sec><jats:label>1.1</jats:label><jats:title>Introduction</jats:title><jats:p>Spinal Cord Injury (SCI) is a major cause of disability, with complications post-injury often lead... Read More about A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome.

Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs) (2018)
Presentation / Conference
Hulme, C., Wilson, E., Fuller, H., Roberts, S., Richardson, J., Gallacher, P., …Wright, K. (2018, July). Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs). Poster presented at Matrix Biology Europe – July 2018 Meeting Celebrating 50 years of Federation of European Connective Tissue Societies Meetings, Manchester, United Kingdom

Introduction: Autologous chondrocyte implantation (ACI) is a cell therapy used to treat cartilage defects and early osteoarthritis. During initial surgery (Stage I), healthy cartilage is harvested from the joint. Chondrocytes are isolated and culture... Read More about Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs).