Outputs (31)

Cancer event rate and mortality with thienopyridines: a systematic review and meta-analysis (2016)
Journal Article
Mamas. (2016). Cancer event rate and mortality with thienopyridines: a systematic review and meta-analysis. Drug Safety, 229-240. https://doi.org/10.1007/s40264-016-0481-2

Introduction Thienopyridines are a class of antiplatelet drugs widely used in cardiovascular disease prevention and treatment. A recent concern has come to light regarding the safety of thienopyridines because of the possible risk of malignancy. We... Read More about Cancer event rate and mortality with thienopyridines: a systematic review and meta-analysis.

Impact of incomplete percutaneous revascularization in patients with multi-vessel coronary artery disease: a systematic review and meta-analysis (2016)
Journal Article
Nagaraja, V., Ooi, S., Nolan, J., Large, A., De Belder, M., Ludman, P., …Mamas, M. A. (2016). Impact of incomplete percutaneous revascularization in patients with multi-vessel coronary artery disease: a systematic review and meta-analysis. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, 5(12), https://doi.org/10.1161/JAHA.116.004598

Background Up to half of patients undergoing percutaneous coronary intervention have multivessel coronary artery disease (MVD) with conflicting data regarding optimal revascularization strategy in such patients. This paper assesses the evidence for... Read More about Impact of incomplete percutaneous revascularization in patients with multi-vessel coronary artery disease: a systematic review and meta-analysis.

Relationship between anemia and mortality outcomes in a national ACS cohort: insights from the UK MINAP registry (2016)
Journal Article
Mamas. (2016). Relationship between anemia and mortality outcomes in a national ACS cohort: insights from the UK MINAP registry. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/JAHA.116.003348

Background We aim to determine the prevalence of anemia in acute coronary syndrome (ACS) patients and compare their clinical characteristics, management, and clinical outcomes to those without anemia in an unselected national ACS cohort. Methods... Read More about Relationship between anemia and mortality outcomes in a national ACS cohort: insights from the UK MINAP registry.

Relationship Between Anemia and Mortality Outcomes in a National Acute Coronary Syndrome Cohort: Insights from the UK Myocardial Ischemia National Audit Project Registry (2016)
Journal Article
Mamas, M. A., Shing Kwok, C., Kontopantelis, E., Fryer, A. A., Buchan, I., Bachmann, M. O., …Myint, P. K. (2016). Relationship Between Anemia and Mortality Outcomes in a National Acute Coronary Syndrome Cohort: Insights from the UK Myocardial Ischemia National Audit Project Registry. Journal of the American Heart Association, 5(11), https://doi.org/10.1161/JAHA.116.003348

BACKGROUND: We aim to determine the prevalence of anemia in acute coronary syndrome (ACS) patients and compare their clinical characteristics, management, and clinical outcomes to those without anemia in an unselected national ACS cohort. METHODS AND... Read More about Relationship Between Anemia and Mortality Outcomes in a National Acute Coronary Syndrome Cohort: Insights from the UK Myocardial Ischemia National Audit Project Registry.

Ultrafiltration for acute decompensated cardiac failure: A systematic review and meta-analysis (2016)
Journal Article
Davies, & Mamas. (2016). Ultrafiltration for acute decompensated cardiac failure: A systematic review and meta-analysis. International Journal of Cardiology, 122-128. https://doi.org/10.1016/j.ijcard.2016.11.136

Background Ultrafiltration is a method used to achieve diuresis in acute decompensated heart failure (ADHF) when there is diuretic resistance, but its efficacy in other settings is unclear. We therefore conducted a systematic review and meta-analysi... Read More about Ultrafiltration for acute decompensated cardiac failure: A systematic review and meta-analysis.

Review of early hospitalization after percutaneous coronary intervention (2016)
Journal Article
Mamas. (2016). Review of early hospitalization after percutaneous coronary intervention. International Journal of Cardiology, 370-377. https://doi.org/10.1016/j.ijcard.2016.11.050

Background Percutaneous coronary intervention (PCI) is the most common modality of revascularization in patients with coronary artery disease. Understanding the readmission rates and reasons for readmission after PCI is important because readmission... Read More about Review of early hospitalization after percutaneous coronary intervention.

Inadequacy of Existing Clinical Prediction Models for Predicting Mortality after Transcatheter Aortic Valve Implantation (2016)
Journal Article
Mamas. (2016). Inadequacy of Existing Clinical Prediction Models for Predicting Mortality after Transcatheter Aortic Valve Implantation. American Heart Journal, 97-105. https://doi.org/10.1016/j.ahj.2016.10.020

Background The performance of emerging transcatheter aortic valve implantation (TAVI) clinical prediction models (CPMs) in national TAVI cohorts distinct from those where they have been derived is unknown. This study aimed to investigate the perform... Read More about Inadequacy of Existing Clinical Prediction Models for Predicting Mortality after Transcatheter Aortic Valve Implantation.

Predicting Mortality from Change-over-time in the Charlson Comorbidity Index: A retrospective cohort study in a data-intensive UK health system (2016)
Journal Article
Mamas, M., & Mallen, C. (2016). Predicting Mortality from Change-over-time in the Charlson Comorbidity Index: A retrospective cohort study in a data-intensive UK health system. Medicine, e4973. https://doi.org/10.1097/md.0000000000004973

Multimorbidity is common among older people and presents a major challenge to health systems worldwide. Metrics of multimorbidity are, however, crude: focusing on measuring comorbid conditions at single time-points rather than reflecting the longitud... Read More about Predicting Mortality from Change-over-time in the Charlson Comorbidity Index: A retrospective cohort study in a data-intensive UK health system.

Comparison of the Effects of Incomplete Revascularization on 12-month Mortality in Patients <80 compared to =80 Years of Age Undergoing Percutaneous Coronary Intervention (2016)
Journal Article
Mamas. (2016). Comparison of the Effects of Incomplete Revascularization on 12-month Mortality in Patients

Although randomized trial data suggest that complete revascularization improves outcomes after percutaneous coronary intervention (PCI), the impact of differing revascularization strategies in octogenarians is not well defined. We performed a retrosp... Read More about Comparison of the Effects of Incomplete Revascularization on 12-month Mortality in Patients <80 compared to =80 Years of Age Undergoing Percutaneous Coronary Intervention.

Rheumatic mitral valve disease is associated with worse outcomes in stroke: a Thailand National Database Study (2016)
Journal Article
Mamas. (2016). Rheumatic mitral valve disease is associated with worse outcomes in stroke: a Thailand National Database Study. Stroke, 2695-2701. https://doi.org/10.1161/STROKEAHA.116.014512

Background and Purpose— Rheumatic valvular heart disease is associated with the increased risk of cerebrovascular events, although there are limited data on the prognosis of patients with rheumatic mitral valve disease (RMVD) after stroke. Method... Read More about Rheumatic mitral valve disease is associated with worse outcomes in stroke: a Thailand National Database Study.

The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice (2016)
Journal Article
Mamas. (2016). The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice. Biochemical and Biophysical Research Communications, 708-714. https://doi.org/10.1016/j.bbrc.2016.09.147

The G-protein-coupled receptors (GPCRs) family of proteins play essential roles in the heart, including in the regulation of cardiac hypertrophy. One member of this family, the oxoglutarate receptor 1 (OXGR1), may have a crucial role in the heart bec... Read More about The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice.

Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis (2016)
Journal Article
Wu, P., Shing Kwok, C., Haththotuwa, R., Kotronias, R. A., Babu, A., Fryer, A. A., …Mamas, M. A. (2016). Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis. Diabetologia, 59, 2518-2526. https://doi.org/10.1007/s00125-016-4098-x

Aims/hypothesis: Pre-eclampsia is a pregnancy-specific multi-system disorder and a state of physiological insulin resistance. Our aim is to systematically evaluate and quantify the evidence on the relationship between pre-eclampsia and the future ris... Read More about Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis.

Influence of access site choice for cardiac catheterization on risk of adverse neurological events: a systematic review and meta-analysis (2016)
Journal Article
Mamas, & Nolan. (2016). Influence of access site choice for cardiac catheterization on risk of adverse neurological events: a systematic review and meta-analysis. American Heart Journal, 107-119. https://doi.org/10.1016/j.ahj.2016.06.027

Background: Stroke is a rare but potentially catastrophic complication of cardiac catheterization. While some procedural aspects are known to influence stroke risk, the impact of radial versus femoral access site use is unclear. Early observational s... Read More about Influence of access site choice for cardiac catheterization on risk of adverse neurological events: a systematic review and meta-analysis.

Impact of hemoglobin levels and anemia on mortality in acute stroke: analysis of UK regional registry data, systematic review and meta-analysis (2016)
Journal Article
Mamas. (2016). Impact of hemoglobin levels and anemia on mortality in acute stroke: analysis of UK regional registry data, systematic review and meta-analysis. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/JAHA.115.003019

Background: The impact of hemoglobin levels and anemia on stroke mortality remains controversial. We aimed to systematically assess this association and quantify the evidence. Methods and Results: We analysed data from a cohort of 8,013 stroke patien... Read More about Impact of hemoglobin levels and anemia on mortality in acute stroke: analysis of UK regional registry data, systematic review and meta-analysis.

The incidence, determinants and outcomes of coronary perforation during percutaneous coronary intervention in the United Kingdom between 2006–2013: an analysis of 527,121 cases from the British Cardiovascular Intervention Society database (2016)
Journal Article
Mamas. (2016). The incidence, determinants and outcomes of coronary perforation during percutaneous coronary intervention in the United Kingdom between 2006–2013: an analysis of 527,121 cases from the British Cardiovascular Intervention Society database. Circulation: Cardiovascular Interventions, https://doi.org/10.1161/CIRCINTERVENTIONS.115.003449

Background: As coronary perforation (CP) is a rare but serious complication of percutaneous coronary intervention (PCI) the current evidence base is limited to small series. Using a national PCI database the incidence, predictors and outcomes of CP a... Read More about The incidence, determinants and outcomes of coronary perforation during percutaneous coronary intervention in the United Kingdom between 2006–2013: an analysis of 527,121 cases from the British Cardiovascular Intervention Society database.

Meta-analysis of Percutaneous Coronary Intervention with Drug Eluting Stent Versus Coronary Artery Bypass Grafting for Isolated Proximal Left Anterior Descending Coronary Disease (2016)
Journal Article
Mamas. (2016). Meta-analysis of Percutaneous Coronary Intervention with Drug Eluting Stent Versus Coronary Artery Bypass Grafting for Isolated Proximal Left Anterior Descending Coronary Disease. American Journal of Cardiology, 1171-1177. https://doi.org/10.1016/j.amjcard.2016.07.030

We performed a meta-analysis of the studies comparing the efficacy and safety of coronary artery bypass surgery (CABG) against percutaneous coronary intervention with drug-eluting stents (PCI-DES) among patients with isolated LAD disease. Due to limi... Read More about Meta-analysis of Percutaneous Coronary Intervention with Drug Eluting Stent Versus Coronary Artery Bypass Grafting for Isolated Proximal Left Anterior Descending Coronary Disease.

Soft drinks and sweetened beverages and the risk of cardiovascular disease and mortality: a systematic review and meta-analysis (2016)
Journal Article
Mamas. (2016). Soft drinks and sweetened beverages and the risk of cardiovascular disease and mortality: a systematic review and meta-analysis. International Journal of Clinical Practice, 791-805. https://doi.org/10.1111/ijcp.12841

Background Soft drink consumption is associated with adverse health behaviours that predispose to adverse cardiovascular risk factor profiles; however, it is unclear whether their intake independently leads to an increased risk of cardiovascular eve... Read More about Soft drinks and sweetened beverages and the risk of cardiovascular disease and mortality: a systematic review and meta-analysis.

Radial Access Failure: Association with Both Physician and Patient Factors (aka 'STEMI PCI access: minimise risk—keep it in the wrist') (2016)
Journal Article
Mamas. (2016). Radial Access Failure: Association with Both Physician and Patient Factors (aka 'STEMI PCI access: minimise risk—keep it in the wrist'). Heart, 897-898. https://doi.org/10.1136/heartjnl-2015-309158

The importance of interactions between atrial fibrillation and heart failure (2016)
Journal Article
Mamas. (2016). The importance of interactions between atrial fibrillation and heart failure. Clinical Medicine, 272 -276. https://doi.org/10.7861/clinmedicine.16-3-272

Heart failure (HF) and atrial fibrillation (AF) are among the commonest cardiovascular conditions encountered in clinical practice and frequently coexist. Over the last decade, they have evolved into global cardiovascular epidemics. This, in turn, ha... Read More about The importance of interactions between atrial fibrillation and heart failure.

Association between osteoarthritis and cardiovascular disease: systematic review and meta-analysis (2016)
Journal Article
Mamas. (2016). Association between osteoarthritis and cardiovascular disease: systematic review and meta-analysis. European Journal of Preventive Cardiology, 938-946. https://doi.org/10.1177/2047487315610663

Background To examine for a possible relationship between osteoarthritis and cardiovascular disease. Design A systematic review and meta-analysis. Methods Published and unpublished literature from: MEDLINE, EMBASE, CINAHL, the Cochrane Libra... Read More about Association between osteoarthritis and cardiovascular disease: systematic review and meta-analysis.

Meta-analysis of the prognostic impact of anemia in patients undergoing percutaneous coronary intervention (2016)
Journal Article
Mamas, & Nolan. (2016). Meta-analysis of the prognostic impact of anemia in patients undergoing percutaneous coronary intervention. American Journal of Cardiology, 610-620. https://doi.org/10.1016/j.amjcard.2016.05.059

Anemia is common in patients undergoing percutaneous coronary intervention (PCI), and current guidelines fail to offer recommendations for its management. This review aims to examine the relation between baseline anemia and mortality, major adverse c... Read More about Meta-analysis of the prognostic impact of anemia in patients undergoing percutaneous coronary intervention.

Determinants and outcomes of stroke following percutaneous coronary intervention by indication (2016)
Journal Article
Roffe, & Mamas. (2016). Determinants and outcomes of stroke following percutaneous coronary intervention by indication. Stroke, 1500-1507. https://doi.org/10.1161/strokeaha.116.012700

Background and Purpose—Stroke after percutaneous coronary intervention (PCI) is a serious complication, but its determinants and outcomes after PCI in different clinical settings are poorly documented. Methods—The British Cardiovascular Interventi... Read More about Determinants and outcomes of stroke following percutaneous coronary intervention by indication.

Is there a relationship of operator and center volume with access site related outcomes?: an analysis from the British Cardiovascular Intervention Society (2016)
Journal Article
Nolan, & Mamas. (2016). Is there a relationship of operator and center volume with access site related outcomes?: an analysis from the British Cardiovascular Intervention Society. Circulation: Cardiovascular Interventions, https://doi.org/10.1161/circinterventions.115.003333

Background: Transradial access (TRA) is associated with reduced access site related bleeding complications and mortality post percutaneous coronary intervention (PCI). The objective of this study is to examine the relationship between access site pra... Read More about Is there a relationship of operator and center volume with access site related outcomes?: an analysis from the British Cardiovascular Intervention Society.

A contemporary risk model for predicting 30-day mortality following percutaneous coronary intervention in England and Wales (2016)
Journal Article
Mamas. (2016). A contemporary risk model for predicting 30-day mortality following percutaneous coronary intervention in England and Wales. International Journal of Cardiology, 125-132. https://doi.org/10.1016/j.ijcard.2016.02.085

Aims: The current risk model for percutaneous coronary intervention (PCI) in the UK is based on outcomes of patients who were treated in a different era of interventional cardiology. This study aimed to create a new model, based on a contemporary coh... Read More about A contemporary risk model for predicting 30-day mortality following percutaneous coronary intervention in England and Wales.

Outcomes following primary percutaneous coronary intervention in patients with previous coronary artery bypass surgery (2016)
Journal Article
Mamas. (2016). Outcomes following primary percutaneous coronary intervention in patients with previous coronary artery bypass surgery. Circulation: Cardiovascular Interventions, https://doi.org/10.1161/circinterventions.115.003151

Background: There are limited data on outcomes of patients with previous coronary artery bypass grafting (CABG) presenting with ST-segment elevation myocardial infarction (STEMI) and undergoing primary percutaneous coronary intervention (PPCI). We re... Read More about Outcomes following primary percutaneous coronary intervention in patients with previous coronary artery bypass surgery.

Explaining inequalities in receipt of care in the older patient with acute coronary syndrome (2016)
Journal Article
Mamas. (2016). Explaining inequalities in receipt of care in the older patient with acute coronary syndrome. European Heart Journal - Quality of Care and Clinical Outcomes, 59-61. https://doi.org/10.1093/ehjqcco/qcw011

The world's population is ageing and patients with acute coronary syndromes (ACS) are presenting later in life such that a third or more are now aged =70.1 ACS mortality rates are higher in older patients,1 and absolute benefits of treatment are, the... Read More about Explaining inequalities in receipt of care in the older patient with acute coronary syndrome.

Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis (2016)
Journal Article
Mamas, Rashid, M., & Nolan, J. (2016). Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis. Heart, https://doi.org/10.1136/heartjnl-2015-308956

Abstract Objective: First-degree atrioventricular block is frequently encountered in clinical practice and is generally considered a benign process. However, there is emerging evidence that prolonged PR interval may be associated with adverse outcome... Read More about Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: a systematic review and meta-analysis.

Habitual chocolate consumption and the risk of incident heart failure among healthy men and women (2016)
Journal Article
Mamas. (2016). Habitual chocolate consumption and the risk of incident heart failure among healthy men and women. Nutrition, Metabolism and Cardiovascular Diseases, 722-734. https://doi.org/10.1016/j.numecd.2016.01.003

Background: We aimed to examine the association between chocolate intake and the risk of incident heart failure in a UK general population. We conducted a systematic review and meta-analysis to quantify this association. Methods and results: We used... Read More about Habitual chocolate consumption and the risk of incident heart failure among healthy men and women.

Habitual chocolate consumption and the risk of incident heart failure among healthy men and women (2016)
Journal Article
Mamas. (2016). Habitual chocolate consumption and the risk of incident heart failure among healthy men and women. Nutrition, Metabolism and Cardiovascular Diseases, 722 -734. https://doi.org/10.1016/j.numecd.2016.01.003

BACKGROUND: We aimed to examine the association between chocolate intake and the risk of incident heart failure in a UK general population. We conducted a systematic review and meta-analysis to quantify this association. METHODS AND RESULTS: We used... Read More about Habitual chocolate consumption and the risk of incident heart failure among healthy men and women.

Revascularization for Left Anterior Descending Artery Stenosis: A Review of the Evidence That Supports Practice (2016)
Journal Article
Mamas. (2016). Revascularization for Left Anterior Descending Artery Stenosis: A Review of the Evidence That Supports Practice. Cardiology in Review, https://doi.org/10.1097/CRD.0000000000000097

Disease of the proximal left anterior descending (LAD) artery is a common pathological finding often combined with disease in other coronary arteries. In this article we review specifically the evidence (and the guidelines arising from the data) for... Read More about Revascularization for Left Anterior Descending Artery Stenosis: A Review of the Evidence That Supports Practice.

Impact of operator volume for percutaneous coronary intervention (PCI) on clinical outcomes: what do the numbers say? (2016)
Journal Article
Mamas, M., & Rashid, M. (2016). Impact of operator volume for percutaneous coronary intervention (PCI) on clinical outcomes: what do the numbers say?. European Heart Journal, 16-22. https://doi.org/10.1093/ehjqcco/qcv030

The impact of operator and centre volume on clinical outcomes and quality of care has been of considerable debate in recent years in a number of surgical- and procedural-based specialities. A relationship between higher volumes at both the institutio... Read More about Impact of operator volume for percutaneous coronary intervention (PCI) on clinical outcomes: what do the numbers say?.