Skip to main content

Research Repository

Advanced Search

Daniel Tonge's Outputs (29)

Genomic-transcriptomic analysis identifies the Syrian hamster as a superior animal model for human diseases (2025)
Journal Article
Wang, C., Cheng, Z., Miao, J., Xue, X., Dong, Y., Zhao, L., Guo, H., Wang, J., Wang, Z., Lu, S., Fang, G., Peng, Y., Zhai, Y., Zhang, Z., Gao, D., Wang, Z., Wang, P., Zhang, L., Dunmall, L. S. C., Wang, J., …Wang, Y. (in press). Genomic-transcriptomic analysis identifies the Syrian hamster as a superior animal model for human diseases. BMC Genomics, 26(1), 1-18. https://doi.org/10.1186/s12864-025-11393-4

Background: The Syrian hamster (Mesocricetus auratus) has shown promise as a human diseases model, recapitulating features of different human diseases including COVID-19. However, the landscape of its genome and transcriptome has not been systematica... Read More about Genomic-transcriptomic analysis identifies the Syrian hamster as a superior animal model for human diseases.

444 Differential Transcriptome Signatures of Success are Identified within Different Cell Populations used for Treating Cartilage Defects in the Knee (2024)
Presentation / Conference
Tierney, L., Jones, A., McCarthy, H. S., Roberts, S., Tonge, D., & Wright, K. T. (2024, April). 444 Differential Transcriptome Signatures of Success are Identified within Different Cell Populations used for Treating Cartilage Defects in the Knee. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models. (2023)
Journal Article
Hoolachan, J. M., McCallion, E., Sutton, E. R., Çetin, Ö., Pacheco-Torres, P., Dimitriadi, M., Sari, S., Miller, G. J., Okoh, M., Walter, L. M., Claus, P., Wood, M. J., Tonge, D., & Bowerman, M. (2024). A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models. Human molecular genetics, 33(5), 400–425. https://doi.org/10.1093/hmg/ddad192

Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder caused by the reduction of survival of motor neuron (SMN) protein levels. Although three SMN-augmentation therapies are clinically approved that significantly slow down disease progres... Read More about A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models..

Single-cell profiling of Anopheles gambiae spermatogenesis defines the onset of meiotic silencing and premeiotic overexpression of the X chromosome (2023)
Journal Article
Page, N., Taxiarchi, C., Tonge, D., Kuburic, J., Chesters, E., Kriezis, A., Game, L., Kyrou, K., Game, L., Nolan, T., & Galizi, R. (2023). Single-cell profiling of Anopheles gambiae spermatogenesis defines the onset of meiotic silencing and premeiotic overexpression of the X chromosome. Communications Biology, 6(1), Article 850. https://doi.org/10.1038/s42003-023-05224-z

Understanding development and genetic regulation in the Anopheles gambiae germline is essential to engineer effective genetic control strategies targeting this malaria mosquito vector. These include targeting the germline to induce sterility or using... Read More about Single-cell profiling of Anopheles gambiae spermatogenesis defines the onset of meiotic silencing and premeiotic overexpression of the X chromosome.

Single-cell profiling of mosquito spermatogenesis defines the onset of meiotic silencing and pre-meiotic overexpression of the X chromosome. (2023)
Journal Article
Page, N., Taxiarchi, C., Tonge, D., Kuburic, J., Chesters, E., Kriezis, A., Kyrou, K., Game, L., Nolan, T., & Galizi, R. (in press). Single-cell profiling of mosquito spermatogenesis defines the onset of meiotic silencing and pre-meiotic overexpression of the X chromosome. Communications Biology, 6, Article 850. https://doi.org/10.1038/s42003-023-05224-z

Understanding development and genetic regulation in the Anopheles gambiae germline is essential to engineer effective genetic control strategies targeting this malaria mosquito vector. These include targeting the germline to induce sterility or using... Read More about Single-cell profiling of mosquito spermatogenesis defines the onset of meiotic silencing and pre-meiotic overexpression of the X chromosome..

Platelets bridging the gap between gut dysbiosis and neuroinflammation in stress-linked disorders: A narrative review. (2023)
Journal Article
Rust, C., Malan-Muller, S., van den Heuvel, L. L., Tonge, D., Seedat, S., Pretorius, E., & Hemmings, S. M. J. (2023). Platelets bridging the gap between gut dysbiosis and neuroinflammation in stress-linked disorders: A narrative review. Journal of Neuroimmunology, 382, Article 578155. https://doi.org/10.1016/j.jneuroim.2023.578155

In this narrative review, we examine the association between gut dysbiosis, neuroinflammation, and stress-linked disorders, including depression, anxiety, and post-traumatic stress disorder (PTSD), and investigate whether tryptophan (TRP) metabolism... Read More about Platelets bridging the gap between gut dysbiosis and neuroinflammation in stress-linked disorders: A narrative review..

Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming (2023)
Journal Article
Hyland, M., Mennan, C., Davies, R., Wilson, E., Tonge, D. P., Clayton, A., & Kehoe, O. (2023). Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming. Stem Cell Reviews and Reports, 19, 2391–2406. https://doi.org/10.1007/s12015-023-10586-2

Autoimmune conditions, such as rheumatoid arthritis, are characterised by a loss of immune tolerance, whereby the immune cells attack self-antigens causing pain and inflammation. These conditions can be brought into remission using pharmaceutical tre... Read More about Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming.

The 2022 dengue outbreak in Bangladesh: hypotheses for the late resurgence of cases and fatalities (2023)
Journal Article
Haider, N., N, H., Hasan, M. N., MN, H., Khalil, I., I, K., Tonge, D., D, T., Hegde, S., S, H., Chowdhury, M. A. B., MAB, C., Rahman, M., M, R., Khan, M. H., MH, K., Ansumana, R., R, A., Zumla, A., A, Z., …MJ, U. (2023). The 2022 dengue outbreak in Bangladesh: hypotheses for the late resurgence of cases and fatalities. Journal of Medical Entomology, 60(4), 847-852. https://doi.org/10.1093/jme/tjad057

Bangladesh reported the highest number of annual deaths (n = 281) related to dengue virus infection in 2022 since the virus reappeared in the country in 2000. Earlier studies showed that >92% of the annual cases occurred between the months of... Read More about The 2022 dengue outbreak in Bangladesh: hypotheses for the late resurgence of cases and fatalities.

Single-cell profiling of mosquito spermatogenesis defines the onset of meiotic silencing and pre-meiotic overexpression of the X chromosome. (2023)
Other
Page, N., Taxiarchi, C., Tonge, D., Kuburic, J., Chesters, E., Kriezis, A., Kyrou, K., Game, L., Nolan, T., & Galizi, R. (2023). Single-cell profiling of mosquito spermatogenesis defines the onset of meiotic silencing and pre-meiotic overexpression of the X chromosome

Understanding development and genetic regulation in the Anopheles gambiae germline is essential to engineer effective genetic control strategies targeting this malaria mosquito vector. These include targeting the germline to induce sterility or using... Read More about Single-cell profiling of mosquito spermatogenesis defines the onset of meiotic silencing and pre-meiotic overexpression of the X chromosome..

Whole genome sequencing revealed a high level of antimicrobial resistance genes and virulence factors in a multidrug-resistant Citrobacter freundii BAU_TM8 strain isolated from a domesticated duck in Bangladesh (2023)
Other
Ahmed, T., Islam, S., Haider, N., Tonge, D., Hasan, B., Nuruzzaman, M., Sadekuzzaman, M., Lutful Kabir, S., Rahman, T., & Rahman Khan, S. (2023). Whole genome sequencing revealed a high level of antimicrobial resistance genes and virulence factors in a multidrug-resistant Citrobacter freundii BAU_TM8 strain isolated from a domesticated duck in Bangladesh

New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate (2023)
Journal Article
Kavousi, N., Tonge, D. P., & Mourtada-Maarabouni, M. (2023). New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate. International Journal of Biological Macromolecules, 233, Article 123467. https://doi.org/10.1016/j.ijbiomac.2023.123467

The serine/threonine protein phosphatase 4 holoenzyme consists of a PP4 catalytic subunit (PP4c), which interacts with four different regulatory subunits. Previous studies have shown that PP4c acts as a tumour suppressor. Emerging evidence suggests t... Read More about New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate.

Whole-genome-scale identification of novel non-protein-coding RNAs controlling cell proliferation and survival through a functional forward genetics strategy (2022)
Journal Article
Darling, D., Farzaneh, F., Williams, G., & Tonge, D. (2022). Whole-genome-scale identification of novel non-protein-coding RNAs controlling cell proliferation and survival through a functional forward genetics strategy. Scientific reports, 12, Article 182. https://doi.org/10.1038/s41598-021-03983-5

<jats:title>Abstract</jats:title><jats:p>Identification of cell fate-controlling lncRNAs is essential to our understanding of molecular cell biology. Here we present a human genome-scale forward-genetics approach for the identification of lncRNAs bas... Read More about Whole-genome-scale identification of novel non-protein-coding RNAs controlling cell proliferation and survival through a functional forward genetics strategy.

Molecular Characterization of Circulating Microbiome Signatures in Rheumatoid Arthritis (2020)
Journal Article
Hammad, D., Hider, S., Liyanapathirana, V., & Tonge, D. (2020). Molecular Characterization of Circulating Microbiome Signatures in Rheumatoid Arthritis. Frontiers in Cellular and Infection Microbiology, 9, Article 440. https://doi.org/10.3389/fcimb.2019.00440

Rheumatoid Arthritis (RA) has been increasingly associated with perturbations to the microbial communities that reside in and on the body (the microbiome), in both human and animal studies. To date, such studies have mainly focused on the microbial c... Read More about Molecular Characterization of Circulating Microbiome Signatures in Rheumatoid Arthritis.

Multi-Method Molecular Characterisation of Human Dust-Mite-associated Allergic Asthma (2019)
Journal Article
Tonge. (2019). Multi-Method Molecular Characterisation of Human Dust-Mite-associated Allergic Asthma. Scientific reports, 9, Article 8912. https://doi.org/10.1038/s41598-019-45257-1

Asthma is a chronic inflammatory disorder of the airways. Disease presentation varies greatly in terms of cause, development, severity, and response to medication, and thus the condition has been subdivided into a number of asthma phenotypes. There i... Read More about Multi-Method Molecular Characterisation of Human Dust-Mite-associated Allergic Asthma.

RNA sequencing reveals a key role for the long non-coding RNA MIAT in regulating neuroblastoma and glioblastoma cell fate (2019)
Journal Article
Bountal, A., Tonge, D. P., & Mourtada-Maarabouni, M. (2019). RNA sequencing reveals a key role for the long non-coding RNA MIAT in regulating neuroblastoma and glioblastoma cell fate. International Journal of Biological Macromolecules, 878-891. https://doi.org/10.1016/j.ijbiomac.2019.03.005

Myocardial Infarction Associated Transcript (MIAT) is a subnuclear lncRNA that interferes with alternative splicing and is associated with increased risk of various heart conditions and nervous system tumours. The current study aims to elucidate the... Read More about RNA sequencing reveals a key role for the long non-coding RNA MIAT in regulating neuroblastoma and glioblastoma cell fate.

Identification of differentially expressed lncrnas in metformin resistant SH-SY5Y neuroblastoma cells (2018)
Presentation / Conference Contribution
Bountali, K., Maarabouni, M., & Tonge, D. Identification of differentially expressed lncrnas in metformin resistant SH-SY5Y neuroblastoma cells. Presented at 25th Biennial Congress of the European Association for Cancer Research

Abstract
Introduction Of the total human DNA only 1.2% o codes for proteins, with the rest only being transcribed into regulatory RNA, known as non-coding RNA. Long non-coding RNAs (lncRNAs) are non-coding RNAs that have no or limited protein-coding... Read More about Identification of differentially expressed lncrnas in metformin resistant SH-SY5Y neuroblastoma cells.

What is normal? Next generation sequencing-driven analysis of the human circulating miRNAOme (2016)
Journal Article
Tonge, D., & Gant, T. (2016). What is normal? Next generation sequencing-driven analysis of the human circulating miRNAOme. BMC Molecular Biology, https://doi.org/10.1186/s12867-016-0057-9

Background
MicroRNAs (miRNAs) are short non-protein-coding RNA species that have a regulatory function in modulating protein translation and degradation of specific mRNAs. MicroRNAs are estimated to target approximately 60 % of all human mRNAs and a... Read More about What is normal? Next generation sequencing-driven analysis of the human circulating miRNAOme.