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Professor Anthony Fryer's Outputs (177)

Morning Salivary Cortisone Versus Serum Cortisol in the Overnight Dexamethasone Suppression Test (ODNST): Evaluation in a Clinical Setting (2025)
Journal Article
Mordaunt, M., Heald, A., Majeed, W., Kochhar, R., Syed, A., Mudaliar, R. N., Alshames, R., Hanna, F., Marshall, D., Keevil, B., & Fryer, A. A. (in press). Morning Salivary Cortisone Versus Serum Cortisol in the Overnight Dexamethasone Suppression Test (ODNST): Evaluation in a Clinical Setting. Clinical Endocrinology, 1-8. https://doi.org/10.1111/cen.15233

Introduction: Saliva hormone measurement is increasingly being applied in everyday clinical practice. In relation to salivary cortisone measurement, there is a particular advantage, with minimal chance of cross‐reaction with prescribed glucocorticoid... Read More about Morning Salivary Cortisone Versus Serum Cortisol in the Overnight Dexamethasone Suppression Test (ODNST): Evaluation in a Clinical Setting.

The Impact of Age and Sex on Fasting Plasma Glucose and Glycated Haemoglobin (HbA1c) in the Non-diabetes Population. (2024)
Journal Article
Stedman, M., Heald, A. H., Holland, D., Halsall, I., Green, L., Wu, P., Patel, K., Scargill, J., Gibson, M., Hanna, F. W. F., & Fryer, A. A. (in press). The Impact of Age and Sex on Fasting Plasma Glucose and Glycated Haemoglobin (HbA1c) in the Non-diabetes Population. Diabetes Therapy, https://doi.org/10.1007/s13300-024-01680-w

We previously reported sex differences in the distribution of glycated haemoglobin (HbA1c) for men/women aged < 50 years vs older individuals, with implications for delayed diabetes diagnosis. Here, we explored whether this pattern was also seen in m...

How Does Thyroid Hormone Profile Differ on and Off Replacement Treatment? (2024)
Journal Article
Heald, A. H., Premawardhana, L. D., Taylor, P. N., Baker, A., Chaudhury, N., Fryer, A. A., Okosieme, O. E., Dayan, C. M., & Stedman, M. (in press). How Does Thyroid Hormone Profile Differ on and Off Replacement Treatment?. Clinical Endocrinology, 1-6. https://doi.org/10.1111/cen.15185

Introduction: There continues to be much discussion around optimisation of thyroid hormone status in hypothyroid individuals. We here looked the way that free T4(FT4) and thyroid‐stimulating hormone (TSH) related to each other in a large laboratory s... Read More about How Does Thyroid Hormone Profile Differ on and Off Replacement Treatment?.

Using maternal glycosylated haemoglobin as well as glucose tolerance tests identified significantly more mothers with high birth weight in their offspring (2024)
Presentation / Conference Contribution
Wu, P., Stedman, M., Fryer, A., Green, L., Holland, D., Scargill, J., Pankaja, S., Christian, S., & Heald, A. Using maternal glycosylated haemoglobin as well as glucose tolerance tests identified significantly more mothers with high birth weight in their offspring. Presented at 60th EASD Annual Meeting of the European Association for the Study of Diabetes, Madrid, Spain

The link between age, sex, fasting plasma glucose and glycated haemoglobin (HbA 1c ) (2024)
Presentation / Conference Contribution
Stedman, M., Heald, A., Holland, D., Halsall, I., Green, L., Wu, P., Scargill, J., Hanna, F., Colclough, K., Gibson, M., & Fryer, A. The link between age, sex, fasting plasma glucose and glycated haemoglobin (HbA 1c ). Presented at 60th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Madrid, Spain

Counting the Lifetime Cost of Obesity: Analysis based on National England Data (2024)
Journal Article
Fryer, A. A., Heald, A., Stedman, M., Stedman, M., Davies, M. B., Rutter, M. K., Gibson, J. M., & Whyte, M. (2024). Counting the Lifetime Cost of Obesity: Analysis based on National England Data. Diabetes, Obesity and Metabolism, 26(4), 1464-1478. https://doi.org/10.1111/dom.15447

Aim
Obesity has a significant impact on all-cause mortality rate and overall health care resource use (HCRU). These outcomes are also strongly linked to age, sex and local deprivation of the population. We aimed to establish the lifetime costs of ob... Read More about Counting the Lifetime Cost of Obesity: Analysis based on National England Data.

The INSIGHT project: reflections on the co-production of a quality recognition programme to showcase excellence in public involvement in health and care research (2023)
Journal Article
Blackburn, S., Hine, R., Fairbanks, S., Parkes, P., Murinas, D., Meakin, A., Taylor, R., Parton, L., Jones, M., Tunmore, J., Lench, J., Evans, N., Lewney, K., O’Mara, L., & Fryer, A. A. (2023). The INSIGHT project: reflections on the co-production of a quality recognition programme to showcase excellence in public involvement in health and care research. Research Involvement and Engagement, 9(1), 99. https://doi.org/10.1186/s40900-023-00508-4

Background: The quality of Patient and Public Involvement (PPI) in healthcare research varies considerably and is frequently tokenistic. We aimed to co-produce the Insight | Public Involvement Quality Recognition and Awards programme, based on the UK... Read More about The INSIGHT project: reflections on the co-production of a quality recognition programme to showcase excellence in public involvement in health and care research.

Is the Current Cut Point for Glycated Haemoglobin (HbA1c) Correct for Diagnosing Diabetes Mellitus in Premenopausal Women? Evidence to Inform Discussion (2023)
Journal Article
Holland, D., Fryer, A. A., Stedman, M., Hanna, F. W. F., Duff, C. J., Green, L., Scargill, J., Halsall, I., Gaskell, N., Howe, J. D., Heald, A. H., & Wu, P. (2023). Is the Current Cut Point for Glycated Haemoglobin (HbA1c) Correct for Diagnosing Diabetes Mellitus in Premenopausal Women? Evidence to Inform Discussion. Diabetes Therapy, https://doi.org/10.1007/s13300-023-01482-6

Women are on average diagnosed with diabetes mellitus at later age than men but have higher mortality. As the diagnosis of diabetes mellitus is primarily based on HbA1c, the use of a non-specific reference range and cut point for diabetes mellitus th... Read More about Is the Current Cut Point for Glycated Haemoglobin (HbA1c) Correct for Diagnosing Diabetes Mellitus in Premenopausal Women? Evidence to Inform Discussion.

Failure to control conventional cardiovascular risk factors in women with type 2 diabetes might explain worse mortality (2023)
Journal Article
Stedman, M., Whyte, M. B., Laing, I., Fryer, A. A., Torres, B. M., Robinson, A., Mannan, F., Gibson, J. M., Rayman, G., & Heald, A. H. (2023). Failure to control conventional cardiovascular risk factors in women with type 2 diabetes might explain worse mortality. Diabetes/Metabolism Research and Reviews, 39(8), Article e3695. https://doi.org/10.1002/dmrr.3695

Introduction: The standardised mortality rate (SMR) for people with diabetes in England is 1.5–1.7, with differences in outcomes between sexes. There has been little work examining the factors that could have an impact on this or on what may determin... Read More about Failure to control conventional cardiovascular risk factors in women with type 2 diabetes might explain worse mortality.

Diabetes detection in women with gestational diabetes and polycystic ovarian syndrome (2023)
Journal Article
Hanna, F., Wu, P., Heald, A., & Fryer, A. (2023). Diabetes detection in women with gestational diabetes and polycystic ovarian syndrome. BMJ, 382, Article e071675. https://doi.org/10.1136/bmj-2022-071675

Gestational diabetes mellitus (GDM) and polycystic ovarian syndrome (PCOS) represent two of the highest risk factors for development of type 2 diabetes mellitus in young women. As these increasingly common conditions generally affect younger women, e... Read More about Diabetes detection in women with gestational diabetes and polycystic ovarian syndrome.

The Utility of Salivary Cortisone in the Overnight Dexamethasone Suppression Test in Adrenal Incidentalomas (2023)
Journal Article
Issa, B. G., Hanna, F. W. F., Fryer, A. A., Ensah, G., Ebere, I., Marshall, D., & Keevil, B. (2023). The Utility of Salivary Cortisone in the Overnight Dexamethasone Suppression Test in Adrenal Incidentalomas. Journal of Clinical Endocrinology and Metabolism, 108(10), e937-e943. https://doi.org/10.1210/clinem/dgad242

BackgroundGuidelines recommend the assessment of cortisol secretion in patients with adrenal incidentalomas (AI) using the overnight dexamethasone suppression test (ONDST). This requires attendance to a health care facility and venepuncture. Alternat... Read More about The Utility of Salivary Cortisone in the Overnight Dexamethasone Suppression Test in Adrenal Incidentalomas.

Quantifying the prevalence and impact of risk factors that might explain why women with type 2 diabetes have higher mortality rate than men of similar age using the retrospective data from Salford Hospital, England (2023)
Presentation / Conference
Whyte, M., Laing, I., Meza-Torres, B., Robinson, A., Fryer, A., & Heald, A. (2023, April). Quantifying the prevalence and impact of risk factors that might explain why women with type 2 diabetes have higher mortality rate than men of similar age using the retrospective data from Salford Hospital, England. Presented at Diabetes UK Professional Conference 2023, Exhibition Centre Liverpool, Liverpool, England, UK

The Effect of the COVID-19 Pandemic on HbA1c Testing: Prioritization of High-Risk Cases and Impact of Social Deprivation (2023)
Journal Article
Holland, D., Heald, A. H., Hanna, F. F., Stedman, M., Wu, P., Sim, J., Duff, C. J., Duce, H., Green, L., Scargill, J., Howe, J. D., Robinson, S., Halsall, I., Gaskell, N., Davison, A., Simms, M., Denny, A., Langan, M., & Fryer, A. A. (2023). The Effect of the COVID-19 Pandemic on HbA1c Testing: Prioritization of High-Risk Cases and Impact of Social Deprivation. Diabetes Therapy, 14, 691-707. https://doi.org/10.1007/s13300-023-01380-x

INTRODUCTION: Studies show that the COVID-19 pandemic disproportionately affected people with diabetes and those from disadvantaged backgrounds. During the first 6 months of the UK lockdown,?>?6.6 M glycated haemoglobin (HbA1c) tests were missed. We... Read More about The Effect of the COVID-19 Pandemic on HbA1c Testing: Prioritization of High-Risk Cases and Impact of Social Deprivation.

Evaluation of thyroid function monitoring in people treated with lithium: Advice based on real‐world data (2023)
Journal Article
Duce, H. L., Duff, C. J., Zaidi, S., Parfitt, C., Heald, A. H., & Fryer, A. A. (2023). Evaluation of thyroid function monitoring in people treated with lithium: Advice based on real‐world data. Bipolar Disorders, 25(5), 402-409. https://doi.org/10.1111/bdi.13298

INTRODUCTION: Blood test monitoring is essential for management of lithium treatment and NICE guidance recommends 6-monthly serum testing of thyroid function. We examined conformity to these guidelines and impact of monitoring outside these intervals... Read More about Evaluation of thyroid function monitoring in people treated with lithium: Advice based on real‐world data.

Health Inequality and its link to HbA1c Test Recovery in a Developed Health Economy: In a 'Nearly Post COVID-19' World (2022)
Presentation / Conference
Heald, A., Holland, D., Duff, C. J., Scargill, J., Hanna, F., & Fryer, A. (2022, November). Health Inequality and its link to HbA1c Test Recovery in a Developed Health Economy: In a 'Nearly Post COVID-19' World. Poster presented at Society for Endocrinology BES 2022, Harrogate, United Kingdom

Background: We previously showed that in first 6 months of the UK Covid-19(C19) pandemic >6.6million HbA1c tests were missed, including 1.4million in people with diabetes(DM). Furthermore, C19 more significantly impacts people with DM / socioeconomic... Read More about Health Inequality and its link to HbA1c Test Recovery in a Developed Health Economy: In a 'Nearly Post COVID-19' World.

Speed of recovery of testing for management of diabetes in the aftermath of COVID-19 is slower in areas of greater social deprivation: findings from a UK study (2022)
Presentation / Conference
Holland, D., Heald, A., Hanna, F., Wu, P., & Fry, A. (2022, September). Speed of recovery of testing for management of diabetes in the aftermath of COVID-19 is slower in areas of greater social deprivation: findings from a UK study. Poster presented at 58 th EASD Annual Meeting of the European Association for the Study of Diabetes, Stockholm, Sweden

Background and aims: We have previously shown that, during the first 6 months of the UK COVID-19-associated lockdown, >6.6M HbA1c tests were missed/delayed, including 1.41M missed/delayed in people with diabetes (0.51M in those with suboptimal contro... Read More about Speed of recovery of testing for management of diabetes in the aftermath of COVID-19 is slower in areas of greater social deprivation: findings from a UK study.

Variability in Test Interval Is Linked to Glycated Haemoglobin (HbA1c) Trajectory over Time (2022)
Journal Article
Fryer, A. A., Holland, D., Stedman, M., Duff, C. J., Green, L., Scargill, J., Hanna, F. W., Wu, P., Pemberton, R. J., Bloor, C., & Heald, A. H. (2022). Variability in Test Interval Is Linked to Glycated Haemoglobin (HbA1c) Trajectory over Time. Journal of Diabetes Research, 2022, 1 - 11. https://doi.org/10.1155/2022/7093707

Aims. We previously showed that the glycated haemoglobin (HbA1c) testing frequency links to diabetes control. Here, we examine the effect of variability in test interval, adjusted for the frequency, on change in HbA1c (delta HbA1c). Materials & Metho... Read More about Variability in Test Interval Is Linked to Glycated Haemoglobin (HbA1c) Trajectory over Time.

Variability in test interval is linked to glycated haemoglobin (HbA1c) trajectory over time in people with diabetes (2022)
Presentation / Conference Contribution
Fryer, A., Holland, D., Stedman, M., Duff, C., Green, L., Scargill, J., Hanna, F., Pemeberton, R., Bloor, C., & Heald, A. (2022, March). Variability in test interval is linked to glycated haemoglobin (HbA1c) trajectory over time in people with diabetes. Poster presented at Diabetes UK Professional Conference 2022, Hybrid/Online

Introduction: Frequency of HbA1c testing links to outcome in terms of HbA1c control in diabetes. The influence of the variability of test-retest interval on HbA1c change needs to be determined.

Methods: HbA1c results were collected from laboratory... Read More about Variability in test interval is linked to glycated haemoglobin (HbA1c) trajectory over time in people with diabetes.