Professor Anthony Fryer's Outputs (9)

Genome-wide profiling in treatment-naive early rheumatoid arthritis reveals DNA methylome changes in T and B lymphocytes (2015)
Journal Article
Glossop, J. R., Emes, R. D., Nixon, N. B., Packham, J. C., Fryer, A. A., Mattey, D. L., & Farrell, W. E. (2016). Genome-wide profiling in treatment-naive early rheumatoid arthritis reveals DNA methylome changes in T and B lymphocytes. Epigenomics, 8(2), 209-224. https://doi.org/10.2217/epi.15.103

Aim: Although aberrant DNA methylation has been described in rheumatoid arthritis (RA), no studies have interrogated this epigenetic modification in early disease. Following recent investigations of T and B lymphocytes in established disease, we now... Read More about Genome-wide profiling in treatment-naive early rheumatoid arthritis reveals DNA methylome changes in T and B lymphocytes.

Are cholesterol levels being checked and managed appropriately in UK primary care type 2 diabetes? (2015)
Journal Article
Livingston, M., Robinson, J. C., Brown, C. E., Narayanan, R. P., Holland, D., Fryer, A. A., & Heald, A. H. (2015). Are cholesterol levels being checked and managed appropriately in UK primary care type 2 diabetes?. International Journal of Clinical Practice, 69(11), 1389-1391. https://doi.org/10.1111/ijcp.12717

Methylation of HOXA9 and ISL1 Predicts Patient Outcome in High-Grade Non-Invasive Bladder Cancer. (2015)
Journal Article
Kitchen, M. O., Bryan, R. T., Haworth, K. E., Emes, R. D., Luscombe, C., Gommersall, L., …Farrell, W. E. (2015). Methylation of HOXA9 and ISL1 Predicts Patient Outcome in High-Grade Non-Invasive Bladder Cancer. PloS one, e0137003 - ?. https://doi.org/10.1371/journal.pone.0137003

INTRODUCTION: Inappropriate DNA methylation is frequently associated with human tumour development, and in specific cases, is associated with clinical outcomes. Previous reports of DNA methylation in low/intermediate grade non-muscle invasive bladder... Read More about Methylation of HOXA9 and ISL1 Predicts Patient Outcome in High-Grade Non-Invasive Bladder Cancer..

DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS (2015)
Journal Article
Glossop, J. R., Haworth, K. E., Emes, R. D., Nixon, N. B., Packham, J. C., Dawes, P. T., …Farrell, W. E. (2015). DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS. Epigenomics, 7(4), 539 -551. https://doi.org/10.2217/epi.15.15

AIM: Alterations in DNA methylation contribute to the abnormal phenotype of fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA). We profiled genome-wide DNA methylation in these cells from synovial fluid, a more readily ac... Read More about DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS.

O51. DNA Methylation Profiling of Synovial Fluid-Derived Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis Reveals Common and Distinct Changes Relative to their Tissue-Derived Counterparts (2015)
Journal Article
Glossop, J. R., Haworth, K. E., Emes, R. D., Nixon, N. B., Packham, J. C., Dawes, P. T., …Farrell, W. E. (2015). O51. DNA Methylation Profiling of Synovial Fluid-Derived Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis Reveals Common and Distinct Changes Relative to their Tissue-Derived Counterparts. Rheumatology, 54(S1), i48. https://doi.org/10.1093/rheumatology/kev087.003

Background: Fibroblast-like synoviocytes (FLS) from patients with RA display an aggressive, invasive phenotype and play a key role in joint destruction. Increasing evidence indicates that alterations to the epigenome, including DNA methylation, contr... Read More about O51. DNA Methylation Profiling of Synovial Fluid-Derived Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis Reveals Common and Distinct Changes Relative to their Tissue-Derived Counterparts.

Revisiting screening for type 2 diabetes mellitus: the case for and against using HbA1c (2015)
Journal Article
Hanna, F. W. F., Wilkie, V., Issa, B. G., & Fryer, A. A. (2015). Revisiting screening for type 2 diabetes mellitus: the case for and against using HbA1c. British Journal of General Practice (BJGP), 65(633), E278-E280. https://doi.org/10.3399/bjgp15X684637

Type 2 diabetes mellitus is a major cause of morbidity and premature mortality in the Western world. It is responsible for about 10% of the NHS spend (about £286/second in the UK). Of those diagnosed with type 2 diabetes, 25% are thought already to h... Read More about Revisiting screening for type 2 diabetes mellitus: the case for and against using HbA1c.

Relationship between HbA1c and fasting plasma glucose in pregnancy and haemoglobinopathy trait (2015)
Presentation / Conference
Shanmugasundaram, M., Fryer, A., & Nayak, A. (2015, March). Relationship between HbA1c and fasting plasma glucose in pregnancy and haemoglobinopathy trait. Paper presented at UK Professional Conference 2015, ExCel, London, England, UK

Timing of HbA1c pre-admission: impact on readmission and in-hospital mortality in patients with diabetes (2015)
Presentation / Conference
Arora, A., Shanmugasundaram, M., Varughese, G., Duffs, C., Fryer, A., & Nayak, A. (2015, March). Timing of HbA1c pre-admission: impact on readmission and in-hospital mortality in patients with diabetes. Poster presented at Diabetes UK Professional Conference 2015, ExCel London, UK

Aims: Association between high HbA1c and risk of all-cause hospital admissions is recognised. We aimed to investigate the impact of HbA1c screening pre-admission the time of admission, on readmission rates and in-hospital mortality.
Methods: Amongst... Read More about Timing of HbA1c pre-admission: impact on readmission and in-hospital mortality in patients with diabetes.

Are cholesterol levels being checked and managed appropriately in primary care Type 2 diabetes patients? (2015)
Presentation / Conference
Livingston, M., Robinson, J., Brown, E., Holland, D., Fryer, A., & Heald, A. (2015, March). Are cholesterol levels being checked and managed appropriately in primary care Type 2 diabetes patients?. Poster presented at Diabetes UK Professional Conference 2015, ExCeL London, UK