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Pensee Wu's Outputs (93)

Impact of Covid-19 on antenatal care: evidence from Madagascar Demographic and Health Survey (2025)
Journal Article
Magadi, M. A., Obare, F. O., Kaseje, N., & Wu, P. (in press). Impact of Covid-19 on antenatal care: evidence from Madagascar Demographic and Health Survey. Journal of Biosocial Science, 1-19. https://doi.org/10.1017/S0021932025000112

Despite the growing literature on the impact of Covid-19 on antenatal care (ANC) and maternal/neonatal and child health outcomes globally, substantial knowledge gaps remain about the population-level impact in sub-Saharan Africa (SSA). Existing evide... Read More about Impact of Covid-19 on antenatal care: evidence from Madagascar Demographic and Health Survey.

Maternal perinatal anxiety and infant primary care use in 1998–2016: a UK cohort study (2025)
Journal Article
Smith, H. C., Archer, C., Bailey, J., Chew Graham, C., Evans, J., Fisher, T., Kessler, D., Kingstone, T., Procter, J., Shivji, N., Silverwood, V., Spruce, A., Turner, K., Wu, P., Yu, D., & Petersen, I. (2025). Maternal perinatal anxiety and infant primary care use in 1998–2016: a UK cohort study. BMJ Mental Health, 28(1), 1-8. https://doi.org/10.1136/bmjment-2024-301160

There is some evidence that perinatal anxiety (PNA) is associated with lower rates of infant vaccinations and decreased access to preventative infant healthcare, but results across studies have not been conclusive. To investigate the relationship bet... Read More about Maternal perinatal anxiety and infant primary care use in 1998–2016: a UK cohort study.

The Impact of Age and Sex on Fasting Plasma Glucose and Glycated Haemoglobin (HbA1c) in the Non-diabetes Population. (2024)
Journal Article
Stedman, M., Heald, A. H., Holland, D., Halsall, I., Green, L., Wu, P., Patel, K., Scargill, J., Gibson, M., Hanna, F. W. F., & Fryer, A. A. (in press). The Impact of Age and Sex on Fasting Plasma Glucose and Glycated Haemoglobin (HbA1c) in the Non-diabetes Population. Diabetes Therapy, https://doi.org/10.1007/s13300-024-01680-w

We previously reported sex differences in the distribution of glycated haemoglobin (HbA1c) for men/women aged < 50 years vs older individuals, with implications for delayed diabetes diagnosis. Here, we explored whether this pattern was also seen in m...

The link between age, sex, fasting plasma glucose and glycated haemoglobin (HbA 1c ) (2024)
Presentation / Conference Contribution
Stedman, M., Heald, A., Holland, D., Halsall, I., Green, L., Wu, P., Scargill, J., Hanna, F., Colclough, K., Gibson, M., & Fryer, A. The link between age, sex, fasting plasma glucose and glycated haemoglobin (HbA 1c ). Presented at 60th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Madrid, Spain

Using maternal glycosylated haemoglobin as well as glucose tolerance tests identified significantly more mothers with high birth weight in their offspring (2024)
Presentation / Conference Contribution
Wu, P., Stedman, M., Fryer, A., Green, L., Holland, D., Scargill, J., Pankaja, S., Christian, S., & Heald, A. Using maternal glycosylated haemoglobin as well as glucose tolerance tests identified significantly more mothers with high birth weight in their offspring. Presented at 60th EASD Annual Meeting of the European Association for the Study of Diabetes, Madrid, Spain

The OBS UK Dashboard: an interactive tool for representative trial site selection to facilitate equality and diversity in maternity research (2024)
Journal Article
Elsmore, A., Rai, T., Pallmann, P., Townson, J., Kotecha, S., Black, M., Sanders, J., Collis, R., Collins, P., Karunakaran, B., Wu, P., Bell, S., & Parry-Smith, W. (in press). The OBS UK Dashboard: an interactive tool for representative trial site selection to facilitate equality and diversity in maternity research. Trials, 25(1), Article 629. https://doi.org/10.1186/s13063-024-08487-x

Background: Obstetric Bleeding Study UK (OBS UK) (award ID: 152057) is a National Institute for Health and Care Research (NIHR)-funded stepped wedge cluster randomised controlled trial of a complex intervention for postpartum haemorrhage. This was de... Read More about The OBS UK Dashboard: an interactive tool for representative trial site selection to facilitate equality and diversity in maternity research.

O24 ACUTE KIDNEY INJURY IN PREGNANCY AND CARDIO-RENAL OUTCOMES: A SYSTEMATIC REVIEW AND META-ANALYSIS (2024)
Presentation / Conference
Jeyaraman, D., Peiris, T. D. P., Alahmdi, H., Fish, R., Lambie, M., & Wu, P. (2024, September). O24 ACUTE KIDNEY INJURY IN PREGNANCY AND CARDIO-RENAL OUTCOMES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Presented at 30th Congress of the International Society of Hypertension, Cartegena de Indias, Colombia

Background and Objective: Acute kidney injury (AKI) is a common problem in pregnancy but adverse cardio-renal outcomes following AKI in pregnancy has not been systematically evaluated. We aimed to quantify the risk of adverse cardio-renal outcomes of... Read More about O24 ACUTE KIDNEY INJURY IN PREGNANCY AND CARDIO-RENAL OUTCOMES: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Syngeneic mesenchymal stem cells loaded with telomerase-dependent oncolytic adenoviruses enhance anti-metastatic efficacy. (2024)
Journal Article
Yang, M.-L., Hu, C.-Y., Lee, Y.-C., Chang, C.-C., Chen, Y.-C., Lee, P.-R., Su, B.-H., Chen, P.-C., Shiau, A.-L., Shieh, G.-S., Wu, C.-L., & Wu, P. (in press). Syngeneic mesenchymal stem cells loaded with telomerase-dependent oncolytic adenoviruses enhance anti-metastatic efficacy. Stem Cells Translational Medicine, Article szae039. https://doi.org/10.1093/stcltm/szae039

Oncolytic adenoviruses have emerged as a promising therapeutic approach for cancer therapy. However, systemic delivery of the viruses to metastatic tumors remains a major challenge. Mesenchymal stem cells (MSCs) possess tumor tropism property and can... Read More about Syngeneic mesenchymal stem cells loaded with telomerase-dependent oncolytic adenoviruses enhance anti-metastatic efficacy..

Effects of vitamin D in pregnancy on maternal and offspring health-related outcomes: An umbrella review of systematic review and meta-analyses (2024)
Journal Article
Chien, M.-C., Huang, C.-Y., Wang, J.-H., Shih, C.-L., & Wu, P. (in press). Effects of vitamin D in pregnancy on maternal and offspring health-related outcomes: An umbrella review of systematic review and meta-analyses. Nutrition and Diabetes, 14(1), Article 35. https://doi.org/10.1038/s41387-024-00296-0

Background
Vitamin D deficiency has been linked with several adverse maternal and fetal outcomes.

Objective
To summarize systematic reviews and meta-analyses evaluating the effects of vitamin D deficiency and of vitamin D supplementation in preg... Read More about Effects of vitamin D in pregnancy on maternal and offspring health-related outcomes: An umbrella review of systematic review and meta-analyses.

Could primary care records be used to identify women at risk of perinatal anxiety? A mixed-methods study. (2024)
Presentation / Conference Contribution
Fisher, T., Archer, C., Bailey, J., Evans, J., Kessler, D. S., Kingstone, T., Petersen, I., Proctor, J., Shivji, N., Spruce, A., Silverwood, V., Smith, H., Turner, K., Wu, P., Yu, D., & Chew-Graham, C. (2024, March). Could primary care records be used to identify women at risk of perinatal anxiety? A mixed-methods study. Presented at BJGP Research & Publishing Conference, RCGP Headquarters in London, England, UK

Perinatal anxiety (PNA) occurs throughout the antenatal period or up to 1 year after childbirth, with a prevalence of 21%. To investigate if primary care records could be used to identify women at 'higher risk' of PNA. Mixed-methods approach using qu... Read More about Could primary care records be used to identify women at risk of perinatal anxiety? A mixed-methods study..

Pregnancy-Associated Cancer: A Systematic Review and Meta-Analysis (2024)
Journal Article
Walters, B., Midwinter, I., A. Chew-Graham, C., P. Jordan, K., Sharma, G., C. Chappell, L., J. Crosbie, E., Parwani, P., A. Mamas, M., & Wu, P. (2024). Pregnancy-Associated Cancer: A Systematic Review and Meta-Analysis. Mayo Clinic Proceedings, 8(2), 188-199. https://doi.org/10.1016/j.mayocpiqo.2024.02.002

This study aimed to systematically evaluate and quantify the risk of adverse maternal and neonatal outcomes in patients with pregnancy-associated cancer (PAC). This study was conducted from February 13, 2021, through July 24, 2023.... Read More about Pregnancy-Associated Cancer: A Systematic Review and Meta-Analysis.

Adverse pregnancy outcomes in pregnant women with chronic kidney disease: A systematic review and meta‐analysis (2024)
Journal Article
Jeyaraman, D., Walters, B., Bramham, K., Fish, R., Lambie, M., & Wu, P. (2024). Adverse pregnancy outcomes in pregnant women with chronic kidney disease: A systematic review and meta‐analysis. BJOG: An International Journal of Obstetrics and Gynaecology, https://doi.org/10.1111/1471-0528.17807

Background
Chronic kidney disease (CKD) is associated with an increased risk of adverse pregnancy outcomes, but the risk at different stages of CKD (defined by estimated glomerular filtration rate, eGFR) compared with women without CKD has not been... Read More about Adverse pregnancy outcomes in pregnant women with chronic kidney disease: A systematic review and meta‐analysis.

Correction to: Is the Current Cut Point for Glycated Haemoglobin (HbA1c) Correct for Diagnosing Diabetes Mellitus in Premenopausal Women? Evidence to Inform Discussion (2023)
Journal Article
Holland, D., A. Fryer, A., Stedman, M., W. F. Hanna, F., J. Duff, C., Green, L., Scargill, J., Halsall, I., Gaskell, N., D. Howe, J., H. Heald, A., & Wu, P. (2023). Correction to: Is the Current Cut Point for Glycated Haemoglobin (HbA1c) Correct for Diagnosing Diabetes Mellitus in Premenopausal Women? Evidence to Inform Discussion. Diabetes Therapy, https://doi.org/10.1007/s13300-023-01498-y

Cohort profile: Improved Pregnancy Outcomes via Early Detection (IMPROvED), an International Multicentre Prospective Cohort [version 1; peer review: 1 approved with reservations] (2023)
Journal Article
Maher, G. M., Kenny, L. C., Navaratnam, K., Alfirevic, Z., Sheehan, D., Baker, P. N., Gluud, C., Tuytten, R., Kublickas, M., Niklasson, B., Duvekot, J. J., van den Berg, C. B., Wu, P., Kublickiene, K., McCarthy, F. P., & Khashan, A. S. (2023). Cohort profile: Improved Pregnancy Outcomes via Early Detection (IMPROvED), an International Multicentre Prospective Cohort [version 1; peer review: 1 approved with reservations]. HRB Open Research, 6(65), https://doi.org/10.12688/hrbopenres.13812.1

Background
Improved Pregnancy Outcomes via Early Detection (IMPROvED) is a multi-centre, European phase IIa clinical study. The primary aim of IMPROvED is to enable the assessment and refinement of innovative prototype preeclampsia risk assessment t... Read More about Cohort profile: Improved Pregnancy Outcomes via Early Detection (IMPROvED), an International Multicentre Prospective Cohort [version 1; peer review: 1 approved with reservations].

Cohort profile: Improved Pregnancy Outcomes via Early Detection (IMPROvED), an International Multicentre Prospective Cohort. (2023)
Journal Article
Maher, G. M., Kenny, L. C., Navaratnam, K., Alfirevic, Z., Sheehan, D., Baker, P. N., Gluud, C., Tuytten, R., Kublickas, M., Niklasson, B., Duvekot, J. J., van den Berg, C. B., Wu, P., Kublickiene, K., McCarthy, F. P., & Khashan, A. S. (2023). Cohort profile: Improved Pregnancy Outcomes via Early Detection (IMPROvED), an International Multicentre Prospective Cohort. HRB Open Research, 6(65), 1-19. https://doi.org/10.12688/hrbopenres.13812.2

BackgroundImproved Pregnancy Outcomes via Early Detection (IMPROvED) is a multi-centre, European phase IIa clinical study. The primary aim of IMPROvED is to enable the assessment and refinement of innovative prototype preeclampsia risk assessment tes... Read More about Cohort profile: Improved Pregnancy Outcomes via Early Detection (IMPROvED), an International Multicentre Prospective Cohort..

Is the Current Cut Point for Glycated Haemoglobin (HbA1c) Correct for Diagnosing Diabetes Mellitus in Premenopausal Women? Evidence to Inform Discussion (2023)
Journal Article
Holland, D., Fryer, A. A., Stedman, M., Hanna, F. W. F., Duff, C. J., Green, L., Scargill, J., Halsall, I., Gaskell, N., Howe, J. D., Heald, A. H., & Wu, P. (2023). Is the Current Cut Point for Glycated Haemoglobin (HbA1c) Correct for Diagnosing Diabetes Mellitus in Premenopausal Women? Evidence to Inform Discussion. Diabetes Therapy, https://doi.org/10.1007/s13300-023-01482-6

Women are on average diagnosed with diabetes mellitus at later age than men but have higher mortality. As the diagnosis of diabetes mellitus is primarily based on HbA1c, the use of a non-specific reference range and cut point for diabetes mellitus th... Read More about Is the Current Cut Point for Glycated Haemoglobin (HbA1c) Correct for Diagnosing Diabetes Mellitus in Premenopausal Women? Evidence to Inform Discussion.

Substance Use in Pregnancy and its Association With Cardiovascular Events (2023)
Journal Article
Evans, K., Wu, P., Mamas, M. A., Irwin, C., Kang, P., Perlow, J. H., Foley, M., & Gulati, M. (2023). Substance Use in Pregnancy and its Association With Cardiovascular Events. JACC: Advances, 2(8), 100619. https://doi.org/10.1016/j.jacadv.2023.100619

Background
Substance use and cardiovascular (CV) events are increasing among pregnant women in the United States, but association between substance use in pregnancy and CV events remains unknown.

Objectives
The purpose of this stu... Read More about Substance Use in Pregnancy and its Association With Cardiovascular Events.

Diabetes detection in women with gestational diabetes and polycystic ovarian syndrome (2023)
Journal Article
Hanna, F., Wu, P., Heald, A., & Fryer, A. (2023). Diabetes detection in women with gestational diabetes and polycystic ovarian syndrome. BMJ, 382, Article e071675. https://doi.org/10.1136/bmj-2022-071675

Gestational diabetes mellitus (GDM) and polycystic ovarian syndrome (PCOS) represent two of the highest risk factors for development of type 2 diabetes mellitus in young women. As these increasingly common conditions generally affect younger women, e... Read More about Diabetes detection in women with gestational diabetes and polycystic ovarian syndrome.

Hypertensive disorders of pregnancy. (2023)
Journal Article
Wu, P., Green, M., & Myers, J. (2023). Hypertensive disorders of pregnancy. BMJ, 381, Article e071653. https://doi.org/10.1136/bmj-2022-071653

Hypertensive disorders of pregnancy (HDP) are one of the most commonly occurring complications of pregnancy and include chronic hypertension, gestational hypertension, and pre-eclampsia. New developments in early pregnancy screening to identify women... Read More about Hypertensive disorders of pregnancy..