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Substance Use in Pregnancy and its Association With Cardiovascular Events

Evans, Kari; Wu, Pensée; Mamas, Mamas A.; Irwin, Chase; Kang, Paul; Perlow, Jordan H.; Foley, Michael; Gulati, Martha


Kari Evans

Chase Irwin

Paul Kang

Jordan H. Perlow

Michael Foley

Martha Gulati


Substance use and cardiovascular (CV) events are increasing among pregnant women in the United States, but association between substance use in pregnancy and CV events remains unknown.

The purpose of this study was to examine the association between substance use and acute CV events in pregnancy.

We identified all women with a delivery hospitalization between 2004 and 2018 in the Nationwide Inpatient Sample, stratified on the presence or absence of substance use. The primary outcome was any acute CV event, defined as the presence of: acute myocardial infarction, stroke, arrhythmia, endocarditis, acute cardiomyopathy or heart failure, or cardiac arrest. Secondary outcomes were individual acute CV events, major adverse cardiac events, and maternal mortality. The association between substance use and outcomes were examined using multivariable logistical regression.

A total of 60,014,368 delivery hospitalizations occurred from 2004 to 2018, with substance use complicating 955,531 (1.6%) deliveries. Substance use was independently associated with CV events (adjusted odds ratio [aOR]: 1.61; 95% CI: 1.53-1.70; P < 0.001), major adverse cardiac events (aOR: 1.53; 95% CI: 1.46-1.61; P < 0.001), and maternal mortality (aOR: 2.65; 95% CI: 2.15-3.25; P < 0.001) during delivery hospitalization. All individual substances had an increased association with CV events; however, amphetamine/methamphetamine had the strongest association (aOR: 2.71; 95% CI: 2.35-3.12; P < 0.001). All substances other than cocaine and cannabis had a significant association with maternal death.

Substance use has a strong association with acute CV events and maternal mortality during hospitalization for delivery and women with substance use warrant increased surveillance for CV events during this time.

Journal Article Type Article
Acceptance Date Jul 17, 2023
Online Publication Date Sep 14, 2023
Publication Date 2023-10
Deposit Date Oct 3, 2023
Publicly Available Date Oct 3, 2023
Journal JACC: Advances
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 2
Issue 8
Pages 100619
Keywords cardiovascular, cardiovascular disease, maternal mortality pregnancy, substance use


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