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Outputs (85)

Quality improvement project assessing the feasibility of using canister weight to estimate remaining doses in a salbutamol pressurised metered-dose inhaler. (2024)
Journal Article
Beckett, R. S., Jagadish, A., Carroll, W., & Gilchrist, F. J. (in press). Quality improvement project assessing the feasibility of using canister weight to estimate remaining doses in a salbutamol pressurised metered-dose inhaler. Archives of Disease in Childhood, archdischild-2023-326678. https://doi.org/10.1136/archdischild-2023-326678

Outcome data from 15 years of cystic fibrosis newborn screening in a large UK region (2023)
Journal Article
Driscoll, S. J., Heinz, K., Goddard, P., Desai, M., & Gilchrist, F. J. (in press). Outcome data from 15 years of cystic fibrosis newborn screening in a large UK region. Archives of Disease in Childhood, https://doi.org/10.1136/archdischild-2023-325955

Background: The West Midlands Newborn Bloodspot Screening Laboratory is one of 16 in the UK and serves two tertiary paediatric cystic fibrosis (CF) centres (Staffordshire Children’s Hospital at Royal Stoke and Birmingham Children’s Hospital). CF newb... Read More about Outcome data from 15 years of cystic fibrosis newborn screening in a large UK region.

ALPINE2: Efficacy and safety of 14-day vs 28-day inhaled aztreonam for Pa eradication in children with cystic fibrosis. (2023)
Journal Article
Gilchrist, F. J., Bui, S., Gartner, S., McColley, S. A., Tiddens, H., Ruiz, G., …Skov, M. (in press). ALPINE2: Efficacy and safety of 14-day vs 28-day inhaled aztreonam for Pa eradication in children with cystic fibrosis. Journal of Cystic Fibrosis, 23(1), 80-86. https://doi.org/10.1016/j.jcf.2023.06.008

Antibiotic eradication therapies recommended for newly isolated Pseudomonas aeruginosa (Pa) in people with cystic fibrosis (pwCF) can be burdensome. ALPINE2 compared the efficacy and safety of a shortened 14-day course of aztreonam for inhalation sol... Read More about ALPINE2: Efficacy and safety of 14-day vs 28-day inhaled aztreonam for Pa eradication in children with cystic fibrosis..

The prevalence of children in the UK Cystic Fibrosis Registry on long term anti-Pseudomonas aeruginosa (PA) inhaled antibiotics who become culture negative for PA and a survey of practice for discontinuing treatment (2023)
Journal Article
Gilchrist, F., Davies, B., & Brodlie, M. (2023). The prevalence of children in the UK Cystic Fibrosis Registry on long term anti-Pseudomonas aeruginosa (PA) inhaled antibiotics who become culture negative for PA and a survey of practice for discontinuing treatment. Journal of Cystic Fibrosis, https://doi.org/10.1016/j.jcf.2023.05.007

Implementation of a primary care asthma management quality improvement programme across 68 general practice sites (2023)
Journal Article
Gilchrist, F. J., Carroll, W. D., Clayton, S., Price, D., Jarrold, I., Small, I., …Lenney, W. (in press). Implementation of a primary care asthma management quality improvement programme across 68 general practice sites. npj Primary Care Respiratory Medicine, 33(1), Article 21. https://doi.org/10.1038/s41533-023-00341-y

Despite national and international guidelines, asthma is frequently misdiagnosed, control is poor and unnecessary deaths are far too common. Large scale asthma management programme such as that undertaken in Finland, can improve asthma outcomes. A pr... Read More about Implementation of a primary care asthma management quality improvement programme across 68 general practice sites.

Symptom patterns and life with post-acute COVID-19 in children aged 8-17: a mixed methods studyprotocol. (2023)
Journal Article
Faux-Nightingale, A., Burton, C., Twohig, H., Bucknall, M., Carroll, W., Chew-Graham, C., …Welsh, V. (2023). Symptom patterns and life with post-acute COVID-19 in children aged 8-17: a mixed methods studyprotocol. British Journal of General Practice Open (BJGP Open), 7(2), Article BJGPO20220149. https://doi.org/10.3399/bjgpo.2022.0149

Background: While there is a substantial body of knowledge about acute COVID-19, less is known about long-COVID, where symptoms continue beyond 4 weeks. Aim: To describe longer-term effects of COVID-19 infection in children and young people (CYP)... Read More about Symptom patterns and life with post-acute COVID-19 in children aged 8-17: a mixed methods studyprotocol..

Protocol for CLASSIC PBB: comparison of lower airway sampling strategies in children with protracted bacterial bronchitis (2022)
Journal Article
Gilchrist, F., Aspey, M., Bowler, R., Brodlie, M., Desai, S., Harris, C., …Carroll, W. D. (2022). Protocol for CLASSIC PBB: comparison of lower airway sampling strategies in children with protracted bacterial bronchitis. BMJ Paediatrics Open, e001722 - e001722. https://doi.org/10.1136/bmjpo-2022-001722

Background Protracted bacterial bronchitis (PBB) is an endobronchial infection and a the most common cause of chronic wet cough in young children. It is treated with antibiotics, which can only be targeted if the causative organism is known. As most... Read More about Protocol for CLASSIC PBB: comparison of lower airway sampling strategies in children with protracted bacterial bronchitis.

Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis (2021)
Journal Article
Carroll, W., Green, J., & Gilchrist, F. J. (in press). Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis. Cochrane Database of Systematic Reviews, 2021(12), https://doi.org/10.1002/14651858.cd012619.pub3

Background Cystic fibrosis (CF) is the most common, life‐limiting, genetically inherited disease. It affects multiple organs, particularly the respiratory system. However, gastrointestinal problems such as constipation and distal intestinal obstruct... Read More about Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis.

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis (2021)
Journal Article
Gilchrist, F. J., Green, J., & Carroll, W. (2021). Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis. Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.CD012798.pub3

BACKGROUND: Cystic fibrosis is the most common life-limiting autosomal recessive genetic disorder in white populations. Distal intestinal obstruction syndrome (DIOS) is an important morbidity in cystic fibrosis. It is the result of the accumulation o... Read More about Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis.

Why are children with asthma bullied? A risk factor analysis. (2021)
Journal Article
Gilchrist. (2021). Why are children with asthma bullied? A risk factor analysis. Archives of Disease in Childhood, https://doi.org/10.1136/archdischild-2021-321641

The links between bullying and asthma have not been explored in children. We wanted to determine the child/parent factors and attitudes associated with asthma-related bullying. Individual child/parent responses of children with asthma (N=943) from th... Read More about Why are children with asthma bullied? A risk factor analysis..

Managing chronic wet cough in children: another piece of the puzzle. (2021)
Journal Article
Gilchrist. (2021). Managing chronic wet cough in children: another piece of the puzzle. Lancet Respiratory Medicine, 1078 - 1079. https://doi.org/10.1016/S2213-2600%2821%2900159-4

Chronic wet cough is the hallmark of chronic obstructive pulmonary disease in older people and bronchiectasis in adults and older children. In young children, the commonest cause of chronic wet cough is protracted bacterial bronchitis (PBB) but there... Read More about Managing chronic wet cough in children: another piece of the puzzle..

Longitudinal assessment of lung clearance index to monitor disease progression in children and adults with cystic fibrosis. (2021)
Journal Article
Horsley, A. R., Belcher, J., Bayfield, K., Bianco, B., Cunningham, S., Fullwood, C., …Gilchrist, F. J. (2021). Longitudinal assessment of lung clearance index to monitor disease progression in children and adults with cystic fibrosis. Thorax, 77(4), https://doi.org/10.1136/thoraxjnl-2021-216928

BACKGROUND: Lung clearance index (LCI) is a valuable research tool in cystic fibrosis (CF) but clinical application has been limited by technical challenges and uncertainty about how to interpret longitudinal change. In order to help inform clinical... Read More about Longitudinal assessment of lung clearance index to monitor disease progression in children and adults with cystic fibrosis..

Respiratory Disorders (2021)
Book Chapter
Gilchrist, F., & Carroll, W. D. (2021). Respiratory Disorders. In Illustrated Textbook of Paediatrics. (6th). Elsevier

This sixth edition of the acclaimed and award-winning ‘Sunflower book’ comprehensively covers the undergraduate curriculum in paediatrics and child health. Topics are made accessible with numerous colour images, diagrams and case studies, and revisio... Read More about Respiratory Disorders.

Chapter 17: Respiratory Disorders (2021)
Book Chapter
Gilchrist, F., & Carroll, W. (2021). Chapter 17: Respiratory Disorders. In Illustrated Textbook of Paediatrics, 6th Edition. Elsevier

Single-centre survey of parents regarding the hidden burden of paediatric flexible bronchoscopy. (2021)
Journal Article
Gilchrist. (2021). Single-centre survey of parents regarding the hidden burden of paediatric flexible bronchoscopy. BMJ Paediatrics Open, e000991 - ?. https://doi.org/10.1136/bmjpo-2020-000991

Although paediatric flexible bronchoscopy is safe with relatively few side effects, parents frequently report an associated burden. To assess this, we undertook 25 semi-structured interviews with the parents of children who had recently undergone thi... Read More about Single-centre survey of parents regarding the hidden burden of paediatric flexible bronchoscopy..

Why are children with asthma bullied? A quantitative analysis of bullying risk factors in the Room to Breathe cohort (2020)
Presentation / Conference
Gilchrist. (2020, September). Why are children with asthma bullied? A quantitative analysis of bullying risk factors in the Room to Breathe cohort. Presented at ERS International Congress 2020

Background: Bullying and asthma are common challenges faced by children worldwide. It has been shown that children with chronic health conditions are at higher risk of being bullied, but this has not been explored in detail in asthma. Aims and Object... Read More about Why are children with asthma bullied? A quantitative analysis of bullying risk factors in the Room to Breathe cohort.

Practical Paediatric Prescribing, 1st Edition (2020)
Book
Carroll, W., Gilchrist, F. J., Mitchell, M., Sammons, H., & Srinivas, J. (2020). Practical Paediatric Prescribing, 1st Edition. Elsevier

Prescribing for children is problematic. Children are not small adults in terms of their physiology, and they cannot be subjects in clinical trials. This makes prescribing for them something of an art and a daunting one at that for trainees. Will Car... Read More about Practical Paediatric Prescribing, 1st Edition.

Lung clearance index in healthy volunteers, measured using a novel portable system with a closed circuit wash-in (2020)
Journal Article
Gilchrist. (2020). Lung clearance index in healthy volunteers, measured using a novel portable system with a closed circuit wash-in. PloS one, https://doi.org/10.1371/journal.pone.0229300

INTRODUCTION: Lung clearance index (LCI) is a sensitive measure of early lung disease, but adoption into clinical practice has been slow. Challenges include the time taken to perform each test. We recently described a closed-circuit inert gas wash-in... Read More about Lung clearance index in healthy volunteers, measured using a novel portable system with a closed circuit wash-in.

Developing a core outcome set for children with protracted bacterial bronchitis. (2020)
Journal Article
Gilchrist. (2020). Developing a core outcome set for children with protracted bacterial bronchitis. ERJ Open Research, https://doi.org/10.1183/23120541.00344-2019

Background: Protracted bacterial bronchitis (PBB) is a chronic endobrochial infection and a leading cause of chronic wet cough in children. There is an urgent need for a randomised controlled trial to investigate the optimal treatment but there is no... Read More about Developing a core outcome set for children with protracted bacterial bronchitis..

A public health emergency among young people. (2019)
Journal Article
Bush, A., Bhatt, J. M., Connett, G. J., Doull, I., Gilchrist, F. J., Grigg, J., …Sinha, I. P. (2019). A public health emergency among young people. Lancet Respiratory Medicine, 8(3), 231-233. https://doi.org/10.1016/S2213-2600%2819%2930468-0

While some countries have banned the use of e-cigarettes or vaping products altogether (eg, India), and others have strongly advised against their use (eg, Australia), in the UK, Public Health England (PHE) appears to be a lone voice in stating that... Read More about A public health emergency among young people..

Healthcare utilisation in children with SMA type 1 treated with nusinersen: a single centre retrospective review. (2019)
Journal Article
Gilchrist. (2019). Healthcare utilisation in children with SMA type 1 treated with nusinersen: a single centre retrospective review. BMJ Paediatrics Open, https://doi.org/10.1136/bmjpo-2019-000572

Background: Nusinersen has been used to treat spinal muscular atrophy type 1 (SMA1) in the UK since 2017. While initial trials showed neuromuscular benefit from treating SMA1, there is little information on the respiratory effects of nusinersen. We a... Read More about Healthcare utilisation in children with SMA type 1 treated with nusinersen: a single centre retrospective review..

Factors affecting the growth of infants diagnosed with cystic fibrosis by newborn screening (2019)
Journal Article
Gilchrist, & Kyriacou. (2019). Factors affecting the growth of infants diagnosed with cystic fibrosis by newborn screening. BMC Pediatrics, https://doi.org/10.1186/s12887-019-1727-9

Newborn screening (NBS) for cystic fibrosis (CF) improves nutritional outcomes. Despite early dietetic intervention some children fail to grow optimally. We report growth from birth to 2 years in a cohort of children diagnosed with CF by NBS and iden... Read More about Factors affecting the growth of infants diagnosed with cystic fibrosis by newborn screening.

Less sun, more cough: Annual hours of sunshine are inversely associated with hospital admissions for children with lower respiratory tract infection (2019)
Presentation / Conference
Gilchrist. (2019, September). Less sun, more cough: Annual hours of sunshine are inversely associated with hospital admissions for children with lower respiratory tract infection. Presented at ERS International Congress 2019, IFEMA, Madrid

Background: Vitamin D deficiency affects immune function increasing susceptibility to respiratory tract infections (RTI). Randomised controlled trials show vitamin D supplementation protects against acute RTIs. Most vitamin D (>90%) is acquired from... Read More about Less sun, more cough: Annual hours of sunshine are inversely associated with hospital admissions for children with lower respiratory tract infection.

Duration of initial antibiotic course is associated with recurrent relapse in protracted bacterial bronchitis (2019)
Presentation / Conference
Grose-Hodge, E., Carroll, W., Rainford, N., Gamble, C., & Gilchrist, F. (2019, September). Duration of initial antibiotic course is associated with recurrent relapse in protracted bacterial bronchitis. Presented at ERS International Congress 2019, Madrid, Spain

Background: Protracted Bacterial Bronchitis (PBB) is a leading cause of chronic wet cough in children. Antibiotic response is a diagnostic criterion but there is little evidence to inform duration of treatment. Relapse is common and those who relapse... Read More about Duration of initial antibiotic course is associated with recurrent relapse in protracted bacterial bronchitis.

Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres (2019)
Journal Article
Ditchfield, N., Carroll, W., & Gilchrist, F. (2019). Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres. Journal of Cystic Fibrosis, https://doi.org/10.1016/j.jcf.2019.09.004

Highlights IV aminoglycosides are frequently used to treat infective exacerbations in CF due to efficacy against PA. The side effects of aminoglycosides include nephrotoxicity, ototoxicity and vestibulotoxicity. More than one third of UK CF... Read More about Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres.

An approach to the child with a wet cough. (2019)
Journal Article
Gilchrist. (2019). An approach to the child with a wet cough. Paediatric Respiratory Reviews, 75-81. https://doi.org/10.1016/j.prrv.2018.11.002

When children have a wet cough, it suggests the presence of secretions in their airways. This often has an infectious aetiology which is usually a self-limiting viral infection requiring no investigation or treatment. In those with acute wet cough it... Read More about An approach to the child with a wet cough..

UNWARRANTED USE OF NEPHROTOXIC ANTIBIOTICS IN CHILDREN WITH CYSTIC FIBROSIS (2018)
Presentation / Conference
Gilchrist. (2018, December). UNWARRANTED USE OF NEPHROTOXIC ANTIBIOTICS IN CHILDREN WITH CYSTIC FIBROSIS. Presented at British Thoracic Society Winter Meeting 2018, QEII Centre, Broad Sanctuary, Westminster, London, England

Introduction As life expectancy of individuals with cystic fibrosis (CF) continues to increase, complications resulting from lifetime drug exposures and CF comorbidities are becoming more prevalent. An example of this is chronic kidney disease (CKD).... Read More about UNWARRANTED USE OF NEPHROTOXIC ANTIBIOTICS IN CHILDREN WITH CYSTIC FIBROSIS.

Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres. (2018)
Journal Article
Gilchrist. (2018). Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres. BMJ Paediatrics Open, e000367 - ?. https://doi.org/10.1136/bmjpo-2018-000367

Objectives: Chest CT is increasingly used to monitor disease progression in children with cystic fibrosis (CF) but there is no national guideline regarding its use. Our objective was to assess the indications for undertaking chest CT and the protocol... Read More about Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres..

Identifying Asthmatic Children using Tidal Breathing Parameters Measured by Structured Light Plethysmography (SLP) (2018)
Presentation / Conference
Gilchrist. (2018, September). Identifying Asthmatic Children using Tidal Breathing Parameters Measured by Structured Light Plethysmography (SLP). Presented at ERS International Congress 2018, Paris, France

Introduction: We have previously shown that several tidal breathing parameters measured using SLP varied between asthmatic children and healthy (Hmeidi et al., 2017). However, we did not test the classification power of a model which incorporates the... Read More about Identifying Asthmatic Children using Tidal Breathing Parameters Measured by Structured Light Plethysmography (SLP).

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis. (2018)
Journal Article
Gilchrist. (2018). Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis. Cochrane Database of Systematic Reviews, CD012798 - ?. https://doi.org/10.1002/14651858.CD012798.pub2

BACKGROUND: Cystic fibrosis is the most common life-limiting autosomal recessive genetic disorder in white populations. Distal intestinal obstruction syndrome (DIOS) is an important morbidity in cystic fibrosis. It is the result of the accumulation o... Read More about Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis..

Tidal breathing parameters measured by structured light plethysmography in children aged 2-12 years recovering from acute asthma/wheeze compared with healthy children (2018)
Journal Article
Gilchrist. (2018). Tidal breathing parameters measured by structured light plethysmography in children aged 2-12 years recovering from acute asthma/wheeze compared with healthy children. Physiological Reports, e13752. https://doi.org/10.14814/phy2.13752

Measurement of lung function can be difficult in young children. Structured light plethysmography (SLP) is a novel, noncontact method of measuring tidal breathing that monitors displacement of the thoraco-abdominal wall. SLP was used to compare breat... Read More about Tidal breathing parameters measured by structured light plethysmography in children aged 2-12 years recovering from acute asthma/wheeze compared with healthy children.

Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis. (2018)
Journal Article
Green, J., Gilchrist, F., & Carroll, W. (2018). Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis. Cochrane Database of Systematic Reviews, CD012619 - ?. https://doi.org/10.1002/14651858.CD012619.pub2

BACKGROUND: Cystic fibrosis (CF) is the most common, life-limiting, genetically inherited disease. It affects multiple organs, particularly the respiratory system. However, gastrointestinal problems such as constipation and distal intestinal obstruct... Read More about Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis..

Is hypnotherapy an acceptable treatment option for children with habit cough? (2018)
Journal Article
Gilchrist, F. (2018). Is hypnotherapy an acceptable treatment option for children with habit cough?. Complementary Therapies in Medicine, 27 - 28. https://doi.org/10.1016/j.ctim.2018.01.005

Habit cough is a chronic, persistent dry cough which occurs in children only when awake. It is considered functional (non-organic) and can have a significant impact on the quality of life of the child and their family. One possible treatment option f... Read More about Is hypnotherapy an acceptable treatment option for children with habit cough?.

The British Lung Foundation asthma management programme - improving asthma control in adults (2017)
Presentation / Conference
Gilchrist. (2017, September). The British Lung Foundation asthma management programme - improving asthma control in adults. Presented at ERS International Congress 2017, Milan, Italy

Background: The 10-year Finland asthma programme showed that educating healthcare workers, patients and families reduces hospital admissions and asthma-related deaths (1). Aim: The Department of Health and the Scottish Government funded a 2-year p... Read More about The British Lung Foundation asthma management programme - improving asthma control in adults.

Tracking Tidal Breathing Parameters in Infants with Acute Viral Bronchiolitis (0 - 1) Year Using Structured Light Plethysmography (SLP) (2017)
Presentation / Conference
Hmeidi, H., Chadwick, E., Lenney, W., Gilchrist, F., Motamedi Fakhr, S., Wilson, R., …Alexander, J. (2017, May). Tracking Tidal Breathing Parameters in Infants with Acute Viral Bronchiolitis (0 - 1) Year Using Structured Light Plethysmography (SLP). Poster presented at American Thoracic Society 2017 International Conference, Washington, DC, USA

Annual hospitalisation rates for children with asthma are inversely associated with total hours of sunshine in English regions (2017)
Journal Article
Gilchrist. (2017). Annual hospitalisation rates for children with asthma are inversely associated with total hours of sunshine in English regions. Clinical and Experimental Allergy, 838-840. https://doi.org/10.1111/cea.12946

During childhood, exacerbation of asthma is the most common medical reason for admission to hospital in the UK. Each year 44,000 children are admitted to hospital in the UK with 40-50 children dying as a result of asthma [1]. Weather patterns and sea... Read More about Annual hospitalisation rates for children with asthma are inversely associated with total hours of sunshine in English regions.

Tidal breathing parameters measured using structured light plethysmography in healthy children and those with asthma before and after bronchodilator (2017)
Journal Article
Gilchrist. (2017). Tidal breathing parameters measured using structured light plethysmography in healthy children and those with asthma before and after bronchodilator. Physiological Reports, https://doi.org/10.14814/phy2.13168

Structured light plethysmography (SLP) is a light-based, noncontact technique that measures tidal breathing by monitoring displacements of the thoracoabdominal (TA) wall. We used SLP to measure tidal breathing parameters and their within-subject vari... Read More about Tidal breathing parameters measured using structured light plethysmography in healthy children and those with asthma before and after bronchodilator.

Chronic Cough In Children (2017)
Journal Article
Hine, C., Gilchrist, F., & Carroll, W. (2017). Chronic Cough In Children. Paediatrics and Child Health, 27(3), 121 - 127. https://doi.org/10.1016/j.paed.2017.02.001

All children cough. Despite the ubiquity of this common symptom, it remains a concern for many parents and results in a significant number of health consultations. Nearly every child in the UK will present to their family doctor with cough as the pre... Read More about Chronic Cough In Children.

Structured light plethysmography measures asynchronous breathing patterns in patients with acute stroke (Meeting Abstract) (2016)
Journal Article
Gilchrist, & Roffe. (2016). Structured light plethysmography measures asynchronous breathing patterns in patients with acute stroke (Meeting Abstract). European Respiratory Journal, https://doi.org/10.1183/13993003.congress-2016.PA4156

Background The extent of respiratory compromise following a stroke depends on any pre-existing respiratory illness and the aetiology, location and extent of the lesion. Acquired respiratory infection in subsequent days may alter respiratory function... Read More about Structured light plethysmography measures asynchronous breathing patterns in patients with acute stroke (Meeting Abstract).

IE50 Measured by Structured Light Plethysmography (SLP) Can Differentiate Between Children with and Without Asthma, and Can Detect Response to a Bronchodilator (2016)
Presentation / Conference
Hmeidi, H., Chadwick, E., Lenney, W., Gilchrist, F., Motamedi-Fakhr, S., Wilson, R., …Alexander, J. (2016, May). IE50 Measured by Structured Light Plethysmography (SLP) Can Differentiate Between Children with and Without Asthma, and Can Detect Response to a Bronchodilator. Poster presented at American Thoracic Society 2016 International Conference, San Francisco, USA

Assessing chronic cough in children (2016)
Journal Article
Gilchrist. (2016). Assessing chronic cough in children. Paediatrics and Child Health, 273-275. https://doi.org/10.1016/j.paed.2016.03.002

Cough is a protective physiological reflex that aids the clearance of airway secretions and aspirated material. As such, it is normal to cough. Coughing becomes abnormal when the frequency or severity impacts on the child's ability to eat, sleep, pla... Read More about Assessing chronic cough in children.

A review of prednisolone prescribing for children with acute asthma in the UK (2016)
Journal Article
Gilchrist, F. J., Ahmad, A. N., Batchelor, H. K., Marriott, J. F., & Lenney, W. (2016). A review of prednisolone prescribing for children with acute asthma in the UK. Journal of Asthma, 53(6), 563 -566. https://doi.org/10.3109/02770903.2015.1118498

INTRODUCTION: Worldwide asthma guidelines recommend short courses of oral prednisolone in children with acute exacerbations generating high prescription numbers. There is a paucity of evidence to inform the optimal dose and course duration. This has... Read More about A review of prednisolone prescribing for children with acute asthma in the UK.

A systematic review of early life factors which adversely affect subsequent lung function (2016)
Journal Article
Kouzouna, A., Gilchrist, F., Ball, V., Kyriacou, T., Henderson, J., Pandyan, A., & Lenney, W. (2016). A systematic review of early life factors which adversely affect subsequent lung function. Paediatric Respiratory Reviews, 20, 67-75. https://doi.org/10.1016/j.prrv.2016.03.003

It has been known for many years that multiple early life factors can adversely affect lung function and future respiratory health. This is the first systematic review to attempt to analyse all these factors simultaneously. We adhered to strict a pri... Read More about A systematic review of early life factors which adversely affect subsequent lung function.

Diabetic retinopathy in patients who do not meet the diagnostic criteria for cystic fibrosis related diabetes (2015)
Journal Article
Gilchrist, F. (2015). Diabetic retinopathy in patients who do not meet the diagnostic criteria for cystic fibrosis related diabetes. Practical Diabetes, 333-335a. https://doi.org/10.1002/pdi.1984

The UK Cystic Fibrosis (CF) Trust guidelines state that the diagnosis of CF related diabetes (CFRD) should only be made after an oral glucose tolerance test in the diabetic range and hyperglycaemia on serial monitoring. We report three patients with... Read More about Diabetic retinopathy in patients who do not meet the diagnostic criteria for cystic fibrosis related diabetes.

Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis (2015)
Journal Article
Gilchrist, F. J., Belcher, J., Jones, A. M., Smith, D., Smyth, A. R., Southern, K. W., …Lenney, W. (2015). Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis. ERJ Open Research, 1(2), https://doi.org/10.1183/23120541.00044-2015

Hydrogen cyanide is readily detected in the headspace above Pseudomonas aeruginosa cultures and in the breath of cystic fibrosis (CF) patients with chronic (P. aeruginosa) infection. We investigated if exhaled breath HCN is an early marker of P. aeru... Read More about Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis.

Research is the Future, the Future is……. (2015)
Journal Article
Gilchrist, F. J. (2015). Research is the Future, the Future is……. Paediatric Respiratory Reviews, 17, 32 - 33. https://doi.org/10.1016/j.prrv.2015.08.008

Over the past two decades, Professor Lenney has established the Paediatric Respiratory Department at the Royal Stoke University Hospital as a centre recognised for high quality research. A broad portfolio of clinical and laboratory based research is... Read More about Research is the Future, the Future is……..

Developing a handheld record for patients with cystic fibrosis (2015)
Journal Article
Narayan, O., Davies, S., Tibbins, C., Rees, J., Lenney, W., & Gilchrist, F. (2015). Developing a handheld record for patients with cystic fibrosis. Patient Related Outcome Measures, 2015(6), 225 - 228. https://doi.org/10.2147/PROM.S86298

Patient handheld records (PHHRs) promote self-management and empower the holder to take a more active role in the management of their disease. They have been used successfully in improving preventative care for children and have contributed to improv... Read More about Developing a handheld record for patients with cystic fibrosis.

The in vitro identification and quantification of volatile biomarkers released by cystic fibrosis pathogens (2015)
Journal Article
Gilchrist. (2015). The in vitro identification and quantification of volatile biomarkers released by cystic fibrosis pathogens. Analytical Methods, 818 -824. https://doi.org/10.1039/c4ay02981j

There is interest in the development of exhaled breath tests for the detection of lower airway infection in children with cystic fibrosis. The first stage of this process is the identification of volatile organic compounds (VOCs) released into the ga... Read More about The in vitro identification and quantification of volatile biomarkers released by cystic fibrosis pathogens.

THE INCIDENCE OF NEW PSEUDOMONAS AERUGINOSA INFECTION IN CHILDREN WITH CYSTIC FIBROSIS (2014)
Presentation / Conference
Gilchrist, F. J., Belcher, J., Jones, A. M., Smith, D., Smyth, A., Southern, K. W., …Lenney, W. (2014, December). THE INCIDENCE OF NEW PSEUDOMONAS AERUGINOSA INFECTION IN CHILDREN WITH CYSTIC FIBROSIS. Poster presented at British Thoracic Society Winter Meeting 2014, The Queen Elizabeth II Conference Centre, Broad Sanctuary, Westminster, London

Introduction Pseudomonas aeruginosa (PA) is one of the most important pathogens in cystic fibrosis (CF). Although there is a wealth of data about the prevalence of chronic PA infection, there is a paucity of evidence about the incidence of new PA inf... Read More about THE INCIDENCE OF NEW PSEUDOMONAS AERUGINOSA INFECTION IN CHILDREN WITH CYSTIC FIBROSIS.

The problems and limitations of cohort studies (2014)
Journal Article
Gilchrist. (2014). The problems and limitations of cohort studies. Breathe, 306-311. https://doi.org/10.1183/20734735.002313

Chronic obstructive pulmonary disease (COPD) is the third most common cause of mortality worldwide and it is important to discover whether risk factors can be identified from studies undertaken in childhood. Numerous longitudinal cohort studies ha... Read More about The problems and limitations of cohort studies.

Bacterial distribution in the lungs of children with protracted bacterial bronchitis (2014)
Journal Article
Narang, R., Bakewell, K., Peach, J., Clayton, S., Samuels, M., Alexander, J., …Gilchrist, F. J. (2014). Bacterial distribution in the lungs of children with protracted bacterial bronchitis. PloS one, 9(9), Article e108523. https://doi.org/10.1371/journal.pone.0108523

OBJECTIVES: Flexible bronchoscopy with bronchoalveolar lavage (FB-BAL) is increasingly used for the microbiological confirmation of protracted bacterial bronchitis (PBB) in children with a chronic wet cough. At our centre, when performing FB-BAL for... Read More about Bacterial distribution in the lungs of children with protracted bacterial bronchitis.

The sensitivity and specificity of pseudomonas aeruginosa detection using hydrogen cyanide concentration in exhaled breath - The SPACE study (2014)
Presentation / Conference
Gilchrist, F., Jones, A., Webb, K., Smith, D., & Lenney, W. (2014, September). The sensitivity and specificity of pseudomonas aeruginosa detection using hydrogen cyanide concentration in exhaled breath - The SPACE study. Presented at ERS 22nd Annual Congress 2014, Munich, Germany

Introduction Hydrogen cyanide (HCN) is an in-vitro marker of Pseudomonas aeruginosa (PA). This is the first in-vivo study to investigate if HCN is an early marker of PA infection in children with cystic fibrosis (CF). Methods Children who ha... Read More about The sensitivity and specificity of pseudomonas aeruginosa detection using hydrogen cyanide concentration in exhaled breath - The SPACE study.

The screening and diagnosis of cystic fibrosis-related diabetes in the United Kingdom (2014)
Journal Article
Wickens-Mitchell, K. L., Gilchrist, F. J., McKenna, D., Raffeeq, P., & Lenney, W. (2014). The screening and diagnosis of cystic fibrosis-related diabetes in the United Kingdom. Journal of Cystic Fibrosis, 13(5), 589-592. https://doi.org/10.1016/j.jcf.2014.01.008

Introduction The cystic fibrosis-related diabetes (CFRD) guidelines produced by the UK CF Trust differ from those used in Europe and the US. We conducted a study to establish current practice. Method Paediatric and adult questionnaires were devi... Read More about The screening and diagnosis of cystic fibrosis-related diabetes in the United Kingdom.

Itraconazole and inhaled fluticasone causing hypothalamic–pituitary–adrenal axis suppression in adults with cystic fibrosis (2013)
Journal Article
Gilchrist, F. J. (2013). Itraconazole and inhaled fluticasone causing hypothalamic–pituitary–adrenal axis suppression in adults with cystic fibrosis. Journal of Cystic Fibrosis, 399-402. https://doi.org/10.1016/j.jcf.2012.10.007

Background Although there have been case reports of hypothalamic–pituitary–adrenal (HPA) axis suppression in patients with cystic fibrosis (CF) caused by the combination of oral itraconazole and inhaled fluticasone, to date no study has assessed the... Read More about Itraconazole and inhaled fluticasone causing hypothalamic–pituitary–adrenal axis suppression in adults with cystic fibrosis.

The potential of closed circuit lung clearance index (LCI) to provide longitudinal clinical utility in cystic fibrosis (CF)
Presentation / Conference
Gilchrist. The potential of closed circuit lung clearance index (LCI) to provide longitudinal clinical utility in cystic fibrosis (CF). Presented at https://erj.ersjournals.com/content/54/suppl_63/PA332

Background: Closed circuit washin offers a quicker test with the advantages of an exogenous tracer to measure FRC and LCI. We measured LCI in CF paediatric and adult outpatient clinics to assess repeatability of LCI and track changes over time, and i... Read More about The potential of closed circuit lung clearance index (LCI) to provide longitudinal clinical utility in cystic fibrosis (CF).

Rapid and portable MBW measurements for clinical application of LCI in routine clinics
Presentation / Conference
Gilchrist. Rapid and portable MBW measurements for clinical application of LCI in routine clinics. Presented at ERS Lung Science Conference 2016

Background: Assessment of lung clearance index (LCI) is typically a prolonged process (>20mins), performed in physiology labs. This has hindered routine clinical application and restricted repeat assessments to annual reviews. We have developed a por... Read More about Rapid and portable MBW measurements for clinical application of LCI in routine clinics.

REPRODUCIBILITY OF LUNG CLEARANCE INDEX (LCI) IN CLINICALLY STABLE ADULTS WITH MILD CYSTIC FIBROSIS (CF)
Presentation / Conference
Gilchrist. REPRODUCIBILITY OF LUNG CLEARANCE INDEX (LCI) IN CLINICALLY STABLE ADULTS WITH MILD CYSTIC FIBROSIS (CF). Presented at British Thoracic Society Winter Meeting 2016

Background In order for lung clearance index (LCI) to be a clinically useful measurement, a better understanding is required of short-term variability. LCI-SEARCH is a longitudinal study in children and adults with CF, with LCI measured at each clini... Read More about REPRODUCIBILITY OF LUNG CLEARANCE INDEX (LCI) IN CLINICALLY STABLE ADULTS WITH MILD CYSTIC FIBROSIS (CF).

Female sex is associated with increased risk of early readmission with asthma in Staffordshire children
Presentation / Conference
Gilchrist. Female sex is associated with increased risk of early readmission with asthma in Staffordshire children. Presented at ERS International Congress 2017

Background: Asthma is the commonest medical reason for a child to be admitted to hospital in the UK. c.15% are readmitted within 3 months. Aim: We undertook a retrospective case-control study to determine the predictors of readmission. Methods:... Read More about Female sex is associated with increased risk of early readmission with asthma in Staffordshire children.

The British Lung Foundation asthma management programme improving children's asthma control
Presentation / Conference
Gilchrist. The British Lung Foundation asthma management programme improving children's asthma control. Presented at ERS International Congress 2017

Background: The 10-year Finland asthma programme showed that educating healthcare workers, patients and families reduces hospital admissions and asthma-related deaths (1). Aim: The Department of Health and the Scottish Government funded a 2-year p... Read More about The British Lung Foundation asthma management programme improving children's asthma control.

Incidence of post-procedure complications in children undergoing elective flexible bronchoscopy
Presentation / Conference
Gilchrist. Incidence of post-procedure complications in children undergoing elective flexible bronchoscopy. Presented at ERS International Congress 2019

Background: Paediatric flexible bronchoscopy with bronchoalveolar lavage (FB-BAL) is a safe procedure with a low incidence of intra-procedure complications. There is a paucity of data on the incidence of post-procedure complications. Aim: To inves... Read More about Incidence of post-procedure complications in children undergoing elective flexible bronchoscopy.