Alan Harper's Outputs (3)

Nicergoline inhibits human platelet Ca2+ signalling through triggering a microtubule-dependent reorganisation of the platelet ultrastructure (2015)
Journal Article
Harper. (2015). Nicergoline inhibits human platelet Ca2+ signalling through triggering a microtubule-dependent reorganisation of the platelet ultrastructure. British Journal of Pharmacology, 234-247. https://doi.org/10.1111/bph.13361

BACKGROUND AND PURPOSE:
Recently, we demonstrated that a pericellular Ca(2+) recycling system potentiates agonist-evoked Ca(2+) signalling and granule secretion in human platelets and hypothesized a role for the membrane complex (MC) in orchestratin... Read More about Nicergoline inhibits human platelet Ca2+ signalling through triggering a microtubule-dependent reorganisation of the platelet ultrastructure.

Conventional Protein Kinase C isoforms differentially regulate ADP- and thrombin-evoked Ca2+ signalling in human platelets (2015)
Journal Article
Harper. (2015). Conventional Protein Kinase C isoforms differentially regulate ADP- and thrombin-evoked Ca2+ signalling in human platelets. Cell Calcium, 577-588. https://doi.org/10.1016/j.ceca.2015.09.005

Rises in cytosolic Ca2+ concentration ([Ca2+]cyt) are central in platelet activation, yet many aspects of the underlying mechanisms are poorly understood. Most studies examine how experimental manipulations affect agonist-evoked rises in [Ca2+]cyt, b... Read More about Conventional Protein Kinase C isoforms differentially regulate ADP- and thrombin-evoked Ca2+ signalling in human platelets.

Validating A 3D tissue-engineered human blood vessel model for use as a novel model system for the assessment of thrombus formation (2015)
Journal Article
Musa, F. I., Harper, A. G. S., & Yang, Y. (2015). Validating A 3D tissue-engineered human blood vessel model for use as a novel model system for the assessment of thrombus formation. Journal of Thrombosis and Haemostasis, 13, 110-111