Outputs (17)

Alteration of the expression of sirtuins and var genes by heat shock in the malaria parasite Plasmodium falciparum (2022)
Journal Article

Background In Plasmodium falciparum the monoallelic expression of var virulence genes is regulated through epigenetic mechanisms. A study in the Gambia showed that an increase in var gene expression is associated with fever, high blood lactate with... Read More about Alteration of the expression of sirtuins and var genes by heat shock in the malaria parasite Plasmodium falciparum.

How can microbial interactions with the blood-brain barrier modulate astroglial and neuronal function?: How can the blood-brain barrier endothelium influence the brain? (2011)
Journal Article

The vascular endothelium of the blood–brain barrier (BBB) is regarded as a part of the neurovascular unit (NVU). This emerging NVU concept emphasizes the need for homeostatic signalling among the neuronal, glial and vascular endothelial cellular comp... Read More about How can microbial interactions with the blood-brain barrier modulate astroglial and neuronal function?: How can the blood-brain barrier endothelium influence the brain?.

Plasmodium falciparum icam-1-based cytoadherence-related signalling in endothelical cells (2008)
Journal Article

Background: Cytoadherence of Plasmodium falciparum infected erythrocytes to host endothelium has been associated with pathology in severe malaria, but despite extensive information on the primary processes involved in the adhesive interactions the me... Read More about Plasmodium falciparum icam-1-based cytoadherence-related signalling in endothelical cells.

Host response to cytoadherence inPlasmodium falciparum (2008)
Journal Article

Cytoadherence of PRBCs (Plasmodium falciparum-infected red blood cells) to host endothelium has been associated with pathology in severe malaria, but, despite extensive information on the primary processes involved in the adhesive interactions, the m... Read More about Host response to cytoadherence inPlasmodium falciparum.

The role of von Willebrand factor in malaria pathogenesis (2008)
Presentation / Conference

Altered phenotype and gene transcription in endothelial cells, induced by Plasmodium falciparum-infected red blood cells: Pathogenic or protective? (2007)
Journal Article

Severe malaria is associated with sequestration of Plasmodium falciparum-infected red blood cells (PRBC) in the microvasculature and elevation of intercellular adhesion molecule-1 (ICAM-1) and TNF. In vitro co-culture of human umbilical vein endothel... Read More about Altered phenotype and gene transcription in endothelial cells, induced by Plasmodium falciparum-infected red blood cells: Pathogenic or protective?.

An in vitro model for analysing neutrophil migration into and away from the sub-endothelial space: Roles of flow and CD31 (2006)
Journal Article

To model the later stages of neutrophil migration into tissue, we developed an assay in which human umbilical vein endothelial cells (HUVEC) were cultured on porous filters, treated with the inflammatory cytokine tumour necrosis factor-α (TNF), and t... Read More about An in vitro model for analysing neutrophil migration into and away from the sub-endothelial space: Roles of flow and CD31.

The effect of Plasmodium falciparum infection on expression of monocyte surface molecules (2006)
Journal Article

Plasmodium falciparum infection may result in severe malaria in susceptible individuals. The pathogenesis of severe disease is probably a combination of the sequestration of infected erythrocytes and overstimulation of the immune response. Monocytes... Read More about The effect of Plasmodium falciparum infection on expression of monocyte surface molecules.

von Willebrand factor propeptide in malaria: evidence of acute endothelial cell activation (2006)
Journal Article

Rational Design of Anticytoadherence Inhibitors forPlasmodium falciparumBased on the Crystal Structure of Human Intercellular Adhesion Molecule 1 (2006)
Journal Article

Adhesion of Plasmodium falciparum-infected erythrocytes (IE) to host endothelium has been associated with pathology in malaria. Although the interaction with endothelial cells can be complex due to the relatively large number of host receptors availa... Read More about Rational Design of Anticytoadherence Inhibitors forPlasmodium falciparumBased on the Crystal Structure of Human Intercellular Adhesion Molecule 1.

PfEMP1 expression is reduced on the surface of knoblessPlasmodium falciparuminfected erythrocytes (2005)
Journal Article

The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a key virulence factor for this species of human malarial parasite. PfEMP1 is expressed on the surface of infected erythrocytes (IEs) and directly mediates adhesion to a variety of... Read More about PfEMP1 expression is reduced on the surface of knoblessPlasmodium falciparuminfected erythrocytes.

The role of ICAM-1 in Plasmodium falciparum cytoadherence (2004)
Journal Article

Parasite sequestration at microvascular sites is a fundamental phenomenon in the manifestation of the symptoms of malaria and the progression to severe disease. Here, we review the endothelial cell-expressed intercellular adhesion molecule-1 (ICAM-1)... Read More about The role of ICAM-1 in Plasmodium falciparum cytoadherence.

Fractalkine expression on human renal tubular epithelial cells: potential role in mononuclear cell adhesion (2002)
Journal Article

Fractalkine (CX3CL1) is a transmembrane molecule with a CX3C chemokine domain attached to an extracellular mucin stalk which can induce both adhesion and migration of leucocytes. Mononuclear cell infiltration at renal tubular sites and associated tub... Read More about Fractalkine expression on human renal tubular epithelial cells: potential role in mononuclear cell adhesion.

Chemoattraction of T cells expressing CCR5, CXCR3 and CX3CR1 by proximal tubular epithelial cell chemokines (2002)
Journal Article

Background. Chemokines produced by resident renal cells promote the infiltration of leukocyte subsets. We have analysed the chemotactic responses of CD3+ peripheral blood lymphocytes (PBLs) to factors secreted by proximal tubular epithelial cells (PT... Read More about Chemoattraction of T cells expressing CCR5, CXCR3 and CX3CR1 by proximal tubular epithelial cell chemokines.

Fractalkine expression in human renal inflammation (2001)
Journal Article

Immune and inflammatory human renal disease is associated with heavy mononuclear cell infiltration. The trafficking of these cells to extravascular sites is directed by local production of chemokines. Fractalkine is the first described cell-surface a... Read More about Fractalkine expression in human renal inflammation.

Potential role for monocyte chemotactic protein-4 (MCP-4) in monocyte/macrophage recruitment in acute renal inflammation (2001)
Journal Article

The CC chemokine, monocyte chemoattractant protein-4 (MCP-4), is an important chemoattractant for monocytes and T cells. Recent data indicate a role in renal inflammation. This study has used in situ hybridization and immunohistochemical analysis of... Read More about Potential role for monocyte chemotactic protein-4 (MCP-4) in monocyte/macrophage recruitment in acute renal inflammation.

T Lymphocyte Adhesion Mechanisms within Inflamed Human Kidney (1999)
Journal Article