Melanie Holden's Outputs (105)

The experiences of physical therapists delivering a very low energy diet and exercise intervention for weight loss in people with knee osteoarthritis: A qualitative study (2025)
Journal Article
Allison, K., Nelligan, R. K., Lawford, B., Jones, S. E., Hinman, R. S., Pardo, J., Quicke, J. G., Sumithran, P., Prendergast, J., George, E. S., Holden, M. A., Foster, N. E., & Bennell, K. L. (in press). The experiences of physical therapists delivering a very low energy diet and exercise intervention for weight loss in people with knee osteoarthritis: A qualitative study. Brazilian Journal of Physical Therapy, 29(2), 1-8. https://doi.org/10.1016/j.bjpt.2025.101172

Background
Exercise and weight loss are core treatments for knee osteoarthritis (OA). While physical therapists are considered well placed to engage in weight management alongside exercise (not replacing dietician care), evidence surrounding physica... Read More about The experiences of physical therapists delivering a very low energy diet and exercise intervention for weight loss in people with knee osteoarthritis: A qualitative study.

Physiotherapists' Experiences and Perceived Acceptability of Delivering a Knee Bracing Intervention for People With Symptomatic Knee Osteoarthritis in a Randomised Trial (PROP OA): A Qualitative Study (2024)
Journal Article
Bullock, L., Holden, M. A., Jinks, C., Atiah Asamane, E., Herron, D., Borrelli, B., Callaghan, M. J., Birrell, F., Halliday, N., Marshall, M., Sowden, G., Ingram, C., McBeth, J., Dziedzic, K., Foster, N. E., Jowett, S., Lawton, S., Mallen, C. D., & Peat, G. (2024). Physiotherapists' Experiences and Perceived Acceptability of Delivering a Knee Bracing Intervention for People With Symptomatic Knee Osteoarthritis in a Randomised Trial (PROP OA): A Qualitative Study. Musculoskeletal Care, 22(4), Article e70021. https://doi.org/10.1002/msc.70021

Objectives: To explore physiotherapists' experiences and perceived acceptability of delivering a bracing intervention for knee osteoarthritis (OA) in the ‘PROvision of braces for Patients with knee OA’ (PROP OA) randomised controlled trial. Method: S... Read More about Physiotherapists' Experiences and Perceived Acceptability of Delivering a Knee Bracing Intervention for People With Symptomatic Knee Osteoarthritis in a Randomised Trial (PROP OA): A Qualitative Study.

CSP2023: 208 Translating resources for activity pacing to primary care to support the management of chronic pain: a protocol (2024)
Presentation / Conference
Antcliff, D., McCray, G., Marriott-Smith, J., & Holden, M. (2024, October). CSP2023: 208 Translating resources for activity pacing to primary care to support the management of chronic pain: a protocol. Poster presented at Chartered Society of Physiotherapy (CSP) 2023 Annual Conference, London, England, UK

Individual participant data meta‐analysis to examine linear or non‐linear treatment‐covariate interactions at multiple time‐points for a continuous outcome (2024)
Journal Article
Hattle, M., Ensor, J., Scandrett, K., van Middelkoop, M., van der Windt, D. A., Holden, M. A., & Riley, R. D. (2024). Individual participant data meta‐analysis to examine linear or non‐linear treatment‐covariate interactions at multiple time‐points for a continuous outcome. Research Synthesis Methods, https://doi.org/10.1002/jrsm.1750

Individual participant data (IPD) meta‐analysis projects obtain, harmonise, and synthesise original data from multiple studies. Many IPD meta‐analyses of randomised trials are initiated to identify treatment effect modifiers at the individual level,... Read More about Individual participant data meta‐analysis to examine linear or non‐linear treatment‐covariate interactions at multiple time‐points for a continuous outcome.

Knee braces for knee osteoarthritis: A scoping review and narrative synthesis of interventions in randomised controlled trials (2024)
Journal Article
Holden, M. A., Murphy, M., Simkins, J., Thomas, M. J., Huckfield, L., Quicke, J. G., Halliday, N., Birrell, F. N., Borrelli, B., Callaghan, M. J., Dziedzic, K., Felson, D., Foster, N. E., Ingram, C., Jinks, C., Jowett, S., Nicholls, E., & Peat, G. (2024). Knee braces for knee osteoarthritis: A scoping review and narrative synthesis of interventions in randomised controlled trials. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2024.08.010

Objective
To identify and synthesise the content of knee bracing interventions in randomised controlled trials (RCTs) of knee osteoarthritis (OA).

Design
In this scoping review, three electronic databases (PubMed, Web of Science, Cochrane) were... Read More about Knee braces for knee osteoarthritis: A scoping review and narrative synthesis of interventions in randomised controlled trials.

People with short symptom duration of knee osteoarthritis benefit more from exercise therapy than people with longer symptom duration: An individual participant data meta-analysis from the OA trial bank. (2024)
Journal Article
van Middelkoop, M., Schiphof, D., Middelkoop M, V., Hattle, M., D, S., Simkins, J., M, H., Bennell, K. L., J, S., Hinman, R. S., KL, B., Allen, K. D., RS, H., Knoop, J., KD, A., van Baar, M. E., J, K., Bossen, D., Baar ME, V., Wallis, J., …SMA, B.-Z. (2024). People with short symptom duration of knee osteoarthritis benefit more from exercise therapy than people with longer symptom duration: An individual participant data meta-analysis from the OA trial bank. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2024.07.007

To investigate whether duration of knee symptoms influenced the magnitude of the effect of exercise therapy compared to non-exercise control interventions on pain and physical function in people with knee osteoarthritis (OA). We undertook an individu... Read More about People with short symptom duration of knee osteoarthritis benefit more from exercise therapy than people with longer symptom duration: An individual participant data meta-analysis from the OA trial bank..

Exploring Experiences of People With Knee Osteoarthritis Who Received a Physiotherapist-Delivered Dietary Weight Loss and Exercise Intervention: A Mixed Methods Study. (2024)
Journal Article
Lawford, B. J., Allison, K., Nelligan, R., Campbell, P., Hinman, R. S., Jones, S. E., Pardo, J., Quicke, J. G., Sumithran, P., Prendergast, J., George, E. S., Holden, M. A., Foster, N. E., & Bennell, K. L. (2024). Exploring Experiences of People With Knee Osteoarthritis Who Received a Physiotherapist-Delivered Dietary Weight Loss and Exercise Intervention: A Mixed Methods Study. Arthritis Care & Research, https://doi.org/10.1002/acr.25401

Explore the experiences of people with knee osteoarthritis who received a very low energy diet (VLED) and exercise program from a physiotherapist. Mixed methods study involving questionnaires (n=42) and semi-structured interviews (n=22) with randomiz... Read More about Exploring Experiences of People With Knee Osteoarthritis Who Received a Physiotherapist-Delivered Dietary Weight Loss and Exercise Intervention: A Mixed Methods Study..

Alternative models to support weight loss in chronic musculoskeletal conditions: effectiveness of a physiotherapist-delivered intensive diet programme for knee osteoarthritis, the POWER randomised controlled trial (2024)
Journal Article
Allison, K., Jones, S., Hinman, R. S., Pardo, J., Li, P., DeSilva, A., Quicke, J. G., Sumithran, P., Prendergast, J., George, E., Holden, M. A., Foster, N. E., & Bennell, K. L. (2024). Alternative models to support weight loss in chronic musculoskeletal conditions: effectiveness of a physiotherapist-delivered intensive diet programme for knee osteoarthritis, the POWER randomised controlled trial. British Journal of Sports Medicine, 58(10), 538-547. https://doi.org/10.1136/bjsports-2023-107793

Objectives: To determine if physiotherapists can deliver a clinically effective very low energy diet (VLED) supplementary to exercise in people with knee osteoarthritis (OA) and overweight or obesity.

Methods: 88 participants with knee OA and bod... Read More about Alternative models to support weight loss in chronic musculoskeletal conditions: effectiveness of a physiotherapist-delivered intensive diet programme for knee osteoarthritis, the POWER randomised controlled trial.

818 NEITHER ANALYSIS APPROACH NOR RISK OF BIAS EXPLAIN THE LIMITED OVERALL BENEFIT OF THERAPEUTIC EXERCISE FOR KNEE AND/OR HIP OSTEOARTHRITIS IN INDIVIDUAL PARTICIPANT DATA META-ANALYSIS (2024)
Presentation / Conference Contribution
Runhaar, J., Holden, M., Hattle, M., Quicke, J., Healey, E. L., van der Windt, D., Dziedzic, K. S., van Middelkoop, M., Bierma-Zeinstra, S., & Foster, N. (2024, April). 818 NEITHER ANALYSIS APPROACH NOR RISK OF BIAS EXPLAIN THE LIMITED OVERALL BENEFIT OF THERAPEUTIC EXERCISE FOR KNEE AND/OR HIP OSTEOARTHRITIS IN INDIVIDUAL PARTICIPANT DATA META-ANALYSIS. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

775 BRACING ACCEPTABILITY AND ADHERENCE FOR KNEE OSTEOARTHRITIS: FINDINGS FROM A QUALITATIVE STUDY IN THE PROP-OA MULTICENTRE TRIAL (2024)
Presentation / Conference Contribution
Jinks, C., Holden, M., Asaname, E., Bullock, L., Herron, D., Halliday, N., Armitt, G., Bathers, S., Birrell, F., Borrelli, B., Browell, R., Callaghan, M. J., Dobb, K., Dziedzic, K. S., Felson, D., Foster, N., Hartshorne, E., Huckfield, L., Humphries, K., Ingram, C., …Peat, G. (2024, April). 775 BRACING ACCEPTABILITY AND ADHERENCE FOR KNEE OSTEOARTHRITIS: FINDINGS FROM A QUALITATIVE STUDY IN THE PROP-OA MULTICENTRE TRIAL. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

768 STAKEHOLDER CO-DESIGN OF AN EXTENDED COMMUNITY PHARMACY ROLE AND SERVICE DELIVERY MODEL FOR PROVIDING OSTEOARTHRITS CARE: THE PHARMOA MODEL (2024)
Presentation / Conference Contribution
Holden, M., Stanford, C., Simkins, J., Babatunde, O. O., White, S., O'Brien, N., Chudyk, A., Dziedzic, K. S., Todd, A., Long, A., Walker, C., Cork, T., Cottrell, E., Edwards, J., Nicholls, E., Mallen, C., & Healey, E. L. (2024, April). 768 STAKEHOLDER CO-DESIGN OF AN EXTENDED COMMUNITY PHARMACY ROLE AND SERVICE DELIVERY MODEL FOR PROVIDING OSTEOARTHRITS CARE: THE PHARMOA MODEL. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

767 EXPLORING THE POTENTIAL EXTENDED ROLE OF COMMUNITY PHARMACY IN THE MANAGEMENT OF OSTEOARTHRITIS: SURVEYS AND INTERVIEWS WITH COMMUNITY PHARMACY STAFF AND OTHER HEALTHCARE PROFESSIONALS (2024)
Presentation / Conference Contribution
Simkins, J., Holden, M., Babatunde, O. O., White, S., Nicholls, E., Long, A., Dziedzic, K. S., Chudyk, A., Todd, A., Walker, C., Stanford, C., Cottrell, E., Edwards, J., Healey, E. L., Cork, T., Mallen, C., & O'Brien, N. (2024, April). 767 EXPLORING THE POTENTIAL EXTENDED ROLE OF COMMUNITY PHARMACY IN THE MANAGEMENT OF OSTEOARTHRITIS: SURVEYS AND INTERVIEWS WITH COMMUNITY PHARMACY STAFF AND OTHER HEALTHCARE PROFESSIONALS. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

269 CLINICAL GUIDELINE RESEARCH RECOMMENDATIONS FOR THE NON-SURGICAL MANAGEMENT OF OSTEOARTHRITIS: A THEMATIC SYNTHESIS. (2024)
Presentation / Conference Contribution
Woodcock, C., English, E., Jinks, C., Healey, E. L., Parry, E., Paskins, Z., Roddy, E., Simkins, J., Thomas, M., Bennell, K., Hinman, R. S., & Holden, M. (2024, April). 269 CLINICAL GUIDELINE RESEARCH RECOMMENDATIONS FOR THE NON-SURGICAL MANAGEMENT OF OSTEOARTHRITIS: A THEMATIC SYNTHESIS. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

783 FEASIBILITY OF A COMORBIDITY-TAILORED EXERCISE AND EDUCATION INTERVENTION FOR PEOPLE AGED 80 YEARS OR OLDER WITH HIP OR KNEE OSTEOARTHRITIS. (2024)
Presentation / Conference
Nicolson, P., Holden, M., Marian, I., Saeedi, E., Williamson, E., Hopewell, S., & Lamb, S. (2024, April). 783 FEASIBILITY OF A COMORBIDITY-TAILORED EXERCISE AND EDUCATION INTERVENTION FOR PEOPLE AGED 80 YEARS OR OLDER WITH HIP OR KNEE OSTEOARTHRITIS. Poster presented at 24 OARSI World Congress on Osteoarthritis, Vienna, Austria

Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals (2024)
Journal Article
Simkins, J., Holden, M. A., Babatunde, O., White, S., Nicholls, E., Long, A., Dziedzic, K., Chudyk, A., Todd, A., Walker, C., Stanford, C., Cottrell, E., Edwards, J., Healey, E. L., Cork, T., Mallen, C., & O’Brien, N. (2024). Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals. Musculoskeletal Care, 22(1), Article e1873. https://doi.org/10.1002/msc.1873

Introduction
Osteoarthritis is the commonest form of chronic joint pain, which patients often self-manage before seeking healthcare advice. Patients frequently seek advice from community pharmacies, and a recent policy has recommended integrating co... Read More about Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals.

Changing the Narrative on Osteoarthritis: A Call for Global Action (2024)
Journal Article
Jinks, C., Botto-van Bemden, A., Bunzli, S., Bowden, J., Eyles, J., Egerton, T., Foster, N., Healey, E. L., Maddison, J., O’Brien, D., Quicke, J. G., Schiphof, D., Parry, E., Thomas, M. J., & Holden, M. A. (2024). Changing the Narrative on Osteoarthritis: A Call for Global Action. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2024.02.004

Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA) (2024)
Journal Article
Babatunde, O. O., Cottrell, E., White, S., Chudyk, A., Healey, E. L., Edwards, J., Nicholls, E., O’Brien, N., Todd, A., Walker, C., Stanford, C., Cork, T., Long, A., Simkins, J., Mallen, C. D., Dziedzic, K., & Holden, M. A. (2024). Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA). BMC Musculoskeletal Disorders, 25(1), Article 54. https://doi.org/10.1186/s12891-023-07105-2

Background
Osteoarthritis is a common, painful and disabling long-term condition. Delivery of high-quality guideline-informed osteoarthritis care that successfully promotes and maintains supported self-management is imperative. However, osteoarthrit... Read More about Co-development and testing of an extended community pharmacy model of service delivery for managing osteoarthritis: protocol for a sequential, multi-methods study (PharmOA).

The cost-effectiveness of adding an ultrasound corticosteroid and local anaesthetic injection to advice and education for hip osteoarthritis (2023)
Journal Article
Kigozi, J., Oppong, R., Paskins, Z., Bromley, K., Lewis, M., Hughes, G., Hughes, E., Hennings, S., Cherrington, A., Hall, A., Holden, M. A., Stevenson, K., Menon, A., Roberts, P., Peat, G., Jinks, C., Foster, N. E., Mallen, C. D., & Roddy, E. (2023). The cost-effectiveness of adding an ultrasound corticosteroid and local anaesthetic injection to advice and education for hip osteoarthritis. Rheumatology, https://doi.org/10.1093/rheumatology/kead659

Objectives. Evidence for the comparative cost-effectiveness of intra-articular corticosteroid injection in people with hip osteoarthritis (OA) remains unclear. This study investigated the cost-effectiveness of best current treatment (BCT) comprising... Read More about The cost-effectiveness of adding an ultrasound corticosteroid and local anaesthetic injection to advice and education for hip osteoarthritis.

A new measure of exercise adherence: the ATEMPT (Adherence To Exercise for Musculoskeletal Pain Tool) (2023)
Journal Article
Bailey, D. L., Bishop, A., McCray, G., Foster, N. E., & Holden, M. A. (2023). A new measure of exercise adherence: the ATEMPT (Adherence To Exercise for Musculoskeletal Pain Tool). British Journal of Sports Medicine, 58(2), bjsports-2022-106347. https://doi.org/10.1136/bjsports-2022-106347

Objectives: This study aimed to (1) develop a new measure of adherence to exercise for musculoskeletal (MSK) pain (Adherence To Exercise for Musculoskeletal Pain Tool: ATEMPT) based on previously conceptualised domains of exercise adherence, (2) repo... Read More about A new measure of exercise adherence: the ATEMPT (Adherence To Exercise for Musculoskeletal Pain Tool).

CSP2023: 460 Exploring healthcare professionals' perspectives on how community pharmacy could better support people living with osteoarthritis: A qualitative interview study (2023)
Presentation / Conference
Simkins, J., White, S., Babatunde, O., & Holden, M. (2023, November). CSP2023: 460 Exploring healthcare professionals' perspectives on how community pharmacy could better support people living with osteoarthritis: A qualitative interview study. Poster presented at Chartered Society of Physiotherapy (CSP) 2023 Annual Conference, Birmingham Conference and Events Centre, Hill Street, , Birmingham, B5 4EW

Osteoarthritis (OA) is a highly prevalent and painful condition that is commonly managed in primary care by various healthcare professionals (HCPs), including physiotherapists (1). Community pharmacy staff have transferable skills that make them well... Read More about CSP2023: 460 Exploring healthcare professionals' perspectives on how community pharmacy could better support people living with osteoarthritis: A qualitative interview study.