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Christian Mallen's Outputs (564)

Stakeholder involvement in the development of a new proactive clinical review of patients prescribed opioid medicines long-term for persistent pain in primary care (2025)
Journal Article
Harrisson, S. A., Jinks, C., Cornwall, N., Woodcock, C., Helliwell, T., Dikomitis, L., Higginbottom, A., Lefroy, J., Knaggs, R., Pincus, T., Santar, M., Sillitto, C., Webb, M., White, S., Mallen, C. D., & Ashworth, J. (in press). Stakeholder involvement in the development of a new proactive clinical review of patients prescribed opioid medicines long-term for persistent pain in primary care. Health Expectations,

Reducing pressurised metered dose inhaler prescriptions for asthma to reduce carbon emissions: a qualitative study of healthcare professional perspectives (2025)
Journal Article
Franklin, L., Mallen, C., & Twohig, H. (in press). Reducing pressurised metered dose inhaler prescriptions for asthma to reduce carbon emissions: a qualitative study of healthcare professional perspectives. British Journal of General Practice Open (BJGP Open), 1-17. https://doi.org/10.3399/BJGPO.2024.0208

Background
Prescribing of pressurised metered dose inhalers (pMDIs) is a key NHS carbon hotspot and reducing the number of these devices prescribed will help achieve NHS net zero targets.

Aim
To explore primary healthcare professionals’ perspe... Read More about Reducing pressurised metered dose inhaler prescriptions for asthma to reduce carbon emissions: a qualitative study of healthcare professional perspectives.

Quality of Care and Long-term Survival After ST-elevation Myocardial Infarction in Adults with Cancer (2025)
Journal Article
Dafaalla, M., Walter Dhillon Shanmuganathan, J., Wijeysundera, H. C., Roberts, D. J., Khan, S. U., Elbadawi, A., Elgendy, I. Y., Freeman, P., Mallen, C., & Mamas, M. A. (in press). Quality of Care and Long-term Survival After ST-elevation Myocardial Infarction in Adults with Cancer. European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcaf004

Background While current evidence suggests that the clinical outcomes of ST-elevation myocardial infarction (STEMI) are worse among patients with cancer, it is unknown what role the quality of care received during admission plays. We aimed to evaluat... Read More about Quality of Care and Long-term Survival After ST-elevation Myocardial Infarction in Adults with Cancer.

CLINICAL AND COST-EFFECTIVENESS OF A PERSONALISED GUIDED CONSULTATION VERSUS USUAL PHYSIOTHERAPY CARE IN PEOPLE PRESENTING WITH SHOULDER PAIN: A PROTOCOL FOR THE PANDA-S CLUSTER RANDOMISED CONTROLLED TRIAL AND PROCESS EVALUATION (2025)
Preprint / Working Paper
A Harrisson, S., Myers, H., Wynne Jones, G., Bajpai, R., Bratt, C., Burton, C., Harrison, R., Jowett, S., A Lawton, S., Saunders, B., J Beard, D., Bucknall, M., Chester, R., Heneghan, C., Huckfield, L., Lewis, M., D Mallen, C., Pincus, T., L Rees, J., Roddy, E., & A Van der Windt, D. CLINICAL AND COST-EFFECTIVENESS OF A PERSONALISED GUIDED CONSULTATION VERSUS USUAL PHYSIOTHERAPY CARE IN PEOPLE PRESENTING WITH SHOULDER PAIN: A PROTOCOL FOR THE PANDA-S CLUSTER RANDOMISED CONTROLLED TRIAL AND PROCESS EVALUATION

Introduction Musculoskeletal shoulder pain is a common reason for people to be treated in physiotherapy services, but diagnosis can be difficult and often does not guide treatment or predict outcome. People with shoulder pain cite a need for clear in... Read More about CLINICAL AND COST-EFFECTIVENESS OF A PERSONALISED GUIDED CONSULTATION VERSUS USUAL PHYSIOTHERAPY CARE IN PEOPLE PRESENTING WITH SHOULDER PAIN: A PROTOCOL FOR THE PANDA-S CLUSTER RANDOMISED CONTROLLED TRIAL AND PROCESS EVALUATION.

30-day Unplanned Readmission Rates and Causes in Patients Hospitalized for Acute Coronary Syndrome Based on DANish CoMorbidity Index for Acute Myocardial Infarction Score. (2025)
Journal Article
Sokhal, B. S., Matetić, A., Marshall, M., Twohig, H., Shepherd, T., Mallen, C. D., & Mamas, M. A. (2025). 30-day Unplanned Readmission Rates and Causes in Patients Hospitalized for Acute Coronary Syndrome Based on DANish CoMorbidity Index for Acute Myocardial Infarction Score. Hellenic Journal of Cardiology, https://doi.org/10.1016/j.hjc.2025.01.006

Introduction
This study aimed to investigate the association of the DANish CoMorbidity Index for Acute Myocardial Infarction (DANCAMI) score with 30-day unplanned readmission rates and causes in patients with acut... Read More about 30-day Unplanned Readmission Rates and Causes in Patients Hospitalized for Acute Coronary Syndrome Based on DANish CoMorbidity Index for Acute Myocardial Infarction Score..

Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review (2025)
Journal Article
Cox, N., Mallen, C. D., & Scott, I. C. (2025). Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review. BMC Medicine, 23(1), Article 54. https://doi.org/10.1186/s12916-025-03870-0

Background: Pain is a major challenge for patients with rheumatoid arthritis (RA), with many people suffering chronic pain. Current RA management guidelines focus on assessing and reducing disease activity using disease-modifying anti-rheumatic drugs... Read More about Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review.

Monitoring for 5-aminosalicylate nephrotoxicity in adults with inflammatory bowel disease: prognostic model development and validation using data from the Clinical Practice Research Datalink (2025)
Journal Article
Abhishek, A., Nakafero, G., Card, T., Taal, M. W., Grainge, M. J., Aithal, G. P., Mallen, C. D., Stevenson, M. D., & Riley, R. D. (2025). Monitoring for 5-aminosalicylate nephrotoxicity in adults with inflammatory bowel disease: prognostic model development and validation using data from the Clinical Practice Research Datalink. BMJ Open Gastroenterology, 12(1), https://doi.org/10.1136/bmjgast-2024-001627

Objective: To develop and validate a prognostic model for risk-stratified monitoring of 5-aminosalicylate nephrotoxicity. Methods: This UK retrospective cohort study used data from the Clinical Practice Research Datalink Aurum and Gold for model deve... Read More about Monitoring for 5-aminosalicylate nephrotoxicity in adults with inflammatory bowel disease: prognostic model development and validation using data from the Clinical Practice Research Datalink.

OP0074 MULTIMORBIDITY CLUSTERS, DETERMINANTS AND TRAJECTORIES IN OSTEOARTHRITIS IN THE UK: FINDINGS FROM THE CLINICAL PRACTICE RESEARCH DATALINK (2025)
Presentation / Conference Contribution
Swain, S., Coupland, C., Strauss, V., Mallen, C., Kuo, C., Sarmanova, A., Doherty, M., & Zhang, W. OP0074 MULTIMORBIDITY CLUSTERS, DETERMINANTS AND TRAJECTORIES IN OSTEOARTHRITIS IN THE UK: FINDINGS FROM THE CLINICAL PRACTICE RESEARCH DATALINK. Presented at EULAR 2020, online

Background:
Multimorbidity (≥2 chronic conditions) escalates the risk of adverse health outcomes. However, its burden in people with osteoarthritis (OA) remains largely unknown.... Read More about OP0074 MULTIMORBIDITY CLUSTERS, DETERMINANTS AND TRAJECTORIES IN OSTEOARTHRITIS IN THE UK: FINDINGS FROM THE CLINICAL PRACTICE RESEARCH DATALINK.

OP0264-HPR PERSPECTIVES ON APPROACHES TO PREDICT THE DEVELOPMENT OF RHEUMATOID ARTHRITIS: A QUANTITATIVE ASSESSMENT OF PATIENTS AND THEIR FIRST DEGREE RELATIVES (2025)
Presentation / Conference Contribution
Wells, I., Simons, G., Stack, R., Mallen, C., Nightingale, P., Raza, K., & Falahee, M. OP0264-HPR PERSPECTIVES ON APPROACHES TO PREDICT THE DEVELOPMENT OF RHEUMATOID ARTHRITIS: A QUANTITATIVE ASSESSMENT OF PATIENTS AND THEIR FIRST DEGREE RELATIVES. Presented at EULAR 2020, online

Background:
There is considerable interest within the medical research community in the identification of individuals at risk of developing rheumatoid arthritis (RA), to identify those who may benefit from prevent... Read More about OP0264-HPR PERSPECTIVES ON APPROACHES TO PREDICT THE DEVELOPMENT OF RHEUMATOID ARTHRITIS: A QUANTITATIVE ASSESSMENT OF PATIENTS AND THEIR FIRST DEGREE RELATIVES.

OP0230 COMORBIDITIES IN PEOPLE WITH OSTEOARTHRITIS IN FOUR EUROPEAN PRIMARY CARE SETTINGS - COMPREHENSIVE EVIDENCE FROM THE ComOA STUDY (2025)
Presentation / Conference Contribution
Swain, S., Coupland, C., Kamps, A., Runhaar, J., Dell’isola, A., Mallen, C., Kuo, C., Doherty, M., Prieto-Alhambra, D., Englund, M., Bierma-Zeinstra, S., & Zhang, W. OP0230 COMORBIDITIES IN PEOPLE WITH OSTEOARTHRITIS IN FOUR EUROPEAN PRIMARY CARE SETTINGS - COMPREHENSIVE EVIDENCE FROM THE ComOA STUDY. Presented at EULAR 2024, Vienna, Austria

Background:
Associations of osteoarthritis (OA) with different comorbidities have gained attention recently. However, there is no literature on the congruency across different large primary care settings.... Read More about OP0230 COMORBIDITIES IN PEOPLE WITH OSTEOARTHRITIS IN FOUR EUROPEAN PRIMARY CARE SETTINGS - COMPREHENSIVE EVIDENCE FROM THE ComOA STUDY.

POS1483-HPR A QUANTITATIVE ASSESSMENT OF THE LIKELIHOOD THAT PATIENTS WITH RHEUMATOID ARTHRITIS WILL COMMUNICATE INFORMATION ABOUT RHEUMATOID ARTHRITIS RISK TO RELATIVES (2025)
Presentation / Conference Contribution
Wells, I., Nightingale, P., Simons, G., Mallen, C., Raza, K., & Falahee, M. POS1483-HPR A QUANTITATIVE ASSESSMENT OF THE LIKELIHOOD THAT PATIENTS WITH RHEUMATOID ARTHRITIS WILL COMMUNICATE INFORMATION ABOUT RHEUMATOID ARTHRITIS RISK TO RELATIVES. Presented at EULAR 2021, online

Background:
First-degree relatives (FDRs) of patients with rheumatoid arthritis (RA) are at increased risk of RA and are being recruited to studies of predictive and preventive approaches. Access to FDRs is usuall... Read More about POS1483-HPR A QUANTITATIVE ASSESSMENT OF THE LIKELIHOOD THAT PATIENTS WITH RHEUMATOID ARTHRITIS WILL COMMUNICATE INFORMATION ABOUT RHEUMATOID ARTHRITIS RISK TO RELATIVES.

POS0597 PREDICTORS OF PERCEIVED RISK IN FIRST DEGREE RELATIVES OF RHEUMATOID ARTHRITIS PATIENTS (2025)
Presentation / Conference Contribution
Bunnewell, S., Wells, I., Zemedikun, D., Simons, G., Mallen, C., Raza, K., & Falahee, M. POS0597 PREDICTORS OF PERCEIVED RISK IN FIRST DEGREE RELATIVES OF RHEUMATOID ARTHRITIS PATIENTS. Presented at EULAR 2022, Copenhagen, Denmark

Background
Risk of rheumatoid arthritis (RA) is 3-5 times higher in first-degree relatives (FDRs). Efforts are increasing to develop preventive interventions for this at risk group. Risk perception is a key predic... Read More about POS0597 PREDICTORS OF PERCEIVED RISK IN FIRST DEGREE RELATIVES OF RHEUMATOID ARTHRITIS PATIENTS.

Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States [version 1; peer review: awaiting peer review] (2024)
Journal Article
Imantalab, D., Singh Sokhal, B., Prasanna Kumar Menon, S., Kalra, S., Muller, S., & Mallen, C. (2024). Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States [version 1; peer review: awaiting peer review]. NIHR Open Research, 1-14. https://doi.org/10.3310/nihropenres.13786.1

Motor Neurone Disease (MND) is a neurodegenerative condition affecting motor neurons in spinal cord and brainstem, leading to a reduced life expectancy. This study describes demographic trends in MND-associated mortality in the United States over a 2... Read More about Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States [version 1; peer review: awaiting peer review].

Physiotherapists' Experiences and Perceived Acceptability of Delivering a Knee Bracing Intervention for People With Symptomatic Knee Osteoarthritis in a Randomised Trial (PROP OA): A Qualitative Study (2024)
Journal Article
Bullock, L., Holden, M. A., Jinks, C., Atiah Asamane, E., Herron, D., Borrelli, B., Callaghan, M. J., Birrell, F., Halliday, N., Marshall, M., Sowden, G., Ingram, C., McBeth, J., Dziedzic, K., Foster, N. E., Jowett, S., Lawton, S., Mallen, C. D., & Peat, G. (2024). Physiotherapists' Experiences and Perceived Acceptability of Delivering a Knee Bracing Intervention for People With Symptomatic Knee Osteoarthritis in a Randomised Trial (PROP OA): A Qualitative Study. Musculoskeletal Care, 22(4), Article e70021. https://doi.org/10.1002/msc.70021

Objectives: To explore physiotherapists' experiences and perceived acceptability of delivering a bracing intervention for knee osteoarthritis (OA) in the ‘PROvision of braces for Patients with knee OA’ (PROP OA) randomised controlled trial. Method: S... Read More about Physiotherapists' Experiences and Perceived Acceptability of Delivering a Knee Bracing Intervention for People With Symptomatic Knee Osteoarthritis in a Randomised Trial (PROP OA): A Qualitative Study.

Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum (2024)
Journal Article
Scott, I. C., Daud, N., Bailey, J., Twohig, H., Hider, S. L., Mallen, C. D., Jordan, K. P., & Muller, S. (2024). Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum. BMC Medicine, 22(1), 575. https://doi.org/10.1186/s12916-024-03774-5

Background: Gabapentinoids are increasingly prescribed in inflammatory arthritis (IA), despite no trial evidence for efficacy at managing pain in this population. Observational studies in non-IA populations suggest gabapentinoids are associated with... Read More about Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum.

Everyday living with osteoarthritis in the global South: A qualitative focus group inquiry in Nigeria. (2024)
Journal Article
Owoyemi, T., Alonge, I., Adetunji, O., Ogbu, E., Ogunbanjo, A., White, S., Adebajo, A., Mallen, C., Babatunde, O. O., & Dziedzic, K. (2025). Everyday living with osteoarthritis in the global South: A qualitative focus group inquiry in Nigeria. Osteoarthritis and Cartilage Open, 7(1), Article 100555. https://doi.org/10.1016/j.ocarto.2024.100555

Objective
Africa contributes significantly to the increasing global prevalence (>37%), unmet need and treatment burden for people with osteoarthritis. Despite this, little research has examined the expressed needs of patients with osteoarthritis (OA... Read More about Everyday living with osteoarthritis in the global South: A qualitative focus group inquiry in Nigeria..

Incidence of Side Effects Associated With Acetaminophen in People Aged 65 Years or More: A Prospective Cohort Study Using Data From the Clinical Practice Research Datalink (2024)
Journal Article
Kaur, J., Nakafero, G., Abhishek, A., Mallen, C., Doherty, M., & Zhang, W. (2024). Incidence of Side Effects Associated With Acetaminophen in People Aged 65 Years or More: A Prospective Cohort Study Using Data From the Clinical Practice Research Datalink. Arthritis Care & Research, https://doi.org/10.1002/acr.25471

Objective The main objective of this study is to examine the safety of oral acetaminophen at its therapeutic dose in adults aged 65 years or more. Methods This population‐based cohort study used the Clinical Practice Research Datalink‐Gold data. Part... Read More about Incidence of Side Effects Associated With Acetaminophen in People Aged 65 Years or More: A Prospective Cohort Study Using Data From the Clinical Practice Research Datalink.

Pain management in people with inflammatory arthritis: British Society for Rheumatology guideline scope (2024)
Journal Article
Scott, I. C., Babatunde, O., Barker, C., Beesley, R., Beesley, R., Birkinshaw, H., Brooke, M., Chaplin, H., Chapman, L., Ciurtin, C., Dale, J., Dockrell, D., Dures, E., Harrison, K., Jani, M., Lee, C., McCarron, M., Mallen, C. D., O’Connor, A., Pidgeon, C., …Shenker, N. G. (in press). Pain management in people with inflammatory arthritis: British Society for Rheumatology guideline scope. Rheumatology Advances in Practice, 8(4), Article rkae128. https://doi.org/10.1093/rap/rkae128

Lay Summary: What does this mean for patients? Inflammatory arthritis includes conditions causing swollen and painful joints. The main types are rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis and juvenile idiopathic arthritis. It... Read More about Pain management in people with inflammatory arthritis: British Society for Rheumatology guideline scope.

Should all people starting urate-lowering therapy for gout receive anti-inflammatory prophylaxis? (2024)
Journal Article
Roddy, E., Prior, J. A., & Mallen, C. D. (2024). Should all people starting urate-lowering therapy for gout receive anti-inflammatory prophylaxis?. Exploration of Musculoskeletal Diseases, 2, 521-528. https://doi.org/10.37349/emd.2024.00076

Co-prescription of anti-inflammatory prophylaxis with colchicine, non-steroidal anti-inflammatory drugs (NSAIDs), or corticosteroids when initiating urate-lowering therapy (ULT) for gout is recommended in clinical guidelines to prevent ULT-induced fl... Read More about Should all people starting urate-lowering therapy for gout receive anti-inflammatory prophylaxis?.