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Christian Mallen's Outputs (580)

Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: protocol for the TREADON randomised multi-arm multi-stage adaptive trial (2025)
Other
Thomas, M. J., Hughes, G., Cooke, K., Butler-Walley, S., Marshall, E., Bowyer, L., Wathall, S., Smith, J., Lawton, S. A., Brammar, J., Burnett, T., Drake, C., Foster, N. E., Hendry, G. J., Holden, M. A., Jaki, T., Joseph, R., Keenan, A.-M., Kigozi, J., Lewis, M., …Roddy, E. (2025). Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: protocol for the TREADON randomised multi-arm multi-stage adaptive trial

Background
Plantar heel pain (PHP) is the most common soft tissue foot condition and impairs mobility, physical function, ability to work, and quality of life. Systematic reviews highlight a need for high-quality randomised controlled trials (RCTs)... Read More about Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: protocol for the TREADON randomised multi-arm multi-stage adaptive trial.

Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation (2025)
Journal Article
A Harrisson, S., Myers, H., Wynne Jones, G., Bajpai, R., Bratt, C., Burton, C., Harrison, R., Jowett, S., A Lawton, S., Saunders, B., J Beard, D., Bucknall, M., Chester, R., Heneghan, C., Huckfield, L., Lewis, M., D Mallen, C., Pincus, T., L Rees, J., Roddy, E., & A Van der Windt, D. (2025). Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation. BMJ Open, 15(5), https://doi.org/10.1136/bmjopen-2025-100501

Introduction: Musculoskeletal shoulder pain is a common reason for people to be treated in physiotherapy services, but diagnosis can be difficult and often does not guide treatment or predict outcome. People with shoulder pain cite a need for clear i... Read More about Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation.

Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care (2025)
Journal Article
Harrisson, S. A., Jinks, C., Cornwall, N., Woodcock, C., Dikomitis, L., Helliwell, T., Higginbottom, A., Lefroy, J., Knaggs, R., Pincus, T., Santar, M., Sillitto, C., Webb, M., White, S., Mallen, C. D., & Ashworth, J. (2025). Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care. Health Expectations, 28(3), Article e70264. https://doi.org/10.1111/hex.70264

Background: Stakeholder involvement is a core element of the Medical Research Council (MRC) framework for developing and evaluating complex interventions, but approaches to involve stakeholders are not well‐reported. We outline how stakeholders contr... Read More about Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care.

Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study (2025)
Journal Article
Ashworth, J., Cornwall, N., Harrisson, S., Woodcock, C., Nicholls, E., Lancaster, G., Wathall, S., Laing, L., Helliwell, T., Jowett, S., Kigozi, J., Mallen, C., Avery, A., Knaggs, R., Pincus, T., White, S., & Jinks, C. (2025). Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study. Pilot and Feasibility Studies, 11(1), Article 53. https://doi.org/10.1186/s40814-025-01636-2

Background: Given the poor long-term effectiveness of opioids for persistent non-cancer pain, and their potential for harm, evidence-based interventions to address opioid overprescribing for persistent pain are needed. This study aimed to explore the... Read More about Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study.

001 PSYCHOLOGICAL AND PAIN RELATED COMORBIDITIES IN PEOPLE WITH OSTEOARTHRITIS IN EUROPE - EVIDENCE FROM THE ComOA STUDY (2025)
Presentation / Conference Contribution
Swain, S., Coupland, C., Thompson, W., Mallen, C., Alhambra, D. P., Englund, M., Bierma-Zeinstra, S., Doherty, M., & Zhang, W. (2025, April). 001 PSYCHOLOGICAL AND PAIN RELATED COMORBIDITIES IN PEOPLE WITH OSTEOARTHRITIS IN EUROPE - EVIDENCE FROM THE ComOA STUDY. Presented at 2025 OARSI World Congress on Osteoarthritis, Incheon, South Korea

A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children (2025)
Journal Article
Twohig, H., Franklin, L., Carroll, W., Corp, N., Jackson, E., Mallen, C., Ruan, B., Yapp, L., Van Der Windt, D., & Smith, J. (2025). A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children. Paediatric Respiratory Reviews, 1-37. https://doi.org/10.1016/j.prrv.2025.04.005

Background
Dry powder inhalers (DPIs) are a lower-carbon option than pressurised metered dose inhalers (pMDIs). However, DPIs require a forceful inhalation to achieve good lung deposition and there is uncertainty as to whether younger children can e... Read More about A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children.

JIGSAW-A PROCESS AND FEASIBILITY OF IMPLEMENTING GUIDELINE RECOMMENDATIONS FOR THE CARE OF OSTEOARTHRITIS IN WEST-AFRICA (2025)
Journal Article
Babatunde, O., Adetunji, O., Alonge, I., Owoyemi, T., Ayinmode, E., Ogunbanjo, A., White, S., Adebajo, A., Mallen, C., & Dziedzic, K. (in press). JIGSAW-A PROCESS AND FEASIBILITY OF IMPLEMENTING GUIDELINE RECOMMENDATIONS FOR THE CARE OF OSTEOARTHRITIS IN WEST-AFRICA. BMJ Global Health,

Objectives: To assess the feasibility of a guideline-informed model of care for osteoarthritis in primary healthcare and community pharmacy settings in West-African context.

Methods: 4-phase mixed-methods programme of research undertaken in south-... Read More about JIGSAW-A PROCESS AND FEASIBILITY OF IMPLEMENTING GUIDELINE RECOMMENDATIONS FOR THE CARE OF OSTEOARTHRITIS IN WEST-AFRICA.

Clinical and cost-effectiveness of communication skills e-learning for primary care practitioners on patients' musculoskeletal pain and enablement: the Talking in Primary care (TIP) cluster-randomised controlled trial (2025)
Preprint / Working Paper
Bishop, F. L., Becque, T., Garfield, K., Cross, N., Dewar-Haggart, R., Teasdale, E., Herbert, A., Robinson, M. E., Ridd, M. J., Mallen, C., Clarson, L., Bostock, J., Stuart, B., Morrison, L., Pollet, S., Vennik, J., Atherton, H., Howick, J., Leydon, G. M., Nuttall, J., …Everitt, H. A. (2025). Clinical and cost-effectiveness of communication skills e-learning for primary care practitioners on patients' musculoskeletal pain and enablement: the Talking in Primary care (TIP) cluster-randomised controlled trial

Objectives To determine the effectiveness and cost-effectiveness of a brief communication skills e-learning package on empathy and optimism for practitioners consulting with adult primary care patients presenting with musculoskeletal (MSK) pain.

D... Read More about Clinical and cost-effectiveness of communication skills e-learning for primary care practitioners on patients' musculoskeletal pain and enablement: the Talking in Primary care (TIP) cluster-randomised controlled trial.

Reducing pressurised metered dose inhaler prescriptions for asthma to reduce carbon emissions: a qualitative study of healthcare professional perspectives (2025)
Journal Article
Franklin, L., Mallen, C., & Twohig, H. (in press). Reducing pressurised metered dose inhaler prescriptions for asthma to reduce carbon emissions: a qualitative study of healthcare professional perspectives. British Journal of General Practice Open (BJGP Open), 1-17. https://doi.org/10.3399/BJGPO.2024.0208

Background
Prescribing of pressurised metered dose inhalers (pMDIs) is a key NHS carbon hotspot and reducing the number of these devices prescribed will help achieve NHS net zero targets.

Aim
To explore primary healthcare professionals’ perspe... Read More about Reducing pressurised metered dose inhaler prescriptions for asthma to reduce carbon emissions: a qualitative study of healthcare professional perspectives.

Anxiety, Fear, and Kinesiophobia: Challenges Faced by UK Physiotherapists in Managing Polymyalgia Rheumatica - Findings from a Qualitative Study (2025)
Presentation / Conference Contribution
O’Brien, A., Muller, S., Liddle, J., Thomas, M., & Mallen, C. (2025, March). Anxiety, Fear, and Kinesiophobia: Challenges Faced by UK Physiotherapists in Managing Polymyalgia Rheumatica - Findings from a Qualitative Study. Presented at Midlands Rheumatology Society Spring Meeting, British Motor Museum, Banbury Road, Gaydon, Warwickshire

Perceived barriers to smoking cessation in patients with myocardial infarction: a systematic review (2025)
Journal Article
Lovatt, S., Chowdury, N., Mallen, C., & Cooke, A. (2025). Perceived barriers to smoking cessation in patients with myocardial infarction: a systematic review. British Journal of Cardiac Nursing, 20(3), 1-16. https://doi.org/10.12968/bjca.2024.0028

Myocardial infarction is a major cause of mortality and morbidity, with smoking being a major risk factor. However, a large proportion of patients continue to smoke following a myocardial infarction, suggesting that there are significant barriers to... Read More about Perceived barriers to smoking cessation in patients with myocardial infarction: a systematic review.

Quality of Care and Long-term Survival After ST-elevation Myocardial Infarction in Adults with Cancer (2025)
Journal Article
Dafaalla, M., Walter Dhillon Shanmuganathan, J., Wijeysundera, H. C., Roberts, D. J., Khan, S. U., Elbadawi, A., Elgendy, I. Y., Freeman, P., Mallen, C., & Mamas, M. A. (in press). Quality of Care and Long-term Survival After ST-elevation Myocardial Infarction in Adults with Cancer. European Heart Journal - Quality of Care and Clinical Outcomes, https://doi.org/10.1093/ehjqcco/qcaf004

Background While current evidence suggests that the clinical outcomes of ST-elevation myocardial infarction (STEMI) are worse among patients with cancer, it is unknown what role the quality of care received during admission plays. We aimed to evaluat... Read More about Quality of Care and Long-term Survival After ST-elevation Myocardial Infarction in Adults with Cancer.

30-day Unplanned Readmission Rates and Causes in Patients Hospitalized for Acute Coronary Syndrome Based on DANish CoMorbidity Index for Acute Myocardial Infarction Score. (2025)
Journal Article
Sokhal, B. S., Matetić, A., Marshall, M., Twohig, H., Shepherd, T., Mallen, C. D., & Mamas, M. A. (2025). 30-day Unplanned Readmission Rates and Causes in Patients Hospitalized for Acute Coronary Syndrome Based on DANish CoMorbidity Index for Acute Myocardial Infarction Score. Hellenic Journal of Cardiology, https://doi.org/10.1016/j.hjc.2025.01.006

Introduction
This study aimed to investigate the association of the DANish CoMorbidity Index for Acute Myocardial Infarction (DANCAMI) score with 30-day unplanned readmission rates and causes in patients with acut... Read More about 30-day Unplanned Readmission Rates and Causes in Patients Hospitalized for Acute Coronary Syndrome Based on DANish CoMorbidity Index for Acute Myocardial Infarction Score..

Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review (2025)
Journal Article
Cox, N., Mallen, C. D., & Scott, I. C. (2025). Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review. BMC Medicine, 23(1), Article 54. https://doi.org/10.1186/s12916-025-03870-0

Background: Pain is a major challenge for patients with rheumatoid arthritis (RA), with many people suffering chronic pain. Current RA management guidelines focus on assessing and reducing disease activity using disease-modifying anti-rheumatic drugs... Read More about Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review.

Monitoring for 5-aminosalicylate nephrotoxicity in adults with inflammatory bowel disease: prognostic model development and validation using data from the Clinical Practice Research Datalink (2025)
Journal Article
Abhishek, A., Nakafero, G., Card, T., Taal, M. W., Grainge, M. J., Aithal, G. P., Mallen, C. D., Stevenson, M. D., & Riley, R. D. (2025). Monitoring for 5-aminosalicylate nephrotoxicity in adults with inflammatory bowel disease: prognostic model development and validation using data from the Clinical Practice Research Datalink. BMJ Open Gastroenterology, 12(1), https://doi.org/10.1136/bmjgast-2024-001627

Objective: To develop and validate a prognostic model for risk-stratified monitoring of 5-aminosalicylate nephrotoxicity. Methods: This UK retrospective cohort study used data from the Clinical Practice Research Datalink Aurum and Gold for model deve... Read More about Monitoring for 5-aminosalicylate nephrotoxicity in adults with inflammatory bowel disease: prognostic model development and validation using data from the Clinical Practice Research Datalink.

OP0074 MULTIMORBIDITY CLUSTERS, DETERMINANTS AND TRAJECTORIES IN OSTEOARTHRITIS IN THE UK: FINDINGS FROM THE CLINICAL PRACTICE RESEARCH DATALINK (2025)
Presentation / Conference Contribution
Swain, S., Coupland, C., Strauss, V., Mallen, C., Kuo, C., Sarmanova, A., Doherty, M., & Zhang, W. OP0074 MULTIMORBIDITY CLUSTERS, DETERMINANTS AND TRAJECTORIES IN OSTEOARTHRITIS IN THE UK: FINDINGS FROM THE CLINICAL PRACTICE RESEARCH DATALINK. Presented at EULAR 2020, online

Background:
Multimorbidity (≥2 chronic conditions) escalates the risk of adverse health outcomes. However, its burden in people with osteoarthritis (OA) remains largely unknown.... Read More about OP0074 MULTIMORBIDITY CLUSTERS, DETERMINANTS AND TRAJECTORIES IN OSTEOARTHRITIS IN THE UK: FINDINGS FROM THE CLINICAL PRACTICE RESEARCH DATALINK.

OP0264-HPR PERSPECTIVES ON APPROACHES TO PREDICT THE DEVELOPMENT OF RHEUMATOID ARTHRITIS: A QUANTITATIVE ASSESSMENT OF PATIENTS AND THEIR FIRST DEGREE RELATIVES (2025)
Presentation / Conference Contribution
Wells, I., Simons, G., Stack, R., Mallen, C., Nightingale, P., Raza, K., & Falahee, M. OP0264-HPR PERSPECTIVES ON APPROACHES TO PREDICT THE DEVELOPMENT OF RHEUMATOID ARTHRITIS: A QUANTITATIVE ASSESSMENT OF PATIENTS AND THEIR FIRST DEGREE RELATIVES. Presented at EULAR 2020, online

Background:
There is considerable interest within the medical research community in the identification of individuals at risk of developing rheumatoid arthritis (RA), to identify those who may benefit from prevent... Read More about OP0264-HPR PERSPECTIVES ON APPROACHES TO PREDICT THE DEVELOPMENT OF RHEUMATOID ARTHRITIS: A QUANTITATIVE ASSESSMENT OF PATIENTS AND THEIR FIRST DEGREE RELATIVES.