Skip to main content

Research Repository

Advanced Search

Outputs (39)

The development and initial validation of a questionnaire to measure help-seeking behaviour in patients with new onset rheumatoid arthritis (2015)
Journal Article
Stack, R. J., Mallen, C., Deighton, C., Kiely, P., Shaw, K. L., Booth, A., …Raza, K. (2015). The development and initial validation of a questionnaire to measure help-seeking behaviour in patients with new onset rheumatoid arthritis. Health Expectations, 18(6), 2340-2355. https://doi.org/10.1111/hex.12203

BACKGROUND: Early treatment for rheumatoid arthritis (RA) is vital. However, people often delay in seeking help at symptom onset. An assessment of the reasons behind patient delay is necessary to develop interventions to promote rapid consultation. O... Read More about The development and initial validation of a questionnaire to measure help-seeking behaviour in patients with new onset rheumatoid arthritis.

"Why me? I don't fit the mould...I am a freak of nature": a qualitative study of women's experience of gout (2015)
Journal Article
Richardson, J. C., Liddle, J., Mallen, C. D., Roddy, E., Prinjha, S., Ziebland, S., & Hider, S. (2015). "Why me? I don't fit the mould...I am a freak of nature": a qualitative study of women's experience of gout. BMC Women's Health, Article 122. https://doi.org/10.1186/s12905-015-0277-z

Background Gout is more common in men, and is often perceived by both patients and health practitioners to be a disorder of men, but its prevalence in women is increasing. Little is known about women’s experience of gout and the impact it has on the... Read More about "Why me? I don't fit the mould...I am a freak of nature": a qualitative study of women's experience of gout.

Improving the care of people with long-term conditions in primary care: (2015)
Journal Article
Healey, E. L., Jinks, C., Tan, V. A., Chew-Graham, C. A., Lawton, S. A., Nicholls, E., …Mallen, C. D. (2015). Improving the care of people with long-term conditions in primary care:. Journal of Comorbidity, 2015(5), 135-149. https://doi.org/10.15256/joc.2015.5.60

Background Long-term conditions (LTCs) are important determinants of quality of life and healthcare expenditure worldwide. Whilst multimorbidity is increasingly the norm in primary care, clinical guidelines and the delivery of care remain focused on... Read More about Improving the care of people with long-term conditions in primary care:.

Impact of gout on the risk of atrial fibrillation. (2015)
Journal Article
Mallen. (2015). Impact of gout on the risk of atrial fibrillation. Rheumatology, 721 - 728. https://doi.org/10.1093/rheumatology/kev418

OBJECTIVES: To examine the risk of atrial fibrillation (AF) at the time of first diagnosis of gout compared with matched controls and to follow incident gout patients and their matched controls after diagnosis to compare their subsequent risk of AF.... Read More about Impact of gout on the risk of atrial fibrillation..

Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score-matched landmark analysis. (2015)
Journal Article
Mallen. (2015). Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score-matched landmark analysis. https://doi.org/10.1093/rheumatology/kev246

OBJECTIVE: To examine the association between allopurinol use and all-cause mortality for patients with incident gout. METHODS: We compared all-cause mortality in incident gout patients who received allopurinol for at least 6 months within the exposu... Read More about Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score-matched landmark analysis..

Physician's prescribing preference as an instrumental variable: exploring assumptions using survey data (2015)
Journal Article
Mallen, C. (2015). Physician's prescribing preference as an instrumental variable: exploring assumptions using survey data. Epidemiology, 276-283. https://doi.org/10.1097/EDE.0000000000000425

Background: Physician's prescribing preference is increasingly used as an instrumental variable in studies of therapeutic effects. However, differences in prescribing patterns among physicians may reflect differences in preferences or in case-mix. Fu... Read More about Physician's prescribing preference as an instrumental variable: exploring assumptions using survey data.

The triple whammy anxiety depression and osteoarthritis in long-term conditions (2015)
Journal Article
Jinks, Chew-Graham, Mallen, & Healey. (2015). The triple whammy anxiety depression and osteoarthritis in long-term conditions. BMC Family Practice, Article 163. https://doi.org/10.1186/s12875-015-0346-2

Improving the management of people with long-term conditions is a key priority of the UK National Health Service. Whilst the coexistence of two or more long-term conditions in one person is increasingly the norm in primary care, guidelines and delive... Read More about The triple whammy anxiety depression and osteoarthritis in long-term conditions.

Discussing prognosis with patients with osteoarthritis: a cross-sectional survey in general practice. (2015)
Journal Article
Mallen. (2015). Discussing prognosis with patients with osteoarthritis: a cross-sectional survey in general practice. Clinical Rheumatology, https://doi.org/10.1186/1471-2296-10-50

Osteoarthritis is a leading cause of chronic pain and disability and one of the most common conditions diagnosed and managed in primary care. Despite the evidence that patients would value discussions about the course of osteoarthritis to help them m... Read More about Discussing prognosis with patients with osteoarthritis: a cross-sectional survey in general practice..

Discussing prognosis with patients with osteoarthritis: a cross-sectional survey in general practice (2015)
Journal Article
Clarson, L. E., Nicholl, B. I., Bishop, A., Daniel, R., & Mallen, C. D. (2016). Discussing prognosis with patients with osteoarthritis: a cross-sectional survey in general practice. Clinical Rheumatology, 35(4), 1011-1017. https://doi.org/10.1007/s10067-015-3094-8

Osteoarthritis is a leading cause of chronic pain and disability and one of the most common conditions diagnosed and managed in primary care. Despite the evidence that patients would value discussions about the course of osteoarthritis to help them m... Read More about Discussing prognosis with patients with osteoarthritis: a cross-sectional survey in general practice.

Mapping patients experiences from initial symptoms to gout diagnosis: a qualitative exploration (2015)
Journal Article
Roddy, Mallen, & Hider. (2015). Mapping patients experiences from initial symptoms to gout diagnosis: a qualitative exploration. BMJ Open, https://doi.org/10.1136/bmjopen-2015-008323

Objective To explore patients’ experiences from initial symptoms to receiving a diagnosis of gout. Design Data from in-depth semistructured interviews were used to construct themes to describe key features of patients’ experiences of gout diagnosi... Read More about Mapping patients experiences from initial symptoms to gout diagnosis: a qualitative exploration.

2015 recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. (2015)
Journal Article
Dejaco, C., Singh, Y. P., Perel, P., Hutchings, A., Camellino, D., Mackie, S., …Dasgupta, B. (2015). 2015 recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. Arthritis & Rheumatology, 2569 - 2580. https://doi.org/10.1002/art.39333

Therapy for polymyalgia rheumatica (PMR) varies widely in clinical practice as international recommendations for PMR treatment are not currently available. In this paper, we report the 2015 European League Against Rheumatism (EULAR)/American College... Read More about 2015 recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative..

2015 Recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. (2015)
Journal Article
Dejaco, C., Singh, Y. P., Perel, P., Hutchings, A., Camellino, D., Mackie, S., …Dasgupta, B. (2015). 2015 Recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. Annals of the Rheumatic Diseases, 74(10), 1799 - 1807. https://doi.org/10.1136/annrheumdis-2015-207492

Therapy for polymyalgia rheumatica (PMR) varies widely in clinical practice as international recommendations for PMR treatment are not currently available. In this paper, we report the 2015 European League Against Rheumatism (EULAR)/American College... Read More about 2015 Recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative..

An Economic Evaluation of TENS in Addition to Usual Primary Care Management for the Treatment of Tennis Elbow: Results from the TATE Randomized Controlled Trial (2015)
Journal Article
Lewis, M., Chesterton, L., Sim, J., Hay, E., Mallen, C., & Van Der Windt, D. (2015). An Economic Evaluation of TENS in Addition to Usual Primary Care Management for the Treatment of Tennis Elbow: Results from the TATE Randomized Controlled Trial. PloS one, https://doi.org/10.1371/journal.pone.0135460

Background The TATE trial was a multicentre pragmatic randomized controlled trial of supplementing primary care management (PCM)–consisting of a GP consultation followed by information and advice on exercises–with transcutaneous electrical nerve sti... Read More about An Economic Evaluation of TENS in Addition to Usual Primary Care Management for the Treatment of Tennis Elbow: Results from the TATE Randomized Controlled Trial.

You want to get on with the rest of your life: a qualitative study of health-related quality of life in gout (2015)
Journal Article
Chandratre, P., Mallen, C. D., Roddy, E., Liddle, J., & Richardson, J. (2015). You want to get on with the rest of your life: a qualitative study of health-related quality of life in gout. Clinical Rheumatology, 35, 1197-1205. https://doi.org/10.1007/s10067-015-3039-2

The objective of the study is to examine the impact of gout and its treatments on health-related quality of life (HRQOL) using focus group interviews. From the baseline phase of a cohort study of HRQOL in gout, 17 participants (15 males, mean age 71... Read More about You want to get on with the rest of your life: a qualitative study of health-related quality of life in gout.

Foot problems in people with gout in primary care: baseline findings from a prospective cohort study (2015)
Journal Article
Bucknall, Roddy, Mallen, Hider, & Muller. (2015). Foot problems in people with gout in primary care: baseline findings from a prospective cohort study. Journal of Foot and Ankle Research, 31 - ?. https://doi.org/10.1186/s13047-015-0090-9

BACKGROUND: Foot problems are common in people with gout yet the prevalence of current foot problems in people with gout and the burden they present to healthcare systems is not known. This cross-sectional study aimed to determine the prevalence and... Read More about Foot problems in people with gout in primary care: baseline findings from a prospective cohort study.

Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score-matched landmark analysis (2015)
Journal Article
Kuo, C., Grainge, M. J., Mallen, C., Zhang, W., & Doherty, M. (2015). Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score-matched landmark analysis. Rheumatology, 54(12), 2145-2150. https://doi.org/10.1093/rheumatology/kev246

Objective. To examine the association between allopurinol use and all-cause mortality for patients with incident gout. Methods. We compared all-cause mortality in incident gout patients who received allopurinol for at least 6 months within the exposu... Read More about Effect of allopurinol on all-cause mortality in adults with incident gout: propensity score-matched landmark analysis.

The ‘ENHANCE’ long-term condition review: Identifying co-morbid joint pain, depression and anxiety in patients with long-term conditions (2015)
Presentation / Conference
Tan, V., Jinks, C., Porcheret, M., Chew-Graham, C. A., Cooper, V., Healey, E. L., …Finney, A. G. (2015, July). The ‘ENHANCE’ long-term condition review: Identifying co-morbid joint pain, depression and anxiety in patients with long-term conditions. Presented at Health Service Research Network conference (HSRN) Conference (Nottingham), Nottingham Conference Centre, Burton Street, Nottingham, UK

AB0843 Case-Finding for Joint Pain and Anxiety and Depression: the Enhance Study (2015)
Journal Article
Jinks, C., Morden, A., Chew-Graham, C., Porcheret, M., Finney, A., Dziedzic, K., …Mallen, C. (2015). AB0843 Case-Finding for Joint Pain and Anxiety and Depression: the Enhance Study. Annals of the Rheumatic Diseases, 74(Suppl 2), 1182.2-1182. https://doi.org/10.1136/annrheumdis-2015-eular.2270

Background Osteoarthritis (OA) related joint pain and mental health problems are common and often co-exist in patients with other long term conditions (LTCs), but are under-detected and sub-optimally managed in primary care. The ENHANCE study aims to... Read More about AB0843 Case-Finding for Joint Pain and Anxiety and Depression: the Enhance Study.

One-year trajectories of depression and anxiety symptoms in older patients presenting in general practice with musculoskeletal pain: A latent class growth analysis. (2015)
Journal Article
Rzewuska, M., Mallen, C. D., Strauss, V. Y., Belcher, J., & Peat, G. (2015). One-year trajectories of depression and anxiety symptoms in older patients presenting in general practice with musculoskeletal pain: A latent class growth analysis. Journal of Psychosomatic Research, 79(3), 195 - 201. https://doi.org/10.1016/j.jpsychores.2015.05.016

OBJECTIVE: Distinguishing transient from persistent anxiety and depression symptoms in older people presenting to general practice with musculoskeletal pain is potentially important for effective management. This study sought to identify distinct pos... Read More about One-year trajectories of depression and anxiety symptoms in older patients presenting in general practice with musculoskeletal pain: A latent class growth analysis..

306. How Do General Practitioners Manage Suspected Giant Cell Arteritis (2015)
Journal Article
Helliwell, T., Muller, S., Hider, S. L., Richardson, J., & Mallen, C. (2015). 306. How Do General Practitioners Manage Suspected Giant Cell Arteritis. Rheumatology, 54(S1), https://doi.org/10.1093/rheumatology/kev090.071

Background: Background: GCA is the commonest large vessel vasculitis yet a full time UK general practitioner (GP) can expect to see just one case, at most every 1–2 years. Untreated GCA can lead to permanent visual loss, thus it is essential GPs reco... Read More about 306. How Do General Practitioners Manage Suspected Giant Cell Arteritis.

046. Integrating Care for Joint Pain and Anxiety and Depression into Reviews for Long-Term Conditions: The Enhance Study (2015)
Journal Article
Jinks, C., Morden, A., Chew-Graham, C., Porcheret, M., Finney, A., Dziedzic, K., …Mallen, C. (2015). 046. Integrating Care for Joint Pain and Anxiety and Depression into Reviews for Long-Term Conditions: The Enhance Study. Rheumatology, 54(S1), https://doi.org/10.1093/rheumatology/kev088.046

Joint pain and mental health problems are common and often co-exist with other long-term conditions (LTCs), but are under-detected and sub-optimally managed in primary care. The aim of the ENHANCE study is to develop and test the feasibility and acc... Read More about 046. Integrating Care for Joint Pain and Anxiety and Depression into Reviews for Long-Term Conditions: The Enhance Study.

O31. Gout and Risk of Subsequent Vascular Event: A Discrete-Time Event History Analysis in the Clinical Practice Research Datalink (2015)
Journal Article
Clarson, L. E., Hider, S. L., Belcher, J., Roddy, E., Heneghan, C., & Mallen, C. D. (2015). O31. Gout and Risk of Subsequent Vascular Event: A Discrete-Time Event History Analysis in the Clinical Practice Research Datalink. Rheumatology, 54(S1), https://doi.org/10.1093/rheumatology/kev084.001

Background: Current evidence suggests that gout is an independent risk factor for excess cardiovascular morbidity and mortality; yet, suboptimal care for patients with gout in primary care persists. We aimed to identify risk factors specific to these... Read More about O31. Gout and Risk of Subsequent Vascular Event: A Discrete-Time Event History Analysis in the Clinical Practice Research Datalink.

Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study. (2015)
Journal Article
Mallen. (2015). Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study. Annals of the Rheumatic Diseases, 661 - 667. https://doi.org/10.1136/annrheumdis-2013-204463

OBJECTIVES: To describe trends in the epidemiology of gout and patterns of urate-lowering treatment (ULT) in the UK general population from 1997 to 2012. METHODS: We used the Clinical Practice Research Datalink to estimate the prevalence and incidenc... Read More about Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study..

Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies (2015)
Journal Article
Mallen, Roddy, & Belcher. (2015). Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies. Arthritis Research and Therapy, 17, Article 90. https://doi.org/10.1186/s13075-015-0610-9

ntroduction To determine the prevalence of chronic kidney disease and nephrolithiasis in people with gout, and the association between gout and prevalent or incident chronic kidney disease and nephrolithiasis. Methods Systematic review and meta-... Read More about Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies.

Prevalence of genital prolapse symptoms in primary care: a cross-sectional survey. (2015)
Journal Article
Cooper, J., Annappa, M., Dracocardos, D., Cooper, W., Muller, S., & Mallen, C. (2015). Prevalence of genital prolapse symptoms in primary care: a cross-sectional survey. International Urogynecology Journal, 505 - 510. https://doi.org/10.1007/s00192-014-2556-x

INTRODUCTION AND HYPOTHESIS: The aim of our study was to determine the prevalence of pelvic organ prolapse (POP) symptoms in a community-dwelling population in the United Kingdom. METHODS: All women over the age of 18 from a community practice were s... Read More about Prevalence of genital prolapse symptoms in primary care: a cross-sectional survey..

A qualitative investigation of the barriers to help-seeking among members of the public presented with symptoms of new-onset rheumatoid arthritis. (2015)
Journal Article
Mallen. (2015). A qualitative investigation of the barriers to help-seeking among members of the public presented with symptoms of new-onset rheumatoid arthritis. Journal of Rheumatology, 585 - 592. https://doi.org/10.3899/jrheum.140913

OBJECTIVE: Treating patients with rheumatoid arthritis (RA) within 3 months of symptom onset leads to significantly improved clinical outcomes. However, many people with RA symptoms wait a long time before seeking medical attention. To develop effect... Read More about A qualitative investigation of the barriers to help-seeking among members of the public presented with symptoms of new-onset rheumatoid arthritis..

Increased cardiovascular mortality associated with gout: a systematic review and meta-analysis (2015)
Journal Article
Roddy, Mallen, Belcher, Clarson, & Hider. (2015). Increased cardiovascular mortality associated with gout: a systematic review and meta-analysis. European Journal of Preventive Cardiology, 22(3), 335 -343. https://doi.org/10.1177/2047487313514895

BACKGROUND: Hyperuricaemia, the biochemical precursor to gout, has been shown to be an independent risk factor for mortality from cardiovascular disease (CVD), although studies examining the clinical phenomenon of gout and risk of CVD mortality repor... Read More about Increased cardiovascular mortality associated with gout: a systematic review and meta-analysis.

International variation in GP treatment strategies for subclinical hypothyroidism in older adults: a case-based survey. (2015)
Journal Article
Mallen. (2015). International variation in GP treatment strategies for subclinical hypothyroidism in older adults: a case-based survey. British Journal of General Practice (BJGP), e121 - e132. https://doi.org/10.3399/bjgp15X683569

BACKGROUND: There is limited evidence about the impact of treatment for subclinical hypothyroidism, especially among older people. AIM: To investigate the variation in GP treatment strategies for older patients with subclinical hypothyroidism dependi... Read More about International variation in GP treatment strategies for subclinical hypothyroidism in older adults: a case-based survey..

Improving the care of people with long-term conditions in primary care: protocol for the ENHANCE pilot trial (2015)
Journal Article
Healey, E. L., Jinks, C., Tan, V. A., Chew-Graham, C. A., Lawton, S. A., Nicholls, E., …Mallen, C. D. (2015). Improving the care of people with long-term conditions in primary care: protocol for the ENHANCE pilot trial. Journal of Comorbidity, 5(1), 135 -149. https://doi.org/10.15256/joc.2015.5.60

Background: Long-term conditions (LTCs) are important determinants of quality of life and healthcare expenditure worldwide. Whilst multimorbidity is increasingly the norm in primary care, clinical guidelines and the delivery of care remain focused o... Read More about Improving the care of people with long-term conditions in primary care: protocol for the ENHANCE pilot trial.

Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK clinical practice research datalink (2015)
Journal Article
Roddy, Mallen, Belcher, & Hider. (2015). Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK clinical practice research datalink. Annals of the Rheumatic Diseases, 642 - 647. https://doi.org/10.1136/annrheumdis-2014-206432

OBJECTIVES: To determine whether gout increases risk of incident coronary heart disease (CHD), cerebrovascular (CVD) and peripheral vascular disease (PVD) in a large cohort of primary care patients with gout, since there have been no such large studi... Read More about Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK clinical practice research datalink.

"I suddenly felt I'd aged": a qualitative study of patient experiences of polymyalgia rheumatica (PMR). (2015)
Journal Article
Twohig, H., Mitchell, C., Mallen, C., Adebajo, A., & Mathers, N. (2015). "I suddenly felt I'd aged": a qualitative study of patient experiences of polymyalgia rheumatica (PMR). Patient Education and Counseling, 98(5), 645 - 650. https://doi.org/10.1016/j.pec.2014.12.013

OBJECTIVES: To explore patient experiences of living with, and receiving treatment for, PMR. METHODS: Semi-structured qualitative interviews, with 22 patients with PMR recruited from general practices in South Yorkshire. Thematic analysis using a con... Read More about "I suddenly felt I'd aged": a qualitative study of patient experiences of polymyalgia rheumatica (PMR)..

An algorithm to identify rheumatoid arthritis in primary care: a Clinical Practice Research Datalink study. (2015)
Journal Article
Muller, S., Hider, S. L., Raza, K., Stack, R. J., Hayward, R. A., & Mallen, C. D. (2015). An algorithm to identify rheumatoid arthritis in primary care: a Clinical Practice Research Datalink study. BMJ Open, 5(12), Article e009309. https://doi.org/10.1136/bmjopen-2015-009309

OBJECTIVE: Rheumatoid arthritis (RA) is a multisystem, inflammatory disorder associated with increased levels of morbidity and mortality. While much research into the condition is conducted in the secondary care setting, routinely collected primary c... Read More about An algorithm to identify rheumatoid arthritis in primary care: a Clinical Practice Research Datalink study..