Outputs (31)

Chain length impact on the retro Diels-Alder mediated release of gemcitabine from hybrid nanoparticles towards pancreatic cancer therapy. (2023)
Journal Article

Previously reported gold coated iron oxide nanoparticles (Au-IONP's) have demonstrated their effectiveness as drug delivery vehicles for gemcitabine conjugated to a thermally labile Diels-Alder linker containing a chain of 4 carbon atoms (TTLD4) for... Read More about Chain length impact on the retro Diels-Alder mediated release of gemcitabine from hybrid nanoparticles towards pancreatic cancer therapy..

New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan (2023)
Journal Article

Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is an important enzyme in the DNA repair system. The ability of the enzyme to repair DNA damage induced by a topoisomerase 1 poison such as the anticancer drug topotecan makes TDP1 a promising target for complex... Read More about New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan.

Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles (2021)
Journal Article

Hybrid iron oxide-gold nanoparticles are of increasing interest for applications in nanomedicine, photonics, energy storage, etc. However, they are often difficult to synthesise without experience or 'know-how'. Additionally, standard protocols do no... Read More about Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles.

Thermally reactive N-(2-hydroxypropyl)methacrylamide (HPMA) amphiphiles for drug solubilisation (2021)
Journal Article

Thermally active polymers, can respond structurally to temperature changes, making them interesting as potential drug delivery vehicles. Polymers of N-(3-aminopropyl) methacrylamide hydrochloride (APMA) are cationic with primary amine groups in their... Read More about Thermally reactive N-(2-hydroxypropyl)methacrylamide (HPMA) amphiphiles for drug solubilisation.

Effect of Poly(allylamine) Molecular Weight on Drug Loading and Release Abilities of Nano-Aggregates for Potential in Cancer Nanomedicine (2020)
Journal Article

Silver Nanoparticle-Mediated Therapies in the Treatment of Pancreatic Cancer (2019)
Journal Article

Pancreatic cancer is an extremely aggressive disease for which patient prognosis is poor and survival is extremely unlikely. It is an extremely under-represented cancer in the research field, due to the dense tumors formed and complexities surroundin... Read More about Silver Nanoparticle-Mediated Therapies in the Treatment of Pancreatic Cancer.

The use of nanotechnology in cardiovascular disease (2018)
Journal Article

Cardiovascular diseases claim a number of lives globally; many of which are preventable. With the increase in diets that consist of high saturated fat, salt, and sugar, people often living sedentary lifestyles, and a rise in cases of obesity, the inc... Read More about The use of nanotechnology in cardiovascular disease.

A Novel PAA Derivative with Enhanced Drug Efficacy in Pancreatic Cancer Cell Lines (2018)
Journal Article

Nanoparticles have been shown to be effective drug carriers in cancer therapy. Pancreatic cancer forms dense tumours which are often resistant to drug molecules. In order to overcome such multidrug resistance, new drug entities, novel delivery system... Read More about A Novel PAA Derivative with Enhanced Drug Efficacy in Pancreatic Cancer Cell Lines.

Stimuli Responsive Polymeric Systems for Cancer Therapy. (2018)
Journal Article

Nanoscale polymers systems have dominated the revolution of drug delivery advancement. Their potential in the fight against cancer is unrivalled with other technologies. Their functionality increase, targeting ability and stimuli responsive nature ha... Read More about Stimuli Responsive Polymeric Systems for Cancer Therapy..

Dual Acting Polymeric Nano-Aggregates for Liver Cancer Therapy (2018)
Journal Article

Liver cancer treatments are often hindered by poor drug physicochemical properties, hence there is a need for improvement in order to increase patient survival and outlook. Combination therapies have been studied in order to evaluate whether increase... Read More about Dual Acting Polymeric Nano-Aggregates for Liver Cancer Therapy.

Combined effect of anticancer agents and cytochrome C decorated hybrid nanoparticles for liver cancer therapy (2018)
Journal Article

Hepatocellular carcinoma is an aggressive form of liver cancer that displays minimal symptoms until its late stages. Unfortunately, patient prognosis still remains poor with only 10% of patients surviving more than five years after diagnosis. Current... Read More about Combined effect of anticancer agents and cytochrome C decorated hybrid nanoparticles for liver cancer therapy.

Application of Nanoparticle Technologies in the Combat against Anti-Microbial Resistance (2018)
Journal Article

Anti-microbial resistance is a growing problem that has impacted the world and brought about the beginning of the end for the old generation of antibiotics. Increasingly, more antibiotics are being prescribed unnecessarily and this reckless practice... Read More about Application of Nanoparticle Technologies in the Combat against Anti-Microbial Resistance.

Nanotechnologies in Pancreatic Cancer Therapy. (2017)
Journal Article

Pancreatic cancer has been classified as a cancer of unmet need. After diagnosis the patient prognosis is dismal with few surviving over 5 years. Treatment regimes are highly patient variable and often the patients are too sick to undergo surgical re... Read More about Nanotechnologies in Pancreatic Cancer Therapy..

Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy (2017)
Journal Article

Hybrid nanoparticles (HNPs) have shown huge potential as drug delivery vehicles for pancreatic cancer. Currently, the first line treatment, gemcitabine, is only effective in 23.8% of patients. To improve this, a thermally activated system was develop... Read More about Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy.

Thermally Triggered Theranostics for Pancreatic Cancer Therapy (2017)
Journal Article

Hybrid iron oxide-gold nanoparticles (HNPs) are capable of drug binding onto their surface with a triggered release at elevated temperatures. The iron oxide core allows for diagnostic imaging whilst heating of the gold shell upon laser irradiation re... Read More about Thermally Triggered Theranostics for Pancreatic Cancer Therapy.

The co-administration of anticancer and pro-apoptotic agents as novel approach in liver cancer therapy (2017)
Presentation / Conference

Further correction: Synthesis and characterization of TPGS-gemcitabine prodrug micelles for pancreatic cancer therapy (2017)
Journal Article

Further correction for ’Synthesis and characterization of TPGS-gemcitabine prodrug micelles for pancreatic cancer therapy’ by Vaibhav Khare et al., RSC Adv., 2016, 6, 60126-60137.

Synthesis and characterization of TPGS-gemcitabine prodrug micelles for pancreatic cancer therapy (2017)
Journal Article

Correction for ‘Synthesis and characterization of TPGS–gemcitabine prodrug micelles for pancreatic cancer therapy’ by Vaibhav Khare et al., RSC Adv., 2016, 6, 60126–60137.

Potential of hybrid iron oxide–gold nanoparticles as thermal triggers for pancreatic cancer therapy (2016)
Journal Article

Theranostics are emerging platforms for rapid cancer diagnosis and therapy. Hybrid iron oxide–gold nanoparticles (HNPs) have shown potential as theranostics due to their ability for imaging using MRI, heating using laser irradiation and carrier abili... Read More about Potential of hybrid iron oxide–gold nanoparticles as thermal triggers for pancreatic cancer therapy.

Synthesis of novel hybrid nanoparticle-prodrug constructs for pancreatic cancer therapy (2016)
Presentation / Conference

Temperature Controlled Theranostics for Pancreatic Cancer (2016)
Presentation / Conference

Novel Iron Oxide-Gold Nanohybrids with Heat Triggered Surface Manipulation (2016)
Presentation / Conference

Thermoresponsive copolymer: (HPMA-CO-(APMA-R))-co-PEG polymer synthesis and physiochemical characterization (2016)
Presentation / Conference

Heat Dissipation of Hybrid Iron Oxide-Gold Nanoparticles in an Agar Phantom (2015)
Journal Article

Hybrid iron oxide-gold nanoparticles (HNPs) have shown potential in cancer therapy as agents for tumour ablation and thermal switches for targeted drug release. Heat generation occurs by exploitation of the surface plasmon resonance of the gold coati... Read More about Heat Dissipation of Hybrid Iron Oxide-Gold Nanoparticles in an Agar Phantom.

Potential use of hybrid iron oxide gold nanoparticles as drug carriers (2015)
Book Chapter

Hybrid nanoparticles are composed of more than one material fused together to increase functionality. These often consist of polymers coated onto the surface of metallic nanoparticles to render them useful in biomedicine [1,2]. In this chapter the te... Read More about Potential use of hybrid iron oxide gold nanoparticles as drug carriers.

Simple Calix[n]arenes and Calix[4]resorcinarenes as Drug Solubilizing Agents (2015)
Journal Article

Many drug molecules have low solubility in aqueous media and, hence, poor bioavailability. The formation of a host-guest complex with some other compound which has a good solubility profile can facilitate solubilization of hydrophobic drugs. Complex... Read More about Simple Calix[n]arenes and Calix[4]resorcinarenes as Drug Solubilizing Agents.

Enhancement of the Cytotoxic Effect of Anticancer Agent by Cytochrome c Functionalised Hybrid Nanoparticles in Hepatocellular Cancer Cells (2014)
Journal Article

Treatment of hepatocellular cancer with chemotherapeutic agents has limited success in clinical practice and their efficient IC50 concentration would require extremely high doses of drug administration which could not be tolerated due to systemic sid... Read More about Enhancement of the Cytotoxic Effect of Anticancer Agent by Cytochrome c Functionalised Hybrid Nanoparticles in Hepatocellular Cancer Cells.

The Use of Iron Oxide Nanoparticles for Pancreatic Cancer Therapy (2014)
Journal Article

Over the last decade major advances have been made in the treatment of cancer such as breast and leukaemia. However, no satisfactory progress has been made in the effective treatment of pancreatic cancer. Treatment of this disease is hindered by resi... Read More about The Use of Iron Oxide Nanoparticles for Pancreatic Cancer Therapy.

Simulated Drug Discovery Process to Conduct a Synoptic Assessment of Pharmacy Students (2014)
Journal Article

Objective. To implement and assess a task-based learning exercise that prompts pharmacy students to integrate their understanding of different disciplines. Design. Master of pharmacy (MPharm degree) students were provided with simulated informatio... Read More about Simulated Drug Discovery Process to Conduct a Synoptic Assessment of Pharmacy Students.

Poly(allylamine) Magnetomicelles for Image Guided Drug Delivery (2013)
Journal Article

Preclinical evaluation of statins as a treatment for ovarian cancer (2013)
Journal Article

Objective To evaluate the potential for statins to treat ovarian cancer. Methods The sensitivity of 7 ovarian cancer cell lines to either statins or statins combined with either carboplatin or paclitaxel was assessed using monolayer cultures. Se... Read More about Preclinical evaluation of statins as a treatment for ovarian cancer.