Thermally Triggered Theranostics for Pancreatic Cancer Therapy

Malekigorji, M; Alfahad, M; Kong Thoo Lin, P; Jones, S; Curtis, ADM; Hoskins, C

Abstract

Hybrid iron oxide-gold nanoparticles (HNPs) are capable of drug binding onto their surface with a triggered release at elevated temperatures. The iron oxide core allows for diagnostic imaging whilst heating of the gold shell upon laser irradiation reverses drug binding. This study exploits the reversible binding of novel polyamine based drugs in order to provide specific and effective method for pancreatic cancer treatment. Here we used novel bisnaphthalamido (BNIP) based drug series. Our hybrid nanoparticles (50 nm) were capable of drug loading onto their surface (3:1:0.25, Drug:Fe:Au). By exploiting the surface-to-drug electrostatic interaction of a range of BNIP agents, heat triggered drug release was achieved. 12-fold reduction in IC50 after 24 h in vitro and 5-fold reduction of tumour retardation in vivo compared with free drug in pancreatic models after treatment with the HNP-formulation and laser irradiation. This heat activated system could provide a key platform for future therapy strategies.

Citation

Malekigorji, M., Alfahad, M., Kong Thoo Lin, P., Jones, S., Curtis, A., & Hoskins, C. (2017). Thermally Triggered Theranostics for Pancreatic Cancer Therapy. Nanoscale, https://doi.org/10.1039/C7NR02751F

• Acceptance Date: Jul 31, 2017
• Publication Date: Aug 3, 2017
• Journal: Nanoscale
• Print ISSN: 2040-3364
• Publisher: Royal Society of Chemistry
• DOI: https://doi.org/10.1039/C7NR02751F
• Keywords: theranostic, pancreatic cancer, thermo-responsive drug delivery, laser; irradiation
• Publisher URL: https://doi.org/10.1039/C7NR02751F