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Muriel Desbois' Outputs (3)

Integrin adhesome axis inhibits the RPM-1 ubiquitin ligase signaling hub to regulate growth cone and axon development (2024)
Journal Article
Amezquita, J., Desbois, M., Opperman, K. J., Pak, J. S., Christensen, E. L., Nguyen, N. T., …Grill, B. (2024). Integrin adhesome axis inhibits the RPM-1 ubiquitin ligase signaling hub to regulate growth cone and axon development. PLOS genetics, 20(12), Article e1011496. https://doi.org/10.1371/journal.pgen.1011496

Integrin signaling plays important roles in development and disease. An adhesion signaling network called the integrin adhesome has been principally defined using bioinformatics and cell-based proteomics. To date, the adhesome has not been studied us... Read More about Integrin adhesome axis inhibits the RPM-1 ubiquitin ligase signaling hub to regulate growth cone and axon development.

Molecular regulation of axon termination in mechanosensory neurons (2024)
Journal Article
Desbois, M., & Grill, B. (2024). Molecular regulation of axon termination in mechanosensory neurons. Development, 151(17), https://doi.org/10.1242/dev.202945

Spatially and temporally accurate termination of axon outgrowth, a process called axon termination, is required for efficient, precise nervous system construction and wiring. The mechanosensory neurons that sense low-threshold mechanical stimulation... Read More about Molecular regulation of axon termination in mechanosensory neurons.

Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function (2024)
Journal Article
Chang, C., Banerjee, S. L., Park, S. S., Zhang, X. L., Cotnoir-White, D., Opperman, K. J., …Kania, A. (2024). Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function. eLife, 12, Article RP89176. https://doi.org/10.7554/elife.89176

Eph receptor tyrosine kinases participate in a variety of normal and pathogenic processes during development and throughout adulthood. This versatility is likely facilitated by the ability of Eph receptors to signal through diverse cellular signallin... Read More about Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function.