The prognostic value of mean platelet volume in patients with coronary artery disease: An updated systematic review with meta-analyses. (2024)
Journal Article
Galimzhanov, A., Tun, H. N., Sabitov, Y., Perone, F., Kursat, T. M., Tenekecioglu, E., & Mamas, M. A. (in press). The prognostic value of mean platelet volume in patients with coronary artery disease: An updated systematic review with meta-analyses. European Journal of Clinical Investigation, Article e14295. https://doi.org/10.1111/eci.14295

Mean platelet volume (MPV) is a widely available laboratory index, however its prognostic significance in patients with coronary artery disease (CAD) is still unclear. We intended to investigate and pool the evidence on the prognostic utility of admi... Read More about The prognostic value of mean platelet volume in patients with coronary artery disease: An updated systematic review with meta-analyses..

Angioembolization in the management of joint pain: current concepts. (2024)
Journal Article
Jeyaraman, N., Migliorini, F., Ramkumar, V., Ramasubramanian, S., Patro, B. P., Maffulli, N., & Jeyaraman, M. (in press). Angioembolization in the management of joint pain: current concepts. Die Orthopädie, https://doi.org/10.1007/s00132-024-04531-5

Joint pain is a common complaint owing to its origin in inflammatory and degenerative joint diseases. Recent research has helped narrow down inadequate angiogenesis as one of the causes. Angioembolization has emerged as a treatment option for this co... Read More about Angioembolization in the management of joint pain: current concepts..

Google Internet searches related to inflammatory arthritis: An observational study using Google Trends data (2024)
Journal Article
Akthar, M., Mason, K. J., & Scott, I. C. (2024). Google Internet searches related to inflammatory arthritis: An observational study using Google Trends data. Musculoskeletal Care, 22(3), Article e1916. https://doi.org/10.1002/msc.1916

Objective: The Internet has transformed how patients access health information. We examined Google search engine data to understand which aspects of health are most often searched for in combination with inflammatory arthritis (IA). Methods: Using Go... Read More about Google Internet searches related to inflammatory arthritis: An observational study using Google Trends data.

Musculoskeletal Health and Work: Development and Internal–External Cross-Validation of a Model to Predict Risk of Work Absence and Presenteeism in People Seeking Primary Healthcare (2024)
Journal Article
Archer, L., Peat, G., Snell, K. I. E., Hill, J. C., Dunn, K. M., Foster, N. E., Bishop, A., van der Windt, D., & Wynne-Jones, G. (2024). Musculoskeletal Health and Work: Development and Internal–External Cross-Validation of a Model to Predict Risk of Work Absence and Presenteeism in People Seeking Primary Healthcare. Journal of Occupational Rehabilitation, https://doi.org/10.1007/s10926-024-10223-w

Purpose
To develop and validate prediction models for the risk of future work absence and level of presenteeism, in adults seeking primary healthcare with musculoskeletal disorders (MSD).

Methods
Six studies from the West-Midlands/Northwest regi... Read More about Musculoskeletal Health and Work: Development and Internal–External Cross-Validation of a Model to Predict Risk of Work Absence and Presenteeism in People Seeking Primary Healthcare.

Understanding the preferences of young adults with type 2 diabetes mellitus with regard to diabetes self-management education: a qualitative study (2024)
Journal Article
Sim, R. R. J., Soon, W., Smith, H. E., Griva, K., & Wong, S. K. W. (2024). Understanding the preferences of young adults with type 2 diabetes mellitus with regard to diabetes self-management education: a qualitative study. BMJ Open, 14(7), Article e086133. https://doi.org/10.1136/bmjopen-2024-086133

Aim: Young-onset type 2 diabetes (YOD) is associated with poorer clinical outcomes. To support the development of more effective diabetes self-management education (DSME) programmes, this study aimed to understand the preferences of young adults with... Read More about Understanding the preferences of young adults with type 2 diabetes mellitus with regard to diabetes self-management education: a qualitative study.

Machine-learning clustering analysis identifies novel phenogroups in patients with ST-elevation acute myocardial infarction. (2024)
Journal Article
Matetic, A., Kyriacou, T., & Mamas, M. A. (2024). Machine-learning clustering analysis identifies novel phenogroups in patients with ST-elevation acute myocardial infarction. International Journal of Cardiology, 411, 1-9. https://doi.org/10.1016/j.ijcard.2024.132272

Machine learning clustering of patients with ST-elevation acute myocardial infarction (STEMI) may provide important insights into their risk profile, management and prognosis. All adult discharges for STEMI in the National Inpatient Sample (October 2... Read More about Machine-learning clustering analysis identifies novel phenogroups in patients with ST-elevation acute myocardial infarction..

Syngeneic mesenchymal stem cells loaded with telomerase-dependent oncolytic adenoviruses enhance anti-metastatic efficacy. (2024)
Journal Article
Yang, M.-L., Hu, C.-Y., Lee, Y.-C., Chang, C.-C., Chen, Y.-C., Lee, P.-R., Su, B.-H., Chen, P.-C., Shiau, A.-L., Shieh, G.-S., Wu, C.-L., & Wu, P. (in press). Syngeneic mesenchymal stem cells loaded with telomerase-dependent oncolytic adenoviruses enhance anti-metastatic efficacy. Stem Cells Translational Medicine, Article szae039. https://doi.org/10.1093/stcltm/szae039

Oncolytic adenoviruses have emerged as a promising therapeutic approach for cancer therapy. However, systemic delivery of the viruses to metastatic tumors remains a major challenge. Mesenchymal stem cells (MSCs) possess tumor tropism property and can... Read More about Syngeneic mesenchymal stem cells loaded with telomerase-dependent oncolytic adenoviruses enhance anti-metastatic efficacy..

GPs’ views of prescribing beta- blockers for people with anxiety disorders: a qualitative study (2024)
Journal Article
Archer, C., Kessler, D., Wiles, N., Chew-Graham, C. A., & Turner, K. (2024). GPs’ views of prescribing beta- blockers for people with anxiety disorders: a qualitative study. British Journal of General Practice (BJGP), Article BJGP.2024.0091. https://doi.org/10.3399/BJGP.2024.0091

Between 2003-2018, incident prescriptions of beta-blockers for anxiety increased substantially, particularly in young adults. NICE guidance for anxiety does not recommend beta-blockers, probably due to a lack of evidence to support such use. Recent r... Read More about GPs’ views of prescribing beta- blockers for people with anxiety disorders: a qualitative study.

Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway. (2024)
Journal Article
Ebrahim, N., Al Saihati, H. A., Alali, Z., Aleniz, F. Q., Mahmoud, S. Y. M., Badr, O. A., Dessouky, A. A., Mostafa, O., Hussien, N. I., Farid, A. S., El-Sherbiny, M., Salim, R. F., Forsyth, N. R., Ali, F. E. M., & Alsabeelah, N. F. (2024). Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway. Biomedicine and Pharmacotherapy, 176, Article 116836. https://doi.org/10.1016/j.biopha.2024.116836

Alzheimer's disease (AD) is a devastating neurological condition characterized by cognitive decline, motor coordination impairment, and amyloid plaque accumulation. The underlying molecular mechanisms involve oxidative stress, inflammation, and neuro... Read More about Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway..

Exploring the relationship between gut microbiome modulation and blood pressure in type 2 diabetes: An umbrella review. (2024)
Journal Article
Amini-Salehi, E., Mahapatro, A., Korsapati, R. R., Korsapati, A. R., Jain, S. M., Babaeizad, A., Mohammadi, S., Rashidian, P., Hashemi, M., Dave, T., Jamilian, P., Hassanipour, S., Keivanlou, M.-H., & Patel, D. (in press). Exploring the relationship between gut microbiome modulation and blood pressure in type 2 diabetes: An umbrella review. Nutrition, Metabolism and Cardiovascular Diseases, https://doi.org/10.1016/j.numecd.2024.05.017

Given the epidemic proportions of type 2 diabetes mellitus (T2DM) globally, it's crucial to comprehensively understand the factors influencing its management. The gut microbiome, known for its influence on various aspects of health, has emerged as a... Read More about Exploring the relationship between gut microbiome modulation and blood pressure in type 2 diabetes: An umbrella review..

Radiation Exposure, Training, and Safety in Cardiology. (2024)
Journal Article
Tamirisa, K. P., Alasnag, M., Calvert, P., Islam, S., Bhardwaj, A., Pakanati, K., Zieroth, S., Razminia, M., Dalal, A. S., Mamas, M., Russo, A. M., & Kort, S. (2024). Radiation Exposure, Training, and Safety in Cardiology. JACC: Advances, 3(4), Article 100863. https://doi.org/10.1016/j.jacadv.2024.100863

Exposure to ionizing radiation is an inherent occupational health hazard in clinical cardiology. Health risks have been reported previously, including predilection to cancer. In addition, orthopedic injury due to prolonged wearing of heavy protective... Read More about Radiation Exposure, Training, and Safety in Cardiology..