Skip to main content

Research Repository

Advanced Search

The prognostic value of mean platelet volume in patients with coronary artery disease: An updated systematic review with meta-analyses.

Galimzhanov, Akhmetzhan; Tun, Han Naung; Sabitov, Yersyn; Perone, Francesco; Kursat, Tigen Mustafa; Tenekecioglu, Erhan; Mamas, Mamas A.

Authors

Akhmetzhan Galimzhanov

Han Naung Tun

Yersyn Sabitov

Francesco Perone

Tigen Mustafa Kursat

Erhan Tenekecioglu



Abstract

Mean platelet volume (MPV) is a widely available laboratory index, however its prognostic significance in patients with coronary artery disease (CAD) is still unclear. We intended to investigate and pool the evidence on the prognostic utility of admission MPV in predicting clinical outcomes in patients with CAD. PubMed, Web of Science, and Scopus were the major databases used for literature search. The risk of bias was assessed using the quality in prognostic factor studies. We used random-effects pairwise analysis with the Knapp and Hartung approach supported further with permutation tests and prediction intervals (PIs). We identified 52 studies with 47,066 patients. A meta-analysis of nine studies with 14,864 patients demonstrated that one femtoliter increase in MPV values was associated with a rise of 29% in the risk of long-term mortality (hazard ratio [HR] 1.29, 95% confidence interval [CI] 1.22-1.37) in CAD as a whole. The results were further supported with PIs, permutation tests and leave-one-out sensitivity analyses. MPV also demonstrated its stable and significant prognostic utility in predicting long-term mortality as a linear variable in patients treated with percutaneous coronary intervention (PCI) and presented with acute coronary syndrome (ACS) (HR 1.29, 95% CI 1.20-1.39, and 1.29, 95% CI 1.19-1.39, respectively). The meta-analysis found robust evidence on the link between admission MPV and the increased risk of long-term mortality in patients with CAD patients, as well as in patients who underwent PCI and patients presented with ACS. [Abstract copyright: © 2024 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.]

Citation

Galimzhanov, A., Tun, H. N., Sabitov, Y., Perone, F., Kursat, T. M., Tenekecioglu, E., & Mamas, M. A. (in press). The prognostic value of mean platelet volume in patients with coronary artery disease: An updated systematic review with meta-analyses. European Journal of Clinical Investigation, Article e14295. https://doi.org/10.1111/eci.14295

Journal Article Type Article
Acceptance Date Jul 23, 2024
Online Publication Date Jul 31, 2024
Deposit Date Aug 22, 2024
Journal European journal of clinical investigation
Print ISSN 0014-2972
Publisher Wiley
Peer Reviewed Peer Reviewed
Article Number e14295
DOI https://doi.org/10.1111/eci.14295
Keywords systematic review, mortality, mean platelet volume; coronary artery disease, prognosis
Public URL https://keele-repository.worktribe.com/output/885140
Publisher URL https://onlinelibrary.wiley.com/doi/10.1111/eci.14295