Outputs (44)

Bone amyloidosis: A rare case in a young adult (2025)
Journal Article
Inês Magalhães Rodrigues, M., Kaur, S., Cool, P., Tyrrell, P., & Winn, N. (2025). Bone amyloidosis: A rare case in a young adult. EURORAD, https://doi.org/10.35100/EURORAD/CASE.18903

A 26-year-old male presented with progressively worsening pain in his right leg, along with increasing thigh swelling
and leg shortening. Four years prior, he had sustained a right femur fracture, which was managed conservatively.
Initial investi... Read More about Bone amyloidosis: A rare case in a young adult.

A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome (2025)
Journal Article
Harrington, G. M. B., Cool, P., Hulme, C., Stokes-Fisher, J., Peffers, M., El Masri, W., Osman, A., Chowdhury, J. R., Kumar, N., Budithi, S., & Wright, K. (2025). A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome. Journal of Neurotrauma, 42(3-4), https://doi.org/10.1101/2022.07.12.499696

Spinal cord injury (SCI) is a major cause of disability, with complications postinjury often leading to lifelong health issues with the need for extensive treatment. Neurological outcome post-SCI can be variable and difficult to predict, particularly... Read More about A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome.

A Comprehensive Proteomic and Bioinformatic Analysis of Human Spinal Cord Injury Plasma Identifies Proteins Associated with the Complement Cascade and Liver Function as Potential Prognostic Indicators of Neurological Outcome (2025)
Journal Article
Mateus Bernardo Harrington, G., Cool, P., Hulme, C., Fisher-Stokes, J., Peffers, M., El Masri, W., Osman, A., Roy Chowdhury, J., Kumar, N., Budithi, S., & Wright, K. (2025). A Comprehensive Proteomic and Bioinformatic Analysis of Human Spinal Cord Injury Plasma Identifies Proteins Associated with the Complement Cascade and Liver Function as Potential Prognostic Indicators of Neurological Outcome. Journal of Neurotrauma, 42(3-4), 292-306. https://doi.org/10.1089/neu.2023.0064

Spinal cord injury (SCI) is a major cause of disability, with complications postinjury often leading to lifelong health issues with the need for extensive treatment. Neurological outcome post-SCI can be variable and difficult to predict, particularly... Read More about A Comprehensive Proteomic and Bioinformatic Analysis of Human Spinal Cord Injury Plasma Identifies Proteins Associated with the Complement Cascade and Liver Function as Potential Prognostic Indicators of Neurological Outcome.

A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides (2024)
Journal Article
Shen, Z., Simard, M., Brand, D., Andrei, V., Al-Khader, A., Oumlil, F., Trevers, K., Butters, T., Haefliger, S., Kara, E., Amary, F., Tirabosco, R., Cool, P., Royle, G., Hawkins, M. A., Flanagan, A. M., & Collins-Fekete, C.-A. (in press). A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides. Communications Biology, 7(1), 1674. https://doi.org/10.1038/s42003-024-07398-6

Mitotic activity is an important feature for grading several cancer types. However, counting mitotic figures (cells in division) is a time-consuming and laborious task prone to inter-observer variation. Inaccurate recognition of MFs can lead to incor... Read More about A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides.

Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model (2024)
Journal Article
Perry, J., Mennan, C., Cool, P., McCarthy, H., Newell, K., Hopkins, T., Hulme, C., Wright, K., Henson, F., & Roberts, S. (2024). Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model. Cartilage, https://doi.org/10.1177/19476035241287832

Objective
To determine if mesenchymal stromal cells (MSCs) derived from human umbilical cords (hUC) could reduce degeneration developing when injected into the knee of a large animal model of osteoarthritis (OA).
Design
Ten million culture-expande... Read More about Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model.

Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model (2024)
Journal Article
Perry, J., Mennan, C., Cool, P., McCarthy, H. S., Newell, K., Hopkins, T., Hulme, C., Wright, K. T., Henson, F. M., & Roberts, S. (2024). Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model. Cartilage, https://doi.org/10.1177/19476035241287832

Objective To determine if mesenchymal stromal cells (MSCs) derived from human umbilical cords (hUC) could reduce degeneration developing when injected into the knee of a large animal model of osteoarthritis (OA). Design Ten million culture-expanded U... Read More about Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model.

681 USING NANOPORE SEQUENCING TO DIAGNOSE PROSTHETIC JOINT INFECTIONS (2024)
Presentation / Conference
Wilkinson, H., Cool, P., Perry, J., Wright, K. T., McCarthy, H. S., & Hulme, C. H. (2024, April). 681 USING NANOPORE SEQUENCING TO DIAGNOSE PROSTHETIC JOINT INFECTIONS. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study (2024)
Journal Article
Wilkinson, H., McDonald, J., McCarthy, H., Perry, J., Wright, K., Hulme, C., & Cool, P. (in press). Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study. Briefings in Functional Genomics, Article elae008. https://doi.org/10.1093/bfgp/elae008

This project investigates if third-generation genomic sequencing can be used to identify the species of bacteria causing prosthetic joint infections (PJIs) at the time of revision surgery. Samples of prosthetic fluid were taken during revision surger... Read More about Using Nanopore sequencing to identify bacterial infection in joint replacements: A Preliminary study.

PRELIMINARY FINDINGS ON THE USE OF GENOMIC SEQUENCING TO DIAGNOSE ORTHOPAEDIC INFECTIONS (2023)
Presentation / Conference Contribution
Wilkinson, H., & Cool, P. PRELIMINARY FINDINGS ON THE USE OF GENOMIC SEQUENCING TO DIAGNOSE ORTHOPAEDIC INFECTIONS. Presented at The British Orthopaedic Research Society (BORS) 2023 Meeting (25–26 Sept 2023), Cambridge, England, UK

AbstractObjectivesThe objective of this study is to investigate if genomic sequencing is a useful method to diagnose orthopaedic infections. Current methods used to identify the species of bacteria causing orthopaedic infections take considerable tim... Read More about PRELIMINARY FINDINGS ON THE USE OF GENOMIC SEQUENCING TO DIAGNOSE ORTHOPAEDIC INFECTIONS.

Aneurysmal bone cysts: A UK wide tumor center experience (2023)
Journal Article
Bavan, L., Eastley, N., Stevenson, J., Mifsud, M., Bayliss, L., Mahmoud, S., Baker, G., Cusick, L., Nail, R., Rankin, K., Crooks, S., Cool, P., Williams, D., Kandarakis, G., Duncan, R., & Kothari, A. (in press). Aneurysmal bone cysts: A UK wide tumor center experience. Journal of Surgical Oncology, 129(3), 601-608. https://doi.org/10.1002/jso.27499

Background and Objectives
This multicenter retrospective series of consecutive extra-spinal aneurysmal bone cysts aims to identify risk factors for treatment failure.

Methods
Aneurysmal bone cysts treated within seven collaborating centers with... Read More about Aneurysmal bone cysts: A UK wide tumor center experience.