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Outputs (623)

Impact of Body Mass Index on outcomes in hospitalized heart failure patients with reduced versus preserved ejection fraction: a 1,699,494-individual analysis from the United States National Inpatient Sample. (2023)
Journal Article
Ansari, S. A., Suheb, M. Z., Rashid, M., Maqsood, M. H., Rashid, A. M., Javaid, S. S., & Siddiqi, A. K. (in press). Impact of Body Mass Index on outcomes in hospitalized heart failure patients with reduced versus preserved ejection fraction: a 1,699,494-individual analysis from the United States National Inpatient Sample. Minerva Cardiology and Angiology, https://doi.org/10.23736/S2724-5683.23.06367-6

Obesity's effect on outcomes in heart failure (HF) patients with reduced versus maintained ejection fraction (HFrEF and HFpEF) remains debatable. We evaluated hospital outcomes and healthcare expenditures in these patients based on their Body Mass In... Read More about Impact of Body Mass Index on outcomes in hospitalized heart failure patients with reduced versus preserved ejection fraction: a 1,699,494-individual analysis from the United States National Inpatient Sample..

Association between Surgeon/anesthesiologist Sex Discordance and One-year Mortality Among Adults Undergoing Noncardiac Surgery (2023)
Journal Article
Etherington, C., Boet, S., Chen, I., Duffy, M., Mamas, M. A., Eddeen, A. B., …Sun, L. Y. (in press). Association between Surgeon/anesthesiologist Sex Discordance and One-year Mortality Among Adults Undergoing Noncardiac Surgery. Annals of Surgery, 279(4), 563-568. https://doi.org/10.1097/sla.0000000000006111

Objective: To investigate the association between surgeon-anesthesiologist sex discordance and patient mortality after noncardiac surgery. Background: Evidence suggests different practice patterns exist among female and male physicians. Howeve... Read More about Association between Surgeon/anesthesiologist Sex Discordance and One-year Mortality Among Adults Undergoing Noncardiac Surgery.

An Induced Pluripotent Stem Cell-Derived Human Blood–Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides (2023)
Journal Article
Selvakumaran, J., Ursu, S., Bowerman, M., Lu-Nguyen, N., Wood, M. J., Malerba, A., & Yáñez-Muñoz, R. J. (2023). An Induced Pluripotent Stem Cell-Derived Human Blood–Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides. Biomedicines, 11(10), Article 2700. https://doi.org/10.3390/biomedicines11102700

The blood–brain barrier (BBB) is the specialised microvasculature system that shields the central nervous system (CNS) from potentially toxic agents. Attempts to develop therapeutic agents targeting the CNS have been hindered by the lack of predictiv... Read More about An Induced Pluripotent Stem Cell-Derived Human Blood–Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides.

An Induced Pluripotent Stem Cell-Derived Human Blood–Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides (2023)
Journal Article
Selvakumaran, J., Ursu, S., Bowerman, M., Lu-Nguyen, N., Wood, M. J., Malerba, A., & Yáñez-Muñoz, R. J. (2023). An Induced Pluripotent Stem Cell-Derived Human Blood–Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides. Biomedicines, 11(10), Article 2700. https://doi.org/10.3390/xxxxx

The blood-brain barrier (BBB) is the specialised microvasculature system that shields the central nervous system (CNS) from potentially toxic agents. Attempts to develop therapeutic agents targeting the CNS have been hindered by the lack of predictiv... Read More about An Induced Pluripotent Stem Cell-Derived Human Blood–Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides.

Stakeholder perceptions of preventive approaches to rheumatoid arthritis: qualitative study of healthcare professionals’ perspectives on predictive and preventive strategies (2023)
Journal Article
Wells, I., Simons, G., Kanacherril, J. P., Mallen, C. D., Raza, K., & Falahee, M. (in press). Stakeholder perceptions of preventive approaches to rheumatoid arthritis: qualitative study of healthcare professionals’ perspectives on predictive and preventive strategies. BMC Rheumatology, 7(1), Article 35. https://doi.org/10.1186/s41927-023-00361-8

Background: There is increasing research interest in the development of preventive treatment for individuals at risk of rheumatoid arthritis (RA). Previous studies have explored the perceptions of at-risk groups and patients about predictive and prev... Read More about Stakeholder perceptions of preventive approaches to rheumatoid arthritis: qualitative study of healthcare professionals’ perspectives on predictive and preventive strategies.

Social disparities in cardiovascular mortality of patients with cancer in the USA between 1999 and 2019 (2023)
Journal Article
Raisi-Estabragh, Z., Kobo, O., López-Fernández, T., Qadir, H. A., Chew, N. W., Wojakowski, W., …Mamas, M. A. (2023). Social disparities in cardiovascular mortality of patients with cancer in the USA between 1999 and 2019. International Journal of Cardiology Cardiovascular Risk and Prevention, 19, Article 200218. https://doi.org/10.1016/j.ijcrp.2023.200218

Background Temporal trends of the impact of social determinants on cardiovascular outcomes of cancer patients has not been previously studied. Objectives This study examined social disparities in cardiovascular mortality of people... Read More about Social disparities in cardiovascular mortality of patients with cancer in the USA between 1999 and 2019.

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors (2023)
Journal Article
Alexander, S. P. H., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A. A., Peters, J. A., …Ye, R. D. (2023). The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. British Journal of Pharmacology, 180, S23-S144. https://doi.org/10.1111/bph.16177

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interacti... Read More about The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.

Detecting transthyretin amyloid cardiomyopathy (ATTR-CM) using machine learning: an evaluation of the performance of an algorithm in a UK setting (2023)
Journal Article
Tsang, C., Huda, A., Norman, M., Dickerson, C., Leo, V., Brownrigg, J., …Elliott, P. (2023). Detecting transthyretin amyloid cardiomyopathy (ATTR-CM) using machine learning: an evaluation of the performance of an algorithm in a UK setting. BMJ Open, 13(10), Article e070028. https://doi.org/10.1136/bmjopen-2022-070028

Objective: The aim of this study was to evaluate the potential real-world application of a machine learning (ML) algorithm, developed and trained on heart failure (HF) cohorts in the USA, to detect patients with undiagnosed wild type cardiac amyloido... Read More about Detecting transthyretin amyloid cardiomyopathy (ATTR-CM) using machine learning: an evaluation of the performance of an algorithm in a UK setting.

The British Orthopaedic Oncology Management (BOOM) audit (2023)
Journal Article
Archer, J. E., Chauhan, G. S., Dewan, V., Osman, K., Thomson, C., Nandra, R. S., …Stevenson, J. (2023). The British Orthopaedic Oncology Management (BOOM) audit. The Bone & Joint Journal, 105-B(10), 1115-1122. https://doi.org/10.1302/0301-620x.105b10.bjj-2023-0443.r1

AimsMost patients with advanced malignancy suffer bone metastases, which pose a significant challenge to orthopaedic services and burden to the health economy. This study aimed to assess adherence to the British Orthopaedic Oncology Society (BOOS)/Br... Read More about The British Orthopaedic Oncology Management (BOOM) audit.