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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

Alexander, Stephen P. H.; Christopoulos, Arthur; Davenport, Anthony P.; Kelly, Eamonn; Mathie, Alistair A.; Peters, John A.; Veale, Emma L.; Armstrong, Jane F.; Faccenda, Elena; Harding, Simon D.; Davies, Jamie A.; Abbracchio, Maria Pia; Abraham, George; Agoulnik, Alexander; Alexander, Wayne; Al‐hosaini, Khaled; Bäck, Magnus; Baker, Jillian G.; Barnes, Nicholas M.; Bathgate, Ross; Beaulieu, Jean‐Martin; Beck‐Sickinger, Annette G.; Behrens, Maik; Bernstein, Kenneth E.; Bettler, Bernhard; Birdsall, Nigel J. M.; Blaho, Victoria; Boulay, Francois; Bousquet, Corinne; Bräuner‐Osborne, Hans; Burnstock, Geoffrey; Caló, Girolamo; Castaño, Justo P.; Catt, Kevin J.; Ceruti, Stefania; Chazot, Paul; Chiang, Nan; Chini, Bice; Chun, Jerold; Cianciulli, Antonia; Civelli, Olivier; Clapp, Lucie H.; Couture, Réjean; Cox, Helen M.; Csaba, Zsolt; Dahlgren, Claes; Dent, Gordon; Douglas, Steven D.; Dournaud, Pascal; Eguchi, Satoru; Escher, Emanuel; Filardo, Edward J.; Fong, Tung; Fumagalli, Marta; Gainetdino...

Authors

Stephen P. H. Alexander

Arthur Christopoulos

Anthony P. Davenport

Eamonn Kelly

Alistair A. Mathie

John A. Peters

Emma L. Veale

Jane F. Armstrong

Elena Faccenda

Simon D. Harding

Jamie A. Davies

Maria Pia Abbracchio

George Abraham

Alexander Agoulnik

Wayne Alexander

Khaled Al‐hosaini

Magnus Bäck

Jillian G. Baker

Nicholas M. Barnes

Ross Bathgate

Jean‐Martin Beaulieu

Annette G. Beck‐Sickinger

Maik Behrens

Kenneth E. Bernstein

Bernhard Bettler

Nigel J. M. Birdsall

Victoria Blaho

Francois Boulay

Corinne Bousquet

Hans Bräuner‐Osborne

Geoffrey Burnstock

Girolamo Caló

Justo P. Castaño

Kevin J. Catt

Stefania Ceruti

Paul Chazot

Nan Chiang

Bice Chini

Jerold Chun

Antonia Cianciulli

Olivier Civelli

Lucie H. Clapp

Réjean Couture

Helen M. Cox

Zsolt Csaba

Claes Dahlgren

Steven D. Douglas

Pascal Dournaud

Satoru Eguchi

Emanuel Escher

Edward J. Filardo

Tung Fong

Marta Fumagalli

Raul R. Gainetdinov

Michael L. Garelja

Marc de Gasparo

Craig Gerard

Marvin Gershengorn

Fernand Gobeil

Theodore L. Goodfriend

Cyril Goudet

Lukas Grätz

Karen J. Gregory

Andrew L. Gundlach

Jörg Hamann

Julien Hanson

Richard L. Hauger

Debbie L. Hay

Akos Heinemann

Deron Herr

Morley D. Hollenberg

Nicholas D. Holliday

Mastgugu Horiuchi

Daniel Hoyer

László Hunyady

Ahsan Husain

Adriaan P. IJzerman

Tadashi Inagami

Kenneth A. Jacobson

Robert T. Jensen

Ralf Jockers

Deepa Jonnalagadda

Sadashiva Karnik

Klemens Kaupmann

Jacqueline Kemp

Charles Kennedy

Yasuyuki Kihara

Takio Kitazawa

Pawel Kozielewicz

Hans‐Jürgen Kreienkamp

Jyrki P. Kukkonen

Tobias Langenhan

Dan Larhammar

Katie Leach

Davide Lecca

John D. Lee

Susan E. Leeman

Jérôme Leprince

Xaria X. Li

Stephen J. Lolait

Amelie Lupp

Robyn Macrae

Janet Maguire

Davide Malfacini

Jean Mazella

Craig A. McArdle

Shlomo Melmed

Martin C. Michel

Laurence J. Miller

Vincenzo Mitolo

Bernard Mouillac

Christa E. Müller

Philip M. Murphy

Jean‐Louis Nahon

Tony Ngo

Xavier Norel

Duuamene Nyimanu

Anne‐Marie O’Carroll

Stefan Offermanns

Maria Antonietta Panaro

Marc Parmentier

Roger G. Pertwee

Jean‐Philippe Pin

Eric R. Prossnitz

Mark Quinn

Rithwik Ramachandran

Manisha Ray

Rainer K. Reinscheid

Philippe Rondard

G. Enrico Rovati

Chiara Ruzza

Gareth J. Sanger

Torsten Schöneberg

Gunnar Schulte

Stefan Schulz

Deborah L. Segaloff

Charles N. Serhan

Khuraijam Dhanachandra Singh

Craig M. Smith

Leigh A. Stoddart

Yukihiko Sugimoto

Roger Summers

Valerie P. Tan

David Thal

Walter ( Wally) Thomas

Pieter B. M. W. M. Timmermans

Kalyan Tirupula

Lawrence Toll

Giovanni Tulipano

Hamiyet Unal

Thomas Unger

Celine Valant

Patrick Vanderheyden

David Vaudry

Hubert Vaudry

Jean‐Pierre Vilardaga

Christopher S. Walker

Ji Ming Wang

Donald T. Ward

Hans‐Jürgen Wester

Gary B. Willars

Tom Lloyd Williams

Trent M. Woodruff

Chengcan Yao

Richard D. Ye



Abstract

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.16177. G protein‐coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

Citation

Alexander, S. P. H., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A. A., Peters, J. A., …Ye, R. D. (2023). The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. British Journal of Pharmacology, 180, S23-S144. https://doi.org/10.1111/bph.16177

Journal Article Type Article
Acceptance Date Dec 20, 2023
Online Publication Date Dec 20, 2023
Publication Date Oct 1, 2023
Deposit Date Jan 8, 2024
Journal British Journal of Pharmacology
Print ISSN 0007-1188
Electronic ISSN 1476-5381
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 180
Pages S23-S144
DOI https://doi.org/10.1111/bph.16177