Outputs (5131)

Is acupuncture a useful adjunct to physiotherapy for older adults with knee pain?: the "acupuncture, physiotherapy and exercise" (APEX) study [ISRCTN88597683] (2004)
Journal Article
(2004). Is acupuncture a useful adjunct to physiotherapy for older adults with knee pain?: the "acupuncture, physiotherapy and exercise" (APEX) study [ISRCTN88597683]. BMC Musculoskeletal Disorders, 31 - ?. https://doi.org/10.1186/1471-2474-5-31

Acupuncture is a popular non-pharmacological modality for treating musculoskeletal pain. Physiotherapists are one of the largest groups of acupuncture providers within the NHS, and they commonly use it alongside advice and exercise. Conclusive eviden... Read More about Is acupuncture a useful adjunct to physiotherapy for older adults with knee pain?: the "acupuncture, physiotherapy and exercise" (APEX) study [ISRCTN88597683].

The Knee Clinical Assessment Study--CAS(K). A prospective study of knee pain and knee osteoarthritis in the general population (2004)
Journal Article
(2004). The Knee Clinical Assessment Study--CAS(K). A prospective study of knee pain and knee osteoarthritis in the general population. BMC Musculoskeletal Disorders, 4 -?. https://doi.org/10.1186/1471-2474-5-4

BACKGROUND: Knee pain affects an estimated 25% of the adult population aged 50 years and over. Osteoarthritis is the most common diagnosis made in older adults consulting with knee pain in primary care. However, the relationship between this diagnosi... Read More about The Knee Clinical Assessment Study--CAS(K). A prospective study of knee pain and knee osteoarthritis in the general population.

The North Staffordshire Osteoarthritis Project--NorStOP: prospective, 3-year study of the epidemiology and management of clinical osteoarthritis in a general population of older adults (2004)
Journal Article
(2004). The North Staffordshire Osteoarthritis Project--NorStOP: prospective, 3-year study of the epidemiology and management of clinical osteoarthritis in a general population of older adults. BMC Musculoskeletal Disorders, 2 -?. https://doi.org/10.1186/1471-2474-5-2

BACKGROUND: The clinical syndrome of joint pain and stiffness in older people is the commonest cause of disability and health care consultation in this age group. Yet there have been few prospective studies of its course over time and its impact on p... Read More about The North Staffordshire Osteoarthritis Project--NorStOP: prospective, 3-year study of the epidemiology and management of clinical osteoarthritis in a general population of older adults.

An evaluation of a multidisciplinary team for intermediate care at home. (2004)
Journal Article
(2004). An evaluation of a multidisciplinary team for intermediate care at home. International Journal of Integrated Care, e02 - ?

BACKGROUND: The implementation of the National Health Service Plan for the UK will see an expansion of services for intermediate care. Such services are usually targeted at older people and aim to: prevent 'avoidable' admissions to acute inpatient ca... Read More about An evaluation of a multidisciplinary team for intermediate care at home..

Decline in Rate of Colonization of Oligodendrocyte Progenitor Cell (OPC)-Depleted Tissue by Adult OPCs with Age (2003)
Journal Article
Chari, D. M., Crang, A. J., & Blakemore, W. F. (2003). Decline in Rate of Colonization of Oligodendrocyte Progenitor Cell (OPC)-Depleted Tissue by Adult OPCs with Age. Journal of Neuropathology and Experimental Neurology, 62(9), 908-916. https://doi.org/10.1093/jnen/62.9.908

Rates of remyelination decline with age and this has been attributed to slower recruitment of oligodendrocyte progenitor cells (OPCs) into areas of demyelination and slower differentiation of OPCs into remyelinating oligodendrocytes. When considering... Read More about Decline in Rate of Colonization of Oligodendrocyte Progenitor Cell (OPC)-Depleted Tissue by Adult OPCs with Age.

Dysfunctional oligodendrocyte progenitor cell (OPC) populations may inhibit repopulation of OPC depleted tissue (2003)
Journal Article
Chari, D., Huang, W., & Blakemore, W. (2003). Dysfunctional oligodendrocyte progenitor cell (OPC) populations may inhibit repopulation of OPC depleted tissue. Journal of Neuroscience Research, 73(6), 787-793. https://doi.org/10.1002/jnr.10700

We have attempted to extend a previously described rat model of focal oligodendrocyte progenitor cell (OPC) depletion, using 40 Gy X-irradiation (Chari and Blakemore [2002] Glia 37:307–313), to the adult mouse spinal cord, to examine the ability of O... Read More about Dysfunctional oligodendrocyte progenitor cell (OPC) populations may inhibit repopulation of OPC depleted tissue.

Why are eligible patients not prescribed aspirin in primary care?: a qualitative study indicating measures for improvement (2003)
Journal Article
(2003). Why are eligible patients not prescribed aspirin in primary care?: a qualitative study indicating measures for improvement. BMC Family Practice, 9 -?. https://doi.org/10.1186/1471-2296-4-9

BACKGROUND: Despite evidence-based guidelines, aspirin prescribing for the secondary prevention of stroke is sub-optimal. Little is known about why general practitioners do not prescribe aspirin to indicated patients. We sought to identify and descri... Read More about Why are eligible patients not prescribed aspirin in primary care?: a qualitative study indicating measures for improvement.

New insights into remyelination failure in multiple sclerosis: implications for glial cell transplantation (2002)
Journal Article
Chari, D., & Blakemore, W. (2002). New insights into remyelination failure in multiple sclerosis: implications for glial cell transplantation. Multiple Sclerosis, 8(4), 271-277. https://doi.org/10.1191/1352458502ms842oa

This review considers aspects of remyelination that require further clarification if successful strategies are to be devised to enhance remyelination in multiple sclerosis (MS). We speculate, based on our understanding of the rate with which oligoden... Read More about New insights into remyelination failure in multiple sclerosis: implications for glial cell transplantation.

Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS (2002)
Journal Article
Blakemore, W., Chari, D., Gilson, J., & Crang, A. (2002). Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS. Glia, 38(2), 155-168. https://doi.org/10.1002/glia.10067

Transplantation of myelin-forming glial cells may provide a means of achieving remyelination in situations in which endogenous remyelination fails. For this type of cell therapy to be successful, cells will have to migrate long distances in normal ti... Read More about Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS.

Efficient recolonisation of progenitor‐depleted areas of the CNS by adult oligodendrocyte progenitor cells (2002)
Journal Article
Chari, D. M., & Blakemore, W. F. (2002). Efficient recolonisation of progenitor‐depleted areas of the CNS by adult oligodendrocyte progenitor cells. Glia, 37(4), 307-313. https://doi.org/10.1002/glia.10038

A widely quoted hypothesis for the failure of remyelination in multiple sclerosis (MS) is the exhaustion of the oligodendrocyte progenitor cell (OPC) pool that is strongly implicated as the source of remyelinating oligodendrocytes in demyelinating le... Read More about Efficient recolonisation of progenitor‐depleted areas of the CNS by adult oligodendrocyte progenitor cells.