Outputs (5)

Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation (2014)
Journal Article
Robinson, E., Leung, E., Matuszek, A. M., Krogsgaard-Larsen, N., Furkert, D. P., Brimble, M. A., …Reynisson, J. (in press). Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation. MedChemComm, 6(1), 239-246. https://doi.org/10.1039/c4md00420e

Two hit compounds (14 and 62) were identified using virtual high throughput screening (vHTS) inhibiting the autophagy process in A2780 ovarian cancer cells. The expression levels of the LC3-II and p62 autophagy marker proteins were monitored using We... Read More about Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation.

Cytotoxic effects of stem bark extracts and pure compounds from Margaritaria discoidea on human ovarian cancer cell lines (2014)
Journal Article
Johnson-Ajinwo, O. R., Richardson, A., & Li, W. (2015). Cytotoxic effects of stem bark extracts and pure compounds from Margaritaria discoidea on human ovarian cancer cell lines. Phytomedicine, 22(1), 1-4. https://doi.org/10.1016/j.phymed.2014.09.008

Anti-ovarian cancer activities of alkaloids from Triclisia subcordata olive (Menispermecaea) (2014)
Conference Proceeding
Uche, F., Li, W., Richardson, A., & Greenhough, T. Anti-ovarian cancer activities of alkaloids from Triclisia subcordata olive (Menispermecaea). . https://doi.org/10.1055/s-0034-1382585

This study investigates the anticancer activities of Triclisia subcordata, identifies and elucidates the structure(s) of the bioactive anticancer compound. The evaluation of anticancer activity was done by in vitro sulforhodamine B dye method using A... Read More about Anti-ovarian cancer activities of alkaloids from Triclisia subcordata olive (Menispermecaea).

New strategies for the treatment of ovarian cancer (2014)
Journal Article
Robinson, E., Fisher, N., Stamelos, V., Redman, C., & Richardson, A. (2014). New strategies for the treatment of ovarian cancer. Biochemical Society Transactions, 42(1), 125-129. https://doi.org/10.1042/bst20130203

Ovarian cancer usually responds well to chemotherapy, but once the disease becomes resistant to chemotherapy, the treatment options available are inadequate. A number of strategies are currently undergoing clinical evaluation, among which angiogenesi... Read More about New strategies for the treatment of ovarian cancer.

Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas (2014)
Journal Article
Jain, H., Richardson, A., Meyer-Hermann, M., & Byrne, H. (2014). Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas. PloS one, e81582 - ?. https://doi.org/10.1371/journal.pone.0081582

Platinum drug-resistance in ovarian cancers mediated by anti-apoptotic proteins such as Bcl-xL is a major factor contributing to the chemotherapeutic resistance of recurrent disease. Consequently, concurrent inhibition of Bcl-xL in combination with c... Read More about Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas.