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Outputs (39)

Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee. (2016)
Journal Article
Bhattacharjee, A., McCarthy, H. S., Tins, B., Roberts, S., Kuiper, J. H., Harrison, P. E., & Richardson, J. B. (2016). Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee. American Journal of Sports Medicine, 44(5), 1249 - 1259. https://doi.org/10.1177/0363546516631739

BACKGROUND: Structural and functional outcome of bone graft with first- or second-generation autologous chondrocyte implantation (ACI) in treating cartilage and subchondral bone defect has not been reported previously. PURPOSE: To evaluate the outcom... Read More about Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee..

Evaluating Joint Morbidity after Chondral Harvest for Autologous Chondrocyte Implantation (ACI): A Study of ACI-Treated Ankles and Hips with a Knee Chondral Harvest (2015)
Journal Article
McCarthy, H. S., Richardson, J. B., Parker, J. C., & Roberts, S. (2015). Evaluating Joint Morbidity after Chondral Harvest for Autologous Chondrocyte Implantation (ACI): A Study of ACI-Treated Ankles and Hips with a Knee Chondral Harvest. Cartilage, 7(1), 7-15. https://doi.org/10.1177/1947603515607963

Objective
To establish if harvesting cartilage to source chondrocytes for autologous chondrocyte implantation (ACI) results in donor site morbidity.

Design
Twenty-three patients underwent ACI for chondral defects of either the ankle or the hip.... Read More about Evaluating Joint Morbidity after Chondral Harvest for Autologous Chondrocyte Implantation (ACI): A Study of ACI-Treated Ankles and Hips with a Knee Chondral Harvest.

Wnt-signalling in human articular chondrocytes (2015)
Journal Article
McCarthy, H., Owen, S., & Roberts, S. (2015). Wnt-signalling in human articular chondrocytes. International Journal of Experimental Pathology, 96(2), A27

Introduction Aberrant Wnt-signalling in cartilage results inchondrocyte dedifferentiation, hypertrophy, loss of type II collagen, aggrecan and glycosaminoglycans. Articular chondrocytes experience a pO2 gradient from~6% (surface) to~1% (within deeper... Read More about Wnt-signalling in human articular chondrocytes.

A histological comparison of the repair tissue formed when using either Chondrogide® or periosteum during autologous chondrocyte implantation (2013)
Journal Article
McCarthy, H., & Roberts, S. (2013). A histological comparison of the repair tissue formed when using either Chondrogide® or periosteum during autologous chondrocyte implantation. Osteoarthritis and Cartilage, 21(12), 2048-2057. https://doi.org/10.1016/j.joca.2013.10.004

Objective
In this study, we compare the clinical and histological outcome between periosteum and Chondrogide® during autologous chondrocyte implantation (ACI).

Method
This study consisted of 88 patients having received ACI in the knee; 33 treate... Read More about A histological comparison of the repair tissue formed when using either Chondrogide® or periosteum during autologous chondrocyte implantation.

Increased production of clusterin in biopsies of repair tissue following autologous chondrocyte implantation (2013)
Journal Article
McCarthy, H. S., Malda, J., Richardson, J. B., & Roberts, S. (2013). Increased production of clusterin in biopsies of repair tissue following autologous chondrocyte implantation. Cartilage, 4(3), 227 -238. https://doi.org/10.1177/1947603513477652

OBJECTIVE: To characterize the immunolocalization of clusterin in the repair cartilage of patients having undergone autologous chondrocyte implantation (ACI) and evaluate correlation to clinical outcome. DESIGN: Full-depth core biopsies of repair tis... Read More about Increased production of clusterin in biopsies of repair tissue following autologous chondrocyte implantation.

Fourier transform infrared imaging and infrared fiber optic probe spectroscopy identify collagen type in connective tissues (2013)
Journal Article
Hanifi, A., McCarthy, H., Roberts, S., & Pleshko, N. (2013). Fourier transform infrared imaging and infrared fiber optic probe spectroscopy identify collagen type in connective tissues. PloS one, 8(5), Article e64822. https://doi.org/10.1371/journal.pone.0064822

Hyaline cartilage and mechanically inferior fibrocartilage consisting of mixed collagen types are frequently found together in repairing articular cartilage. The present study seeks to develop methodology to identify collagen type and other tissue co... Read More about Fourier transform infrared imaging and infrared fiber optic probe spectroscopy identify collagen type in connective tissues.