Outputs (7)

Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation (2014)
Journal Article
Robinson, E., Leung, E., Matuszek, A. M., Krogsgaard-Larsen, N., Furkert, D. P., Brimble, M. A., …Reynisson, J. (in press). Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation. MedChemComm, 6(1), 239-246. https://doi.org/10.1039/c4md00420e

Two hit compounds (14 and 62) were identified using virtual high throughput screening (vHTS) inhibiting the autophagy process in A2780 ovarian cancer cells. The expression levels of the LC3-II and p62 autophagy marker proteins were monitored using We... Read More about Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation.

Anticancer Ruthenium(η6-p-cymene) Complexes of Nonsteroidal Anti-inflammatory Drug Derivatives (2014)
Journal Article
Aman, F., Hanif, M., Siddiqui, W. A., Ashraf, A., Filak, L. K., Reynisson, J., …Hartinger, C. G. (2014). Anticancer Ruthenium(η6-p-cymene) Complexes of Nonsteroidal Anti-inflammatory Drug Derivatives. Organometallics, 33(19), 5546-5553. https://doi.org/10.1021/om500825h

Oxicams are a versatile family of heterocyclic compounds, and the two representatives meloxicam and piroxicam are widely used drugs for the treatment of a variety of inflammatory and rheumatic diseases in humans. As cancer-associated inflammation is... Read More about Anticancer Ruthenium(η6-p-cymene) Complexes of Nonsteroidal Anti-inflammatory Drug Derivatives.

Fragmentation of the quinoxaline N-oxide bond to the ˙OH radical upon one-electron bioreduction (2014)
Journal Article
Yadav, P., Marshall, A. J., Reynisson, J., Denny, W. A., Hay, M. P., & Anderson, R. F. (in press). Fragmentation of the quinoxaline N-oxide bond to the ˙OH radical upon one-electron bioreduction. Chemical Communications, 50(89), 13729-13731. https://doi.org/10.1039/c4cc05657d

The ˙OH radical is released from 3-trifluoromethyl-quinoxaline 1,4-dioxides upon one-electron reduction by cytochrome P450 oxidoreductase. This process effectively competes with back oxidation of the intermediate radical anion by oxygen and underlies... Read More about Fragmentation of the quinoxaline N-oxide bond to the ˙OH radical upon one-electron bioreduction.

Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives (2014)
Journal Article
Hung, J. M., Arabshahi, H. J., Leung, E., Reynisson, J., & Barker, D. (2014). Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives. European Journal of Medicinal Chemistry, 86, 420-437. https://doi.org/10.1016/j.ejmech.2014.09.001

Forty seven thieno[2,3-b]pyridines-2-carboxamides, furo[2,3-b]pyridines-2-carboxamides and tetrahydrothieno[2,3-b]quinolones-2-carboxamides derivatives were synthesized and tested for their antiproliferative activity against the NCI-60 cell lines. Th... Read More about Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives.

The effect of a phospholipase C gamma inhibitor on the proliferation and phenotype of Du145 prostate cancer cells (2014)
Presentation / Conference
Muzinic, N. R., Mastelic, A., Markotic, A., Culic, V. C., Ross, A., Vuica-Ross, M., …Reynisson, J. (2014, August). The effect of a phospholipase C gamma inhibitor on the proliferation and phenotype of Du145 prostate cancer cells. Poster presented at FEBS EMBO 2014 Conference, Paris, France

Introduction: Prostate cancer remains the second most common cause of cancer related death among men, highlighting the need for new therapies. Many cancer cellular functions have been dis-covered to be regulated by phospholipase C (PLC) gamma activat... Read More about The effect of a phospholipase C gamma inhibitor on the proliferation and phenotype of Du145 prostate cancer cells.

Sorption and biodegradation of organic micropollutants during river bank filtration: A laboratory column study (2014)
Journal Article
Bertelkamp, C., Reungoat, J., Cornelissen, E., Singhal, N., Reynisson, J., Cabo, A., …Verliefde, A. (2014). Sorption and biodegradation of organic micropollutants during river bank filtration: A laboratory column study. Water Research, 52, 231-241. https://doi.org/10.1016/j.watres.2013.10.068

This study investigated sorption and biodegradation behaviour of 14 organic micropollutants (OMP) in soil columns representative of the first metre (oxic conditions) of the river bank filtration (RBF) process. Breakthrough curves were modelled to dif... Read More about Sorption and biodegradation of organic micropollutants during river bank filtration: A laboratory column study.

Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000 (2014)
Journal Article
Anderson, R. F., Yadav, P., Patel, D., Reynisson, J., Tipparaju, S. R., Guise, C. P., …Hay, M. P. (in press). Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000. Organic and Biomolecular Chemistry, 12(21), 3386-3392. https://doi.org/10.1039/c4ob00236a

The radical species underlying the activity of the bioreductive anticancer prodrug, SN30000, have been identified by electron paramagnetic resonance and pulse radiolysis techniques. Spin-trapping experiments indicate both an aryl-type radical and an... Read More about Characterisation of radicals formed by the triazine 1,4-dioxide hypoxia-activated prodrug, SN30000.