Skip to main content

Research Repository

Advanced Search

Outputs (85)

Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability (2015)
Journal Article
Walter, M., Kohli, N., Major, T., Fuller, H., Wright, K., Kuiper, J., & Johnson, W. (2015). Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability. Journal of Stem Cells and Regenerative Medicine, 11(1), 18-24. https://doi.org/10.46582/jsrm.1101004

Mesenchymal stem cells (MSCs) stimulate angiogenesis within a wound environment and this effect is mediated through paracrine interactions with the endothelial cells present. Here we report that human MSC-conditioned medium (n=3 donors) significantly... Read More about Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability.

ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion (2015)
Journal Article
Roberts, S., Evans, H., Wright, K., van Niekerk, L., Caterson, B., Richardson, J., …Kuiper, J. (2015). ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion. Osteoarthritis and Cartilage, 23(9), 1622-1626. https://doi.org/10.1016/j.joca.2015.05.006

Objective To evaluate the potential of ADAMTS-4 (aggrecanase -1) activity in synovial fluid (SF) as a biomarker of knee injury and joint disease. Design We have measured ADAMTS-4 activity in the synovial fluid of 170 orthopaedic patients with di... Read More about ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion.

High content and high throughput screening to assess the angiogenic and neurogenic actions of mesenchymal stem cells in vitro. (2015)
Journal Article
Wright, K. (2015). High content and high throughput screening to assess the angiogenic and neurogenic actions of mesenchymal stem cells in vitro. Experimental Cell Research, 93 - 104. https://doi.org/10.1016/j.yexcr.2014.12.019

Mesenchymal stem cells are universally regarded across many fields of medicine, as one of the most promising cell types for use in cell-based therapies. Although not yet fully understood, the therapeutic effects of these cells are largely attributed... Read More about High content and high throughput screening to assess the angiogenic and neurogenic actions of mesenchymal stem cells in vitro..

Cells isolated from fat pad and synovial fluid. are they suitable for cartilage repair? (2014)
Journal Article
Garica, J., Mennan, C., Richardson, J., Wright, K., & Roberts, S. (2014). Cells isolated from fat pad and synovial fluid. are they suitable for cartilage repair?. Osteoarthritis and Cartilage, 22, S445. https://doi.org/10.1016/j.joca.2014.02.843

Purpose: Autologous Chondrocyte Implantation (ACI) is used as a cellular therapy for treating defects in articular cartilage. Successful ACI depends on high cell number and quality of the cells which varies between patients. Alternative cell sources... Read More about Cells isolated from fat pad and synovial fluid. are they suitable for cartilage repair?.

Spinal motor neurite outgrowth over glial scar inhibitors is enhanced by coculture with bone marrow stromal cells. (2014)
Journal Article
Wright, K., & Roberts, S. (2014). Spinal motor neurite outgrowth over glial scar inhibitors is enhanced by coculture with bone marrow stromal cells. Spine Journal, 1722 - 1733. https://doi.org/10.1016/j.spinee.2014.01.021

BACKGROUND CONTEXT: Transplantation of bone marrow cells into spinal cord lesions promotes functional recovery in animal models, and recent clinical trials suggest possible recovery also in humans. The mechanisms responsible for these improvements ar... Read More about Spinal motor neurite outgrowth over glial scar inhibitors is enhanced by coculture with bone marrow stromal cells..

A computational approach to quantifying axon regeneration in the presence of mesenchymal stem cells (MSCs) (2013)
Conference Proceeding
Lam, K. P., Dempsy, K. P., Smith, W. A., Wright, K. T., Masri, W. E., & Richardson, J. B. (2013). A computational approach to quantifying axon regeneration in the presence of mesenchymal stem cells (MSCs). . https://doi.org/10.1109/ner.2013.6696240

Transplantation of bone marrow stromal cells has shown to encourage functional recovery in animal models of spinal cord injury (SCI) and recent clinical trials suggest possible recovery also in humans. However, two fundamental barriers to the develop... Read More about A computational approach to quantifying axon regeneration in the presence of mesenchymal stem cells (MSCs).

Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases (2013)
Journal Article
Wright, K. T., Mennan, C., Fox, H., Richardson, J. B., Banerjee, R., & Roberts, S. (2013). Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases. Regenerative Medicine, 8(6), 699 - 709. https://doi.org/10.2217/rme.13.67

AIM: Autologous chondrocyte implantation (ACI) is used worldwide for the treatment of cartilage defects. This study has aimed to assess for the first time the cells that are contained within human ACI repair tissues several years post-treatment. We h... Read More about Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases.

Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord. (2013)
Journal Article
Mennan, C., Wright, K., Bhattacharjee, A., Balain, B., Richardson, J., & Roberts, S. (2013). Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord. BioMed Research International, 2013, Article 916136. https://doi.org/10.1155/2013/916136

Umbilical cords as a source of stem cells are of increasing interest for cell therapies as they present little ethical consideration and are reported to contain immune privileged cells which may be suitable for allogeneic based therapies. Mesenchymal... Read More about Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord..