Outputs (16)

Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming (2023)
Journal Article
Hyland, M., Mennan, C., Davies, R., Wilson, E., Tonge, D. P., Clayton, A., & Kehoe, O. (2023). Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming. Stem Cell Reviews and Reports, 19, 2391–2406. https://doi.org/10.1007/s12015-023-10586-2

Autoimmune conditions, such as rheumatoid arthritis, are characterised by a loss of immune tolerance, whereby the immune cells attack self-antigens causing pain and inflammation. These conditions can be brought into remission using pharmaceutical tre... Read More about Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming.

Extracellular Vesicle Depletion Protocols of Foetal Bovine Serum Influence Umbilical Cord Mesenchymal Stromal Cell Phenotype, Immunomodulation, and Particle Release (2023)
Journal Article
Davies, R., Allen, S., Mennan, C., Platt, M., Wright, K., & Kehoe, O. (2023). Extracellular Vesicle Depletion Protocols of Foetal Bovine Serum Influence Umbilical Cord Mesenchymal Stromal Cell Phenotype, Immunomodulation, and Particle Release. International Journal of Molecular Sciences, 24(11), 9242. https://doi.org/10.3390/ijms24119242

The immunomodulatory properties of MSCs can be recreated using their extracellular vesicles (EVs). Yet, the true capabilities of the MSC EVs cannot be distinguished from contaminating bovine EVs and protein derived from supplemental foetal bovine ser... Read More about Extracellular Vesicle Depletion Protocols of Foetal Bovine Serum Influence Umbilical Cord Mesenchymal Stromal Cell Phenotype, Immunomodulation, and Particle Release.

Syndecan-3 regulates MSC adhesion, ERK and AKT signalling in vitro and its deletion enhances MSC efficacy in a model of inflammatory arthritis in vivo (2020)
Journal Article
Jones, F. K., Stefan, A., Kay, A. G., Hyland, M., Morgan, R., Forsyth, N. R., …Kehoe, O. (2020). Syndecan-3 regulates MSC adhesion, ERK and AKT signalling in vitro and its deletion enhances MSC efficacy in a model of inflammatory arthritis in vivo. Scientific reports, https://doi.org/10.1038/s41598-020-77514-z

Rheumatoid arthritis (RA) is a debilitating and painful inflammatory autoimmune disease characterised by the accumulation of leukocytes in the synovium, cartilage destruction and bone erosion. The immunomodulatory effects of bone marrow derived mesen... Read More about Syndecan-3 regulates MSC adhesion, ERK and AKT signalling in vitro and its deletion enhances MSC efficacy in a model of inflammatory arthritis in vivo.

Pro-Inflammatory Priming of Umbilical Cord Mesenchymal Stromal Cells Alters the Protein Cargo of Their Extracellular Vesicles (2020)
Journal Article
Kehoe, O., Hyland, M., Mennan, C., Wilson, E., & Clayton, A. (2020). Pro-Inflammatory Priming of Umbilical Cord Mesenchymal Stromal Cells Alters the Protein Cargo of Their Extracellular Vesicles. Cells, https://doi.org/10.3390/cells9030726

Umbilical cord mesenchymal stromal cells (UCMSCs) have shown an ability to modulate the immune system through the secretion of paracrine mediators, such as extracellular vesicles (EVs). However, the culture conditions that UCMSCs are grown in can alt... Read More about Pro-Inflammatory Priming of Umbilical Cord Mesenchymal Stromal Cells Alters the Protein Cargo of Their Extracellular Vesicles.

Soluble syndecan-3 binds chemokines, reduces leukocyte migration in vitro and ameliorates disease severity in models of rheumatoid arthritis (2019)
Journal Article
Eustace, A., McNaughton, E., King, S., Kehoe, O., Kungl, A., Mattey, D., …Middleton, J. (2019). Soluble syndecan-3 binds chemokines, reduces leukocyte migration in vitro and ameliorates disease severity in models of rheumatoid arthritis. Arthritis Research and Therapy, 21, Article 172. https://doi.org/10.1186/s13075-019-1939-2

Background Syndecans are heparan sulfate proteoglycans that occur in membrane-bound or soluble forms. Syndecan-3, the least well-characterised of the syndecan family, is highly expressed on synovial endothelial cells in rheumatoid arthritis patients... Read More about Soluble syndecan-3 binds chemokines, reduces leukocyte migration in vitro and ameliorates disease severity in models of rheumatoid arthritis.

Novel Anti-Inflammatory Peptides Based on Chemokine-Glycosaminoglycan Interactions Reduce Leukocyte Migration and Disease Severity in a Model of Rheumatoid Arthritis (2018)
Journal Article
Eustace, A., King, S., Sessions, R., Kay, A., Farris, M., Broadbridge, R., …McNaughton, E. (2018). Novel Anti-Inflammatory Peptides Based on Chemokine-Glycosaminoglycan Interactions Reduce Leukocyte Migration and Disease Severity in a Model of Rheumatoid Arthritis. The Journal of Immunology, 3201-3217. https://doi.org/10.4049/jimmunol.1701187

Inflammation is characterized by the infiltration of leukocytes from the circulation and into the inflamed area. Leukocytes are guided throughout this process by chemokines. These are basic proteins that interact with leukocytes to initiate their act... Read More about Novel Anti-Inflammatory Peptides Based on Chemokine-Glycosaminoglycan Interactions Reduce Leukocyte Migration and Disease Severity in a Model of Rheumatoid Arthritis.

Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Osteoarthritis. (2017)
Journal Article
Chapman, V., Markides, H., Sagar, D., Xu, L., Kay, A., Burston, J., …El Haj, A. (2017). Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Osteoarthritis. Stem Cells International, 2905104 - ?. https://doi.org/10.1155/2017/2905104

Background: Mesenchymal stem cells (MSCs) have a therapeutic potential for the treatment of osteoarthritic (OA) joint pathology and pain. The aims of this study were to determine the influence of a passage number on the effects of MSCs on pain behavi... Read More about Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Osteoarthritis..

Mesenchymal Stem Cell- Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis (2017)
Journal Article
Kay, A., Long, G., Broadfoot, S., Piccinini, A., Middleton, J., Kehoe, O., …Stefan, A. (2017). Mesenchymal Stem Cell- Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis. Scientific reports, https://doi.org/10.1038/s41598-017-18144-w

We evaluated the therapeutic potential of mesenchymal stem cell-conditioned medium (CM-MSC) as an alternative to cell therapy in an antigen-induced model of arthritis (AIA). Disease severity and cartilage loss were evaluated by histopathological anal... Read More about Mesenchymal Stem Cell- Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis.

An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium. (2017)
Journal Article
Rump, L., Mattey, D. L., Kehoe, O., & Middleton, J. (2017). An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium. Cytokine, 133 - 140. https://doi.org/10.1016/j.cyto.2017.05.023

Rheumatoid arthritis (RA) is a destructive and chronic autoimmune inflammatory disease. Synovial inflammation is a major feature of RA and is associated with leukocyte recruitment. Leukocytes cross the endothelial cells (ECs) into the synovial tissue... Read More about An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium..

An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium (2017)
Journal Article
Rump, L., Mattey, D. L., Kehoe, O., & Middleton, J. (2017). An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium. Cytokine, 97, 133-140. https://doi.org/10.1016/j.cyto.2017.05.023

Rheumatoid arthritis (RA) is a destructive and chronic autoimmune inflammatory disease. Synovial inflammation is a major feature of RA and is associated with leukocyte recruitment. Leukocytes cross the endothelial cells (ECs) into the synovial tissue... Read More about An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium.