Outputs (4)

Codelivery of anti-cancer agents via double-walled polymeric microparticles/injectable hydrogel: A promising approach for treatment of triple negative breast cancer (2017)
Journal Article
Davoodi, P., Ng, W. C., Srinivasan, M. P., & Wang, C. (2017). Codelivery of anti-cancer agents via double-walled polymeric microparticles/injectable hydrogel: A promising approach for treatment of triple negative breast cancer. Biotechnology and Bioengineering, 114(12), 2931-2946. https://doi.org/10.1002/bit.26406

Triple negative breast cancer (TNBC) is an aggressive sub-type of breast cancer that rarely responds to conventional chemotherapy. Therefore, novel agents or new routes need to be developed to improve treatment efficacy and diminish severe side-effec... Read More about Codelivery of anti-cancer agents via double-walled polymeric microparticles/injectable hydrogel: A promising approach for treatment of triple negative breast cancer.

Coaxial double-walled microspheres for combined release of cytochrome c and doxorubicin (2017)
Journal Article
Feng, F., Neoh, K. Y., Davoodi, P., & Wang, C. (2017). Coaxial double-walled microspheres for combined release of cytochrome c and doxorubicin. Journal of Controlled Release, 259, e30-e31. https://doi.org/10.1016/j.jconrel.2017.03.088

Co-axial electrohydrodynamic atomization (CEHDA) can be adapted to fabricate core/shell microspheres with narrow size distribution in a single step for controlled and sustained release of therapeutic drugs [1]. Our previous studies evaluated the adva... Read More about Coaxial double-walled microspheres for combined release of cytochrome c and doxorubicin.

Effective co-delivery of nutlin-3a and p53 genes via core–shell microparticles for disruption of MDM2–p53 interaction and reactivation of p53 in hepatocellular carcinoma (2017)
Journal Article
Davoodi, P., Srinivasan, M. P., & Wang, C. (in press). Effective co-delivery of nutlin-3a and p53 genes via core–shell microparticles for disruption of MDM2–p53 interaction and reactivation of p53 in hepatocellular carcinoma. Journal of Materials Chemistry B, 5(29), 5816-5834. https://doi.org/10.1039/c7tb00481h

The tumor suppressor protein p53 is the most frequently inactivated, mutated, or deleted transcriptional factor in tumor cells. Recent studies have shown that the negative regulation of p53 by the murine double minute 2 (MDM2) protein in human cells... Read More about Effective co-delivery of nutlin-3a and p53 genes via core–shell microparticles for disruption of MDM2–p53 interaction and reactivation of p53 in hepatocellular carcinoma.

Enhanced intracellular delivery and controlled drug release of magnetic PLGA nanoparticles modified with transferrin (2017)
Journal Article
Cui, Y., Xu, Q., Davoodi, P., Wang, D., & Wang, C. (2017). Enhanced intracellular delivery and controlled drug release of magnetic PLGA nanoparticles modified with transferrin. Acta pharmacologica Sinica, 38(6), 943-953. https://doi.org/10.1038/aps.2017.45

Owing to the presence of multidrug resistance in tumor cells, conventional chemotherapy remains clinically intractable. To enhance the therapeutic efficacy of chemotherapeutic agents, targeting strategies based on magnetic polymeric nanoparticles mod... Read More about Enhanced intracellular delivery and controlled drug release of magnetic PLGA nanoparticles modified with transferrin.