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Correlative Spectromicroscopy and Tomography for Biomedical Applications involving Electron, Ion, and Soft X-ray Microscopies (2019)
Journal Article
Hitchcock, A. P., Wang, X., Grandfield, K., Everett, J., Collingwood, J. F., & Telling, N. D. (2019). Correlative Spectromicroscopy and Tomography for Biomedical Applications involving Electron, Ion, and Soft X-ray Microscopies. Microscopy Today, 27(2), https://doi.org/10.1017/S1551929518001256

Many important scientific and technical problems are best addressed using multiple, microscopy-based analytical techniques that combine the strengths of complementary methods. Here, we provide two examples from biomedical challenges: unravelling the... Read More about Correlative Spectromicroscopy and Tomography for Biomedical Applications involving Electron, Ion, and Soft X-ray Microscopies.

Regenerative Medicine: A Review of the Evolution of Autologous Chondrocyte Implantation (ACI) Therapy. (2019)
Journal Article
(2019). Regenerative Medicine: A Review of the Evolution of Autologous Chondrocyte Implantation (ACI) Therapy. Bioengineering, https://doi.org/10.3390/bioengineering6010022

Articular cartilage is composed of chondrons within a territorial matrix surrounded by a highly organized extracellular matrix comprising collagen II fibrils, proteoglycans, glycosaminoglycans, and non-collagenous proteins. Damaged articular cartilag... Read More about Regenerative Medicine: A Review of the Evolution of Autologous Chondrocyte Implantation (ACI) Therapy..

True 99th centile of high sensitivity cardiac troponin for hospital patients: prospective, observational cohort study? (2019)
Journal Article
Mamas. (2019). True 99th centile of high sensitivity cardiac troponin for hospital patients: prospective, observational cohort study?. BMJ, https://doi.org/10.1136/bmj.l729

OBJECTIVE To determine the distribution, and specifically the true 99th centile, of high sensitivity cardiac troponin I (hs-cTnI) for a whole hospital population by applying the hs-cTnI assay currently used routinely at a large teaching hospital.... Read More about True 99th centile of high sensitivity cardiac troponin for hospital patients: prospective, observational cohort study?.

Point-of-care measurements reveal release of purines into venous blood of stroke patients (2019)
Journal Article
Roffe. (2019). Point-of-care measurements reveal release of purines into venous blood of stroke patients. Purinergic Signalling, 237-246. https://doi.org/10.1007/s11302-019-09647-4

Stroke is a leading cause of death and disability. Here, we examine whether point-of-care measurement of the purines, adenosine, inosine and hypoxanthine, which are downstream metabolites of ATP, has potential to assist the diagnosis of stroke. In a... Read More about Point-of-care measurements reveal release of purines into venous blood of stroke patients.

Comparative Transcriptome and Methylome Analysis in Human Skeletal Muscle Anabolism, Hypertrophy and Epigenetic Memory (2019)
Journal Article
(2019). Comparative Transcriptome and Methylome Analysis in Human Skeletal Muscle Anabolism, Hypertrophy and Epigenetic Memory. Scientific reports, https://doi.org/10.1038/s41598-019-40787-0

Transcriptome wide changes in human skeletal muscle after acute (anabolic) and chronic resistance exercise (RE) induced hypertrophy have been extensively determined in the literature. We have also recently undertaken DNA methylome analysis (850,000?+... Read More about Comparative Transcriptome and Methylome Analysis in Human Skeletal Muscle Anabolism, Hypertrophy and Epigenetic Memory.

A systematic review of the outcome data supporting the Healthy Living Pharmacy concept and lessons from its implementation. (2019)
Journal Article
Jamal Nazar, Z., Nazar, H., White, S., & Rutter, P. (2019). A systematic review of the outcome data supporting the Healthy Living Pharmacy concept and lessons from its implementation. PloS one, 14(3), Article e0213607. https://doi.org/10.1371/journal.pone.0213607

BACKGROUND: The Healthy Living Pharmacy (HLP) project, launched in England, UK in 2009 was a novel approach of introducing public health services within community pharmacy to tackle local health inequalities. A national roll-out followed a reported... Read More about A systematic review of the outcome data supporting the Healthy Living Pharmacy concept and lessons from its implementation..

“Dynamic knee valgus” – are we measuring what we think we’re measuring? An evaluation of static and functional knee calibration methods for application in gait and clinical screening tests of the overhead squat and hurdle step. (2019)
Journal Article
Philp, F., Leboeuf, F., Pandyan, A., & Stewart, C. (2019). “Dynamic knee valgus” – are we measuring what we think we’re measuring? An evaluation of static and functional knee calibration methods for application in gait and clinical screening tests of the overhead squat and hurdle step. Gait and Posture, 70, 298-304. https://doi.org/10.1016/j.gaitpost.2019.03.006

Background Dynamic “knee valgus” has been identified as a risk factor for significant knee injuries, however, the limits and sources of error associated with existing 3D motion analysis methods have not been well established. Research question W... Read More about “Dynamic knee valgus” – are we measuring what we think we’re measuring? An evaluation of static and functional knee calibration methods for application in gait and clinical screening tests of the overhead squat and hurdle step..

Remote manipulation of magnetic nanoparticles using magnetic field gradient to promote cancer cell death (2019)
Journal Article
Lim, J., Dobson, J., Subramanian, M., Miaskowski, A., & Jenkins, S. (2019). Remote manipulation of magnetic nanoparticles using magnetic field gradient to promote cancer cell death. Applied Physics A, https://doi.org/10.1007/s00339-019-2510-3

The manipulation of magnetic nanoparticles (MNPs) using an external magnetic field, has been successfully demonstrated in various biomedical applications. Some have utilised this non-invasive external stimulus and there is an potential to build on th... Read More about Remote manipulation of magnetic nanoparticles using magnetic field gradient to promote cancer cell death.

Low failure rate at short term for 40?mm heads and second generation triple annealed HCLPE liners in hybrid Hip Replacements (2019)
Journal Article
Kuiper. (2019). Low failure rate at short term for 40?mm heads and second generation triple annealed HCLPE liners in hybrid Hip Replacements. Journal of Clinical Orthopaedics and Trauma, 350-357. https://doi.org/10.1016/j.jcot.2017.12.008

Introduction 40?mm large diameter heads offer the advantages of lesser dislocation rates and better stability while highly cross linked polyethylene have lower wear rates than ultra high molecular weight polyethylene. Studies of the survivorship of... Read More about Low failure rate at short term for 40?mm heads and second generation triple annealed HCLPE liners in hybrid Hip Replacements.