Outputs (108)

Incidence of psychoses among drug dependent patients in primary care with no psychiatric history: a retrospective observational matched-cohort study (2013)
Journal Article
Frisher, M., Martino, O. I., Bashford, J., Crome, I., & Croft, P. (in press). Incidence of psychoses among drug dependent patients in primary care with no psychiatric history: a retrospective observational matched-cohort study. The European Journal of Psychiatry, 27(4), 240-247. https://doi.org/10.4321/s0213-61632013000400002

Background and Objectives: While several studies have indicated a link between illicit drug use and the development of psychosis, the confounding role of pre-existing psychiatric illness is unclear. This study controls for this factor to a greater ex... Read More about Incidence of psychoses among drug dependent patients in primary care with no psychiatric history: a retrospective observational matched-cohort study.

aV ß5 and CD44 are oxygen-regulated human embryonic stem cell attachment factors (2013)
Journal Article
(2013). aV ß5 and CD44 are oxygen-regulated human embryonic stem cell attachment factors. BioMed Research International, 729281 - ?. https://doi.org/10.1155/2013/729281

Human embryonic stem cells (hESCs) have great potential for clinical therapeutic use. However, relatively little is known of the mechanisms which dictate their specificity of adhesion to substrates through adhesion proteins including integrins. Previ... Read More about aV ß5 and CD44 are oxygen-regulated human embryonic stem cell attachment factors.

A novel semi-supervised methodology for extracting tumor type-specific MRS sources in human brain data (2013)
Journal Article
(2013). A novel semi-supervised methodology for extracting tumor type-specific MRS sources in human brain data. PloS one, e83773 - e83773. https://doi.org/10.1371/journal.pone.0083773

Background: The clinical investigation of human brain tumors often starts with a non-invasive imaging study, providing information about the tumor extent and location, but little insight into the biochemistry of the analyzed tissue. Magnetic Resonanc... Read More about A novel semi-supervised methodology for extracting tumor type-specific MRS sources in human brain data.

Nicotinamide promotes neuronal differentiation of mouse embryonic stem cells in vitro (2013)
Journal Article
(2013). Nicotinamide promotes neuronal differentiation of mouse embryonic stem cells in vitro. NeuroReport, 1041 -1046. https://doi.org/10.1097/WNR.0000000000000071

Factors controlling proliferation and differentiation are crucial in advancement of neural cell-based experimental neurodegenerative therapies. In this regard, nicotinamide has been shown to determine the fate of neural cells, enhance neuralization,... Read More about Nicotinamide promotes neuronal differentiation of mouse embryonic stem cells in vitro.

Biosynthesis of Zinc Substituted Magnetite Nanoparticles with Enhanced Magnetic Properties (2013)
Journal Article
Byrne, T. M., Coker, V. S., Cespedes, E., Wincott, P. L., Vaughan, D. J., Pattrick, R. A. D., …Telling, N. D. (2014). Biosynthesis of Zinc Substituted Magnetite Nanoparticles with Enhanced Magnetic Properties. Advanced functional materials, 24(17), 2518-2529. https://doi.org/10.1002/adfm.201303230

The magnetic moments of magnetite nanoparticles are dramatically enhanced through the addition of zinc in a microbiologically driven synthesis procedure. The particles are produced through the reduction of Fe(III)-compounds containing Zn(II) by the i... Read More about Biosynthesis of Zinc Substituted Magnetite Nanoparticles with Enhanced Magnetic Properties.

On evaluation of a multiscale-based CT image analysis and visualisation algorithm (2013)
Conference Proceeding
Lam, K., Collins, D., Sule-Suso, J., Bhana, R., & Moloney, A. (2013). On evaluation of a multiscale-based CT image analysis and visualisation algorithm. . https://doi.org/10.1109/BMEI.2013.6746924

Development of computed tomography (CT) protocols that minimise radiation dose for specific clinical treatments continues to be a major research focus. Building on the success of an earlier collaborative case study concerning prostate cancer diagnosi... Read More about On evaluation of a multiscale-based CT image analysis and visualisation algorithm.

The development of thieno[2,3-b]pyridine analogues as anticancer agents applying in silico methods (2013)
Journal Article
Arabshahi, H. J., Leung, E., Barker, D., & Reynisson, J. (2014). The development of thieno[2,3-b]pyridine analogues as anticancer agents applying in silico methods. MedChemComm, 5(2), 186. https://doi.org/10.1039/c3md00320e

The chemical space surrounding a class of thieno[2,3-b]pyridines was investigated by testing their commercially available derivatives against the NCI60 panel of human tumour cell lines. The results from the nineteen analogues revealed that ortho- and... Read More about The development of thieno[2,3-b]pyridine analogues as anticancer agents applying in silico methods.

CuI-catalyzed cycloisomerization of propargyl amides (2013)
Journal Article
Moran, W., & Alhalib, A. (2014). CuI-catalyzed cycloisomerization of propargyl amides. Organic and Biomolecular Chemistry, 12(5), 795-800. https://doi.org/10.1039/c3ob42030b

The synthesis of substituted dihydrooxazoles by the CuI-catalyzed cycloisomerization of terminal propargyl amides is reported. The reaction has been shown to have good substrate scope and experiments to delineate the mechanism have been performed. Su... Read More about CuI-catalyzed cycloisomerization of propargyl amides.

Effects of a specific MCHR1 antagonist (GW803430) on energy budget and glucose metabolism in diet‐induced obese mice (2013)
Journal Article
Zhang, L., Sinclair, R., Selman, C., Mitchell, S., Morgan, D., Clapham, J. C., & Speakman, J. R. (2014). Effects of a specific MCHR1 antagonist (GW803430) on energy budget and glucose metabolism in diet‐induced obese mice. Obesity, 22(3), 681-690. https://doi.org/10.1002/oby.20418

Objective
The melanin-concentrating hormone (MCH) is a centrally acting peptide implicated in the regulation of energy homeostasis and body weight, although its role in glucose homeostasis is uncertain. Our objective was to determine effects of MCHR... Read More about Effects of a specific MCHR1 antagonist (GW803430) on energy budget and glucose metabolism in diet‐induced obese mice.

Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival (2013)
Journal Article
Davies, S. (2013). Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival. Journal of the American Society of Nephrology, 2071 - 2080. https://doi.org/10.1681/ASN.2013030314

Systemic inflammation, as evidenced by elevated inflammatory cytokines, is a feature of advanced renal failure and predicts worse survival. Dialysate IL-6 concentrations associate with variability in peritoneal small solute transport rate (PSTR), whi... Read More about Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival.