Outputs (114)

MicroRNAs in Cancer (2014)
Journal Article
Di Leva, G., Garofalo, M., & Croce, C. M. (2014). MicroRNAs in Cancer. Annual Review of Pathology: Mechanisms of Disease, 9(1), 287-314. https://doi.org/10.1146/annurev-pathol-012513-104715

MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such as inflammation, cell-cycle regulation, stress response, differentiation... Read More about MicroRNAs in Cancer.

New strategies for the treatment of ovarian cancer (2014)
Journal Article
Robinson, E., Fisher, N., Stamelos, V., Redman, C., & Richardson, A. (2014). New strategies for the treatment of ovarian cancer. Biochemical Society Transactions, 42(1), 125-129. https://doi.org/10.1042/bst20130203

Ovarian cancer usually responds well to chemotherapy, but once the disease becomes resistant to chemotherapy, the treatment options available are inadequate. A number of strategies are currently undergoing clinical evaluation, among which angiogenesi... Read More about New strategies for the treatment of ovarian cancer.

Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain (2014)
Journal Article
Jozwiak, A., Liu, Y., Yang, Y., & Gates, M. (2014). Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain. BioMed Research International, 651236 -?. https://doi.org/10.1155/2014/651236

Implanting pieces of tissue or scaffolding material into the mammalian central nervous system (CNS) is wrought with difficulties surrounding the size of tools needed to conduct such implants and the ability to maintain the orientation and integrity o... Read More about Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain.

Development and face validation of an instrument to assess and improve clinical consultation skills (2014)
Journal Article
Lefroy. (2014). Development and face validation of an instrument to assess and improve clinical consultation skills. Advances in health sciences education : theory and practice, 661-685. https://doi.org/10.1007/s10459-014-9493-9

While formative workplace based assessment can improve learners’ skills, it often does not because the procedures used do not facilitate feedback which is sufficiently specific to scaffold improvement. Provision of pre-formulated strategies to addres... Read More about Development and face validation of an instrument to assess and improve clinical consultation skills.

Crystallization kinetics and soft magnetic properties in metalloid-free (Fe, Co)90Zr10 amorphous and nanocrystalline alloys (2014)
Journal Article
Blázquez, J., Ipus, J., Conde, C., Cabrera, D., Franco, V., & Conde, A. (2014). Crystallization kinetics and soft magnetic properties in metalloid-free (Fe, Co)90Zr10 amorphous and nanocrystalline alloys. Journal of Alloys and Compounds, 615, S213-S216. https://doi.org/10.1016/j.jallcom.2014.01.095

Microstructure and magnetic properties of metalloid-free (Fe100−xCox)90Zr10 amorphous and nanocrystalline alloys were characterized. Devitrification of these amorphous alloys occurs in two overlapped transformations leading to the formation of α-Fe(C... Read More about Crystallization kinetics and soft magnetic properties in metalloid-free (Fe, Co)90Zr10 amorphous and nanocrystalline alloys.

Spinal motor neurite outgrowth over glial scar inhibitors is enhanced by coculture with bone marrow stromal cells. (2014)
Journal Article
Wright, K., & Roberts, S. (2014). Spinal motor neurite outgrowth over glial scar inhibitors is enhanced by coculture with bone marrow stromal cells. Spine Journal, 1722 - 1733. https://doi.org/10.1016/j.spinee.2014.01.021

BACKGROUND CONTEXT: Transplantation of bone marrow cells into spinal cord lesions promotes functional recovery in animal models, and recent clinical trials suggest possible recovery also in humans. The mechanisms responsible for these improvements ar... Read More about Spinal motor neurite outgrowth over glial scar inhibitors is enhanced by coculture with bone marrow stromal cells..

Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53. (2014)
Journal Article
Akram, K. M., Lomas, N. J., Forsyth, N. R., & Spiteri, M. A. (2014). Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53. International Journal of Clinical and Experimental Pathology, 7(2), 552-564

Idiopathic pulmonary fibrosis (IPF) is a progressive, debilitating, and fatal lung disease of unknown aetiology with no current cure. The pathogenesis of IPF remains unclear but repeated alveolar epithelial cell (AEC) injuries and subsequent apoptosi... Read More about Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53..

Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy (2014)
Journal Article
Jenkins, S., Pickard, M., Khong, M., Smith, H., Mann, C., Emes, R., & Chari, D. (2014). Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy. ACS chemical neuroscience, 51 -63. https://doi.org/10.1021/cn400167n

Corticosteroid (CS) therapy is used widely in the treatment of a range of pathologies, but can delay production of myelin, the insulating sheath around central nervous system nerve fibers. The cellular targets of CS action are not fully understood, t... Read More about Identifying the cellular targets of drug action in the central nervous system following corticosteroid therapy.

Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development (2014)
Journal Article
Sudiman, J., Ritter, L. J., Feil, D. K., Wang, X., Chan, K., Mottershead, D. G., …Gilchrist, R. B. (2014). Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development. Journal of Assisted Reproduction and Genetics, 31(3), 295-306. https://doi.org/10.1007/s10815-013-0152-5

Purpose We hypothesised that varying native oocyte-secreted factor (OSF) exposure or using different recombinant OSF peptides would have differential effects on post-in vitro maturation (IVM) embryo and fetal development. Methods Mouse cumulus o... Read More about Effects of differing oocyte-secreted factors during mouse in vitro maturation on subsequent embryo and fetal development.

Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas (2014)
Journal Article
Jain, H., Richardson, A., Meyer-Hermann, M., & Byrne, H. (2014). Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas. PloS one, e81582 - ?. https://doi.org/10.1371/journal.pone.0081582

Platinum drug-resistance in ovarian cancers mediated by anti-apoptotic proteins such as Bcl-xL is a major factor contributing to the chemotherapeutic resistance of recurrent disease. Consequently, concurrent inhibition of Bcl-xL in combination with c... Read More about Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas.