Outputs (114)

Bacterially synthesized ferrite nanoparticles for magnetic hyperthermia applications (2014)
Journal Article
Céspedes, E., Byrne, J. M., Farrow, N., Moise, S., Coker, V. S., Bencsik, M., …Telling, N. D. (in press). Bacterially synthesized ferrite nanoparticles for magnetic hyperthermia applications. Nanoscale, 6(21), 12958-12970. https://doi.org/10.1039/c4nr03004d

Magnetic hyperthermia uses AC stimulation of magnetic nanoparticles to generate heat for cancer cell destruction. Whilst nanoparticles produced inside magnetotactic bacteria have shown amongst the highest reported heating to date, these particles are... Read More about Bacterially synthesized ferrite nanoparticles for magnetic hyperthermia applications.

Modulation of Magnetic Heating via Dipolar Magnetic Interactions in Monodisperse and Crystalline Iron Oxide Nanoparticles (2014)
Journal Article
Salas, G., Camarero, J., Cabrera, D., Takacs, H., Varela, M., Ludwig, R., …Teran, F. J. (2014). Modulation of Magnetic Heating via Dipolar Magnetic Interactions in Monodisperse and Crystalline Iron Oxide Nanoparticles. Journal of Physical Chemistry C, 118(34), 19985-19994. https://doi.org/10.1021/jp5041234

In the pursuit of controlling the heat exposure mediated by magnetic nanoparticles, we provide new guidelines for tailoring magnetic relaxation processes via dipolar interactions. For this purpose, highly crystalline and monodisperse magnetic iron ox... Read More about Modulation of Magnetic Heating via Dipolar Magnetic Interactions in Monodisperse and Crystalline Iron Oxide Nanoparticles.

Product ion distributions for the reactions of NO(+) with some physiologically significant volatile organosulfur and organoselenium compounds obtained using a selective reagent ionization time-of-flight mass spectrometer (2014)
Journal Article
(2014). Product ion distributions for the reactions of NO(+) with some physiologically significant volatile organosulfur and organoselenium compounds obtained using a selective reagent ionization time-of-flight mass spectrometer. Rapid communications in mass spectrometry RCM, 1683 - 1690. https://doi.org/10.1002/rcm.6947

RATIONALE: The reactions of NO(+) with volatile organic compounds (VOCs) in Selective Reagent Ionization Time-of-Flight Mass Spectrometry (SRI-TOF-MS) reactors are relatively poorly known, inhibiting their use for trace gas analysis. The rationale fo... Read More about Product ion distributions for the reactions of NO(+) with some physiologically significant volatile organosulfur and organoselenium compounds obtained using a selective reagent ionization time-of-flight mass spectrometer.

A multisystem investigation of raltegravir association with intestinal tissue: implications for pre-exposure prophylaxis and eradication (2014)
Journal Article
(2014). A multisystem investigation of raltegravir association with intestinal tissue: implications for pre-exposure prophylaxis and eradication. Journal of Antimicrobial Chemotherapy, 3275-3281. https://doi.org/10.1093/jac/dku312

Objectives
Recent clinical data have suggested high raltegravir concentrations in gut tissue after oral administration, with implications for treatment and prevention. We have used in silico, in vitro, ex vivo and in vivo models to further investiga... Read More about A multisystem investigation of raltegravir association with intestinal tissue: implications for pre-exposure prophylaxis and eradication.

Renal denervation and blood pressure reduction in resistant hypertension: a systematic review and meta-analysis (2014)
Journal Article
Mamas. (2014). Renal denervation and blood pressure reduction in resistant hypertension: a systematic review and meta-analysis. Open Heart, e000092 -?. https://doi.org/10.1136/openhrt-2014-000092

OBJECTIVE: The objective of this study is to evaluate the efficacy and safety of renal denervation in patients with resistant hypertension. METHODS: We searched MEDLINE and EMBASE for studies that evaluated the use of catheter-based renal sympathetic... Read More about Renal denervation and blood pressure reduction in resistant hypertension: a systematic review and meta-analysis.

Magnetic nanoparticles for oligodendrocyte precursor cell transplantation therapies: progress and challenges (2014)
Journal Article
Jenkins, S., Yiu, H., Rosseinsky, M., & Chari, D. (2014). Magnetic nanoparticles for oligodendrocyte precursor cell transplantation therapies: progress and challenges. Molecular and Cellular Therapies, https://doi.org/10.1186/2052-8426-2-23

Oligodendrocyte precursor cells (OPCs) have shown high promise as a transplant population to promote regeneration in the central nervous system, specifically, for the production of myelin - the protective sheath around nerve fibers. While clinical tr... Read More about Magnetic nanoparticles for oligodendrocyte precursor cell transplantation therapies: progress and challenges.

Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists (2014)
Journal Article
McCoull, W., Barton, P., Brown, A. J., Bowker, S. S., Cameron, J., Clarke, D. S., …Morgan, D. (2014). Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists. Journal of Medicinal Chemistry, 57(14), 6128 - 6140

Ghrelin plays a major physiological role in the control of food intake, and inverse agonists of the ghrelin receptor (GHS-R1a) are widely considered to offer utility as antiobesity agents by lowering the set-point for hunger between meals. We identif... Read More about Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists.

Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence (2014)
Journal Article
Mottershead. (2014). Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence. PloS one, https://doi.org/10.1371/journal.pone.0103563

Developmental competence of in vitro matured (IVM) oocytes needs to be improved and this can potentially be achieved by adding recombinant bone morphogenetic protein 15 (BMP15) or growth differentiation factor (GDF9) to IVM. The aim of this study was... Read More about Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence.

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice (2014)
Journal Article
Chen, R. L., Ogunshola, O. O., Yeoh, K. K., Jani, A., Papadakis, M., Nagel, S., …Buchan, A. M. (2014). HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice. Journal of Neurochemistry, 131(2), 177-189. https://doi.org/10.1111/jnc.12804

This study investigated the effects of 2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido) acetic acid (IOX3), a selective small molecule inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylases, on mouse brains subject to transient focal cerebra... Read More about HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.

Anti-ovarian cancer activities of alkaloids from Triclisia subcordata olive (Menispermecaea) (2014)
Conference Proceeding
Uche, F., Li, W., Richardson, A., & Greenhough, T. Anti-ovarian cancer activities of alkaloids from Triclisia subcordata olive (Menispermecaea). . https://doi.org/10.1055/s-0034-1382585

This study investigates the anticancer activities of Triclisia subcordata, identifies and elucidates the structure(s) of the bioactive anticancer compound. The evaluation of anticancer activity was done by in vitro sulforhodamine B dye method using A... Read More about Anti-ovarian cancer activities of alkaloids from Triclisia subcordata olive (Menispermecaea).