Outputs (158)

Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety (2015)
Journal Article
Zakharenko, A., Khomenko, T., Zhukova, S., Koval, O., Zakharova, O., Anarbaev, R., …Lavrik, O. (2015). Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety. Bioorganic and Medicinal Chemistry, 23(9), 2044-2052. https://doi.org/10.1016/j.bmc.2015.03.020

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a promising target for antitumor therapy based on Top1 poison-mediated DNA damage. Several novel benzopentathiepines were synthesized and tested as inhibitors of TDP1 using a new oligonucleotide-based fluores... Read More about Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety.

Pilot study on virtual imaging for patient information on radiotherapy planning and delivery (2015)
Journal Article
Sule-Suso, J., Finney, S., Bisson, J., Hammersley, S., Jassel, S., Knight, R., …Moloney, A. (2015). Pilot study on virtual imaging for patient information on radiotherapy planning and delivery. Radiography, 273-277. https://doi.org/10.1016/j.radi.2015.02.002

It is widely accepted that health professionals might sometimes underestimate cancer patients' needs for information on the complex process of radiotherapy (RT) planning and delivery. Furthermore, relatives might also feel excluded from the treatment... Read More about Pilot study on virtual imaging for patient information on radiotherapy planning and delivery.

Influence of the aggregation, concentration, and viscosity on the nanomagnetism of iron oxide nanoparticle colloids for magnetic hyperthermia (2015)
Journal Article
Cabrera, D., Camarero, J., Ortega, D., & Teran, F. J. (2015). Influence of the aggregation, concentration, and viscosity on the nanomagnetism of iron oxide nanoparticle colloids for magnetic hyperthermia. Journal of Nanoparticle Research, 17(3), https://doi.org/10.1007/s11051-015-2921-9

Iron oxide nanoparticles have become ubiquitous in many biomedical applications, acting as core elements in an increasing number of therapeutic and diagnostic modalities. These applications mainly rely on their static and dynamic magnetic properties,... Read More about Influence of the aggregation, concentration, and viscosity on the nanomagnetism of iron oxide nanoparticle colloids for magnetic hyperthermia.

Iodoarene-catalyzed cyclizations of unsaturated amides (2015)
Journal Article
Moran, W., Alhalib, A., & Kamouka, S. (2015). Iodoarene-catalyzed cyclizations of unsaturated amides. Organic Letters, https://doi.org/10.1021/acs.orglett.5b00333

The cyclization of N-alkenylamides catalyzed by iodoarenes under oxidative conditions is presented. Five-, six-, and seven-membered rings with a range of substitutions can be prepared by this route. Preliminary data from the use of chiral iodoarenes... Read More about Iodoarene-catalyzed cyclizations of unsaturated amides.

Application of new optical coherence elastography to monitor the mineralization processing in bone tissue engineering constructs (2015)
Journal Article
Guan, G., Song, S., Huang, Z., & Yang, Y. (2015). Application of new optical coherence elastography to monitor the mineralization processing in bone tissue engineering constructs. Proceedings of SPIE, https://doi.org/10.1117/12.2078013

Generation of functional tissue in vitro through tissue engineering technique is a promising direction to repair and replace malfunctioned organ and tissue in the modern medicine for various diseases which could not been treated well by conventional... Read More about Application of new optical coherence elastography to monitor the mineralization processing in bone tissue engineering constructs.

The application of machine learning to the modelling of percutaneous absorption: An overview and guide (2015)
Journal Article
Ashrafi, P., Moss, G., Wilkinson, S., Davey, N., & Sun, Y. (2015). The application of machine learning to the modelling of percutaneous absorption: An overview and guide. SAR and QSAR in Environmental Research, 26(3), 181-204. https://doi.org/10.1080/1062936x.2015.1018941

Machine learning (ML) methods have been applied to the analysis of a range of biological systems. This paper reviews the application of these methods to the problem domain of skin permeability and addresses critically some of the key issues. Specific... Read More about The application of machine learning to the modelling of percutaneous absorption: An overview and guide.

Redox and anti-oxidant state within cattle oocytes following in vitro maturation with bone morphogenetic protein 15 and follicle stimulating hormone (2015)
Journal Article
Sutton-McDowall, M. L., Purdey, M., Brown, H. M., Abell, A. D., Mottershead, D. G., Cetica, P. D., …Thompson, J. G. (2015). Redox and anti-oxidant state within cattle oocytes following in vitro maturation with bone morphogenetic protein 15 and follicle stimulating hormone. Molecular Reproduction and Development, 82(4), 281-294. https://doi.org/10.1002/mrd.22470

The developmental competence of cumulus oocyte complexes (COCs) can be increased during in vitro oocyte maturation with the addition of exogenous oocyte-secreted factors, such as bone morphogenetic protein 15 (BMP15), in combination with hormones. FS... Read More about Redox and anti-oxidant state within cattle oocytes following in vitro maturation with bone morphogenetic protein 15 and follicle stimulating hormone.

Efficient alignment of primary CNS neurites using structurally engineered surfaces and biochemical cues (2015)
Journal Article
Yang. (2015). Efficient alignment of primary CNS neurites using structurally engineered surfaces and biochemical cues. RSC advances, 22053 - 22059 (7). https://doi.org/10.1039/C4RA15739G

Tissue engineering strategies for the central nervous system (CNS) have been largely hampered by the complexity of neural cell interactions and limited ability to control functional circuit formation. Although cultures of primary CNS neurons give key... Read More about Efficient alignment of primary CNS neurites using structurally engineered surfaces and biochemical cues.

High content and high throughput screening to assess the angiogenic and neurogenic actions of mesenchymal stem cells in vitro. (2015)
Journal Article
Wright, K. (2015). High content and high throughput screening to assess the angiogenic and neurogenic actions of mesenchymal stem cells in vitro. Experimental Cell Research, 93 - 104. https://doi.org/10.1016/j.yexcr.2014.12.019

Mesenchymal stem cells are universally regarded across many fields of medicine, as one of the most promising cell types for use in cell-based therapies. Although not yet fully understood, the therapeutic effects of these cells are largely attributed... Read More about High content and high throughput screening to assess the angiogenic and neurogenic actions of mesenchymal stem cells in vitro..

Half-Sandwich Ruthenium(II) Biotin Conjugates as Biological Vectors to Cancer Cells (2015)
Journal Article
Babak, M. V., Plażuk, D., Meier, S. M., Arabshahi, H. J., Reynisson, J., Rychlik, B., …Hartinger, C. G. (2015). Half-Sandwich Ruthenium(II) Biotin Conjugates as Biological Vectors to Cancer Cells. Chemistry - A European Journal, 21(13), 5110-5117. https://doi.org/10.1002/chem.201403974

Ruthenium(II)–arene complexes with biotin-containing ligands were prepared so that a novel drug delivery system based on tumor-specific vitamin-receptor mediated endocytosis could be developed. The complexes were characterized by spectroscopic method... Read More about Half-Sandwich Ruthenium(II) Biotin Conjugates as Biological Vectors to Cancer Cells.