Outputs (243)

Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches (2016)
Journal Article
(2016). Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches. International Journal of Molecular Sciences, 128 - 128. https://doi.org/10.3390/ijms17010128

The tissue turnover of unperturbed adult lung is remarkably slow. However, after injury or insult, a specialised group of facultative lung progenitors become activated to replenish damaged tissue through a reparative process called regeneration. Disr... Read More about Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches.

How well are national guidelines relating to the general sales of aspirin and paracetamol, adhered to by retail stores: a mystery shopper study. (2016)
Journal Article
(2016). How well are national guidelines relating to the general sales of aspirin and paracetamol, adhered to by retail stores: a mystery shopper study. BMJ Open, e010081 - ?. https://doi.org/10.1136/bmjopen-2015-010081

OBJECTIVE: To determine whether non-pharmaceutical retail outlets are aboding to the current Medicines and Healthcare products Regulatory Agency (MHRA) national guidelines for over-the-counter (OTC) sales of aspirin and paracetamol. METHODS: Stages 1... Read More about How well are national guidelines relating to the general sales of aspirin and paracetamol, adhered to by retail stores: a mystery shopper study..

The influence of hydrostatic pressure on tissue engineered bone development (2016)
Journal Article
(2016). The influence of hydrostatic pressure on tissue engineered bone development. Journal of Theoretical Biology, https://doi.org/10.1016/j.jtbi.2015.12.020

The hydrostatic pressure stimulation of an appropriately cell–seeded porous scaffold within a bioreactor is a promising method for engineering bone tissue external to the body. We propose a mathematical model, and employ a suite of candidate constitu... Read More about The influence of hydrostatic pressure on tissue engineered bone development.

"Sometimes we can't fix things": a qualitative study of health care professionals' perceptions of end of life care for patients with heart failure (2016)
Journal Article
(2016). "Sometimes we can't fix things": a qualitative study of health care professionals' perceptions of end of life care for patients with heart failure. BMC Palliative Care, https://doi.org/10.1186/s12904-016-0074-y

Background: Although heart failure has a worse prognosis than some cancers, patients often have restricted access to well-developed end of life (EoL) models of care. Studies show that patients with advanced heart failure may have a poor understanding... Read More about "Sometimes we can't fix things": a qualitative study of health care professionals' perceptions of end of life care for patients with heart failure.

Revascularization for Left Anterior Descending Artery Stenosis: A Review of the Evidence That Supports Practice (2016)
Journal Article
Mamas. (2016). Revascularization for Left Anterior Descending Artery Stenosis: A Review of the Evidence That Supports Practice. Cardiology in Review, https://doi.org/10.1097/CRD.0000000000000097

Disease of the proximal left anterior descending (LAD) artery is a common pathological finding often combined with disease in other coronary arteries. In this article we review specifically the evidence (and the guidelines arising from the data) for... Read More about Revascularization for Left Anterior Descending Artery Stenosis: A Review of the Evidence That Supports Practice.

Impact of operator volume for percutaneous coronary intervention (PCI) on clinical outcomes: what do the numbers say? (2016)
Journal Article
Mamas, M., & Rashid, M. (2016). Impact of operator volume for percutaneous coronary intervention (PCI) on clinical outcomes: what do the numbers say?. European Heart Journal, 16-22. https://doi.org/10.1093/ehjqcco/qcv030

The impact of operator and centre volume on clinical outcomes and quality of care has been of considerable debate in recent years in a number of surgical- and procedural-based specialities. A relationship between higher volumes at both the institutio... Read More about Impact of operator volume for percutaneous coronary intervention (PCI) on clinical outcomes: what do the numbers say?.

Support vector regression to estimate the permeability enhancement of potential transdermal enhancers (2016)
Journal Article
Moss. (2016). Support vector regression to estimate the permeability enhancement of potential transdermal enhancers. Journal of Pharmacy and Pharmacology, 170-184. https://doi.org/10.1111/jphp.12508

Objectives Searching for chemicals that will safely enhance transdermal drug delivery is a significant challenge. This study applies support vector regression (SVR) for the first time to estimating the optimal formulation design of transdermal hydro... Read More about Support vector regression to estimate the permeability enhancement of potential transdermal enhancers.

'Stealth' nanoparticles evade neural immune cells but also evade all major brain cell populations: Implications for PEG-based neurotherapeutics (2016)
Journal Article
Jenkins, S., Weinberg, D., Al-Shakli, A., Fernandes, A., Yiu, H., Telling, N., …Chari, D. (2016). 'Stealth' nanoparticles evade neural immune cells but also evade all major brain cell populations: Implications for PEG-based neurotherapeutics. Journal of Controlled Release, 224, 136-145. https://doi.org/10.1016/j.jconrel.2016.01.013

Surface engineering to control cell behavior is of high interest across the chemical engineering, drug delivery and biomaterial communities. Defined chemical strategies are necessary to tailor nanoscale protein interactions/adsorption, enabling contr... Read More about 'Stealth' nanoparticles evade neural immune cells but also evade all major brain cell populations: Implications for PEG-based neurotherapeutics.

Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development (2016)
Journal Article
Fuller, H., Mandefro, B., Shirran, S., Gross, A., Kaus, A., Botting, C., …Sareen, S. (2016). Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development. Frontiers in Cellular Neuroscience, https://doi.org/10.3389/fncel.2015.00506

Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the proteomic consequences of reduced... Read More about Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development.

In Vivo Deep Tissue Fluorescence and Magnetic Imaging Employing Hybrid Nanostructures (2016)
Journal Article
Ortgies, D. H., de la Cueva, L., del Rosal, B., Sanz-Rodríguez, F., Fernández, N., Iglesias-de la Cruz, M. C., …Martín Rodríguez, E. (2016). In Vivo Deep Tissue Fluorescence and Magnetic Imaging Employing Hybrid Nanostructures. ACS applied materials & interfaces, 8(2), 1406-1414. https://doi.org/10.1021/acsami.5b10617

Breakthroughs in nanotechnology have made it possible to integrate different nanoparticles in one single hybrid nanostructure (HNS), constituting multifunctional nanosized sensors, carriers, and probes with great potential in the life sciences. In ad... Read More about In Vivo Deep Tissue Fluorescence and Magnetic Imaging Employing Hybrid Nanostructures.