Outputs (186)

Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Osteoarthritis. (2017)
Journal Article
Chapman, V., Markides, H., Sagar, D., Xu, L., Kay, A., Burston, J., …El Haj, A. (2017). Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Osteoarthritis. Stem Cells International, 2905104 - ?. https://doi.org/10.1155/2017/2905104

Background: Mesenchymal stem cells (MSCs) have a therapeutic potential for the treatment of osteoarthritic (OA) joint pathology and pain. The aims of this study were to determine the influence of a passage number on the effects of MSCs on pain behavi... Read More about Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Osteoarthritis..

Mesenchymal Stem Cell- Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis (2017)
Journal Article
Kay, A., Long, G., Broadfoot, S., Piccinini, A., Middleton, J., Kehoe, O., …Stefan, A. (2017). Mesenchymal Stem Cell- Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis. Scientific reports, https://doi.org/10.1038/s41598-017-18144-w

We evaluated the therapeutic potential of mesenchymal stem cell-conditioned medium (CM-MSC) as an alternative to cell therapy in an antigen-induced model of arthritis (AIA). Disease severity and cartilage loss were evaluated by histopathological anal... Read More about Mesenchymal Stem Cell- Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis.

Geographical epidemiology of health and overall deprivation in England, its changes and persistence from 2004 to 2015: a longitudinal spatial population study (2017)
Journal Article
Mamas. (2017). Geographical epidemiology of health and overall deprivation in England, its changes and persistence from 2004 to 2015: a longitudinal spatial population study. Journal of epidemiology and community health, 140-147. https://doi.org/10.1136/jech-2017-209999

Background: Socio-economic deprivation is a key determinant for health. In England, the Index of Multiple Deprivation (IMD) is a widely used composite measure of deprivation. However, little is known about its spatial clustering or persistence acros... Read More about Geographical epidemiology of health and overall deprivation in England, its changes and persistence from 2004 to 2015: a longitudinal spatial population study.

Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register (2017)
Journal Article
Mamas. (2017). Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register. Journal of the Neurological Sciences, 26-30. https://doi.org/10.1016/j.jns.2017.09.047

AbstractBackground Previous research has demonstrated an association between anaemia and poor outcomes in acute stroke. This study aimed to assess the impact of anaemia on stroke by anaemia subtype. Methods Data from a prospective UK Regional Stroke... Read More about Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register.

A Novel UK Prognostic Model for 30-day Mortality following Transcatheter Aortic Valve Implantation (2017)
Journal Article
Mamas. (2017). A Novel UK Prognostic Model for 30-day Mortality following Transcatheter Aortic Valve Implantation. Heart, 1109-1116. https://doi.org/10.1136/heartjnl-2017-312489

Objective Existing clinical prediction models (CPM) for short-term mortality after transcatheter aortic valve implantation (TAVI) have limited applicability in the UK due to moderate predictive performance and inconsistent recording practices across... Read More about A Novel UK Prognostic Model for 30-day Mortality following Transcatheter Aortic Valve Implantation.

ABT‑737 and pictilisib synergistically enhance pitavastatin‑induced apoptosis in ovarian cancer cells (2017)
Journal Article
De Wolf, E., De Wolf, C., & Richardson, A. (2018). ABT‑737 and pictilisib synergistically enhance pitavastatin‑induced apoptosis in ovarian cancer cells. Oncology Letters, 15(2), 1979-1984. https://doi.org/10.3892/ol.2017.7516

There is considerable interest in redeploying drugs for use in combination with other oncology therapeutics. The single‑agent activity of statins in ovarian cancer has been widely reported, however the drug concentration required to cause cell death... Read More about ABT‑737 and pictilisib synergistically enhance pitavastatin‑induced apoptosis in ovarian cancer cells.

MANTA - A randomized phase II study of fulvestrant in combination with the dual mTOR inhibitor AZD2014 or everolimus or fulvestrant alone in estrogen receptor-positive advanced or metastatic breast cancer (2017)
Presentation / Conference
Schmid, P., Zaiss, M., Harper-Wynne, C., Ferreira, M., Dubey, S., Chan, S., …Cortes Castan, J. (2017, December). MANTA - A randomized phase II study of fulvestrant in combination with the dual mTOR inhibitor AZD2014 or everolimus or fulvestrant alone in estrogen receptor-positive advanced or metastatic breast cancer. Paper presented at 2017 San Antonio Breast Cancer Symposium, San Antonio, Texas

Background: Resistance to endocrine therapy remains a major clinical challenge with aberrant PI3K/ mTOR pathway activation being one of the main drivers. Randomised clinical trials have demonstrated a substantial benefit of adding everolimus to endoc... Read More about MANTA - A randomized phase II study of fulvestrant in combination with the dual mTOR inhibitor AZD2014 or everolimus or fulvestrant alone in estrogen receptor-positive advanced or metastatic breast cancer.

Evaluation of a pharmacist-led telephone triage service in a GP Practice (2017)
Presentation / Conference
Kit Yan, C., White, S., Patel, B., & Chapman, S. (2017, December). Evaluation of a pharmacist-led telephone triage service in a GP Practice. Poster presented at Royal Pharmaceutical Society (RPS) Winter Summit 2017, London, UK

Poster abstract from Conference; Royal Pharmaceutical Society Winter Summit 2017.

P83: A Pilot Study to assess Peak Systolic Velocity as A Possible Marker of Atherosclerotic Burden Using Ultrasound (2017)
Journal Article
Koenig, C., Atherton, M., Cavazzuti, M., Ramachandran, S., Gomm, C., Strange, R., …Schenkel, T. (2017). P83: A Pilot Study to assess Peak Systolic Velocity as A Possible Marker of Atherosclerotic Burden Using Ultrasound. Artery Research, 20(C), 76-76. https://doi.org/10.1016/j.artres.2017.10.099

Introduction: Ischemic heart disease (IHD) has been associated with lower peak systolic velocity (PSV) on penile Doppler measurements [1]. This study establishes whether carotid ultrasound (US) PSV was associated with computational fluid dynamics (CF... Read More about P83: A Pilot Study to assess Peak Systolic Velocity as A Possible Marker of Atherosclerotic Burden Using Ultrasound.

Impact of Infliximab and Etanercept Biosimilars on Biological Disease-Modifying Antirheumatic Drugs Utilisation and NHS Budget in the UK. (2017)
Journal Article
(2017). Impact of Infliximab and Etanercept Biosimilars on Biological Disease-Modifying Antirheumatic Drugs Utilisation and NHS Budget in the UK. BioDrugs, 533 - 544. https://doi.org/10.1007/s40259-017-0252-3

OBJECTIVE: Biological disease-modifying antirheumatic drugs (bDMARDs) are effective but expensive options for treating rheumatoid arthritis. The introduction of infliximab and etanercept biosimilars presents a significant potential cost saving in a f... Read More about Impact of Infliximab and Etanercept Biosimilars on Biological Disease-Modifying Antirheumatic Drugs Utilisation and NHS Budget in the UK..