Skip to main content

Research Repository

Advanced Search

Outputs (186)

Accelerated versus standard epirubicin followed by cyclophosphamide, methotrexate, and fluorouracil or capecitabine as adjuvant therapy for breast cancer in the randomised UK TACT2 trial (CRUK/05/19): a multicentre, phase 3, open-label, randomised, controlled trial (2017)
Journal Article
Cameron, D., Morden, J. P., Canney, P., Velikova, G., Coleman, R., Bartlett, J., …Bliss, J. M. (2017). Accelerated versus standard epirubicin followed by cyclophosphamide, methotrexate, and fluorouracil or capecitabine as adjuvant therapy for breast cancer in the randomised UK TACT2 trial (CRUK/05/19): a multicentre, phase 3, open-label, randomised, controlled trial. Lancet Oncology, 18(7), 929 - 945. https://doi.org/10.1016/S1470-2045%2817%2930404-7

Background
Adjuvant chemotherapy for early breast cancer has improved outcomes but causes toxicity. The UK TACT2 trial used a 2×2 factorial design to test two hypotheses: whether use of accelerated epirubicin would improve time to tumour recurrence... Read More about Accelerated versus standard epirubicin followed by cyclophosphamide, methotrexate, and fluorouracil or capecitabine as adjuvant therapy for breast cancer in the randomised UK TACT2 trial (CRUK/05/19): a multicentre, phase 3, open-label, randomised, controlled trial.

Facilitating the operational readiness of the NHS for the in-house manufacture and delivery of autologous cell therapy (2017)
Presentation / Conference
Ziya, S., Medcalf, N., El, A., & Wright, K. (2017, June). Facilitating the operational readiness of the NHS for the in-house manufacture and delivery of autologous cell therapy. Poster presented at ISCT 2017 Annual Meeting, London, UK

Introduction: Cell-based therapies (CBTs) have been shown to confer regenerative capacity in various pathologies. The production of such treatments require
a range of business models. These business models either align with or disrupt
the current c... Read More about Facilitating the operational readiness of the NHS for the in-house manufacture and delivery of autologous cell therapy.

Human adipose derived stem cells are superior to human osteoblasts (HOB) in bone tissue engineering on a collagen-fibroin-ELR blend (2017)
Journal Article
(2017). Human adipose derived stem cells are superior to human osteoblasts (HOB) in bone tissue engineering on a collagen-fibroin-ELR blend. Bioactive Materials, 71 - 81. https://doi.org/10.1016/j.bioactmat.2017.04.001

The ultrastructure of the bone provides a unique mechanical strength against compressive, torsional and tensional stresses. An elastin-like recombinamer (ELR) with a nucleation sequence for hydroxyapatite was incorporated into films prepared from a c... Read More about Human adipose derived stem cells are superior to human osteoblasts (HOB) in bone tissue engineering on a collagen-fibroin-ELR blend.

Enhanced intracellular delivery and controlled drug release of magnetic PLGA nanoparticles modified with transferrin (2017)
Journal Article
Cui, Y., Xu, Q., Davoodi, P., Wang, D., & Wang, C. (2017). Enhanced intracellular delivery and controlled drug release of magnetic PLGA nanoparticles modified with transferrin. Acta pharmacologica Sinica, 38(6), 943-953. https://doi.org/10.1038/aps.2017.45

Owing to the presence of multidrug resistance in tumor cells, conventional chemotherapy remains clinically intractable. To enhance the therapeutic efficacy of chemotherapeutic agents, targeting strategies based on magnetic polymeric nanoparticles mod... Read More about Enhanced intracellular delivery and controlled drug release of magnetic PLGA nanoparticles modified with transferrin.

Evaluation of peroxidative stress of cancer cells in vitro by real-time quantification of volatile aldehydes in culture headspace (2017)
Journal Article
Shestivska, V., Rutter, A. V., Sule-Suso, J., Smith, D., & Spanel, P. (2017). Evaluation of peroxidative stress of cancer cells in vitro by real-time quantification of volatile aldehydes in culture headspace. Rapid Communications in Mass Spectrometry, 31(16), 1344-1352. https://doi.org/10.1002/rcm.7911

Rationale
Peroxidation of lipids in cellular membranes results in the release of volatile organic compounds (VOCs), including saturated aldehydes. The real-time quantification of trace VOCs produced by cancer cells during peroxidative stress present... Read More about Evaluation of peroxidative stress of cancer cells in vitro by real-time quantification of volatile aldehydes in culture headspace.

Post-exercise cold-water immersion modulates skeletal muscle PGC-1a mRNA expression in immersed and non-immersed limbs: evidence of systemic regulation. (2017)
Journal Article
(2017). Post-exercise cold-water immersion modulates skeletal muscle PGC-1a mRNA expression in immersed and non-immersed limbs: evidence of systemic regulation. Journal of Applied Physiology, -. https://doi.org/10.1152/japplphysiol.00096.2017

Mechanisms mediating post-exercise cold-induced increases in PGC-1a gene expression in human skeletal muscle are yet to be fully elucidated, but may involve local cooling effects on AMPK and p38 MAPK related signalling and/or increased systemic ß-adr... Read More about Post-exercise cold-water immersion modulates skeletal muscle PGC-1a mRNA expression in immersed and non-immersed limbs: evidence of systemic regulation..

Development of an international comorbidity education framework (2017)
Journal Article
Lawson, C., Pati, S., Green, J., Messina, G., Strömberg, A., Nante, N., …Kadam, U. (2017). Development of an international comorbidity education framework. Nurse Education Today, 55, 82-89. https://doi.org/10.1016/j.nedt.2017.05.011

Context
The increasing number of people living with multiple chronic conditions in addition to an index condition has become an international healthcare priority. Health education curricula have been developed alongside single condition frameworks i... Read More about Development of an international comorbidity education framework.