Outputs (186)

Involvement of the a/ß Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5) (2017)
Journal Article
Hasan, A. M., & Dent, G. (2017). Involvement of the a/ß Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5). American Journal of Immunology, 209-215. https://doi.org/10.3844/ajisp.2017.209.215

Eosinophils are the principal effector cells for allergic inflammation in a variety of diseases, in which they contribute to tissue damage and remodelling processes via the secretion of cytotoxic granular proteins and cytokines. The intracellular mec... Read More about Involvement of the a/ß Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5).

Dialysis following Transcatheter Aortic Valve Implantation: risk factors and outcomes: An analysis from the UK TAVI Registry (2017)
Journal Article
Mamas. (2017). Dialysis following Transcatheter Aortic Valve Implantation: risk factors and outcomes: An analysis from the UK TAVI Registry. JACC. Cardiovascular interventions, 2040-2047. https://doi.org/10.1016/j.jcin.2017.05.020

Objectives
This study sought to determine the risk factors for post-transcatheter aortic valve replacement (TAVR) dialysis and to determine the impact of pre-TAVR or post-TAVR dialysis on mortality.

Background
TAVR is now established as an alter... Read More about Dialysis following Transcatheter Aortic Valve Implantation: risk factors and outcomes: An analysis from the UK TAVI Registry.

Students views of an online ethical decision-support tool (2017)
Journal Article
Allinson, M., & Black, P. (2018). Students views of an online ethical decision-support tool. Currents in Pharmacy Teaching and Learning, 10(2), 226-230. https://doi.org/10.1016/j.cptl.2017.10.008

Background and purpose
Ethical reasoning is a key skill that must be developed during the undergraduate pharmacy course to prepare students for ethical decision-making in future practice as pharmacy professionals. In this initial study, we sought an... Read More about Students views of an online ethical decision-support tool.

Emergence of the Stoner-Wohlfarth astroid in thin films at dynamic regime (2017)
Journal Article
Cuñado, J. L. F., Bollero, A., Pérez-Castañeda, T., Perna, P., Ajejas, F., Pedrosa, J., …Camarero, J. (2017). Emergence of the Stoner-Wohlfarth astroid in thin films at dynamic regime. Scientific Reports, 7, Article 13474. https://doi.org/10.1038/s41598-017-13854-7

The Stoner-Wohlfarth (SW) model is the simplest model that describes adequately the magnetization reversal of nanoscale systems that are small enough to contain single magnetic domains. However for larger sizes where multi-domain effects are present,... Read More about Emergence of the Stoner-Wohlfarth astroid in thin films at dynamic regime.

Relative survival following transcatheter aortic valve implantation: how do TAVI patients fare relative to the general population? (2017)
Journal Article
Mamas. (2017). Relative survival following transcatheter aortic valve implantation: how do TAVI patients fare relative to the general population?. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/JAHA.117.007229

Background
Transcatheter aortic valve implantation (TAVI) is indicated for patients with aortic stenosis who are intermediate-high surgical risk. Although all-cause mortality rates after TAVI are established, survival attributable to the procedure i... Read More about Relative survival following transcatheter aortic valve implantation: how do TAVI patients fare relative to the general population?.

miRNAs in bone metastasis (2017)
Journal Article
Cheung, D. G., Buzzetti, M., & Di Leva, G. (2017). miRNAs in bone metastasis. Expert Review of Endocrinology and Metabolism, 12(6), 451-461. https://doi.org/10.1080/17446651.2017.1383893

INTRODUCTION: Bone metastasis is one of the most common forms of metastasis from a number of different primary carcinomas. MicroRNAs (miRNAs) are short, endogenous RNAs that negatively regulate gene expression to control essential pathways, including... Read More about miRNAs in bone metastasis.

In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line (2017)
Journal Article
(2017). In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line. https://doi.org/10.1002/jin2.32

The antiretroviral drug efavirenz displays many desirable pharmacokinetic properties such as a long half-life enabling once daily dosing but suffers from central nervous system safety issues. Various nanotechnologies have been explored to mitigate so... Read More about In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line.

A prospective, proteomics study identified potential biomarkers of encapsulating peritoneal sclerosis in peritoneal effluent (2017)
Journal Article
Lambie, & Davies. (2017). A prospective, proteomics study identified potential biomarkers of encapsulating peritoneal sclerosis in peritoneal effluent. Kidney International, 988-1002. https://doi.org/10.1016/j.kint.2017.03.030

Encapsulating peritoneal sclerosis (EPS) is a potentially devastating complication of peritoneal dialysis
(PD). Diagnosis is often delayed due to the lack of effective and accurate diagnostic tools. We
therefore examined peritoneal effluent for pot... Read More about A prospective, proteomics study identified potential biomarkers of encapsulating peritoneal sclerosis in peritoneal effluent.

The interplay between TP53 and mevalonate pathway in ovarian cancer (2017)
Journal Article
Abdullah, M., Abed, M., & Richardson, A. (2017). The interplay between TP53 and mevalonate pathway in ovarian cancer. Annals of Oncology, 28(S5), v6. https://doi.org/10.1093/annonc/mdx361.020

Background: TP53 gene is the most commonly mutated tumour suppressor in human malignancies. TP53 is mutated in more than 50% of all human cancers, with over 96% of high-grade serous ovarian cancer displaying changes at this locus. Mutations of TP53 g... Read More about The interplay between TP53 and mevalonate pathway in ovarian cancer.

P31 Role of sesquiterpene lactones against human ovarian cancer (2017)
Journal Article
Fadayomi, I. E., Forsyth, N., & Li, W. (2017). P31 Role of sesquiterpene lactones against human ovarian cancer. Biochemical Pharmacology, 139(11), 134-135. https://doi.org/10.1016/j.bcp.2017.06.032

Background:
Overexpression of microRNA-31 (miR-31) is implicated in the pathogenesis of esophageal squamous cell carcinoma (ESCC), a deadly disease associated with dietary zinc deficiency. Using a rat model that recapitulates features of human ESCC,... Read More about P31 Role of sesquiterpene lactones against human ovarian cancer.