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Outputs (188)

P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection (2019)
Journal Article
Panpho, P., Davies, H., Field, M., Madine, J., Yang, Y., & Akhtar, R. (2019). P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection. Artery Research, 25(Suppl 1), S43-S43. https://doi.org/10.2991/artres.k.191224.036

Background: Aortic dissection is a devastating condition, beginning with a tear through from intima to the medial layer, leading to splitting of aortic layers and creating the false and true lumen with a septum (or flap). Little is known about the pr... Read More about P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection.

Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening. (2019)
Journal Article
Reynisson. (2019). Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening. Bioorganic and Medicinal Chemistry, 115234 - ?. https://doi.org/10.1016/j.bmc.2019.115234

Spinocerebellar ataxia syndrome with axonal neuropathy (SCAN1) is a debilitating neurological disease that is caused by the mutation the Tyrosyl-DNA phosphodiesterase 1 (TDP1) DNA repair enzyme. The crucial His493 in TDP1's binding site is replaced w... Read More about Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening..

Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening (2019)
Journal Article
Reynisson. (2019). Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening. Molecules, https://doi.org/10.3390/molecules24234346

Cancers express tryptophan catabolising enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO2) to produce immunosuppressive tryptophan metabolites that undermine patients' immune systems, leading to poor disease outcomes.... Read More about Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening.

Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials (2019)
Journal Article
Barreto, S., Hamel, L., Schiatti, T., Yang, Y., & George, V. (2019). Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials. Cells, 8(12), https://doi.org/10.3390/cells8121536

Cardiac Progenitor Cells (CPCs) show great potential as a cell resource for restoring cardiac function in patients affected by heart disease or heart failure. CPCs are proliferative and committed to cardiac fate, capable of generating cells of all th... Read More about Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials.

Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents. (2019)
Journal Article
Reynisson. (2019). Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents. European Journal of Medicinal Chemistry, 111919 - ?. https://doi.org/10.1016/j.ejmech.2019.111919

Phosphatidylcholine-specific phospholipase C (PC-PLC) is a promising target for new anticancer treatment. Herein, we report our work in the discovery of novel drug-like PC-PLC inhibitors. Virtual screening led to the identification of promising hits... Read More about Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents..

Rock Inhibitor Y-27632 Enables Feeder-Free, Unlimited Expansion of Sus scrofa domesticus Swine Airway Stem Cells to Facilitate Respiratory Research (2019)
Journal Article
Dale, T. P., Borg D’anastasi, E., Haris, M., & Forsyth, N. R. (2019). Rock Inhibitor Y-27632 Enables Feeder-Free, Unlimited Expansion of Sus scrofa domesticus Swine Airway Stem Cells to Facilitate Respiratory Research. Stem Cells International, 2019, 1 - 15. https://doi.org/10.1155/2019/3010656

Current limitations in the efficacy of treatments for chronic respiratory disorders position them as prospective regenerative medicine therapeutic targets. A substantial barrier to these ambitions is that research requires large numbers of cells whos... Read More about Rock Inhibitor Y-27632 Enables Feeder-Free, Unlimited Expansion of Sus scrofa domesticus Swine Airway Stem Cells to Facilitate Respiratory Research.

Chorionic and amniotic placental membrane‐derived stem cells, from gestational diabetic women, have distinct insulin secreting cell differentiation capacities (2019)
Journal Article
Chen, L., Forsyth, N. R., & Wu, P. (2020). Chorionic and amniotic placental membrane‐derived stem cells, from gestational diabetic women, have distinct insulin secreting cell differentiation capacities. Journal of Tissue Engineering and Regenerative Medicine, 14(2), 243-256. https://doi.org/10.1002/term.2988

Women with gestational diabetes mellitus (GDM), and their offspring, are at high risk of developing type 2 diabetes. Chorionic (CMSCs) and amniotic mesenchymal stem cells (AMSCs) derived from placental membranes provide a source of autologous stem ce... Read More about Chorionic and amniotic placental membrane‐derived stem cells, from gestational diabetic women, have distinct insulin secreting cell differentiation capacities.

Virtual patient technology to teach pharmacists NOAC counselling – Questionnaire development, validation and pilot (2019)
Journal Article
Richardson, C., White, S., & Chapman, S. (2019). Virtual patient technology to teach pharmacists NOAC counselling – Questionnaire development, validation and pilot. BMJ Simulation and Technology Enhanced Learning, A77 - A77. https://doi.org/10.1136/bmjstel-2019-aspihconf.142

Abstract
Background Keele University has developed a virtual patient (VP) educational tool to teach pharmacists how to conduct non-vitamin K oral anticoagulant (NOAC) counselling. The VP’s use will be evaluated, but in order to do so, a validated da... Read More about Virtual patient technology to teach pharmacists NOAC counselling – Questionnaire development, validation and pilot.

Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage (2019)
Journal Article
Roffe. (2019). Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage. Stroke, 3064 -3071. https://doi.org/10.1161/STROKEAHA.119.026389

Background and Purpose
Pilot trials suggest that glyceryl trinitrate (GTN; nitroglycerin) may improve outcome when administered early after stroke onset.

Methods
We undertook a multicentre, paramedic-delivered, ambulance-based, prospective rando... Read More about Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage.