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Outputs (22)

Translating microcalcification biomarker information into the laboratory: A preliminary assessment utilizing core biopsies obtained from sites of mammographic calcification (2024)
Journal Article
Lyburn, I. D., Scott, R., Cornford, E., Bouzy, P., Stone, N., Greenwood, C., …Rogers, K. (2024). Translating microcalcification biomarker information into the laboratory: A preliminary assessment utilizing core biopsies obtained from sites of mammographic calcification. Heliyon, 10(6), Article e27686. https://doi.org/10.1016/j.heliyon.2024.e27686

Rationale and objectives The potential of breast microcalcification chemistry to provide clinically valuable intelligence is being increasingly studied. However, acquisition of crystallographic details has, to dat... Read More about Translating microcalcification biomarker information into the laboratory: A preliminary assessment utilizing core biopsies obtained from sites of mammographic calcification.

Conical shell X-ray beam tomosynthesis and micro-computed tomography for microarchitectural characterisation (2023)
Journal Article
Arnold, E. L., Elarnaut, F., Downes, D., Evans, J. P. O., Greenwood, C., & Rogers, K. D. (in press). Conical shell X-ray beam tomosynthesis and micro-computed tomography for microarchitectural characterisation. Scientific Reports, 13(1), Article 21480. https://doi.org/10.1038/s41598-023-48851-6

Bone quality is commonly used to diagnose bone diseases such as osteoporosis, with many studies focusing on microarchitecture for fracture prediction. In this study a bovine distal femur was imaged using both micro-computed tomography (µCT) and tomos... Read More about Conical shell X-ray beam tomosynthesis and micro-computed tomography for microarchitectural characterisation.

A pilot study: effect of irisin on trabecular bone in a streptozotocin-induced animal model of type 1 diabetic osteopathy utilizing a micro-CT (2023)
Journal Article
Mohsin, S., Brock, F., Kaimala, S., Greenwood, C., Sulaiman, M., Rogers, K., & Adeghate, E. (in press). A pilot study: effect of irisin on trabecular bone in a streptozotocin-induced animal model of type 1 diabetic osteopathy utilizing a micro-CT. PeerJ, 11, Article e16278. https://doi.org/10.7717/peerj.16278

Background: Osteoporosis is a significant co-morbidity of type 1 diabetes mellitus (DM1) leading to increased fracture risk. Exercise-induced hormone ‘irisin’ in low dosage has been shown to have a beneficial effect on bone metabolism by increasing o... Read More about A pilot study: effect of irisin on trabecular bone in a streptozotocin-induced animal model of type 1 diabetic osteopathy utilizing a micro-CT.

Microcalcification crystallography as a potential marker of DCIS recurrence (2023)
Journal Article
Gosling, S. B., Arnold, E. L., Davies, S. K., Cross, H., Bouybayoune, I., Calabrese, D., …van Oirsouw, M. (2023). Microcalcification crystallography as a potential marker of DCIS recurrence. Scientific reports, 13(1), Article 9331. https://doi.org/10.1038/s41598-023-33547-8

Ductal carcinoma in-situ (DCIS) accounts for 20-25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtreatm... Read More about Microcalcification crystallography as a potential marker of DCIS recurrence.

Exploration of utility of combined optical photothermal infrared and Raman imaging for investigating the chemical composition of microcalcifications in breast cancer (2023)
Journal Article
Bouzy, P., Lyburn, I. D., Pinder, S. E., Scott, R., Mansfield, J., Moger, J., …Stone, N. (in press). Exploration of utility of combined optical photothermal infrared and Raman imaging for investigating the chemical composition of microcalcifications in breast cancer. Analytical Methods, 15(13), 1620-1630. https://doi.org/10.1039/d2ay01197b

Microcalcifications play an important role in cancer detection. They are evaluated by their radiological and histological characteristics but it is challenging to find a link between their morphology, their composition and the nature of a specific ty... Read More about Exploration of utility of combined optical photothermal infrared and Raman imaging for investigating the chemical composition of microcalcifications in breast cancer.

Breast calcification micromorphology classification (2022)
Journal Article
Scott, R., Lyburn, I., Cornford, E., Bouzy, P., Stone, N., Greenwood, C., …Rogers, K. (2022). Breast calcification micromorphology classification. British Journal of Radiology, 95(1139), 1- 3. https://doi.org/10.1259/bjr.20220485

Objectives: The importance of consistent terminology in describing the appearance of breast calcifications in mammography is well recognised. Imaging of calcifications using electron microscopy is a globally growing field of research. We therefore su... Read More about Breast calcification micromorphology classification.

A multi-modal exploration of heterogeneous physico–chemical properties of DCIS breast microcalcifications (2022)
Journal Article
Gosling, S., Calabrese, D., Nallala, J., Greenwood, C., Pinder, S., King, L., …Stone, N. (2022). A multi-modal exploration of heterogeneous physico–chemical properties of DCIS breast microcalcifications. Analyst, 147(8), 1641-1654. https://doi.org/10.1039/d1an01548f

Ductal carcinoma in situ (DCIS) is frequently associated with breast calcification. This study combines multiple analytical techniques to investigate the heterogeneity of these calcifications at the micrometre scale. X-ray diffraction, scanning elect... Read More about A multi-modal exploration of heterogeneous physico–chemical properties of DCIS breast microcalcifications.

New insights into the application of pair distribution function studies to biogenic and synthetic hydroxyapatites (2020)
Journal Article
Arnold, E., Keeble, D., Greenwood, C., & Rogers, K. (2020). New insights into the application of pair distribution function studies to biogenic and synthetic hydroxyapatites. Scientific reports, 10, Article 19597. https://doi.org/10.1038/s41598-020-73200-2

Biogenic and synthetic hydroxyapatites are confounding materials whose properties remain uncertain, even after years of study. Pair distribution function (PDF) analysis was applied to hydroxyapatites in the 1970’s and 1980’s, but this area of researc... Read More about New insights into the application of pair distribution function studies to biogenic and synthetic hydroxyapatites.