Outputs (29)

Benign/Cancer Diagnostics Based on X-Ray Diffraction: Comparison of Data Analytics Approaches (2025)
Journal Article
Alekseev, A., Shcherbakov, V., Avdieiev, O., Denisov, S. A., Kubytskyi, V., Blinchevsky, B., Murokh, S., Ajeer, A., Adams, L., Greenwood, C., Rogers, K., Jones, L. J., Mourokh, L., & Lazarev, P. (2025). Benign/Cancer Diagnostics Based on X-Ray Diffraction: Comparison of Data Analytics Approaches. Cancers, 17(10), Article 1662. https://doi.org/10.3390/cancers17101662

Background/Objectives: With the number of detected breast cancer cases growing every year, there is a need to augment histopathological analysis with fast preliminary screening. We examine the feasibility of using X-ray diffraction measurements for t... Read More about Benign/Cancer Diagnostics Based on X-Ray Diffraction: Comparison of Data Analytics Approaches.

Prostate microcalcification crystallography as a marker of pathology (2025)
Journal Article
Gosling, S. B., Arnold, E. L., Adams, L., Cool, P., Geraki, K., Kitchen, M. O., Lyburn, I. D., Rogers, K. D., Snow, T., Stone, N., & Greenwood, C. E. (2025). Prostate microcalcification crystallography as a marker of pathology. Scientific Reports, 15(1), Article 14979. https://doi.org/10.1038/s41598-025-98692-8

Prostate cancer remains the most common male cancer; however, treatment regimens remain unclear in some cases due to a lack of agreement in current testing methods. Therefore, there is an increasing need to identify novel biomarkers to better counsel... Read More about Prostate microcalcification crystallography as a marker of pathology.

Anisotropy visualisation from X-ray diffraction of biological apatite in mixed phase calcified tissue samples (2025)
Journal Article
Scott, R., Lyburn, I. D., Cornford, E., Bouzy, P., Stone, N., Greenwood, C., Gosling, S., Arnold, E. L., Bouybayoune, I., Pinder, S. E., & Rogers, K. (2025). Anisotropy visualisation from X-ray diffraction of biological apatite in mixed phase calcified tissue samples. Scientific reports, 15(1), Article 5478. https://doi.org/10.1038/s41598-025-88940-2

X-ray diffraction is widely used to characterise the mineral component of calcified tissue. Broadening of the diffraction peaks yields valuable information on the size of coherently diffracting domains, sometimes loosely described as crystallite size... Read More about Anisotropy visualisation from X-ray diffraction of biological apatite in mixed phase calcified tissue samples.

Anisotropy visualisation from X-ray diffraction of biological apatite in mixed phase calcified tissue samples (2025)
Journal Article
Scott, R., Lyburn, I. D., Cornford, E., Bouzy, P., Stone, N., Greenwood, C., Gosling, S., Arnold, E. L., Bouybayoune, I., Pinder, S. E., & Rogers, K. (in press). Anisotropy visualisation from X-ray diffraction of biological apatite in mixed phase calcified tissue samples. Scientific reports, 15(1), Article 5478. https://doi.org/10.1038/s41598-025-88940-2

X-ray diffraction is widely used to characterise the mineral component of calcified tissue. Broadening of the diffraction peaks yields valuable information on the size of coherently diffracting domains, sometimes loosely described as crystallite size... Read More about Anisotropy visualisation from X-ray diffraction of biological apatite in mixed phase calcified tissue samples.

Vitacrystallography: Structural Biomarkers of Breast Cancer Obtained by X-ray Scattering (2024)
Journal Article
Denisov, S., Blinchevsky, B., Friedman, J., Gerbelli, B., Ajeer, A., Adams, L., Greenwood, C., Rogers, K., Mourokh, L., & Lazarev, P. (in press). Vitacrystallography: Structural Biomarkers of Breast Cancer Obtained by X-ray Scattering. Cancers, 16(14), Article 2499. https://doi.org/10.3390/cancers16142499

With breast cancer being one of the most widespread causes of death for women, there is an unmet need for its early detection. For this purpose, we propose a non-invasive approach based on X-ray scattering. We measured samples from 107 unique patient... Read More about Vitacrystallography: Structural Biomarkers of Breast Cancer Obtained by X-ray Scattering.

Translating microcalcification biomarker information into the laboratory: A preliminary assessment utilizing core biopsies obtained from sites of mammographic calcification (2024)
Journal Article
Lyburn, I. D., Scott, R., Cornford, E., Bouzy, P., Stone, N., Greenwood, C., Bouybayoune, I., Pinder, S. E., & Rogers, K. (2024). Translating microcalcification biomarker information into the laboratory: A preliminary assessment utilizing core biopsies obtained from sites of mammographic calcification. Heliyon, 10(6), Article e27686. https://doi.org/10.1016/j.heliyon.2024.e27686

Rationale and objectives
The potential of breast microcalcification chemistry to provide clinically valuable intelligence is being increasingly studied. However, acquisition of crystallographic details has, to dat... Read More about Translating microcalcification biomarker information into the laboratory: A preliminary assessment utilizing core biopsies obtained from sites of mammographic calcification.

Conical shell X-ray beam tomosynthesis and micro-computed tomography for microarchitectural characterisation (2023)
Journal Article
Arnold, E. L., Elarnaut, F., Downes, D., Evans, J. P. O., Greenwood, C., & Rogers, K. D. (in press). Conical shell X-ray beam tomosynthesis and micro-computed tomography for microarchitectural characterisation. Scientific Reports, 13(1), Article 21480. https://doi.org/10.1038/s41598-023-48851-6

Bone quality is commonly used to diagnose bone diseases such as osteoporosis, with many studies focusing on microarchitecture for fracture prediction. In this study a bovine distal femur was imaged using both micro-computed tomography (µCT) and tomos... Read More about Conical shell X-ray beam tomosynthesis and micro-computed tomography for microarchitectural characterisation.

A pilot study: effect of irisin on trabecular bone in a streptozotocin-induced animal model of type 1 diabetic osteopathy utilizing a micro-CT (2023)
Journal Article
Mohsin, S., Brock, F., Kaimala, S., Greenwood, C., Sulaiman, M., Rogers, K., & Adeghate, E. (in press). A pilot study: effect of irisin on trabecular bone in a streptozotocin-induced animal model of type 1 diabetic osteopathy utilizing a micro-CT. PeerJ, 11, Article e16278. https://doi.org/10.7717/peerj.16278

Background: Osteoporosis is a significant co-morbidity of type 1 diabetes mellitus (DM1) leading to increased fracture risk. Exercise-induced hormone ‘irisin’ in low dosage has been shown to have a beneficial effect on bone metabolism by increasing o... Read More about A pilot study: effect of irisin on trabecular bone in a streptozotocin-induced animal model of type 1 diabetic osteopathy utilizing a micro-CT.

Microcalcification crystallography as a potential marker of DCIS recurrence (2023)
Journal Article
Gosling, S. B., Arnold, E. L., Davies, S. K., Cross, H., Bouybayoune, I., Calabrese, D., Nallala, J., Pinder, S. E., Fu, L., Lips, E. H., King, L., Marks, J., Hall, A., Grimm, L. J., Lynch, T., Pinto, D., Stobart, H., Shelley Hwang, E., Wesseling, J., Geraki, K., …van Oirsouw, M. (2023). Microcalcification crystallography as a potential marker of DCIS recurrence. Scientific reports, 13(1), Article 9331. https://doi.org/10.1038/s41598-023-33547-8

Ductal carcinoma in-situ (DCIS) accounts for 20-25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtreatm... Read More about Microcalcification crystallography as a potential marker of DCIS recurrence.

Exploration of utility of combined optical photothermal infrared and Raman imaging for investigating the chemical composition of microcalcifications in breast cancer (2023)
Journal Article
Bouzy, P., Lyburn, I. D., Pinder, S. E., Scott, R., Mansfield, J., Moger, J., Greenwood, C., Bouybayoune, I., Cornford, E., Rogers, K., & Stone, N. (in press). Exploration of utility of combined optical photothermal infrared and Raman imaging for investigating the chemical composition of microcalcifications in breast cancer. Analytical Methods, 15(13), 1620-1630. https://doi.org/10.1039/d2ay01197b

Microcalcifications play an important role in cancer detection. They are evaluated by their radiological and histological characteristics but it is challenging to find a link between their morphology, their composition and the nature of a specific ty... Read More about Exploration of utility of combined optical photothermal infrared and Raman imaging for investigating the chemical composition of microcalcifications in breast cancer.