Outputs (20)

Portable, low-cost, Raspberry Pi-based optical sensor (PiSENS): continuous monitoring of atmospheric nitrogen dioxide (2022)
Journal Article
Saiz, E., Banicevic, I., Espinoza Torres, S., Bertata, S., Picasso, G., O'Brien, M., & Radu, A. (in press). Portable, low-cost, Raspberry Pi-based optical sensor (PiSENS): continuous monitoring of atmospheric nitrogen dioxide. Analytical Methods, 15(4), 482-491. https://doi.org/10.1039/d2ay01433e

We have developed a sensing system that utilizes a low-cost computer (Raspberry Pi) and its imaging camera as an optical sensing core for the continuous detection of NO2 in the air (PiSENS-A). The sensor is based on colour development as a consequenc... Read More about Portable, low-cost, Raspberry Pi-based optical sensor (PiSENS): continuous monitoring of atmospheric nitrogen dioxide.

Front Cover: An Automated Computer‐Vision “Bubble‐Counting” Technique to Characterise CO₂ Dissolution into an Acetonitrile Flow Stream in a Teflon AF‐2400 Tube‐in‐Tube Flow Device (ChemPlusChem 1/2023) (2022)
Digital Artefact
O'Brien, M., & Moraru, R. (2023). Front Cover: An Automated Computer‐Vision “Bubble‐Counting” Technique to Characterise CO2 Dissolution into an Acetonitrile Flow Stream in a Teflon AF‐2400 Tube‐in‐Tube Flow Device (ChemPlusChem 1/2023). [Front cover to Journal]

An Automated Computer‐Vision “Bubble‐Counting” Technique to Characterise CO₂ Dissolution into an Acetonitrile Flow Stream in a Teflon AF‐2400 Tube‐in‐Tube Flow Device (2022)
Journal Article
O'Brien, M., & Moraru, R. (2023). An Automated Computer‐Vision “Bubble‐Counting” Technique to Characterise CO2 Dissolution into an Acetonitrile Flow Stream in a Teflon AF‐2400 Tube‐in‐Tube Flow Device. ChemPlusChem, 88(1), https://doi.org/10.1002/cplu.202200167

AbstractA Teflon AF‐2400 based tube‐in‐tube device was used to generate flow streams of CO2 in acetonitrile and a computer‐vision based ‘bubble counting’ technique was used to estimate the amount of CO2 that had passed into solution whilst in the tub... Read More about An Automated Computer‐Vision “Bubble‐Counting” Technique to Characterise CO₂ Dissolution into an Acetonitrile Flow Stream in a Teflon AF‐2400 Tube‐in‐Tube Flow Device.

A tutored discourse on microcontrollers, single board computers and their applications to monitor and control chemical reactions (2020)
Journal Article
Fitzpatrick, D., O'Brien, M., & Ley, S. (2020). A tutored discourse on microcontrollers, single board computers and their applications to monitor and control chemical reactions. Reaction Chemistry and Engineering, 5(2), 201-220. https://doi.org/10.1039/C9RE00407F

This Tutored Discourse constitutes a preliminary exposure on how synthesis chemists can engage positively with inexpensive, low-power microcontrollers to aid control, monitoring and optimisation of chemical reactions. The acquired skillset adds a new... Read More about A tutored discourse on microcontrollers, single board computers and their applications to monitor and control chemical reactions.

9 Immobilized Reagents and Multistep Processes (2018)
Book Chapter
Ley, S. V., Browne, D. L., & O’Brien, M. (2018). 9 Immobilized Reagents and Multistep Processes. In Flow Chemistry in Organic Synthesis (273-312). (1). Thieme Gruppe. https://doi.org/10.1055/sos-sd-228-00177

Multistep continuous-flow processing enables the direct preparation of complex chemical materials from simple input streams through a series of complexity-adding reaction steps. The use of polymer-supported reagents can greatly facilitate this proces... Read More about 9 Immobilized Reagents and Multistep Processes.

Highly diastereoselective boron and titanium mediated aldol reactions of a mannitol derived 2,3-butanediacetal ethyl ketone (2018)
Journal Article
O'Brien, M., Weber, A., Hardy, G., & Ley, S. (2018). Highly diastereoselective boron and titanium mediated aldol reactions of a mannitol derived 2,3-butanediacetal ethyl ketone. Tetrahedron, 5319 - 5329. https://doi.org/10.1016/j.tet.2018.06.041

A mannitol derived 2,3-butanediacetal ethyl ketone displays high levels of diastereoselectivity in boron and titanium mediated aldol reactions with a range of aliphatic and aromatic aldehydes to afford syn aldol products in high yield. The stereochem... Read More about Highly diastereoselective boron and titanium mediated aldol reactions of a mannitol derived 2,3-butanediacetal ethyl ketone.

Gas-liquid flow hydrogenation of nitroarenes: Efficient access to a pharmaceutically relevant pyrrolobenzo[1,4]diazepine scaffold (2018)
Journal Article
Dimitriou, E., Jones, R., Pritchard, R., Miller, G., & O'Brien, M. (2018). Gas-liquid flow hydrogenation of nitroarenes: Efficient access to a pharmaceutically relevant pyrrolobenzo[1,4]diazepine scaffold. Tetrahedron, 74(47), 6795-6803. https://doi.org/10.1016/j.tet.2018.09.025

Using a Tube-in-Tube device based on the amorphous Teflon AF-2400 fluoropolymer, a series of nitroarenes was hydrogenated to afford the corresponding aniline compounds. The system was then applied to the construction of a pyrrolobenzo[1,4]diazapene s... Read More about Gas-liquid flow hydrogenation of nitroarenes: Efficient access to a pharmaceutically relevant pyrrolobenzo[1,4]diazepine scaffold.

An open-source approach to automation in organic synthesis: The flow chemical formation of benzamides using an inline liquid-liquid extraction system and a homemade 3-axis autosampling/product-collection device (2018)
Journal Article
O'Brien, M., Hall, A., Schrauwen, J., & van der Made, J. (2018). An open-source approach to automation in organic synthesis: The flow chemical formation of benzamides using an inline liquid-liquid extraction system and a homemade 3-axis autosampling/product-collection device. Tetrahedron, 3152-3157. https://doi.org/10.1016/j.tet.2018.02.043

Several open-source hardware and software technologies (RAMPS, Python, PySerial, OpenCV) were used to control an automated flow chemical synthesis system. The system was used to effect the synthesis of a series of benzamides. An inexpensive Raspberry... Read More about An open-source approach to automation in organic synthesis: The flow chemical formation of benzamides using an inline liquid-liquid extraction system and a homemade 3-axis autosampling/product-collection device.

An automated colorimetric inline titration of CO2 concentrations in solvent flow streams using a Teflon AF-2400 tube-in-tube device (2017)
Journal Article
O'Brien, M. (2017). An automated colorimetric inline titration of CO2 concentrations in solvent flow streams using a Teflon AF-2400 tube-in-tube device. Journal of Co2 Utilization, 21, 580 - 588. https://doi.org/10.1016/j.jcou.2017.08.020

Abstract Using a number of open source software components (Python, SciPy, OpenCV, PySerial), together with an inexpensive webcam device, an automated inline colorimetric titration methodology was developed to measure CO2 concentration levels in orga... Read More about An automated colorimetric inline titration of CO2 concentrations in solvent flow streams using a Teflon AF-2400 tube-in-tube device.

Harnessing open-source technology for low-cost automation in synthesis: flow chemical deprotection of silyl ethers using a homemade autosampling system. (2017)
Journal Article
O'Brien, M., Konings, L., Martin, M., & Heap, J. (2017). Harnessing open-source technology for low-cost automation in synthesis: flow chemical deprotection of silyl ethers using a homemade autosampling system. Tetrahedron Letters, 2409-2413. https://doi.org/10.1016/j.tetlet.2017.05.008

An inexpensive homemade 3-axis autosampler was used to facilitate the automation of an acid catalysed flow chemical desilylation reaction. Harnessing open-source software technologies (Python, OpenCV), an automated computer-vision controlled liquid-l... Read More about Harnessing open-source technology for low-cost automation in synthesis: flow chemical deprotection of silyl ethers using a homemade autosampling system..