Outputs (70)

Reciprocal regulation of GAS5 lncRNA levels and mTOR inhibitor action in prostate cancer cells (2015)
Journal Article
(2015). Reciprocal regulation of GAS5 lncRNA levels and mTOR inhibitor action in prostate cancer cells. Prostate, 693 -705. https://doi.org/10.1002/pros.22952

BACKGROUND: New therapies are required for castrate-resistant prostate cancer (CRPC), and growth-arrest specific 5 (GAS5) lncRNA, which riborepresses androgen receptor action, may offer novel opportunities in this regard. This lncRNA promotes the apo... Read More about Reciprocal regulation of GAS5 lncRNA levels and mTOR inhibitor action in prostate cancer cells.

Description of Siccibacter colletis sp. nov., a novel species isolated from plant material, and emended description of Siccibacter turicensis (2015)
Journal Article
Masood. (2015). Description of Siccibacter colletis sp. nov., a novel species isolated from plant material, and emended description of Siccibacter turicensis. International Journal of Systematic and Evolutionary Microbiology, 1335 - 1341. https://doi.org/10.1099/ijs.0.000108

A re-evaluation of the taxonomic position of two strains, 1383T and 2249, isolated from poppy seeds and tea leaves, which had been identified as Siccibacter turicensis (formerly Cronobacter zurichensis ), was carried out. The analysis included phenot... Read More about Description of Siccibacter colletis sp. nov., a novel species isolated from plant material, and emended description of Siccibacter turicensis.

Functional analysis of sirtuin genes in multiple Plasmodium falciparum strains. (2015)
Journal Article
(2015). Functional analysis of sirtuin genes in multiple Plasmodium falciparum strains. PloS one, e0118865 - ?. https://doi.org/10.1371/journal.pone.0118865

Plasmodium falciparum, the causative agent of severe human malaria, employs antigenic variation to avoid host immunity. Antigenic variation is achieved by transcriptional switching amongst polymorphic var genes, enforced by epigenetic modification of... Read More about Functional analysis of sirtuin genes in multiple Plasmodium falciparum strains..

SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells (2015)
Journal Article
Vicente, C., Andrade De Lima, M., Nader, H., & Toma, L. (2015). SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells. Journal of Experimental & Clinical Cancer Research, 34, 25--25. https://doi.org/10.1186/s13046-015-0141-x

Background
SULF2 is a 6-O-endosulfatase which removes 6-O sulfate residues from N-glucosamine present on heparan sulfate (HS). The sulfation pattern of HS influences signaling events mediated by heparan sulfate proteoglycans (HSPGs) located on cell... Read More about SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells.

A role for the long non-coding RNA growth arrest specific transcript 5 (GAS5) in cytokine-induced beta cell death (2015)
Journal Article
(2015). A role for the long non-coding RNA growth arrest specific transcript 5 (GAS5) in cytokine-induced beta cell death. Diabetic Medicine, 39 - 39. https://doi.org/10.1111/dme.12668

Pro-inflammatory cytokines are known inducers of beta cell death in the pathogenesis of Type 1 diabetes and mediate their effects through the perturbation of multiple regulatory gene networks. GAS5, a long non-coding RNA whose expression negatively c... Read More about A role for the long non-coding RNA growth arrest specific transcript 5 (GAS5) in cytokine-induced beta cell death.

Heparin derivatives for the targeting of multiple activities in the inflammatory response. (2015)
Journal Article
Veraldi, N., Hughes, A., Rudd, T., Thomas, H., Edwards, S., Hadfield, L., …Yates, E. (2015). Heparin derivatives for the targeting of multiple activities in the inflammatory response. Carbohydrate Polymers, 400 - 407. https://doi.org/10.1016/j.carbpol.2014.09.079

An attractive strategy for ameliorating symptoms arising from the multi-faceted processes of excessive and/or continual inflammation would be to identify compounds able to interfere with multiple effectors of inflammation. The well-tolerated pharmace... Read More about Heparin derivatives for the targeting of multiple activities in the inflammatory response..

Distribution of Lutzomyia longipalpis chemotype populations in São Paulo state, Brazil. (2015)
Journal Article
(2015). Distribution of Lutzomyia longipalpis chemotype populations in São Paulo state, Brazil. PLoS Neglected Tropical Diseases, e0003620 - ?. https://doi.org/10.1371/journal.pntd.0003620

BACKGROUND: American visceral leishmaniasis (AVL) is an emerging disease in the state of São Paulo, Brazil. Its geographical expansion and the increase in the number of human cases has been linked to dispersion of Lutzomyia longipalpis into urban are... Read More about Distribution of Lutzomyia longipalpis chemotype populations in São Paulo state, Brazil..

Synchrotron radiation macromolecular crystallography: science and spin-offs. (2015)
Journal Article
(2015). Synchrotron radiation macromolecular crystallography: science and spin-offs. IUCrJ, 283 - 291. https://doi.org/10.1107/S205225251402795X

A current overview of synchrotron radiation (SR) in macromolecular crystallography (MX) instrumentation, methods and applications is presented. Automation has been and remains a central development in the last decade, as have the rise of remote acces... Read More about Synchrotron radiation macromolecular crystallography: science and spin-offs..

New insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences. (2015)
Journal Article
Forrester-Soto. (2015). New insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences. PloS one, e0117849 - e0117849. https://doi.org/10.1371/journal.pone.0117849

To generate the most diverse phylogenetic dataset for the flaviviruses to date, we determined the genomic sequences and phylogenetic relationships of 14 flaviviruses, of which 10 are primarily associated with Culex spp. mosquitoes. We analyze these d... Read More about New insights into flavivirus evolution, taxonomy and biogeographic history, extended by analysis of canonical and alternative coding sequences..

The germline of the malaria mosquito produces abundant miRNAs, endo-siRNAs, piRNAs and 29-nt small RNAs. (2015)
Journal Article
Castellano, L., Rizzi, E., Krell, J., Di Cristina, M., Galizi, R., Mori, A., …Nolan, T. (2015). The germline of the malaria mosquito produces abundant miRNAs, endo-siRNAs, piRNAs and 29-nt small RNAs. BMC Genomics, 100 - ?. https://doi.org/10.1186/s12864-015-1257-2

BACKGROUND: Small RNAs include different classes essential for endogenous gene regulation and cellular defence against genomic parasites. However, a comprehensive analysis of the small RNA pathways in the germline of the mosquito Anopheles gambiae ha... Read More about The germline of the malaria mosquito produces abundant miRNAs, endo-siRNAs, piRNAs and 29-nt small RNAs..