Outputs (88)

Aluminium in Brain Tissue in Multiple Sclerosis. (2018)
Journal Article
(2018). Aluminium in Brain Tissue in Multiple Sclerosis. International Journal of Environmental Research and Public Health, https://doi.org/10.3390/ijerph15081777

Multiple sclerosis (MS) is a devastating and debilitating neurodegenerative disease of unknown cause. A consensus suggests the involvement of both genetic and environmental factors of which the latter may involve human exposure to aluminium. There ar... Read More about Aluminium in Brain Tissue in Multiple Sclerosis..

Where backyard poultry raisers seek care for sick poultry: implications for avian influenza prevention in Bangladesh (2018)
Journal Article
Rimi, N. A., Sultana, R., Ishtiak-Ahmed, K., Haider, N., Azziz-Baumgartner, E., Nahar, N., & Luby, S. P. (in press). Where backyard poultry raisers seek care for sick poultry: implications for avian influenza prevention in Bangladesh. BMC Public Health, 18, 1-9. https://doi.org/10.1186/s12889-018-5819-5

Background
In Bangladesh, backyard poultry raisers lack awareness of avian influenza and infrequently follow government recommendations for its prevention. Identifying where poultry raisers seek care for their ill poultry might help the government b... Read More about Where backyard poultry raisers seek care for sick poultry: implications for avian influenza prevention in Bangladesh.

Variable changes in nematode infection prevalence and intensity after Rabbit Haemorrhagic Disease Virus emerged in wild rabbits in Scotland and New Zealand (2018)
Journal Article
(2018). Variable changes in nematode infection prevalence and intensity after Rabbit Haemorrhagic Disease Virus emerged in wild rabbits in Scotland and New Zealand. International Journal for Parasitology: Parasites and Wildlife, 187 -195. https://doi.org/10.1016/j.ijppaw.2018.05.002

The myxoma virus (a microparasite) reduced wild rabbit numbers worldwide when introduced in the 1950s, and is known to interact with co-infecting helminths (macroparasites) causing both increases and decreases in macroparasite population size. In the... Read More about Variable changes in nematode infection prevalence and intensity after Rabbit Haemorrhagic Disease Virus emerged in wild rabbits in Scotland and New Zealand.

Maize Chlorotic Mottle Virus Induces Changes in Host Plant Volatiles that Attract Vector Thrips Species (2018)
Journal Article
Bruce, T., Subramanian, S., Mwando, N., Tamiru, A., Nyasani, J., Obonyo, M., & Caulfield, J. (2018). Maize Chlorotic Mottle Virus Induces Changes in Host Plant Volatiles that Attract Vector Thrips Species. Journal of Chemical Ecology, 681-689. https://doi.org/10.1007/s10886-018-0973-x

Maize lethal necrosis is one of the most devastating diseases of maize causing yield losses reaching up to 90% in sub-Saharan Africa. The disease is caused by a combination of maize chlorotic mottle virus (MCMV) and any one of cereal viruses in the P... Read More about Maize Chlorotic Mottle Virus Induces Changes in Host Plant Volatiles that Attract Vector Thrips Species.

Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease (2018)
Journal Article
Mycroft-West, C. J., Yates, E. A., & Skidmore, M. A. (2018). Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease. Biochemical Society Transactions, 46(4), 919-929. https://doi.org/10.1042/bst20170404

Glycosaminoglycans (GAGs), present in the extracellular matrix, are exploited by numerous, distinct microbes for cellular attachment, adhesion, invasion and evasion of the host immune system. Glycosaminoglycans, including the widely used, clinical an... Read More about Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease.

Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA (2018)
Journal Article
Yokoyama, M., Stevens, E., Laabei, M., Bacon, L., Heesom, K., Bayliss, S., …Massey, R. C. (2018). Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA. Genome Biology, 19, Article 94. https://doi.org/10.1186/s13059-018-1469-2

Background
Fitness costs imposed on bacteria by antibiotic resistance mechanisms are believed to hamper their dissemination. The scale of these costs is highly variable. Some, including resistance of Staphylococcus aureus to the clinically important... Read More about Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA.

Sweet Scents: Nectar Specialist Yeasts Enhance Nectar Attraction of a Generalist Aphid Parasitoid Without Affecting Survival (2018)
Journal Article
(2018). Sweet Scents: Nectar Specialist Yeasts Enhance Nectar Attraction of a Generalist Aphid Parasitoid Without Affecting Survival. Frontiers in Plant Science, https://doi.org/10.3389/fpls.2018.01009

Floral nectar is commonly inhabited by microorganisms, mostly yeasts and bacteria, which can have a strong impact on nectar chemistry and scent. Yet, little is known about the effects of nectar microbes on the behavior and survival of insects belongi... Read More about Sweet Scents: Nectar Specialist Yeasts Enhance Nectar Attraction of a Generalist Aphid Parasitoid Without Affecting Survival.

Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays. (2018)
Journal Article
Price, H., Berry, S., Hameed, H., Thomason, A., Maciej-Hulme, M., Saif Abou-Akkada, S., & Horrocks, P. (2018). Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays. PLoS Neglected Tropical Diseases, 12(7), Article e0006639 . https://doi.org/10.1371/journal.pntd.0006639

The protozoan parasite Leishmania causes leishmaniasis; a spectrum of diseases of which there are an estimated 1 million new cases each year. Current treatments are toxic, expensive, difficult to administer, and resistance to them is emerging. New th... Read More about Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays..

PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2 (2018)
Journal Article
Desbois, M., Crawley, O., Evans, P. R., Baker, S. T., Masuho, I., Yasuda, R., & Grill, B. (2018). PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2. Journal of biological chemistry, 293(36), 13897-13909. https://doi.org/10.1074/jbc.ra118.002176

PHR (PAM/Highwire/RPM-1) proteins are conserved RING E3 ubiquitin ligases that function in developmental processes, such as axon termination and synapse formation, as well as axon degeneration. At present, our understanding of how PHR proteins form u... Read More about PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2.

Heparin and heparin-like molecules inhibit the Alzheimer’s ß-secretase (BACE1): considerations for biological assay and future therapeutic development (2018)
Thesis
Hadfield, L. C. (2018). Heparin and heparin-like molecules inhibit the Alzheimer’s ß-secretase (BACE1): considerations for biological assay and future therapeutic development. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411146

The biologically and medically important heparan sulphate and heparin polysaccharides have previously been shown to modulate the activity of an aspartyl protease, ß-secretase (BACE1), implicated in the aetiology of Alzheimer’s disease. Research group... Read More about Heparin and heparin-like molecules inhibit the Alzheimer’s ß-secretase (BACE1): considerations for biological assay and future therapeutic development.