Outputs (88)

Structural characterisation of oligosaccharide recognition by surfactant protein D (2018)
Thesis
Littlejohn, J. R. (2018). Structural characterisation of oligosaccharide recognition by surfactant protein D. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411451

Human surfactant protein D (hSP-D) is a C-type lectin and member of the collectin family that is involved in pathogen recognition as part of the innate immune response. Recognition occurs through the carbohydrate arrays on the surfaces of the pathoge... Read More about Structural characterisation of oligosaccharide recognition by surfactant protein D.

Heparin and heparin-like molecules inhibit the Alzheimer’s ß-secretase (BACE1): considerations for biological assay and future therapeutic development (2018)
Thesis
Hadfield, L. C. (2018). Heparin and heparin-like molecules inhibit the Alzheimer’s ß-secretase (BACE1): considerations for biological assay and future therapeutic development. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411146

The biologically and medically important heparan sulphate and heparin polysaccharides have previously been shown to modulate the activity of an aspartyl protease, ß-secretase (BACE1), implicated in the aetiology of Alzheimer’s disease. Research group... Read More about Heparin and heparin-like molecules inhibit the Alzheimer’s ß-secretase (BACE1): considerations for biological assay and future therapeutic development.

Identification of differentially expressed lncrnas in metformin resistant SH-SY5Y neuroblastoma cells (2018)
Conference Proceeding
Bountali, K., Maarabouni, M., & Tonge, D. (2018). Identification of differentially expressed lncrnas in metformin resistant SH-SY5Y neuroblastoma cells. . https://doi.org/10.1136/esmoopen-2018-EACR25.861

Abstract
Introduction Of the total human DNA only 1.2% o codes for proteins, with the rest only being transcribed into regulatory RNA, known as non-coding RNA. Long non-coding RNAs (lncRNAs) are non-coding RNAs that have no or limited protein-coding... Read More about Identification of differentially expressed lncrnas in metformin resistant SH-SY5Y neuroblastoma cells.

Proteomic Profiling of Enteroid Cultures Skewed toward Development of Specific Epithelial Lineages (2018)
Journal Article
(2018). Proteomic Profiling of Enteroid Cultures Skewed toward Development of Specific Epithelial Lineages. Proteomics, https://doi.org/10.1002/pmic.201800132

Recently, 3D small intestinal organoids (enteroids) have been developed from cultures of intestinal stem cells which differentiate in vitro to generate all the differentiated epithelial cell types associated with the intestine and mimic the structura... Read More about Proteomic Profiling of Enteroid Cultures Skewed toward Development of Specific Epithelial Lineages.

Conformational States of ABC Transporter MsbA in a Lipid Environment Investigated by Small-Angle Scattering Using Stealth Carrier Nanodiscs. (2018)
Journal Article
(2018). Conformational States of ABC Transporter MsbA in a Lipid Environment Investigated by Small-Angle Scattering Using Stealth Carrier Nanodiscs. Structure, 1072 - 1079.e4. https://doi.org/10.1016/j.str.2018.05.007

Structural studies of integral membrane proteins (IMPs) are challenging, as many of them are inactive or insoluble in the absence of a lipid environment. Here, we describe an approach making use of fractionally deuterium labeled "stealth carrier" nan... Read More about Conformational States of ABC Transporter MsbA in a Lipid Environment Investigated by Small-Angle Scattering Using Stealth Carrier Nanodiscs..

Avian influenza surveillance in domestic waterfowl and environment of live bird markets in Bangladesh, 2007–2012 (2018)
Journal Article
Uddin Khan, S., Gurley, E. S., Gerloff, N., Rahman, M. Z., Simpson, N., Rahman, M., …Luby, S. P. (in press). Avian influenza surveillance in domestic waterfowl and environment of live bird markets in Bangladesh, 2007–2012. Scientific reports, 8, 1-10. https://doi.org/10.1038/s41598-018-27515-w

Avian influenza viruses, including highly pathogenic strains, pose severe economic, animal and public health concerns. We implemented live bird market surveillance in Bangladesh to identify the subtypes of avian influenza A viruses in domestic waterf... Read More about Avian influenza surveillance in domestic waterfowl and environment of live bird markets in Bangladesh, 2007–2012.

Structural definition of hSP-D recognition of Salmonella enterica LPS inner core oligosaccharides 1 reveals alternative binding modes for the same LPS (2018)
Journal Article
Littlejohn, J. R., da Silva, R. F., Neale, W. A., Smallcombe, C. C., Clark, H. W., Mackay, R. A., …Shrive, A. K. (2018). Structural definition of hSP-D recognition of Salmonella enterica LPS inner core oligosaccharides 1 reveals alternative binding modes for the same LPS. PloS one, https://doi.org/10.1371/journal.pone.0199175

The crystal structures of a biologically and therapeutically active recombinant homotrimeric fragment of native human SP-D (hSP-D) complexed with the inner core oligosaccharide of the Salmonella enterica sv Minnesota rough strains R5 and R7 (rough mu... Read More about Structural definition of hSP-D recognition of Salmonella enterica LPS inner core oligosaccharides 1 reveals alternative binding modes for the same LPS.

Long noncoding RNA MIAT regulates apoptosis and the apoptotic response to chemotherapeutic agents in breast cancer cell lines (2018)
Journal Article
Almnaseer, Z. A., & Mourtada-Maarabouni, M. (2018). Long noncoding RNA MIAT regulates apoptosis and the apoptotic response to chemotherapeutic agents in breast cancer cell lines. Bioscience Reports, 38(4), https://doi.org/10.1042/BSR20180704

The long noncoding RNA myocardial infarction associated transcript (MIAT) is involved in a number of diseases, including myocardial infarction and diabetic retinopathy. Emerging evidence suggests that MIAT expression levels are increased in different... Read More about Long noncoding RNA MIAT regulates apoptosis and the apoptotic response to chemotherapeutic agents in breast cancer cell lines.

Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation (2018)
Journal Article
(2018). Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation. Nature communications, https://doi.org/10.1038/s41467-018-04581-2

Macrophage migration inhibitory factor (MIF) exerts multiple effects on immune cells, as well as having functions outside the immune system. MIF can promote inflammation through the induction of other cytokines, including TNF, IL-6, and IL-1 family c... Read More about Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation.

Heparin Oligosaccharides Have Antiarrhythmic Effect by Accelerating the Sodium-Calcium Exchanger (2018)
Journal Article
de Godoy, C., Vasques, Ê., Caricati-Neto, A., Tavares, J., Alves, B., Duarte, J., …dos Santos Tersariol, I. (2018). Heparin Oligosaccharides Have Antiarrhythmic Effect by Accelerating the Sodium-Calcium Exchanger. Frontiers in Cardiovascular Medicine, 5, https://doi.org/10.3389/fcvm.2018.00067

Background: Blockage of the Na+/Ca2+ exchanger (NCX) is used to determine the role of NCX in arrhythmogenesis. Trisulfated heparin disaccharide (TD) and Low Molecular Weight Heparins (LMWHs) can directly interact with the NCX and accelerate its activ... Read More about Heparin Oligosaccharides Have Antiarrhythmic Effect by Accelerating the Sodium-Calcium Exchanger.