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Outputs (95)

Placing Leishmaniasis in the Limelight through the Communicable Disease Surveillance System: An Experience from Sri Lanka. (2022)
Journal Article
Gunasekara, S., Nuwangi, H., Wickramasinghe, N., Weerakoon, K., Price, H. P., Dikomitis, L., & Agampodi, S. B. (2022). Placing Leishmaniasis in the Limelight through the Communicable Disease Surveillance System: An Experience from Sri Lanka. Pathogens, 11(6), Article 680. https://doi.org/10.3390/pathogens11060680

Having an effective surveillance system is imperative to take timely and appropriate actions for disease control and prevention. In Sri Lanka, leishmaniasis was declared as a notifiable disease in 2008. This paper presents a comprehensive compilation... Read More about Placing Leishmaniasis in the Limelight through the Communicable Disease Surveillance System: An Experience from Sri Lanka..

The Immune System of Marine Organisms as Source for Drugs against Infectious Diseases (2022)
Journal Article
Falco, A., Adamek, M., Pereiro, P., Hoole, D., Encinar, J., Novoa, B., & Mallavia, R. (2022). The Immune System of Marine Organisms as Source for Drugs against Infectious Diseases. Marine Drugs, 20(6), Article 363. https://doi.org/10.3390/md20060363

The high proliferation of microorganisms in aquatic environments has allowed their coevolution for billions of years with other living beings that also inhabit these niches. Among the different existing types of interaction, the eternal competition f... Read More about The Immune System of Marine Organisms as Source for Drugs against Infectious Diseases.

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction. (2022)
Journal Article
Guimond, S., Mycroft-West, C. J., Gandhi, N. S., Tree, J. A., C.Le, T. T., Spalluto, M., …Turnbull, J. E. (2022). Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction. ACS Central Science, 8(5), 527 - 545. https://doi.org/10.1021/acscentsci.1c01293

Heparan sulfate (HS) is a cell surface polysaccharide recently identified as a coreceptor with the ACE2 protein for the S1 spike protein on SARS-CoV-2 virus, providing a tractable new therapeutic target. Clinically used heparins demonstrate an inhibi... Read More about Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction..

Limits to reproduction and seed size-number trade-offs that shape forest dominance and future recovery. (2022)
Journal Article
(2022). Limits to reproduction and seed size-number trade-offs that shape forest dominance and future recovery. Nature communications, 2381 - ?. https://doi.org/10.1038/s41467-022-30037-9

The relationships that control seed production in trees are fundamental to understanding the evolution of forest species and their capacity to recover from increasing losses to drought, fire, and harvest. A synthesis of fecundity data from 714 specie... Read More about Limits to reproduction and seed size-number trade-offs that shape forest dominance and future recovery..

Wild potato ancestors as potential sources of resistance to the aphid Myzus persicae (2022)
Journal Article
Bruce, T. J., Ali, J., & Sobhy, I. S. (2022). Wild potato ancestors as potential sources of resistance to the aphid Myzus persicae. Pest Management Science, 78(9), 3931-3938. https://doi.org/10.1002/ps.6957

BACKGROUND: Plant resistance to insects can be reduced by crop domestication which means their wild ancestors could provide novel sources of resistance. Thus, crossing wild ancestors with domesticated crops can potentially enhance their resistance ag... Read More about Wild potato ancestors as potential sources of resistance to the aphid Myzus persicae.

Moth declines are most severe in broadleaf woodlands despite a net gain in habitat availability (2022)
Journal Article
Blumgart, D., Botham, M. S., Menéndez, R., & Bell, J. R. (2022). Moth declines are most severe in broadleaf woodlands despite a net gain in habitat availability. Insect Conservation and Diversity, 15(5), 496-509. https://doi.org/10.1111/icad.12578

While agricultural intensification and habitat loss are cited as key drivers of moth decline, these alone cannot explain declines observed in UK woodlands – a habitat that has expanded in area since 1968.
We quantified how moth communities changed a... Read More about Moth declines are most severe in broadleaf woodlands despite a net gain in habitat availability.

Globally, tree fecundity exceeds productivity gradients (2022)
Journal Article
Journé, V., Andrus, R., Aravena, M., Ascoli, D., Berretti, R., Berveiller, D., …Clark, J. S. (2022). Globally, tree fecundity exceeds productivity gradients. Ecology Letters, 25(6), 1471-1482. https://doi.org/10.1111/ele.14012

Lack of tree fecundity data across climatic gradients precludes the analysis of how seed supply contributes to global variation in forest regeneration and biotic interactions responsible for biodiversity. A global synthesis of raw seedproduction data... Read More about Globally, tree fecundity exceeds productivity gradients.

Ubiquitin ligase activity inhibits Cdk5 to control axon termination (2022)
Journal Article
Desbois, M., J. Opperman, K., Amezquita, J., Gaglio, G., Crawley, O., & Grill, B. (2022). Ubiquitin ligase activity inhibits Cdk5 to control axon termination. PLOS genetics, 18(4), Article e1010152. https://doi.org/10.1371/journal.pgen.1010152

The Cdk5 kinase plays prominent roles in nervous system development, plasticity, behavior and disease. It also has important, non-neuronal functions in cancer, the immune system and insulin secretion. At present, we do not fully understand negative r... Read More about Ubiquitin ligase activity inhibits Cdk5 to control axon termination.