Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

Ghezzi, Silvia; Cooper, Lynsay; Rubio, Alicia; Pagani, Isabel; Rosaria Capobianchi, Maria; Ippolito, Giuseppe; Pelletier, Julien; Meneghetti, Maria Cecilia Z.; Lima, Marcelo A.; Skidmore, Mark; Broccoli, Vania; Yates, Edwin A.; Vicenzi, Elisa

Abstract

The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs).

Citation

Ghezzi, S., Cooper, L., Rubio, A., Pagani, I., Rosaria Capobianchi, M., Ippolito, G., Pelletier, J., Meneghetti, M. C. Z., Lima, M. A., Skidmore, M., Broccoli, V., Yates, E. A., & Vicenzi, E. (2017). Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells. Antiviral Research, 140, 13-17. https://doi.org/10.1016/j.antiviral.2016.12.023

• Journal Article Type: Article
• Acceptance Date: Dec 29, 2016
• Publication Date: Jan 5, 2017
• Publicly Available Date: May 26, 2023
• Journal: Antiviral Research
• Print ISSN: 0166-3542
• Publisher: Elsevier
• Volume: 140
• Pages: 13-17
• DOI: https://doi.org/10.1016/j.antiviral.2016.12.023
• Keywords: Cell death, Heparin, Neural progenitor cells, Zika virus (ZIKV), Cell Death, Cytopathogenic Effect, Viral, Drug Repositioning, Heparin, Humans, Neural Stem Cells, Zika Virus
• Public URL: https://keele-repository.worktribe.com/output/407651
• Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28063994