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The Immune System of Marine Organisms as Source for Drugs against Infectious Diseases (2022)
Journal Article
Falco, A., Adamek, M., Pereiro, P., Hoole, D., Encinar, J., Novoa, B., & Mallavia, R. (2022). The Immune System of Marine Organisms as Source for Drugs against Infectious Diseases. Marine Drugs, 20(6), Article 363. https://doi.org/10.3390/md20060363

The high proliferation of microorganisms in aquatic environments has allowed their coevolution for billions of years with other living beings that also inhabit these niches. Among the different existing types of interaction, the eternal competition f... Read More about The Immune System of Marine Organisms as Source for Drugs against Infectious Diseases.

Analysis of protein-heparin interactions using a portable SPR instrument (2022)
Journal Article
Su, D., Li, Y., Yates, E., Skidmore, M., Andrade De Lima, M., & Fernig, D. (2022). Analysis of protein-heparin interactions using a portable SPR instrument. PeerJ Analytical Chemistry, 4, 1-16. https://doi.org/10.7717/peerj-achem.15

<jats:p>Optical biosensors such as those based on surface plasmon resonance (SPR) are a key analytical tool for understanding biomolecular interactions and function as well as the quantitative analysis of analytes in a wide variety of settings. The a... Read More about Analysis of protein-heparin interactions using a portable SPR instrument.

Standardised bioassays reveal that mosquitoes learn to avoid compounds used in chemical vector control after a single sub-lethal exposure. (2022)
Journal Article
(2022). Standardised bioassays reveal that mosquitoes learn to avoid compounds used in chemical vector control after a single sub-lethal exposure. Scientific reports, 2206 - ?. https://doi.org/10.1038/s41598-022-05754-2

Vector-borne diseases are worldwide public health issues. Despite research focused on vectorial capacity determinants in pathogen transmitting mosquitoes, their behavioural plasticity remains poorly understood. Memory and associative learning have be... Read More about Standardised bioassays reveal that mosquitoes learn to avoid compounds used in chemical vector control after a single sub-lethal exposure..

MASTREE+: time-series of plant reproductive effort from six continents. (2022)
Journal Article
(2022). MASTREE+: time-series of plant reproductive effort from six continents. Global Change Biology, 3066-3082. https://doi.org/10.1111/gcb.16130

Significant gaps remain in understanding the response of plant reproduction to environmental change. This is partly because measuring reproduction in long-lived plants requires direct observation over many years and such datasets have rarely been mad... Read More about MASTREE+: time-series of plant reproductive effort from six continents..

Bacterial lipopolysaccharide recognition by surfactant protein D (2021)
Presentation / Conference
Shrive, & Greenhough. (2021, August). Bacterial lipopolysaccharide recognition by surfactant protein D. Presented at XXV IUCr Congress, Prague, Czech Republic

Human surfactant protein D is a collectin and member of the C-type lectin superfamily of proteins that forms an essential part of the mammalian innate immune system. The collectins have been recognised to not only bind to invading pathogens, allowing... Read More about Bacterial lipopolysaccharide recognition by surfactant protein D.

Evolving origin-of-transfer sequences on staphylococcal conjugative and mobilizable plasmids—who’s mimicking whom? (2021)
Journal Article
(2021). Evolving origin-of-transfer sequences on staphylococcal conjugative and mobilizable plasmids—who’s mimicking whom?. Nucleic Acids Research, 5177 - 5188. https://doi.org/10.1093/nar/gkab303

<jats:title>Abstract</jats:title> <jats:p>In Staphylococcus aureus, most multiresistance plasmids lack conjugation or mobilization genes for horizontal transfer. However, most are mobilizable due to carriage of origin-of-transfer (oriT) sequences mim... Read More about Evolving origin-of-transfer sequences on staphylococcal conjugative and mobilizable plasmids—who’s mimicking whom?.

Environmental DNA provides higher resolution assessment of riverine biodiversity and ecosystem function via spatio-temporal nestedness and turnover partitioning (2021)
Journal Article
(2021). Environmental DNA provides higher resolution assessment of riverine biodiversity and ecosystem function via spatio-temporal nestedness and turnover partitioning. Communications Biology, 1-12. https://doi.org/10.1038/s42003-021-02031-2

<jats:title>Abstract</jats:title><jats:p>Rapidly assessing biodiversity is essential for environmental monitoring; however, traditional approaches are limited in the scope needed for most ecological systems. Environmental DNA (eDNA) based assessment... Read More about Environmental DNA provides higher resolution assessment of riverine biodiversity and ecosystem function via spatio-temporal nestedness and turnover partitioning.

ApoE and ApoE Nascent-Like HDL Particles at Model Cellular Membranes: Effect of Protein Isoform and Membrane Composition. (2021)
Journal Article
(2021). ApoE and ApoE Nascent-Like HDL Particles at Model Cellular Membranes: Effect of Protein Isoform and Membrane Composition. Frontiers in Chemistry, 1- 15. https://doi.org/10.3389/fchem.2021.630152

Apolipoprotein E (ApoE), an important mediator of lipid transportation in plasma and the nervous system, plays a large role in diseases such as atherosclerosis and Alzheimer's. The major allele variants ApoE3 and ApoE4 differ only by one amino acid.... Read More about ApoE and ApoE Nascent-Like HDL Particles at Model Cellular Membranes: Effect of Protein Isoform and Membrane Composition..

Temperate zone plant natural products – a novel resource for activity against tropical parasitic diseases (2021)
Journal Article
Hameed, H., King, E., Doleckova, K., Bartholomew, B., Hollinshead, J., Mbye, H., …Price, H. (2021). Temperate zone plant natural products – a novel resource for activity against tropical parasitic diseases. Pharmaceuticals, 14(3), 1-17. https://doi.org/10.3390/ph14030227

The use of plant-derived natural products for the treatment of tropical parasitic diseases often has ethnopharmacological origins. As such, plants grown in temperate regions remain largely untested for novel anti-parasitic activities. We describe her... Read More about Temperate zone plant natural products – a novel resource for activity against tropical parasitic diseases.

ER-Golgi dynamics of HS-modifying enzymes via vesicular trafficking is a critical prerequisite for the delineation of HS biosynthesis (2021)
Journal Article
Meneghetti, M., Deboni, P., Palomino, C., Braga, L., Cavalheiro, R., Viana, G., …Andrade De Lima, M. (2021). ER-Golgi dynamics of HS-modifying enzymes via vesicular trafficking is a critical prerequisite for the delineation of HS biosynthesis. Carbohydrate Polymers, 117477--117477. https://doi.org/10.1016/j.carbpol.2020.117477

The cell surface and extracellular matrix polysaccharide, heparan sulfate (HS) conveys chemical information to control crucial biological processes. HS chains are synthesized in a non-template driven process mainly in the Golgi apparatus, involving a... Read More about ER-Golgi dynamics of HS-modifying enzymes via vesicular trafficking is a critical prerequisite for the delineation of HS biosynthesis.

A Dimerization Site at SCR-17/18 in Factor H Clarifies a New Mechanism for Complement Regulatory Control (2021)
Journal Article
(2021). A Dimerization Site at SCR-17/18 in Factor H Clarifies a New Mechanism for Complement Regulatory Control. Frontiers in Immunology, 601895 - ?. https://doi.org/10.3389/fimmu.2020.601895

Complement Factor H (CFH), with 20 short complement regulator (SCR) domains, regulates the alternative pathway of complement in part through the interaction of its C-terminal SCR-19 and SCR-20 domains with host cell-bound C3b and anionic oligosacchar... Read More about A Dimerization Site at SCR-17/18 in Factor H Clarifies a New Mechanism for Complement Regulatory Control.

In vivo efficacy and metabolism of the antimalarial cycleanine and improved in vitro antiplasmodial activity of novel semisynthetic analogues. (2020)
Journal Article
Ijeoma Uche, F., Guo, X., Okokon, J., Ullah, I., Horrocks, P., Boateng, J., …Li, W. (2020). In vivo efficacy and metabolism of the antimalarial cycleanine and improved in vitro antiplasmodial activity of novel semisynthetic analogues. Antimicrobial Agents and Chemotherapy, https://doi.org/10.1128/AAC.01995-20

Bisbenzylisoquinoline (BBIQ) alkaloids are a diverse group of natural products that demonstrate a range of biological activities. In this study, the in vitro antiplasmodial activity of three BBIQ alkaloids (cycleanine (1), isochondodendrine (2) and 2... Read More about In vivo efficacy and metabolism of the antimalarial cycleanine and improved in vitro antiplasmodial activity of novel semisynthetic analogues..

Engineered RNA-Interacting CRISPR Guide RNAs for Genetic Sensing and Diagnostics (2020)
Journal Article
Galizi, R., Duncan, J. N., Rostain, W., Quinn, C. M., Storch, M., Kushwaha, M., & Jaramillo, A. (2020). Engineered RNA-Interacting CRISPR Guide RNAs for Genetic Sensing and Diagnostics. The CRISPR Journal, 398 - 408. https://doi.org/10.1089/crispr.2020.0029

CRISPR guide RNAs (gRNAs) can be programmed with relative ease to allow the genetic editing of nearly any DNA or RNA sequence. Here, we propose novel molecular architectures to achieve RNA-dependent modulation of CRISPR activity in response to specif... Read More about Engineered RNA-Interacting CRISPR Guide RNAs for Genetic Sensing and Diagnostics.

Lipoprotein ability to exchange and remove lipids from model membranes as a function of fatty acid saturation and presence of cholesterol (2020)
Journal Article
(2020). Lipoprotein ability to exchange and remove lipids from model membranes as a function of fatty acid saturation and presence of cholesterol. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 158769 - ?. https://doi.org/10.1016/j.bbalip.2020.158769

Lipoproteins play a central role in the development of atherosclerosis. High and low-density lipoproteins (HDL and LDL), known as 'good' and 'bad' cholesterol, respectively, remove and/or deposit lipids into the artery wall. Hence, insight into lipid... Read More about Lipoprotein ability to exchange and remove lipids from model membranes as a function of fatty acid saturation and presence of cholesterol.

Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by Neospora caninum. (2020)
Journal Article
Wastling. (2020). Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by Neospora caninum. Pathogens an international, open access journal of pathogens and pathogen-host interactions, https://doi.org/10.3390/pathogens9090749

Despite the importance of bovine neosporosis, relevant knowledge gaps remain concerning the pathogenic mechanisms of Neospora caninum. Infection of the placenta is a crucial event in the pathogenesis of the disease; however, very little is known abou... Read More about Proteomic Characterization of Host-Pathogen Interactions during Bovine Trophoblast Cell Line Infection by Neospora caninum..

Parallelized Manipulation of Adherent Living Cells by Magnetic Nanoparticles-Mediated Forces (2020)
Journal Article
Coppey, M., Piehler, J., Gates, M., Neumann, S., Telling, N., Heumann, R., …Raudzus, F. (2020). Parallelized Manipulation of Adherent Living Cells by Magnetic Nanoparticles-Mediated Forces. International Journal of Molecular Sciences, 21(18), https://doi.org/10.3390/ijms21186560

The remote actuation of cellular processes such as migration or neuronal outgrowth is a challenge for future therapeutic applications in regenerative medicine. Among the different methods that have been proposed, the use of magnetic nanoparticles app... Read More about Parallelized Manipulation of Adherent Living Cells by Magnetic Nanoparticles-Mediated Forces.

Cytotoxic effect of PEI-coated magnetic nanoparticles on the regulation of cellular focal adhesions and actin stress fibres (2020)
Journal Article
Telling. (2020). Cytotoxic effect of PEI-coated magnetic nanoparticles on the regulation of cellular focal adhesions and actin stress fibres. https://doi.org/10.2139/ssrn.3558242

The biocompatibility of surface-coated magnetic nanoparticles (MNPs) is key to their successful use in biomedical applications. Polyethyleneimine-coated MNPs (MNP-PEIs) provide improved in vitro nucleic acid transfection efficiency and are safer comp... Read More about Cytotoxic effect of PEI-coated magnetic nanoparticles on the regulation of cellular focal adhesions and actin stress fibres.

Controlling human platelet activation with calcium-binding nanoparticles (2020)
Journal Article
Cabrera, D., Walker, K., Moise, S., Telling, N. D., & Harper, A. G. (2020). Controlling human platelet activation with calcium-binding nanoparticles. Nano Research, 13, Article 2697–2705. https://doi.org/10.1007/s12274-020-2912-8

We introduce a neural method that is able to fuse concepts from a knowledge base with the context information for the task of grouping of aspect terms. Rather than only using context information, we use the corresponding concepts of aspect terms as a... Read More about Controlling human platelet activation with calcium-binding nanoparticles.

Production of perdeuterated fucose from glyco-engineered bacteria (2020)
Journal Article
(2020). Production of perdeuterated fucose from glyco-engineered bacteria. Glycobiology, 151-158. https://doi.org/10.1093/glycob/cwaa059

L-Fucose and L-fucose-containing polysaccharides, glycoproteins or glycolipids play an important role in a variety of biological processes. L-Fucose-containing glycoconjugates have been implicated in many diseases including cancer and rheumatoid arth... Read More about Production of perdeuterated fucose from glyco-engineered bacteria.